Basic science of the innate immune system and the lung

Paediatric Respiratory Reviews

Volumn 9, Issue 4, 2008, Pages 236-242

  Chaudhuri, Nazia ^a   Sabroe, Ian ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

inflammation; phagocytes; Toll like receptors

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; NOD LIKE RECEPTOR; RECEPTOR PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; SCAVENGER RECEPTOR; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; CELL COMMUNICATION; CELLULAR DISTRIBUTION; DENDRITIC CELL; EPITHELIUM CELL; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; INNATE IMMUNITY; LEUKOCYTE; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; LUNG INJURY; LUNG PARENCHYMA; MOLECULAR DYNAMICS; MONOCYTE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

HUMANS; IMMUNITY, INNATE; LUNG; LUNG DISEASES; PHAGOCYTES; TOLL-LIKE RECEPTORS;

EID: 56049097631     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2008.03.002     Document Type: Review

References (70)

1. Sabroe I., Parker L.C., Dockrell D.H., Davies D.E., Dower S.K., and Whyte M.K. Pulmonary Perspective: targeting the networks that underpin contiguous immunity in asthma and COPD. Am J Respir Crit Care Med 175 (2007) 306-311
2. Ganz T. Antimicrobial polypeptides. J Leukoc Biol 75 (2004) 34-38
3. Parker L.C., Prince L.R., and Sabroe I. Translational mini-review series on Toll-like receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol 147 (2007) 199-207
4. Sabroe I., Parker L.C., Calverley P.M.A., Dower S.K., and Whyte M.K.B. Pathological networking: a new approach to understanding COPD. Thorax 62 (2007) 733-738
5. Sabroe I., Parker L.C., Dower S.K., and Whyte M.K.B. Practical and conceptual models of COPD. Proc Am Thorac Soc 4 8 (2007) 606-610
6. Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81 (2007) 1-5
7. Erridge C., Bennett-Guerrero E., and Poxton I.R. Structure and function of lipopolysaccharides. Microbes Infect 4 (2002) 837-851
8. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., and Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
9. Wakelin S.J., Sabroe I., Gregory C.D., et al. Dirty little secrets" - Endotoxin contamination of recombinant proteins. Immunol Lett 106 (2006) 1-7
10. Tsan M.F., and Gao B. Endogenous ligands of Toll-like receptors. J Leukoc Biol 76 (2004) 514-519
11. Tsan M.F., and Baochong G. Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors. J Endotoxin Res 13 (2007) 6-14
12. Sabroe I., Read R.C., Whyte M.K.B., Dockrell D.H., Vogel S.N., and Dower S.K. Toll-like receptors in health and disease: complex questions remain. J Immunol 171 (2003) 1630-1635
13. Jiang D., Liang J., Fan J., et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11 (2005) 1173-1179
14. Bowie A.G. Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity. Clin Exp Immunol 147 (2007) 217-226
15. Anderson K.V., Jurgens G., and Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42 (1985) 779-789
16. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 (1996) 973-983
17. Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., and Bazan J.F. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A 95 (1998) 588-593
18. Gay N.J., Keith F.J., and Drosophila Toll. IL-1 receptor. Nature 351 (1991) 355-356
19. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
20. Poltorak A., He X., Smirnova I., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 282 (1998) 2085-2088
21. Qureshi S.T., Lariviere L., Leveque G., et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (TLR4). J Exp Med 189 (1999) 615-625
22. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 (2004) 499-511
23. Kaisho T., and Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 117 (2006) 979-987 quiz 988
24. Uematsu S., and Akira S. Toll-like receptors and innate immunity. J Mol Med 84 (2006) 712-725
25. Bell J.K., Askins J., Hall P.R., Davies D.R., and Segal D.M. The dsRNA binding site of human Toll-like receptor 3. Proc Natl Acad Sci U S A 103 (2006) 8792-8797
26. Choe J., Kelker M.S., and Wilson I.A. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 309 (2005) 581-585
27. Triantafilou M., Morath S., Mackie A., Hartung T., and Triantafilou K. Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane. J Cell Sci 117 (2004) 4007-4014
28. Ozinsky A., Underhill D.M., Fontenot J.D., et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci U S A 97 (2000) 13766-13771
29. Wyllie D.H., Kiss-Toth E., Visintin A., et al. Evidence for an accessory protein function for TLR1 in anti-bacterial responses. J Immunol 165 (2000) 7125-7132
30. Hirschfeld M., Ma Y., Weis J.H., Vogel S.N., and Weis J.J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J Immunol 165 (2000) 618-622
31. Malley R., Henneke P., Morse S.C., et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100 (2003) 1966-1971
