-
1
-
-
0028318873
-
In vivo MR evaluation of age-related increases in brain iron
-
8073983
-
Bartzokis G Mintz J Sultzer D Marx P Herzberg JS Phelan CK Marder SR In vivo MR evaluation of age-related increases in brain iron AJNR Am J Neuroradiol 1994, 15:1129-1138 8073983
-
(1994)
AJNR Am J Neuroradiol
, vol.15
, pp. 1129-1138
-
-
Bartzokis, G.1
Mintz, J.2
Sultzer, D.3
Marx, P.4
Herzberg, J.S.5
Phelan, C.K.6
Marder, S.R.7
-
3
-
-
8344265251
-
Iron, brain ageing and neurodegenerative disorders
-
15496864
-
Zecca L Youdim MB Riederer P Connor JR Crichton RR Iron, brain ageing and neurodegenerative disorders Nat Rev Neurosci 2004, 5:863-873 15496864
-
(2004)
Nat Rev Neurosci
, vol.5
, pp. 863-873
-
-
Zecca, L.1
Youdim, M.B.2
Riederer, P.3
Connor, J.R.4
Crichton, R.R.5
-
4
-
-
0034796353
-
Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment
-
11599635
-
Halliwell B Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment Drugs Aging 2001, 18:685-716 11599635
-
(2001)
Drugs Aging
, vol.18
, pp. 685-716
-
-
Halliwell, B.1
-
5
-
-
0035003439
-
Chemistry and biochemistry of oxidative stress in neurodegenerative disease
-
11375746
-
Sayre LM Smith MA Perry G Chemistry and biochemistry of oxidative stress in neurodegenerative disease Curr Med Chem 2001, 8:721-738 11375746
-
(2001)
Curr Med Chem
, vol.8
, pp. 721-738
-
-
Sayre, L.M.1
Smith, M.A.2
Perry, G.3
-
6
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
9667777
-
Lovell MA Robertson JD Teesdale WJ Campbell JL Markesbery WR Copper, iron and zinc in Alzheimer's disease senile plaques J Neurol Sci 1998, 158:47-52 9667777
-
(1998)
J Neurol Sci
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
7
-
-
2142828035
-
Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains
-
10875438
-
Pinero DJ Hu J Connor JR Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains Cell Mol Biol 2000, 46:761-776 10875438
-
(2000)
Cell Mol Biol
, vol.46
, pp. 761-776
-
-
Pinero, D.J.1
Hu, J.2
Connor, J.R.3
-
8
-
-
0031981072
-
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
-
9572310
-
Smith MA Hirai K Hsiao K Pappolla MA Harris PL Siedlak SL Tabaton M Perry G Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress J Neurochem 1998, 70:2212-2215 9572310
-
(1998)
J Neurochem
, vol.70
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
Pappolla, M.A.4
Harris, P.L.5
Siedlak, S.L.6
Tabaton, M.7
Perry, G.8
-
9
-
-
20944449836
-
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
-
15583960
-
Moreira PI Siedlak SL Aliev G Zhu X Cash AD Smith MA Perry G Oxidative stress mechanisms and potential therapeutics in Alzheimer disease J Neural Transm 2005, 112:921-932 15583960
-
(2005)
J Neural Transm
, vol.112
, pp. 921-932
-
-
Moreira, P.I.1
Siedlak, S.L.2
Aliev, G.3
Zhu, X.4
Cash, A.D.5
Smith, M.A.6
Perry, G.7
-
10
-
-
3042838351
-
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease
-
15231239
-
Castellani RJ Honda K Zhu X Cash AD Nunomura A Perry G Smith MA Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease Ageing Res Rev 2004, 3:319-326 15231239
-
(2004)
