Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 773-783

  Zheng, Hailin ^a   Weiner, Lev M ^a   Bar Am, Orit ^b   Epsztejn, Silvina ^c   Cabantchik, Z Ioav ^c   Warshawsky, Abraham ^a   Youdim, Moussa B H ^b   Fridkin, Mati ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

8 Hydroxyquinoline; Antioxidant iron chelator; Lipid peroxidation; Neuroprotection

Indexed keywords

5 (4 PROPARGYLPIPERAZIN 1 YLMETHYL) 8 HYDROXYQUINOLINE; 5 (N METHYL N PROPARGYLAMINOMETHYL) 8 HYDROXYQUINOLINE; 5 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YLMETHYL] 8 HYDROXYQUINOLINE; 8 HYDROXYOXYQUINOLINE; ANTIOXIDANT; DEXTRO N PROPARGYL 3 (8 HYDROXYQUINOLIN 5 YL)ALANINE ETHYL ESTER; ETHYL 4 (8 HYDROXYQUINOLIN 5 YLMETHYL) 1 PIPERAZINECARBOXYLATE; HYDROXYL RADICAL; IRON; IRON CHELATING AGENT; MONOAMINE OXIDASE B INHIBITOR; N (8 HYDROXYQUINOLIN 5 YLMETHYL)CYSTEINE ETHYL ESTER; OXIDOPAMINE; QUINOLINE DERIVATIVE; SCAVENGER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL STRAIN; CHELATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG DESIGN; DRUG PENETRATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NEUROPROTECTION; PARKINSON DISEASE;

ALZHEIMER DISEASE; ANTIOXIDANTS; CELL LINE; CELL MEMBRANE PERMEABILITY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HUMANS; IRON CHELATING AGENTS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE;

EID: 11844255676     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.037     Document Type: Article

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