32. Kurt-Jones E.A., Popova L., Kwinn L., et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1 (2000) 398-401
33. Lien E., Sellati T.J., Yoshimura A., et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274 (1999) 33419-33425
34. Hayashi F., Smith K.D., Ozinsky A., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (2001) 1099-1103
35. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732-738
36. Lund J.M., Alexopoulou L., Sato A., et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A 101 (2004) 5598-5603
37. Heil F., Hemmi H., Hochrein H., et al. Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8. Science 303 (2004) 1526-1529
38. Hemmi H., Takeuchi O., Kawai T., et al. A toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
39. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
40. Kanneganti T.D., Lamkanfi M., and Nunez G. Intracellular NOD-like receptors in host defense and disease. Immunity 27 (2007) 549-559
41. Martinon F., and Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26 (2005) 447-454
42. Mariathasan S., and Monack D.M. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7 (2007) 31-40
43. Martinon F., Petrilli V., Mayor A., Tardivel A., and Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006) 237-241
44. Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., and Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20 (2004) 319-325
45. Meylan E., and Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 22 (2006) 561-569
46. Bowie A.G., and Fitzgerald K.A. RIG-I: tri-ing to discriminate between self and non-self RNA. Trends Immunol (2007)
47. Kawai T., Takahashi K., Sato S., et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6 (2005) 981-988
48. Meylan E., Curran J., Hofmann K., et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 (2005) 1167-1172
49. Meylan E., Tschopp J., and Karin M. Intracellular pattern recognition receptors in the host response. Nature 442 (2006) 39-44
50. Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell 111 (2002) 927-930
51. Perera P.Y., Mayadas T.N., Takeuchi O., et al. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and Taxol-inducible gene expression. J Immunol 166 (2001) 574-581
52. Au B.-A., Williams T.J., and Collins P.D. Zymosan-induced IL-8 release from human neutrophils involves activation via CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator. J Immunol 152 (1994) 5411
53. Brown G.D., Herre J., Williams D.L., Willment J.A., Marshall A.S., and Gordon S. Dectin-1 mediates the biological effects of b-Glucans. J Exp Med 197 (2003) 1119-1124
54. Takabayshi K., Corr M., Hayashi T., et al. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24 (2006) 475-487
55. Sabroe I., Dockrell D.H., Vogel S.N., Renshaw S.A., Whyte M.K., and Dower S.K. Identifying and hurdling obstacles to translational research. Nat Rev Immunol 7 (2007) 77-82
56. Morris G.E., Parker L.C., Ward J.R., et al. Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J 20 (2006) 2153-2155
57. Morris G.E., Whyte M.K.B., Martin G.F., Jose P.J., Dower S.K., and Sabroe I. Agonists of Toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. Am J Respir Crit Care Med 171 (2005) 814-822
58. Hollingsworth J.W., Chen B.J., Brass D.M., et al. The critical role of hematopoietic cells in lipopolysaccharide induced airway inflammation. Am J Respir Crit Care Med 171 (2005) 806-813
59. Armstrong L., Medford A.R., Uppington K.M., et al. Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells. Am J Respir Cell Mol Biol 31 (2004) 241-245
60. Sha Q., Truong-Tran A.Q., Plitt J.R., Beck L.A., and Schleimer R.P. Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 31 (2004) 358-364
61. Guillot L., Le Goffic R., Bloch S., et al. Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280 (2005) 5571-5580
62. Guillot L., Medjane S., Le-Barillec K., et al. Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem 279 (2004) 2712-2718
63. Bainton D.F., Ullyot J.L., and Farquhar M.G. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 134 (1971) 907-934
64. Sabroe I., and Whyte M.K. Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease. Biochem Soc Trans 35 (2007) 1492-1495
65. Parker L.C., Whyte M.K., Dower S.K., and Sabroe I. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol 77 (2005) 886-892
66. Bianchi S.M., Dockrell D.H., Renshaw S.A., Sabroe I., and Whyte M.K. Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clin Sci (Lond) 110 (2006) 293-304
67. Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 31 (2004) 3-7
68. Maus U.A., Janzen S., Wall G., et al. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol 35 (2006) 227-235
69. Mazzoni A., and Segal D.M. Controlling the Toll road to dendritic cell polarization. J Leukoc Biol 75 (2004) 721-730
70. Pasare C., and Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21 (2004) 733-741