Ageing Res Rev
, vol.3
, pp. 319-326
-
-
Castellani, R.J.1
Honda, K.2
Zhu, X.3
Cash, A.D.4
Nunomura, A.5
Perry, G.6
Smith, M.A.7
-
12
-
-
2342429376
-
Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species
-
15096700
-
Casadesus G Smith MA Zhu X Aliev G Cash AD Honda K Petersen RB Perry G Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species J Alzheimers Dis 2004, 6:165-169 15096700
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 165-169
-
-
Casadesus, G.1
Smith, M.A.2
Zhu, X.3
Aliev, G.4
Cash, A.D.5
Honda, K.6
Petersen, R.B.7
Perry, G.8
-
13
-
-
0033836580
-
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification
-
10936206
-
Takeda A Smith MA Avila J Nunomura A Siedlak SL Zhu X Perry G Sayre LM In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification J Neurochem 2000, 75:1234-1241 10936206
-
(2000)
J Neurochem
, vol.75
, pp. 1234-1241
-
-
Takeda, A.1
Smith, M.A.2
Avila, J.3
Nunomura, A.4
Siedlak, S.L.5
Zhu, X.6
Perry, G.7
Sayre, L.M.8
-
14
-
-
0034709603
-
Activation of NADPH oxidase in Alzheimer's disease brains
-
10873554
-
Shimohama S Tanino H Kawakami N Okamura N Kodama H Yamaguchi T Hayakawa T Nunomura A Chiba S Perry G et al. Activation of NADPH oxidase in Alzheimer's disease brains Biochem Biophys Res Commun 2000, 273:5-9 10873554
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 5-9
-
-
Shimohama, S.1
Tanino, H.2
Kawakami, N.3
Okamura, N.4
Kodama, H.5
Yamaguchi, T.6
Hayakawa, T.7
Nunomura, A.8
Chiba, S.9
Perry, G.10
-
15
-
-
0033793044
-
Heme oxygenase-1: Role in brain aging and neurodegeneration
-
11053673
-
Schipper HM Heme oxygenase-1: Role in brain aging and neurodegeneration Exp Gerontol 2000, 35:821-830 11053673
-
(2000)
Exp Gerontol
, vol.35
, pp. 821-830
-
-
Schipper, H.M.1
-
16
-
-
20444383489
-
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
-
15767256
-
Honda K Smith MA Zhu X Baus D Merrick WC Tartakoff AM Hattier T Harris PL Siedlak SL Fujioka H et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron J Biol Chem 2005, 280:20978-20986 15767256
-
(2005)
J Biol Chem
, vol.280
, pp. 20978-20986
-
-
Honda, K.1
Smith, M.A.2
Zhu, X.3
Baus, D.4
Merrick, W.C.5
Tartakoff, A.M.6
Hattier, T.7
Harris, P.L.8
Siedlak, S.L.9
Fujioka, H.10
-
17
-
-
0026513756
-
A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
-
1613823
-
Connor JR Menzies SL St Martin SM Mufson EJ A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains J Neurosci Res 1992, 31:75-83 1613823
-
(1992)
J Neurosci Res
, vol.31
, pp. 75-83
-
-
Connor, J.R.1
Menzies, S.L.2
St Martin, S.M.3
Mufson, E.J.4
-
18
-
-
0032822823
-
Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease
-
10529437
-
Yamada T Tsujioka Y Taguchi J Takahashi M Tsuboi Y Moroo I Yang J Jefferies WA Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease Brain Res 1999, 845:1-5 10529437
-
(1999)
Brain Res
, vol.845
, pp. 1-5
-
-
Yamada, T.1
Tsujioka, Y.2
Taguchi, J.3
Takahashi, M.4
Tsuboi, Y.5
Moroo, I.6
Yang, J.7
Jefferies, W.A.8
-
20
-
-
0034601251
-
Are hereditary hemochromatosis mutations involved in Alzheimer disease?
