Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats

Diabetes

Volumn 50, Issue 12, 2001, Pages 2737-2743

  Lin, Jian Man ^a   Ortsäter, Henrik ^a   Fakhrai Rad, Hossein ^b   Galli, Joakim ^b   Luthman, Holger ^b,c   Bergsten, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Box 571 ^*

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; ALPHA-KETOISOCAPROIC ACID; GLUCOSE; INSULIN; OXOACID; OXYGEN; TOLBUTAMIDE;

ALLELE; ANIMAL; ARTICLE; CHEMISTRY; CROSS BREEDING; DRUG EFFECT; GENETIC PREDISPOSITION; GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PERIODICITY; PHENOTYPE; RAT; RAT STRAIN;

ALLELES; ANIMAL; CROSSES, GENETIC; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; OXYGEN; PERIODICITY; PHENOTYPE; RATS; RATS, INBRED F344; SUPPORT, NON-U.S. GOV'T; TOLBUTAMIDE;

EID: 0035653489     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.12.2737     Document Type: Article

References (52)

1. Barnett AH, Eff C, Leslie RD, Pyke DA: Diabetes in identical twins: a study of 200 pairs. Diabetologia 20:87-93, 1981
2. Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD: Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 30:763-768, 1987
3. Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H: Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study. Diabetologia 42:139-145, 1999
4. Ghosh S, Schork NJ: Genetic analysis of NIDDM: the study of quantitative traits. Diabetes 45:1-14, 1996
5. Turner RC, Hattersley AT, Shaw JT, Levy JC: Type II diabetes: clinical aspects of molecular biological studies. Diabetes 44:1-10, 1995
6. Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H: Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12:31-37, 1996
7. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A: Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12:38-43, 1996
8. Chung WK, Zheng M, Chua M, Kershaw E, Power-Kehoe L, Tsuji M, Wu-Peng XS, Williams J, Chua SC Jr, Leibel RL: Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41:332-344, 1997
9. Watanabe TK, Ono T, Okuno S, Mizoguchi-Miyakita A, Yamasaki Y, Kanemoto N, Hishigaki H, Oga K, Takahashi E, Irie Y: Characterization of newly developed SSLP markers for the rat. Mamm Genome 11:300-305, 2000
10. Kanemoto N, Hishigaki H, Miyakita A, Oga K, Okuno S, Tsuji A, Takagi T, Takahashi E, Nakamura Y, Watanabe TK: Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus. Mamm Genome 9:419-425, 1998
11. Hirayama I, Yi Z, Izumi S, Arai I, Suzuki W, Nagamachi Y, Kuwano H, Takeuchi T, Izumi T: Genetic analysis of obese diabetes in the TSOD mouse. Diabetes 48:1183-1191, 1999
12. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Yamato E, Shibata M, Ogihara T: Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 48:1168-1174, 1999
13. Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K: Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol 139:654-661, 1998
14. Goto Y, Kakizaki M, Masaki N: Spontaneous diabetes produced by selective breeding of normal Wistar rats. Proc Jpn Acad 51:80-85, 1975
15. Goto Y, Kakizaki M: The spontaneous-diabetes rat: a model of noninsulin dependent diabetes mellitus. Proc Jpn Acad 57:381-384, 1981
16. Goto Y, Suzuki K, Ono T, Sasaki M, Toyota T: Development of diabetes in the non-obese NIDDM rat (GK rat). Adv Exp Med Biol 246:29-31, 1988
17. Galli J, Fakhrai-Rad H, Kamel A, Marcus C, Norgren S, Luthman H: Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Diabetes 48:2463-2470, 1999
18. Fakhrai-Rad H, Nikoshkov A, Kamel A, Fernstrom M, Zierath JR, Norgren S, Luthman H, Galli J: Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Hum Mol Genet 9:2149-2158, 2000
19. Bergsten P, Hellman B: Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes 42:670-674, 1993
20. Sykes JA, Moore EB: A new chamber for tissue culture. Proc Soc Exp Biol Med 100:125-127, 1959
21. Revsbech NP: An oxygen microsensor with a guard cathode. Limnol Oceanogr 34:474-478, 1989
22. Ortsäter H, Liss P, Lund PE, Åkerman KEO, Bergsten P: Oscillations in oxygen tension and insulin release of individual pancreatic ob/ob mouse islets. Diabetologia 43:1313-1318, 2000
23. Goto Y, Suzuki KI, Sasaki M, Ono T, Abe S: GK rat as a model of nonobese, noninsulin-dependent diabetes: selective breeding over 35 generations. In Frontiers in Diabetes Research. Lessons From Animal Diabetes II. Shafrir AER, Ed. John Libbey & Company, 1988, p. 301-303
24. Abdel-Halim SM, Guenifi A, Efendic S, Ostenson CG: Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats. Acta Physiol Scand 148:219-226, 1993
25. Bergsten P, Hellman B: Glucose inhibits insulin release when not promoting the entry of calcium into the beta-cells. Biochem Biophys Res Commun 125:875-881, 1984
26. 2+ response to glucose as an indicator of impairment of the pancreatic beta-cell function. Eur J Clin Invest 20 (Suppl. 1):S10-S17, 1990
27. Ostenson CG, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S: Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36:3-8, 1993
28. Giroix MH, Vesco L, Portha B: Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 132:815-822, 1993
29. Zhou YP, Ostenson CG, Ling ZC, Grill V: Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats. Endocrinology 136:3546-3551, 1995
30. Leckstrom A, Ostenson CG, Efendic S, Arnelo U, Permert J, Lundquist I, Westermark P: Increased storage and secretion of islet amyloid polypeptide relative to insulin in the spontaneously diabetic GK rat. Pancreas 13:259-267, 1996
31. Salehi A, Henningsson R, Mosen H, Ostenson CG, Efendic S, Lundquist I: Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat. Endocrinology 140:3045-3053, 1999
32. Abdel-Halim SM, Guenifi A, Khan A, Larsson O, Berggren PO, Ostenson CG, Efendic S: Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP. Diabetes 45:934-940, 1996
33. Ostenson CG, Abdel-Halim SM, Rasschaert J, Malaisse-Lagae F, Meuris S, Sener A, Efendic S, Malaisse WJ: Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia 36:722-726, 1993
34. Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ, Luthman H, Szpirer C: Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Genomics 38:96-99, 1996
35. Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y: Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets. Diabetologia 41:649-653, 1998
36. Ling ZC, Efendic S, Wibom R, Abdel-Halim SM, Ostenson CG, Landau BR, Khan A: Glucose metabolism in Goto-Kakizaki rat islets. Endocrinology 139:2670-2675, 1998
37. Hughes SJ, Faehling M, Thomeley CW, Proks P, Ashcroft FM, Smith PA: Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats. Diabetes 47:73-81, 1998
38. Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH: Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. Diabetes 48:1020-1025, 1999
39. Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E, Wheeler MB: Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486, 1999
40. Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB: Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50:1302-1310, 2001
41. + channel in mouse pancreatic beta-cells. Pflügers Arch 407:493-499, 1986
42. + channels is impaired in beta-cells of the GK rat: a new genetic model of NIDDM. Diabetes 42:1446-1453, 1993
43. Lenzen S, Schmidt W, Rustenbeck I, Panten U: 2-Ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids. Biosci Rep 6:163-169, 1986
44. Renstrom E, Eliasson L, Bokvist K, Rorsman P: Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J Physiol (Lond) 494:41-52, 1996
45. 2+-induced exocytosis in mouse pancreatic B-cells. J Physiol (Lond) 503:399-412, 1997
46. Giroix MH, Saulnier C, Portha B: Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data. Diabetologia 42:965-977, 1999
47. Goodner CJ, Walike BC, Koerker DJ, Ensinck JW, Brown AC, Chideckel EW, Palmer J, Kalnasy L: Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys. Science 195:177-179, 1977
48. Lang DA, Matthews DR, Burnett M, Turner RC: Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 30:435-439, 1981
49. Matthews DR, Naylor BA, Jones RG, Ward GM, Turner RC: Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 32:617-621, 1983
50. Paolisso G, Sgambato S, Torella R, Varricchio M, Scheen A, D'Onofrio F, Lefebvre PJ: Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes. J Clin Endocrinol Metab 66:1220-1226, 1988
51. Goodner CJ, Sweet IR, Harrison HC Jr: Rapid reduction and return of surface insulin receptors after exposure to brief pluses of insulin in perifused rat hepatocytes. Diabetes 37:1316-1323, 1988
52. Bergsten P: Pathophysiology of impaired pulsatile insulin release. Diabetes Metab Res Rev 16:179-191, 2000