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Volumn 2, Issue 5, 2008, Pages 631-643

Preclinical animal models of asthma and chronic obstructive pulmonary disease

Author keywords

Allergen; Animal models; Asthma; Chronic obstructive pulmonary disease; Cigarette smoke; COPD; Drug discovery; Inflammation; Lung

Indexed keywords

ANTIOXIDANT; BRONCHODILATING AGENT; CIGARETTE SMOKE; ELASTASE; GLUCOCORTICOID; IMMUNOGLOBULIN E; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; OMALIZUMAB; OVALBUMIN; PHOSPHODIESTERASE IV INHIBITOR; PROTEINASE INHIBITOR; RETINOIC ACID; STEROID;

EID: 55149117056     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2.5.631     Document Type: Review
Times cited : (22)

References (146)
  • 2
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: It still yields few answers in asthma
    • Wenzel S, Holgate ST. The mouse trap: it still yields few answers in asthma. Am. J. Respir. Crit. Care Med. 174, 1173-1176 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.174 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2
  • 3
    • 0033604544 scopus 로고    scopus 로고
    • The alliance of genes and environment in asthma and allergy
    • Cookson W. The alliance of genes and environment in asthma and allergy. Nature 402(Suppl.), B5-B11 (1999).
    • (1999) Nature , vol.402 , Issue.SUPPL.
    • Cookson, W.1
  • 4
    • 0032524991 scopus 로고    scopus 로고
    • Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses toward the Th2 cytokine profile
    • Prescott SL, Macaubas C, Holt BJ et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J. Immunol. 160, 4730-4737 (1998).
    • (1998) J. Immunol , vol.160 , pp. 4730-4737
    • Prescott, S.L.1    Macaubas, C.2    Holt, B.J.3
  • 5
    • 0024491638 scopus 로고
    • Association of asthma with serum IgE levels and skin-test reactivity to allergens
    • Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 320, 271-277 (1989).
    • (1989) N. Engl. J. Med , vol.320 , pp. 271-277
    • Burrows, B.1    Martinez, F.D.2    Halonen, M.3    Barbee, R.A.4    Cline, M.G.5
  • 6
    • 0034881877 scopus 로고    scopus 로고
    • Solèr M, Matz J, Townley R et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur. Respir. J. 18(2), 254-261. Erratum in: Eur. Respir. J. 18, 739-740 (2001).
    • Solèr M, Matz J, Townley R et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur. Respir. J. 18(2), 254-261. Erratum in: Eur. Respir. J. 18, 739-740 (2001).
  • 9
    • 0019287853 scopus 로고
    • Criteria for development of animal models of diseases of the respiratory system: The comparative approach in respiratory disease model development
    • Slauson DO, Hahn FF. Criteria for development of animal models of diseases of the respiratory system: the comparative approach in respiratory disease model development. Am. J. Pathol. 101, S103-S122 (1980).
    • (1980) Am. J. Pathol , vol.101
    • Slauson, D.O.1    Hahn, F.F.2
  • 10
    • 33748546919 scopus 로고    scopus 로고
    • Current animal models of bronchial asthma
    • Kurucz I, Szelenyi I. Current animal models of bronchial asthma. Curr. Pharm. Des. 12, 3175-3194 (2006).
    • (2006) Curr. Pharm. Des , vol.12 , pp. 3175-3194
    • Kurucz, I.1    Szelenyi, I.2
  • 11
    • 0026873651 scopus 로고
    • Effect of acute and chronic antigen inhalation on airway morphology and responsiveness in actively sensitized rats
    • Kips JC, Cuvelier CA, Pauwels RA. Effect of acute and chronic antigen inhalation on airway morphology and responsiveness in actively sensitized rats. Am. Rev. Respir. Dis. 145, 1306-1130 (1992).
    • (1992) Am. Rev. Respir. Dis , vol.145 , pp. 1306-1130
    • Kips, J.C.1    Cuvelier, C.A.2    Pauwels, R.A.3
  • 12
    • 0027399007 scopus 로고
    • Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats
    • Misawa M, Chiba Y. Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats. Jpn. J. Pharmacol. 61, 41-50 (1993).
    • (1993) Jpn. J. Pharmacol , vol.61 , pp. 41-50
    • Misawa, M.1    Chiba, Y.2
  • 13
    • 0030238541 scopus 로고    scopus 로고
    • Cytokine expression in the presence or absence of late airway responses after antigen challenge of sensitized rats
    • Renzi PM, Al Assaad AS, Yang J, Yasruel Z, Harold Q. Cytokine expression in the presence or absence of late airway responses after antigen challenge of sensitized rats. Am. J. Respir. Cell Mol. Biol. 15, 367-373 (1996).
    • (1996) Am. J. Respir. Cell Mol. Biol , vol.15 , pp. 367-373
    • Renzi, P.M.1    Al Assaad, A.S.2    Yang, J.3    Yasruel, Z.4    Harold, Q.5
  • 14
    • 0031307832 scopus 로고    scopus 로고
    • Kinetics and quantification of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown Norway rat model
    • Schneider T, van Velzen D, Moqbel R, Issekutz AC. Kinetics and quantification of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown Norway rat model. Am. J. Respir. Cell Mol. Biol. 17, 702-712 (1997).
    • (1997) Am. J. Respir. Cell Mol. Biol , vol.17 , pp. 702-712
    • Schneider, T.1    van Velzen, D.2    Moqbel, R.3    Issekutz, A.C.4
  • 15
    • 0034714320 scopus 로고    scopus 로고
    • Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats
    • Nonaka T, Mitsuhashi H, Takahashi K, Sugiyama H, Kishimoto T. Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats. Eur. J. Pharmacol. 402, 287-295 (2000).
    • (2000) Eur. J. Pharmacol , vol.402 , pp. 287-295
    • Nonaka, T.1    Mitsuhashi, H.2    Takahashi, K.3    Sugiyama, H.4    Kishimoto, T.5
  • 17
    • 0029934184 scopus 로고    scopus 로고
    • Parainfluenza-3-virus infection enhances allergic sensitization in the guinea pig
    • Riedel F, Krause A, Slenczka W, Rieger CHL. Parainfluenza-3-virus infection enhances allergic sensitization in the guinea pig. Clin. Exp. Allergy 26, 603-609 (1996).
    • (1996) Clin. Exp. Allergy , vol.26 , pp. 603-609
    • Riedel, F.1    Krause, A.2    Slenczka, W.3    Rieger, C.H.L.4
  • 18
    • 0032957450 scopus 로고    scopus 로고
    • Role of IgE in the development of allergic airway inflammation and airway hyper-responsiveness - a murine model
    • Hamelmann E, Tadeda K, Oshiba A, Gelfand EW. Role of IgE in the development of allergic airway inflammation and airway hyper-responsiveness - a murine model. Allergy 54, 297-305 (1999).
    • (1999) Allergy , vol.54 , pp. 297-305
    • Hamelmann, E.1    Tadeda, K.2    Oshiba, A.3    Gelfand, E.W.4
  • 19
    • 0037090269 scopus 로고    scopus 로고
    • Early phase bronchoconstriction in the mouse requires allergen-specific IgG
    • Crosby JR, Cieslewicz G, Borchers M et al. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J. Immunol. 168, 4050-4054 (2002).
    • (2002) J. Immunol , vol.168 , pp. 4050-4054
    • Crosby, J.R.1    Cieslewicz, G.2    Borchers, M.3
  • 20
    • 0030995954 scopus 로고    scopus 로고
    • Allergic eosinophilrich inflammation develops in lungs and airways of B cell-deficient mice
    • Korsgren M, Erjefält JS, Korsgren O, Sundler F, Persson CG. Allergic eosinophilrich inflammation develops in lungs and airways of B cell-deficient mice. J. Exp. Med. 185, 885-892 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 885-892
    • Korsgren, M.1    Erjefält, J.S.2    Korsgren, O.3    Sundler, F.4    Persson, C.G.5
  • 21
    • 0031020812 scopus 로고    scopus 로고
    • Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice
    • Hamelmann E, Vella AT, Oshiba A, Kappler JW, Marrack P, Gelfand EW. Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc. Natl Acad. Sci. USA 94, 1350-1355 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 1350-1355
    • Hamelmann, E.1    Vella, A.T.2    Oshiba, A.3    Kappler, J.W.4    Marrack, P.5    Gelfand, E.W.6