-
10861683
-
Moalem S Percy ME Andrews DF Kruck TP Wong S Dalton AJ Mehta P Fedor B Warren AC Are hereditary hemochromatosis mutations involved in Alzheimer disease? Am J Med Genet 2000, 93:58-66 10861683
-
(2000)
Am J Med Genet
, vol.93
, pp. 58-66
-
-
Moalem, S.1
Percy, M.E.2
Andrews, D.F.3
Kruck, T.P.4
Wong, S.5
Dalton, A.J.6
Mehta, P.7
Fedor, B.8
Warren, A.C.9
-
22
-
-
0037386086
-
The metallobiology of Alzheimer's disease
-
12689772
-
Bush AI The metallobiology of Alzheimer's disease Trends Neurosci 2003, 26:207-214 12689772
-
(2003)
Trends Neurosci
, vol.26
, pp. 207-214
-
-
Bush, A.I.1
-
23
-
-
3042666730
-
Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease
-
15201484
-
House E Collingwood J Khan A Korchazkina O Berthon G Exley C Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease J Alzheimers Dis 2004, 6:291-301 15201484
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 291-301
-
-
House, E.1
Collingwood, J.2
Khan, A.3
Korchazkina, O.4
Berthon, G.5
Exley, C.6
-
24
-
-
0036724204
-
Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: Implications in the formation of neurofibrillary tangles of Alzheimer's disease
-
12358761
-
Yamamoto A Shin RW Hasegawa K Naiki H Sato H Yoshimasu F Kitamoto T Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: Implications in the formation of neurofibrillary tangles of Alzheimer's disease J Neurochem 2002, 82:1137-1147 12358761
-
(2002)
J Neurochem
, vol.82
, pp. 1137-1147
-
-
Yamamoto, A.1
Shin, R.W.2
Hasegawa, K.3
Naiki, H.4
Sato, H.5
Yoshimasu, F.6
Kitamoto, T.7
-
25
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
12198135
-
Rogers JT Randall JD Cahill CM Eder PS Huang X Gunshin H Leiter L McPhee J Sarang SS Utsuki T et al. An iron-responsive element type II in the 57prime;-untranslated region of the Alzheimer's amyloid precursor protein transcript J Biol Chem 2002, 277:45518-45528 12198135
-
(2002)
J Biol Chem
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
-
26
-
-
0033525735
-
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
-
10037734
-
Rogers JT Leiter LM McPhee J Cahill CM Zhan SS Potter H Nilsson LN Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences J Biol Chem 1999, 274:6421-6431 10037734
-
(1999)
J Biol Chem
, vol.274
, pp. 6421-6431
-
-
Rogers, J.T.1
Leiter, L.M.2
McPhee, J.3
Cahill, C.M.4
Zhan, S.S.5
Potter, H.6
Nilsson, L.N.7
-
27
-
-
0141853765
-
Amyloid-beta: A chameleon walking in two worlds: A review of the trophic and toxic properties of amyloid-beta
-
14499458
-
Atwood CS Obrenovich ME Liu T Chan H Perry G Smith MA Martins RN Amyloid-beta: A chameleon walAing in two worlds: a review of the trophic and toxic properties of amyloid-beta Brain Res Brain Res Rev 2003, 43:1-16 14499458
-
(2003)
Brain Res Brain Res Rev
, vol.43
, pp. 1-16
-
-
Atwood, C.S.1
Obrenovich, M.E.2
Liu, T.3
Chan, H.4
Perry, G.5
Smith, M.A.6
Martins, R.N.7
-
28
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
11487050
-
Nunomura A Perry G Aliev G Hirai K Takeda A Balraj EK Jones PK Ghanbari H Wataya T Shimohama S et al. Oxidative damage is the earliest event in Alzheimer disease J Neuropathol Exp Neurol 2001, 60:759-767 11487050
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
-
29
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
10037741
-
Moechars D Dewachter I Lorent K Reverse D Baekelandt V Naidu A Tesseur I Spittaels K Haute CV Checler F et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain J Biol Chem 1999, 274:6483-6492 10037741
-
(1999)
J Biol Chem
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reverse, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Haute, C.V.9
Checler, F.10
-
30
-
-
0034643895
-
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
-
10841777
-
Misonou H Morishima-Kawashima M Ihara Y Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells Biochemistry 2000, 39:6951-6959 10841777
-
(2000)
Biochemistry
, vol.39
, pp. 6951-6959
-
-
Misonou, H.1
Morishima-Kawashima, M.2
Ihara, Y.3
-
31
-
-
0034673209
-
Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells
-
10679257
-
Paola D Domenicotti C Nitti M Vitali A Borghi R Cottalasso D Zaccheo D Odetti P Strocchi P Marinari UM et al. Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells Biochem Biophys Res Commun 2000, 268:642-646 10679257
-
(2000)
Biochem Biophys Res Commun
, vol.268
, pp. 642-646
-
-
Paola, D.1
Domenicotti, C.2
Nitti, M.3
Vitali, A.4
Borghi, R.5
Cottalasso, D.6
Zaccheo, D.7
Odetti, P.8
Strocchi, P.9
Marinari, U.M.10
-
32
-
-
0031587950
-
Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells
-
9207249
-
Zhang L Zhao B Yew DT Kusiak JW Roth GS Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells Biochem Biophys Res Commun 1997, 235:845-848 9207249
-
(1997)
Biochem Biophys Res Commun
, vol.235
, pp. 845-848
-
-
Zhang, L.1
Zhao, B.2
Yew, D.T.3
Kusiak, J.W.4
Roth, G.S.5
-
33
-
-
0025845529
-
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells
-
1652710
-
Abe K St George-Hyslop PH Tanzi RE Kogure K Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells Neurosci Lett 1991, 125:169-171 1652710
-
(1991)
Neurosci Lett
, vol.125
, pp. 169-171
-
-
Abe, K.1
St George-Hyslop, P.H.2
Tanzi, R.E.3
Kogure, K.4
-
34
-
-
0030727701
-
Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells
-
9406980
-
Shi J Xiang Y Simpkins JW Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells Brain Res 1997, 772:247-251 9406980
-
(1997)
Brain Res
, vol.772
, pp. 247-251
-
-
Shi, J.1
Xiang, Y.2
Simpkins, J.W.3
-
35
-
-
0034603414
-
Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease
-
10867221
-
Shi J Perry G Smith MA Friedland RP Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease Neurobiol Aging 2000, 21:357-361 10867221
-
(2000)
Neurobiol Aging
, vol.21
, pp. 357-361
-
-
Shi, J.1
Perry, G.2
Smith, M.A.3
Friedland, R.P.4
-
36
-
-
0036403838
-
Oxidative stress increases expression and activity of BACE in NT2 neurons
-
12270690
-
Tamagno E Bardini P Obbili A Vitali A Borghi R Zaccheo D Pronzato MA Danni O Smith MA Perry G et al. Oxidative stress increases expression and activity of BACE in NT2 neurons Neurobiol Dis 2002, 10:279-288 12270690
-
(2002)
Neurobiol Dis
, vol.10
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
Vitali, A.4
Borghi, R.5
Zaccheo, D.6
Pronzato, M.A.7
Danni, O.8
Smith, M.A.9
Perry, G.10
-
37
-
-
19944433845
-
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
-
15659232
-
Tamagno E Parola M Bardini P Piccini A Borghi R Guglielmotto M Santoro G Davit A Danni O Smith MA et al. Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways J Neurochem 2005, 92:628-636 15659232
-
(2005)
J Neurochem
, vol.92
, pp. 628-636
-
-
Tamagno, E.1
Parola, M.2
Bardini, P.3
Piccini, A.4
Borghi, R.5
Guglielmotto, M.6
Santoro, G.7
Davit, A.8
Danni, O.9
Smith, M.A.10
-
38
-
-
3442888291
-
Metal and inflammatory targets for Alzheimer's disease
-
15270200
-
Rogers JT Lahiri DK Metal and inflammatory targets for Alzheimer's disease Curr Drug Targets 2004, 5:535-551 15270200
-
(2004)
Curr Drug Targets
, vol.5
, pp. 535-551
-
-
Rogers, J.T.1
Lahiri, D.K.2
-
39
-
-
0036827161
-
Abeta as a bioflocculant: Implication for the amyloid hypothesis of Alzheimer's disease
-
12470802
-
Robinson SR Bishop GM Abeta as a bioflocculant: Implication for the amyloid hypothesis of Alzheimer's disease Neurobiol Aging 2002, 23:1051-1072 12470802
-
(2002)
Neurobiol Aging
, vol.23
, pp. 1051-1072
-
-
Robinson, S.R.1
Bishop, G.M.2
-
40
-
-
0037096251
-
