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Volumn 14, Issue 4, 2004, Pages 448-452

The amyloid paradox: Amyloid-β-metal complexes be neurotoxic and neuroprotective

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; COPPER; IRON; METAL COMPLEX; ZINC;

EID: 8744255638     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2004.tb00089.x     Document Type: Article
Times cited : (60)

References (47)
  • 2
    • 0029866646 scopus 로고    scopus 로고
    • The galvanization of biology: A growing appreciation for the roles of zinc
    • Berg JM, Shi Y (1996) The galvanization of biology: a growing appreciation for the roles of zinc. Science 271:1081-1085.
    • (1996) Science , vol.271 , pp. 1081-1085
    • Berg, J.M.1    Shi, Y.2
  • 3
    • 0035854581 scopus 로고    scopus 로고
    • Quantitative analysis of cell death and ferritin expression in response to cortical iron: Implications for hypoxiaischemia and stroke
    • Bishop GM, Robinson SR (2001) Quantitative analysis of cell death and ferritin expression in response to cortical iron: implications for hypoxiaischemia and stroke. Brain Res 907:175-187.
    • (2001) Brain Res , vol.907 , pp. 175-187
    • Bishop, G.M.1    Robinson, S.R.2
  • 4
    • 0036833988 scopus 로고    scopus 로고
    • The amyloid hypothesis: Let sleeping dogmas lie?
    • Bishop GM, Robinson SR (2002) The amyloid hypothesis: let sleeping dogmas lie? Neurobiol Aging 23:1101-1105.
    • (2002) Neurobiol Aging , vol.23 , pp. 1101-1105
    • Bishop, G.M.1    Robinson, S.R.2
  • 5
    • 0037388672 scopus 로고    scopus 로고
    • Deposits of fibrillar Aβ do not cause neuronal loss or ferritin expression in adult rat brain
    • Bishop GM, Robinson SR (2003) Deposits of fibrillar Aβ do not cause neuronal loss or ferritin expression in adult rat brain. J Neural Transm 110: 381-400.
    • (2003) J Neural Transm , vol.110 , pp. 381-400
    • Bishop, G.M.1    Robinson, S.R.2
  • 6
    • 0042387935 scopus 로고    scopus 로고
    • Human Aβ1-42 protects against iron-induced toxicity in an in vivo model
    • Bishop GM, Robinson SR (2003) Human Aβ1-42 protects against iron-induced toxicity in an in vivo model. J Neurosci Res 73:316-323.
    • (2003) J Neurosci Res , vol.73 , pp. 316-323
    • Bishop, G.M.1    Robinson, S.R.2
  • 7
    • 4344626024 scopus 로고    scopus 로고
    • Physiological roles of amyloid-β and implications for its removal in Alzheimer's disease
    • Bishop GM, Robinson SR (2004) Physiological roles of amyloid-β and implications for its removal in Alzheimer's disease. Drugs Aging 21: 621-630.
    • (2004) Drugs Aging , vol.21 , pp. 621-630
    • Bishop, G.M.1    Robinson, S.R.2
  • 8
    • 0023833925 scopus 로고
    • Zinc neurotoxicity in cortical cell culture
    • Choi DW, Yokoyama M, Koh J (1988) Zinc neurotoxicity in cortical cell culture. Neuroscience 24: 67-79.
    • (1988) Neuroscience , vol.24 , pp. 67-79
    • Choi, D.W.1    Yokoyama, M.2    Koh, J.3
  • 9
    • 0032514159 scopus 로고    scopus 로고
    • Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus
    • Cuajungco MP, Lees GJ (1998) Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus. Brain Res 799:97-107.
    • (1998) Brain Res , vol.799 , pp. 97-107
    • Cuajungco, M.P.1    Lees, G.J.2
  • 10
    • 0032465459 scopus 로고    scopus 로고
    • Pro-inflammatory complement activation by the Aβ peptide of Alzheimer's disease is biologically significant and can be blocked by vaccinia virus complement control protein
    • Daly J, Kotwal GJ (1998) Pro-inflammatory complement activation by the Aβ peptide of Alzheimer's disease is biologically significant and can be blocked by vaccinia virus complement control protein. Neurobiol Aging 19:619-627.
    • (1998) Neurobiol Aging , vol.19 , pp. 619-627
    • Daly, J.1    Kotwal, G.J.2
  • 11
    • 0029990439 scopus 로고    scopus 로고
    • Astrocytes protect neurons from hydrogen peroxide toxicity
    • Desagher S, Glowinski J, Premont J (1996) Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci 16:2553-2562.
