메뉴 건너뛰기




Volumn 7, Issue 1, 2007, Pages 77-82

Identifying and hurdling obstacles to translational research

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; BIOMEDICINE; CYTOKINE RELEASE; ETHICS; HEALTH CARE POLICY; IMMUNOLOGY; MEDICAL RESEARCH; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 33845903333     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1999     Document Type: Review
Times cited : (43)

References (34)
  • 1
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause, D. S. & Van Etten, R. A. Tyrosine kinases as targets for cancer therapy. N. Engl. J. Med. 353, 172-187 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 2
    • 33750528545 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for breast cancer - 30 years later
    • Levine, M. N. & Whelan, T. Adjuvant chemotherapy for breast cancer - 30 years later. N. Engl. J. Med. 355, 1920-1922 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 1920-1922
    • Levine, M.N.1    Whelan, T.2
  • 3
    • 0036644808 scopus 로고    scopus 로고
    • Gelfand, E. W. Pro: mice are a good model of human airway disease. Am. J. Respir. Crit. Care Med. 166, 5-6; discussion 7-8 (2002).
    • Gelfand, E. W. Pro: mice are a good model of human airway disease. Am. J. Respir. Crit. Care Med. 166, 5-6; discussion 7-8 (2002).
  • 5
    • 0036729230 scopus 로고    scopus 로고
    • Modeling allergic asthma in mice: Pitfalls and opportunities
    • Kumar, R. K. & Foster, P. S. Modeling allergic asthma in mice: pitfalls and opportunities. Am. J. Respir. Cell Mol. Biol. 27, 267-272 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , pp. 267-272
    • Kumar, R.K.1    Foster, P.S.2
  • 6
    • 0036644568 scopus 로고    scopus 로고
    • Persson, C. G. Con: mice are not a good model of human airway disease. Am. J. Respir. Crit. Care Med. 166, 6-7; discussion 8 (2002).
    • Persson, C. G. Con: mice are not a good model of human airway disease. Am. J. Respir. Crit. Care Med. 166, 6-7; discussion 8 (2002).
  • 8
    • 10244255039 scopus 로고    scopus 로고
    • Satisfaction (not) guaranteed: Re-evaluating the use of animal models of type 1 diabetes
    • Roep, B. O., Atkinson, M. & von Herrath, M. Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nature Rev. Immunol. 4, 989-997 (2004).
    • (2004) Nature Rev. Immunol , vol.4 , pp. 989-997
    • Roep, B.O.1    Atkinson, M.2    von Herrath, M.3
  • 9
  • 10
    • 27744473566 scopus 로고    scopus 로고
    • Lost in translation: Barriers to implementing clinical immunotherapeutics for autoimmunity
    • von Herrath, M. G. & Nepom, G. T. Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity. J. Exp. Med. 202, 1159-1162 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 1159-1162
    • von Herrath, M.G.1    Nepom, G.T.2
  • 11
    • 0043281537 scopus 로고    scopus 로고
    • Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections
    • Medvedev, A. E. et al. Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J. Exp. Med. 198, 521-531 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 521-531
    • Medvedev, A.E.1
  • 12
    • 0037471003 scopus 로고    scopus 로고
    • Pyogenic bacterial infections in humans with IRAK-4 deficiency
    • Picard, C. et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299, 2076-2079 (2003).
    • (2003) Science , vol.299 , pp. 2076-2079
    • Picard, C.1
  • 13
    • 0037129212 scopus 로고    scopus 로고
    • Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
    • Suzuki, N. et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416, 750-756 (2002).
    • (2002) Nature , vol.416 , pp. 750-756
    • Suzuki, N.1
  • 14
    • 4444374418 scopus 로고    scopus 로고
    • Phenotypes in asthma: Useful guides for therapy, distinct biological processes, or both?
    • Wenzel, S. E. Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both? Am. J. Respir. Crit. Care Med. 170, 579-580 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.170 , pp. 579-580
    • Wenzel, S.E.1
  • 15
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel, S. E. et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am. J. Respir. Crit. Care Med. 160, 1001-1008 (1999).
    • (1999) Am. J. Respir. Crit. Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1
  • 17
    • 33646708952 scopus 로고    scopus 로고
    • Cohen, J. Immunology. Differences in immune cell 'brakes' may explain chimp-human split on AIDS. Science 312, 672-673 (2006).
    • Cohen, J. Immunology. Differences in immune cell 'brakes' may explain chimp-human split on AIDS. Science 312, 672-673 (2006).
  • 18
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam, G. et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N. Engl. J. Med. 355, 1018-1028 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1
  • 19
    • 33646488532 scopus 로고    scopus 로고
    • National survey of British public's views on use of identifiable medical data by the National Cancer Registry
    • Barrett, G., Cassell, J. A., Peacock, J. L. & Coleman, M. P. National survey of British public's views on use of identifiable medical data by the National Cancer Registry. BMJ 332, 1068-1072 (2006).
    • (2006) BMJ , vol.332 , pp. 1068-1072
    • Barrett, G.1    Cassell, J.A.2    Peacock, J.L.3    Coleman, M.P.4
  • 20
    • 33746608068 scopus 로고    scopus 로고
    • Confidentiality in genome research
    • Lin, Z., Altman, R. B. & Owen, A. B. Confidentiality in genome research. Science 313, 441-442 (2006).
    • (2006) Science , vol.313 , pp. 441-442
    • Lin, Z.1    Altman, R.B.2    Owen, A.B.3
  • 21
    • 33646000796 scopus 로고    scopus 로고
    • McGuire, A. L. & Gibbs, R. A. Genetics. No longer de-identified. Science 312, 370-371 (2006).
    • McGuire, A. L. & Gibbs, R. A. Genetics. No longer de-identified. Science 312, 370-371 (2006).
  • 22
    • 0142012149 scopus 로고    scopus 로고
    • Mouse model of airway remodeling: Strain differences
    • Shinagawa, K. & Kojima, M. Mouse model of airway remodeling: strain differences. Am. J. Respir. Crit. Care Med. 168, 959-967 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.168 , pp. 959-967
    • Shinagawa, K.1    Kojima, M.2
  • 23
    • 10744228996 scopus 로고    scopus 로고
    • Murine models of asthma
    • Kips, J. C. et al. Murine models of asthma. Eur. Respir. J. 22, 374-382 (2003).
    • (2003) Eur. Respir. J , vol.22 , pp. 374-382
    • Kips, J.C.1
  • 24
    • 23444454526 scopus 로고    scopus 로고
    • Rodent models of rheumatoid arthritis
    • Brand, D. D. Rodent models of rheumatoid arthritis. Comp. Med. 55, 114-122 (2005).
    • (2005) Comp. Med , vol.55 , pp. 114-122
    • Brand, D.D.1
  • 25
    • 33746910265 scopus 로고    scopus 로고
    • Concordance among gene-expression-based predictors for breast cancer
    • Fan, C. et al. Concordance among gene-expression-based predictors for breast cancer. N. Engl. J. Med. 355, 560-569 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 560-569
    • Fan, C.1
  • 26
    • 33746875641 scopus 로고    scopus 로고
    • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    • Potti, A. et al. A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N. Engl. J. Med. 355, 570-580 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 570-580
    • Potti, A.1
  • 27
    • 33646933785 scopus 로고    scopus 로고
    • A small-molecule screen in C. elegans yields a new calcium channel antagonist
    • Kwok, T. C. et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441, 91-95 (2006).
    • (2006) Nature , vol.441 , pp. 91-95
    • Kwok, T.C.1
  • 28
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon, L. I. & Peterson, R. T. In vivo drug discovery in the zebrafish. Nature Rev. Drug Discov. 4, 35-44 (2005).
    • (2005) Nature Rev. Drug Discov , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 29
    • 33845494471 scopus 로고    scopus 로고
    • A transgenic zebrafish model of neutrophilic inflammation
    • in the press
    • Renshaw, S. A. et al. A transgenic zebrafish model of neutrophilic inflammation. Blood (in the press).
    • Blood
    • Renshaw, S.A.1
  • 30
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith, L. G. & Swartz, M. A. Capturing complex 3D tissue physiology in vitro. Nature Rev. Mol. Cell Biol. 7, 211-224 (2006).
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 31
    • 33845655896 scopus 로고    scopus 로고
    • Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
    • Morris, G. E. et al. Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB J. 20, 2153-2155 (2006).
    • (2006) FASEB J , vol.20 , pp. 2153-2155
    • Morris, G.E.1
  • 32
    • 17644390987 scopus 로고    scopus 로고
    • Agonists of Toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes
    • Morris, G. E. et al. Agonists of Toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. Am. J. Respir. Crit. Care Med. 171, 814-822 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.171 , pp. 814-822
    • Morris, G.E.1
  • 33
    • 33845895809 scopus 로고    scopus 로고
    • Pulmonary perspective: Targeting the networks that underpin contiguous immunity in asthma and COPD
    • in the press
    • Sabroe, I. et al. Pulmonary perspective: targeting the networks that underpin contiguous immunity in asthma and COPD. Am. J. Respir. Crit. Care Med. (in the press).
    • Am. J. Respir. Crit. Care Med
    • Sabroe, I.1
  • 34
    • 33646380353 scopus 로고    scopus 로고
    • A bioinformatician's view of the metabolome
    • Nobeli, I. & Thornton, J. M. A bioinformatician's view of the metabolome. BioEssays 28, 534-545 (2006).
    • (2006) BioEssays , vol.28 , pp. 534-545
    • Nobeli, I.1    Thornton, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.