A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
-
12077180
-
Zou K Gong JS Yanagisawa K Michikawa M A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage J Neurosci 2002, 22:4833-4841 12077180
-
(2002)
J Neurosci
, vol.22
, pp. 4833-4841
-
-
Zou, K.1
Gong, J.S.2
Yanagisawa, K.3
Michikawa, M.4
-
41
-
-
8744255638
-
The amyloid paradox: Amyloid-beta-metal complexes can be neurotoxic and neuroprotective
-
15605992
-
Bishop GM Robinson SR The amyloid paradox: Amyloid-beta-metal complexes can be neurotoxic and neuroprotective Brain Pathol 2004, 14:448-452 15605992
-
(2004)
Brain Pathol
, vol.14
, pp. 448-452
-
-
Bishop, G.M.1
Robinson, S.R.2
-
42
-
-
35948936850
-
Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron
-
17929832
-
Nakamura M Shishido N Nunomura A Smith MA Perry G Hayashi Y Nakayama K Hayashi T Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron Biochemistry 2007, 46:12737-12743 17929832
-
(2007)
Biochemistry
, vol.46
, pp. 12737-12743
-
-
Nakamura, M.1
Shishido, N.2
Nunomura, A.3
Smith, M.A.4
Perry, G.5
Hayashi, Y.6
Nakayama, K.7
Hayashi, T.8
-
43
-
-
0025726462
-
Intramuscular desferrioxamine in patients with Alzheimer's disease
-
1674295
-
Crapper McLachlan DR Dalton AJ Kruck TP Bell MY Smith WL Kalow W Andrews DF Intramuscular desferrioxamine in patients with Alzheimer's disease Lancet 1991, 337:1304-1308 1674295
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crapper McLachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.3
Bell, M.Y.4
Smith, W.L.5
Kalow, W.6
Andrews, D.F.7
-
44
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
11430801
-
Cherny RA Atwood CS Xilinas ME Gray DN Jones WD McLean CA Barnham KJ Volitakis I Fraser FW Kim Y et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice Neuron 2001, 30:665-676 11430801
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.10
-
45
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
14676042
-
Ritchie CW Bush AI Mackinnon A Macfarlane S Mastwyk M MacGregor L Kiers L Cherny R Li QX Tammer A et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial Arch Neurol 2003, 60:1685-1691 14676042
-
(2003)
Arch Neurol
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
Macfarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
-
46
-
-
0036672706
-
Alzheimer's disease drug discovery targeted to the APP mRNA 5′untranslated region
-
12212798
-
Rogers JT Randall JD Eder PS Huang X Bush AI Tanzi RE Venti A Payton SM Giordano T Nagano S et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5′untranslated region J Mol Neurosci 2002, 19:77-82 12212798
-
(2002)
J Mol Neurosci
, vol.19
, pp. 77-82
-
-
Rogers, J.T.1
Randall, J.D.2
Eder, P.S.3
Huang, X.4
Bush, A.I.5
Tanzi, R.E.6
Venti, A.7
Payton, S.M.8
Giordano, T.9
Nagano, S.10
-
47
-
-
0642309509
-
Drug discovery targeted to the Alzheimer's APP mRNA 5′-untranslated region: The action of paroxetine and dimercaptopropanol
-
14501007
-
Payton S Cahill CM Randall JD Gullans SR Rogers JT Drug discovery targeted to the Alzheimer's APP mRNA 5′-untranslated region: The action of paroxetine and dimercaptopropanol J Mol Neurosci 2003, 20:267-275 14501007
-
(2003)
J Mol Neurosci
, vol.20
, pp. 267-275
-
-
Payton, S.1
Cahill, C.M.2
Randall, J.D.3
Gullans, S.R.4
Rogers, J.T.5
-
48
-
-
9744219638
-
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
-
15582280
-
Dedeoglu A Cormier K Payton S Tseitlin KA Kremsky JN Lai L Li X Moir RD Tanzi RE Bush AI et al. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis Exp Gerontol 2004, 39:1641-1649 15582280
-
(2004)
Exp Gerontol
, vol.39
, pp. 1641-1649
-
-
Dedeoglu, A.1
Cormier, K.2
Payton, S.3
Tseitlin, K.A.4
Kremsky, J.N.5
Lai, L.6
Li, X.7
Moir, R.D.8
Tanzi, R.E.9
Bush, A.I.10
-
49
-
-
0346849912
-
Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
-
14680763
-
Ben-Shachar D Kahana N Kampel V Warshawsky A Youdim MBH Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats Neuropharmacology 2004, 46:254-263 14680763
-
(2004)
Neuropharmacology
, vol.46
, pp. 254-263
-
-
Ben-Shachar, D.1
Kahana, N.2
Kampel, V.3
Warshawsky, A.4
Youdim, M.B.H.5
-
50
-
-
11844255676
-
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases
-
15653345
-
Zheng H Weiner LM Bar-Am O Epsztejn S Cabantchik ZI Warshawsky A Youdim MB Fridkin M Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases Bioorg Med Chem 2005, 13:773-783 15653345
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 773-783
-
-
Zheng, H.1
Weiner, L.M.2
Bar-Am, O.3
Epsztejn, S.4
Cabantchik, Z.I.5
Warshawsky, A.6
Youdim, M.B.7
Fridkin, M.8
-
51
-
-
33845879870
-
Therapeutic targets and potential of the novel brain-permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease
-
17144902
-
Avramovich-Tirosh Y Amit T Bar-Am O Zheng H Fridkin M Youdim MBH Therapeutic targets and potential of the novel brain-permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease J Neurochem 2007, 100:490-502 17144902
-
(2007)
J Neurochem
, vol.100
, pp. 490-502
-
-
Avramovich-Tirosh, Y.1
Amit, T.2
Bar-Am, O.3
Zheng, H.4
Fridkin, M.5
Youdim, M.B.H.6
-
52
-
-
0030582664
-
Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes
-
8982267
-
Guo Q Zhao B Li M Shen S Xin W Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes Biochimica et Biophysica Acta 1996, 1304:210-222 8982267
-
(1996)
Biochimica Et Biophysica Acta
, vol.1304
, pp. 210-222
-
-
Guo, Q.1
Zhao, B.2
Li, M.3
Shen, S.4
Xin, W.5
-
54
-
-
4644275696
-
Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
-
367-377 15345806
-
Baum L Ng A Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models J Alzheimers Dis 2004, 6:367-377 443-369. 15345806
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 369-443
-
-
Baum, L.1
Ng, A.2
-
55
-
-
34248562294
-
Green tea catechins as brain-permeable, non toxic iron chelators to 'iron out iron' from the brain
-
16897606
-
Mandel S Weinreb O Reznichenko L Kalfon L Amit T Green tea catechins as brain-permeable, non toxic iron chelators to 'iron out iron' from the brain J Neural Transm 2006, 249-257 16897606
-
(2006)
J Neural Transm
, pp. 249-257
-
-
Mandel, S.1
Weinreb, O.2
Reznichenko, L.3
Kalfon, L.4
Amit, T.5
-
56
-
-
33645294934
-
Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: Implications for iron chelation in Alzheimer's disease
-
16539659
-
Reznichenko L Amit T Zheng H Avramovich-Tirosh Y Youdim MB Weinreb O Mandel S Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease J Neurochem 2006, 97:527-536 16539659
-
(2006)
J Neurochem
, vol.97
, pp. 527-536
-
-
Reznichenko, L.1
Amit, T.2
Zheng, H.3
Avramovich-Tirosh, Y.4
Youdim, M.B.5
Weinreb, O.6
Mandel, S.7
-
57
-
-
25444500410
-
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
-
16177050
-
Rezai-Zadeh K Shytle D Sun N Mori T Hou H Jeanniton D Ehrhart J Townsend K Zeng J Morgan D et al. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice J Neurosci 2005, 25:8807-8814 16177050
-
(2005)
J Neurosci
, vol.25
, pp. 8807-8814
-
-
Rezai-Zadeh, K.1
Shytle, D.2
Sun, N.3
Mori, T.4
Hou, H.5
Jeanniton, D.6
Ehrhart, J.7
Townsend, K.8
Zeng, J.9
Morgan, D.10
-
58
-
-
34548695421
-
Neurorescue activity, APP regulation and amyloid- peptide reduction by novel multi-functional brain permeable iron- chelator- antioxidants, M-30 and green tea polyphenol, EGCG
-
17908043
-
Avramovich-Tirosh Y Reznichenko L Amit T Zheng H Fridkin M Mandel S Youdim MBH Neurorescue activity, APP regulation and amyloid- peptide reduction by novel multi-functional brain permeable iron- chelator- antioxidants, M-30 and green tea polyphenol, EGCG Curr Alzheimer Res 2007, 4:403-411 17908043
