Glucose metabolism in Goto-Kakizaki rat islets

Endocrinology

Volumn 139, Issue 6, 1998, Pages 2670-2675

  Zong Chao, Ling ^b   Efendic, Suad ^b   Wibom, Rolf ^b   Abdel Halim, Samy M ^b   Östenson, Claes Göran ^b   Landau, Bernard R ^b   Khan, Akhtar ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; ELECTRON TRANSPORT; ENZYME SUBSTRATE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; GLYCOLYSIS; INSULIN RELEASE; INSULIN RESPONSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; STIMULUS SECRETION COUPLING;

EID: 0031762809     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.6.6053     Document Type: Article

References (33)

1. Efendic S, Luft R, Wajngot A 1988 Aspects of the pathogenesis of type 2 diabetes. Endocr Rev 5:395-409
2. DeFronzo RA, Bonadonna RC, Ferrannini E 1992 Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15:317-368
3. Goto Y, Kakizaki M 1981 The spontaneous-diabetes rat: a model of non-insulin dependent diabetes mellitus. Proc Jpn Acad 57:381-384
4. Kimura K, Toyota T, Kakizaki M, Kudo M, Takeba K, Goto Y 1982 Impaired insulin secretion in the spontaneous diabetes rats. Tohoku J Exp Med 137:453-459
5. Giroix MH, Sener A, Portha B, Malaisse WJ 1993 Preferential alteration of oxidative relative to total glycolysis in pancreatic islets of two rat models of inherited or acquired type-2 (non-insulin dependent) diabetes mellitus. Diabetologia 36:305-309
6. Rasschaert J, Giroix MH, Conget I, Mercan D, Leclercq-Meyer V, Sener A, Portha B, Malaisse WJ 1994 Pancreatic islet response to dicarboxylic acid esters in rats with type 2 diabetes: enzymatic, metabolic and secretory aspects. J Mol Endocrinol 13:209-217
7. Giroix MH, Sener A, Bailbe D, Leclercq-Meyer V, Portha B, Malaisse WJ 1993 Metabolic, ionic and secretory response to D-glucose in islets from rats with acquired or inherited non-insulin dependent diabetes. Biochem Med Metab Biol 50:301-321
8. Giroix MH, Vesco L, Portha B 1993 Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of non-insulin dependent diabetes. Endocrinology 132:815-822
9. Östenson C-G, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S 1993 Abnormal insulin secretion and glucose metabolism in pancreatic islets from spontaneously diabetic GK rat. Diabetologia 36:3-8
10. Hughes SJ, Suzuki K, Goto Y 1994 The role of islet secretory function in the development of diabetes in the GK Wistar rat. Diabetologia 37:863-870
11. Abdel-Halim SM, Guenifi A, Khan A, Larsson O, Berggren P-O, Östenson C-G, Efendic S 1996 Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats. Diabetes 45:934-940
12. Östenson C-G, Abdel-Halim SM, Rasschaert J, Malaisse-Lagae F, Meuris S, Sener A, Efendic S, Malaiasse WJ 1993 Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia 36:722-726
13. Abdel-Halim SM, Östenson C-G, Andersson A, Jansson L, Efendic A 1996 A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in the mildly diabetic F1 hybrids of GK-Wistar rats. Diabetes 44:1280-1284
14. MacDonald MJ 1993 Metabolism of the insulin secretagogue methyl succinate by pancreatic islets. Arch Biochem Biophys 300:201-205
15. Khan A, Ling ZC, Landau BR 1996 Quantifying the carboxylation of pyruvate in pancreatic islets. J Biol Chem 271:2539-2542
16. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ 1965 Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384
17. Idahl L-Å, Lembert N 1995 Glycerol 3-phosphate induced ATP production in intact mitochondria from pancreatic β-cells. Biochem J 312:287-292
18. Wibom R, Hultman E 1990 ATP production rate in mitochondria isolated from microsamples of human muscle. Am J Physiol 259:E204-E209
19. Wibom R, Lundin A, Hultman E 1990 A sensitive method for measuring ATP-formation in rat muscle mitochondria. Scand J Clin Lab Invest 50:143-152
20. +-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. Biochem J 154:689-700
21. Hinegardner RT 1971 An improved fluorometic assay for DNA. Anal Biochem 39:197-201
22. 2 ratios method for detecting pyruvate carboxylation. Anal Biochem 151:55-62
23. Guenifi A, Abdel-Halim SM, Höög A, Falkmer S, Östenson C-G 1995 Preserved β-cell density in the endocrine pancreas of young spontaneously diabetic Goto-Kakizaki (GK) rats. Pancreas 10:148-153
24. Serradas P, Giroix MH, Saulnier C, et al 1995 Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 136:5623-5631
25. MacDonald MJ 1995 Further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270:20051-20058
26. Sener A, Malaisse-Lagae F, Östenson C-G, Malaisse WJ 1994 Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats. Biochem J 296:329-334
27. Hutton JC, Guest PC, Clark A, et al 1994 Proinsulin biosynthesis and processing in the GK rat model of type 2 diabetes. Diabetologia [Suppl 1] 37:A42
28. Ohneda M, Johnson JH, Inman LR, et al 1993 GLUT2 expression and function in β-cells of GK rats with NIDDM. Diabetes 42:1065-72
29. Östenson C-G, Abdel-Halim SM, Anderson A, Efendic S 1996 Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat. In: Shafrir E (ed) Lessons from Animal Diabetes. Birkhauser, Boston, pp 299-315
30. Sekine N, Cirulli V, Regazzi R, et al 1994 Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. J Biol Chem 269:4895-4902
31. Matschinsky FM 1996 A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241
32. Katayama N, Hughes, SJ, Persaud, SJ, Jones PM, Howell SL 1995 Insulin secretion from islets of GK rats is not impaired after energy generating steps. Mol Cell Endocrinol 111:125-128
33. MacDonald MJ, Efendic S, Östenson C-G 1996 Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45:886-890