    • (1996) J Neurosci , vol.16 , pp. 2553-2562
    • Desagher, S.1    Glowinski, J.2    Premont, J.3
  • 12
    • 0033515564 scopus 로고    scopus 로고
    • Amyloid β peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides
    • Dikalov SI, Vitek MP, Maples KR, Mason RP (1999) Amyloid β peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J Biol Chem 274:9392-9399.
    • (1999) J Biol Chem , vol.274 , pp. 9392-9399
    • Dikalov, S.I.1    Vitek, M.P.2    Maples, K.R.3    Mason, R.P.4
  • 13
    • 0030852097 scopus 로고    scopus 로고
    • Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells
    • Dringen R, Hamprecht B (1997) Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells. Brain Res 759:67-75.
    • (1997) Brain Res , vol.759 , pp. 67-75
    • Dringen, R.1    Hamprecht, B.2
  • 14
    • 0032974143 scopus 로고    scopus 로고
    • The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells
    • Dringen R, Kussmaul L, Gutterer JM, Hirrlinger J, Hamprecht B (1999) The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells. J Neurochem 72: 2523-2530.
    • (1999) J Neurochem , vol.72 , pp. 2523-2530
    • Dringen, R.1    Kussmaul, L.2    Gutterer, J.M.3    Hirrlinger, J.4    Hamprecht, B.5
  • 15
    • 0033555806 scopus 로고    scopus 로고
    • Synthesis of the antioxidant glutathione in neurons: Supply by astrocytes of CysGly as precursor for neuronal glutathione
    • Dringen R, Pfeiffer B, Hamprecht B (1999) Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci 19:562-569
    • (1999) J Neurosci , vol.19 , pp. 562-569
    • Dringen, R.1    Pfeiffer, B.2    Hamprecht, B.3
  • 16
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
    • Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA (1998) Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nat Med 4:827-831.
    • (1998) Nat Med , vol.4 , pp. 827-831
    • Geula, C.1    Wu, C.K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 17
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: An overview
    • Halliwell B, Gutteridge JM (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1-85.
    • (1990) Methods Enzymol , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.2
  • 19
    • 0033991657 scopus 로고    scopus 로고
    • Aβ and perlecan in rat brain: Glial activation, gradual clearance and limited neurotoxicity
    • Holcomb LA, Gordon MN, Benkovic SA, Morgan DG (2000) Aβ and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity. Mech Ageing Dev 112:135-152.
    • (2000) Mech Ageing Dev , vol.112 , pp. 135-152
    • Holcomb, L.A.1    Gordon, M.N.2    Benkovic, S.A.3    Morgan, D.G.4
  • 20
    • 0033959828 scopus 로고    scopus 로고
    • Endogenous mechanisms of neuroprotection: Role of zinc, copper and carnosine
    • Horning MS, Blakemore LJ, Trombley PQ (2000) Endogenous mechanisms of neuroprotection: role of zinc, copper and carnosine. Brain Res 852:56-61.
    • (2000) Brain Res , vol.852 , pp. 56-61
    • Horning, M.S.1    Blakemore, L.J.2    Trombley, P.Q.3
  • 23
    • 0028178458 scopus 로고
    • β-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
    • Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ (1994) β-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol 152:5050-5059.
    • (1994) J Immunol , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cotman, C.W.4    Tenner, A.J.5
  • 24
    • 0006372708 scopus 로고    scopus 로고
    • Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
    • Kim YH, Kim EY, Gwag BJ, Sohn S, Koh JY (1999) Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89:175-182.
    • (1999) Neuroscience , vol.89 , pp. 175-182
    • Kim, Y.H.1    Kim, E.Y.2    Gwag, B.J.3    Sohn, S.4    Koh, J.Y.5
  • 26
    • 0029002838 scopus 로고
    • Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development
    • Langeveld CH, Jongenelen CA, Schepens E, Stoof JC, Bast A, Drukarch B (1995) Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development. Neurosci Lett 192:13-16.
    • (1995) Neurosci Lett , vol.192 , pp. 13-16
    • Langeveld, C.H.1    Jongenelen, C.A.2    Schepens, E.3    Stoof, J.C.4    Bast, A.5    Drukarch, B.6
  • 29
    • 0033608740 scopus 로고    scopus 로고
    • Protection against amyloid beta peptide toxicity by zinc
    • Lovell MA, Xie C, Markesbery WR (1999) Protection against amyloid beta peptide toxicity by zinc. Brain Res 823:88-95.
    • (1999) Brain Res , vol.823 , pp. 88-95
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 30
    • 0034973708 scopus 로고    scopus 로고
    • The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides
    • Monji A, Utsumi H, Ueda T, Imoto T, Yoshida I, Hashioka S, Tashiro K, Tashiro N (2001) The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides. J Neurochem 77:1425-1432.