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 403-411
-
-
Avramovich-Tirosh, Y.1
Reznichenko, L.2
Amit, T.3
Zheng, H.4
Fridkin, M.5
Mandel, S.6
Youdim, M.B.H.7
-
59
-
-
33747089589
-
A high-throughput drug screen targeted to the 5′untranslated region of Alzheimer amyloid precursor protein mRNA
-
16928984
-
Bandyopadhyay S Ni J Ruggiero A Walshe K Rogers MS Chattopadhyay N Glicksman MA Rogers JT A high-throughput drug screen targeted to the 5′untranslated region of Alzheimer amyloid precursor protein mRNA J Biomol Screen 2006, 11:469-480 16928984
-
(2006)
J Biomol Screen
, vol.11
, pp. 469-480
-
-
Bandyopadhyay, S.1
Ni, J.2
Ruggiero, A.3
Walshe, K.4
Rogers, M.S.5
Chattopadhyay, N.6
Glicksman, M.A.7
Rogers, J.T.8
-
60
-
-
0032787503
-
Mitotic signaling by beta-amyloid causes neuronal death
-
10593870
-
Copani A Condorelli F Caruso A Vancheri C Sala A Giuffrida Stella AM Canonico PL Nicoletti F Sortino MA Mitotic signaling by beta-amyloid causes neuronal death FASEB J 1999, 13:2225-2234 10593870
-
(1999)
FASEB J
, vol.13
, pp. 2225-2234
-
-
Copani, A.1
Condorelli, F.2
Caruso, A.3
Vancheri, C.4
Sala, A.5
Giuffrida Stella, A.M.6
Canonico, P.L.7
Nicoletti, F.8
Sortino, M.A.9
-
61
-
-
0033516567
-
Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in B-amyloid-induced neuronal death
-
10383401
-
Giovanni A Wirtz-Brugger F Keramaris E Slack R Park DS Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in B-amyloid-induced neuronal death J Biol Chem 1999, 274:19011-19016 10383401
-
(1999)
J Biol Chem
, vol.274
, pp. 19011-19016
-
-
Giovanni, A.1
Wirtz-Brugger, F.2
Keramaris, E.3
Slack, R.4
Park, D.S.5
-
62
-
-
0033637884
-
Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
-
11124423
-
Wu Q Combs C Cannady SB Geldmacher DS Herrup K Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons Neurobiol Aging 2000, 21:797-806 11124423
-
(2000)
Neurobiol Aging
, vol.21
, pp. 797-806
-
-
Wu, Q.1
Combs, C.2
Cannady, S.B.3
Geldmacher, D.S.4
Herrup, K.5
-
63
-
-
20144371838
-
Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth
-
15934936
-
Reznichenko L Amit T Youdim MB Mandel S Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth J Neurochem 2005, 93:1157-1167 15934936
-
(2005)
J Neurochem
, vol.93
, pp. 1157-1167
-
-
Reznichenko, L.1
Amit, T.2
Youdim, M.B.3
Mandel, S.4
-
64
-
-
33847320669
-
The 5′-untranslated region of Parkinson's disease alpha-synuclein messenger RNA contains a predicted iron responsive element
-
17325711
-
Friedlich AL Tanzi RE Rogers JT The 5′-untranslated region of Parkinson's disease alpha-synuclein messenger RNA contains a predicted iron responsive element Mol Psychiatry 2007, 12:222-223 17325711
-
(2007)
Mol Psychiatry
, vol.12
, pp. 222-223
-
-
Friedlich, A.L.1
Tanzi, R.E.2
Rogers, J.T.3
-
65
-
-
20844459491
-
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5′ untranslated region
-
15974925
-
Tucker S Ahl M Bush A Westaway D Huang X Rogers JT Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5′ untranslated region Curr Alzheimer Res 2005, 2:249-254 15974925
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 249-254
-
-
Tucker, S.1
Ahl, M.2
Bush, A.3
Westaway, D.4
Huang, X.5
Rogers, J.T.6
-
66
-
-
0035912825
-
Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
-
34715 11404470
-
Shaw KT Utsuki T Rogers J Yu QS Sambamurti K Brossi A Ge YW Lahiri DK Greig NH Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development Proc Natl Acad Sci USA 2001, 98:7605-7610 34715 11404470
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7605-7610
-
-
Shaw, K.T.1
Utsuki, T.2
Rogers, J.3
Yu, Q.S.4
Sambamurti, K.5
Brossi, A.6
Ge, Y.W.7
Lahiri, D.K.8
Greig, N.H.9
|