Carbachol restores insulin release in diabetic GK rat islets by mechanisms largely involving hydrolysis of diacylglycerol and direct interaction with the exocytotic machinery

Pancreas

Volumn 22, Issue 2, 2001, Pages 164-171

  Guenifi, Amel ^a,b   Simonsson, Erik ^a,b   Karlsson, Sven ^a,b   Ahrén, Bo ^a,b   Abdel Halim, Samy M ^a,b,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Carbachol; Goto Kakizaki (GK) rats; Insulin release; Phospholipase C; PLC; Type II diabetes

Indexed keywords

CARBACHOL; DIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; EXOCYTOSIS; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONIC ACID; CARBACHOL; CHOLINERGIC AGONISTS; CYCLIC AMP; DIABETES MELLITUS; DIGLYCERIDES; EXOCYTOSIS; HYDROLYSIS; INSULIN; ISLETS OF LANGERHANS; MALE; PERFUSION; PROTEIN KINASE C; RATS;

EID: 0035114422     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200103000-00009     Document Type: Article

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