    • (2001) J Neurochem , vol.77 , pp. 1425-1432
    • Monji, A.1    Utsumi, H.2    Ueda, T.3    Imoto, T.4    Yoshida, I.5    Hashioka, S.6    Tashiro, K.7    Tashiro, N.8
  • 31
    • 0033949740 scopus 로고    scopus 로고
    • Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide
    • Moreira P, Pereira C, Santos MS, Oliveira C (2000) Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide. Antioxid Redox Signal 2:317-325.
    • (2000) Antioxid Redox Signal , vol.2 , pp. 317-325
    • Moreira, P.1    Pereira, C.2    Santos, M.S.3    Oliveira, C.4
  • 34
    • 0025992417 scopus 로고
    • In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
    • Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563:311-314.
    • (1991) Brain Res , vol.563 , pp. 311-314
    • Pike, C.J.1    Walencewicz, A.J.2    Glabe, C.G.3    Cotman, C.W.4
  • 36
    • 0036827161 scopus 로고    scopus 로고
    • Aβ as a bioflocculant: Implications for the amyloid hypothesis of Alzheimer's disease
    • Robinson SR, Bishop GM (2002) Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease. Neurobiol Aging 23: 1051-1072.
    • (2002) Neurobiol Aging , vol.23 , pp. 1051-1072
    • Robinson, S.R.1    Bishop, G.M.2
  • 38
    • 0026065197 scopus 로고
    • β-amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons
    • Roher AE, Ball MJ, Bhave SV, Wakade AR (1991) β-amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons. Biochem Biophys Res Commun 174:572-579.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 572-579
    • Roher, A.E.1    Ball, M.J.2    Bhave, S.V.3    Wakade, A.R.4
  • 41
    • 0027175044 scopus 로고
    • Zinc enhances kainate neurotoxicity in the rat brain
    • Shiraishi K, Nakazawa S, Ito H (1993) Zinc enhances kainate neurotoxicity in the rat brain. Neurol Res 15:113-116.
    • (1993) Neurol Res , vol.15 , pp. 113-116
    • Shiraishi, K.1    Nakazawa, S.2    Ito, H.3
  • 42
    • 0018565112 scopus 로고
    • Inhibition of glutathione peroxidase by cadmium and other metal ions
    • Splittgerber AG, Tappel AL (1979) Inhibition of glutathione peroxidase by cadmium and other metal ions. Arch Biochem Biophys 197:534-542.
    • (1979) Arch Biochem Biophys , vol.197 , pp. 534-542
    • Splittgerber, A.G.1    Tappel, A.L.2
  • 43
    • 0033010755 scopus 로고    scopus 로고
    • Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione
    • White AR, Bush AI, Beyreuther K, Masters CL, Cappai R (1999) Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione. J Neurochem 72:2092-2098.
    • (1999) J Neurochem , vol.72 , pp. 2092-2098
    • White, A.R.1    Bush, A.I.2    Beyreuther, K.3    Masters, C.L.4    Cappai, R.5
  • 44
    • 0035093878 scopus 로고    scopus 로고
    • Homocysteine potentiates copper- and amyloid β peptide-mediated toxicity in primary neuronal cultures: Possible risk factors in the Alzheimer's-type neurodegenerative pathways
    • White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R (2001) Homocysteine potentiates copper- and amyloid β peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J Neurochem 76:1509-1520.
    • (2001) J Neurochem , vol.76 , pp. 1509-1520
    • White, A.R.1    Huang, X.2    Jobling, M.F.3    Barrow, C.J.4    Beyreuther, K.5    Masters, C.L.6    Bush, A.I.7    Cappai, R.8
  • 45
    • 0035879826 scopus 로고    scopus 로고
    • The antioxidant properties of zinc: Interactions with iron and antioxidants
    • Zago MP, Oteiza PI (2001) The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med 31:266-274.
    • (2001) Free Radic Biol Med , vol.31 , pp. 266-274
    • Zago, M.P.1    Oteiza, P.I.2
  • 46
    • 0027232517 scopus 로고
    • Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration
    • Zhang Y, Tatsuno T, Carney JM, Mattson MP (1993) Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J Cereb Blood Flow Metab 13:378-388.
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 378-388
    • Zhang, Y.1    Tatsuno, T.2    Carney, J.M.3    Mattson, M.P.4
  • 47
    • 0037096251 scopus 로고    scopus 로고
    • A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
    • Zou K, Gong JS, Yanagisawa K, Michikawa M (2002) A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci 22:4833-4841.
    • (2002) J Neurosci , vol.22 , pp. 4833-4841
    • Zou, K.1    Gong, J.S.2    Yanagisawa, K.3    Michikawa, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.