  • 22
    • 0038177928 scopus 로고    scopus 로고
    • Modeling asthma and COPD in animals: A pointless exercise?
    • Canning BJ. Modeling asthma and COPD in animals: a pointless exercise? Curr. Opin. Pharmacol. 3, 244-250 (2003).
    • (2003) Curr. Opin. Pharmacol , vol.3 , pp. 244-250
    • Canning, B.J.1
  • 23
    • 0034493299 scopus 로고    scopus 로고
    • Animal models of bronchial asthma
    • Szelenyi I. Animal models of bronchial asthma. Inflamm. Res. 49, 639-654 (2000).
    • (2000) Inflamm. Res , vol.49 , pp. 639-654
    • Szelenyi, I.1
  • 24
    • 0035122373 scopus 로고    scopus 로고
    • Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats
    • Hele DJ, Birrell MA, Webber SE, Foster ML, Belvisi MG. Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats. Br. J. Pharmacol. 132, 481-488 (2001).
    • (2001) Br. J. Pharmacol , vol.132 , pp. 481-488
    • Hele, D.J.1    Birrell, M.A.2    Webber, S.E.3    Foster, M.L.4    Belvisi, M.G.5
  • 25
    • 33646747845 scopus 로고    scopus 로고
    • Mouse models of asthma: What physiological evidence are they based on?
    • Zosky GR, Sly PD, Turner DJ. Mouse models of asthma: what physiological evidence are they based on? Allergy Clin. Immunol. Int. 18, 76-79 (2006).
    • (2006) Allergy Clin. Immunol. Int , vol.18 , pp. 76-79
    • Zosky, G.R.1    Sly, P.D.2    Turner, D.J.3
  • 26
    • 0035126626 scopus 로고    scopus 로고
    • Neural regulation of airway smooth muscle tone
    • Canning BJ, Fischer A. Neural regulation of airway smooth muscle tone. Respir. Physiol. 125, 113-127 (2001).
    • (2001) Respir. Physiol , vol.125 , pp. 113-127
    • Canning, B.J.1    Fischer, A.2
  • 27
    • 0028817013 scopus 로고
    • Airway hyper-responsiveness in asthma: A problem of limited smooth muscle relaxation with inspiration
    • Skloot G, Permutt S, Togias A. Airway hyper-responsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J. Clin. Invest. 96, 2393-2403 (1995).
    • (1995) J. Clin. Invest , vol.96 , pp. 2393-2403
    • Skloot, G.1    Permutt, S.2    Togias, A.3
  • 28
    • 0023896897 scopus 로고
    • Pulmonary responses to bronchoconstrictor agonists in the mouse
    • Martin TR, Gerard NP, Galli SJ, Drazen JM. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64, 2318-2323 (1988).
    • (1988) J. Appl. Physiol , vol.64 , pp. 2318-2323
    • Martin, T.R.1    Gerard, N.P.2    Galli, S.J.3    Drazen, J.M.4
  • 29
    • 0028962429 scopus 로고
    • Role of VLA-4 and LFA-1 in allergen-induced airway hyper-responsiveness and lung inflammation in the rat
    • Laberge S, Rabb H, Issekutz TB, Martin JG. Role of VLA-4 and LFA-1 in allergen-induced airway hyper-responsiveness and lung inflammation in the rat. Am. J. Respir. Crit. Care Med. 151, 822-829 (1995).
    • (1995) Am. J. Respir. Crit. Care Med , vol.151 , pp. 822-829
    • Laberge, S.1    Rabb, H.2    Issekutz, T.B.3    Martin, J.G.4
  • 30
    • 0029890890 scopus 로고    scopus 로고
    • Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitized Brown Norway rats
    • Haczku A, Macary P, Haddad EB et al. Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitized Brown Norway rats. Immunology 88, 247-251 (1996).
    • (1996) Immunology , vol.88 , pp. 247-251
    • Haczku, A.1    Macary, P.2    Haddad, E.B.3
  • 31
    • 0022622329 scopus 로고
    • Comparative anatomy of mammalian respiratory tracts: The nasopharyngeal region and the tracheobronchial region
    • Patra AL. Comparative anatomy of mammalian respiratory tracts: the nasopharyngeal region and the tracheobronchial region. J. Toxicol. Environ. Health 17, 163-174 (1986).
    • (1986) J. Toxicol. Environ. Health , vol.17 , pp. 163-174
    • Patra, A.L.1
  • 32
    • 0027475744 scopus 로고
    • Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat
    • Renzi PM, Olivenstein R, Martin JG. