Hyperglycemia contributes to impaired insulin response in GK rat islets

Diabetes

Volumn 50, Issue SUPPL. 1, 2001, Pages

  Ling, Zong Chao ^a   Hong Lie, Cao ^a   Östenson, Claes Göran ^a   Efendic, Suad ^a   Khan, Akhtar ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; PHLORIZIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0035129125     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2007.s108     Document Type: Conference Paper

References (34)

1. Aspects of pathogenesis of type 2 diabetes
2. Pathogenesis of NIDDM: A balanced overview
3. The spontaneous-diabetes rat: A model of non-insulin dependent diabetes mellitus
4. Impaired insulin secretion in the spontaneous-diabetes rats
5. Functional and metabolic perturbations in isolated pancreatic islets from the GK rat: A genetic model of noninsulin-dependent diabetes
6. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat
7. Glucose metabolism in Goto-Kakizaki rat islets
8. Futile cycles in the metabolism of glucose
9. 2+ concentration in pancreatic β-cells
10. Increased activity of glucose cycle in the liver: Early characteristic of type 11 diabetes
11. Glucose toxicity
12. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
13. Hyperglycemia as an inducer as well as consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes
14. B-cell insensitivity in a rat model of noninsulin dependent diabetes: Evidence for a rapid reversible effect of previous hyperglycemia
15. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
16. Insulin treatment improves glucose-induced insulin release in rats with NIDDM induced by streptozotocin
17. Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment
18. A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in the mildly diabetic F1 hybrids of GK-Wistar rats
19. The role of glucose-6-phosphatase in the action of insulin on hepatic glucose production in the rat
20. Coated charcol immunoassay of insulin
21. An improved fluorometric assay for DNA
22. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: A study in normal rats using chronic in vivo glucose infusions
23. Long-term effects of high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets
24. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the B-cell function
25. Glucose-6-phosphatase activity of mouse pancreatic islets
26. Presence, induction and possible role of glucose-6-phosphates in mammalian pancreatic islets
27. Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone
28. Microsomal membrane permeability and the hepatic glucose-6-phosphatase system
29. Multifunctional glucose-6-phosphatase studied in permeable isolated hepatocytes
30. Calcium clamp of the intracellular environment
31. Effects of 3-mer-captopicolinic acid and a derivative of chlorogenic acid (S-3483) on hepatic and islet glucose-6-phosphatase activity
32. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice
33. Increased glucocorticoid sensitivity in islet beta-cells: Effects on glucose-6-phosphatase, glucose cycling and insulin release
34. Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells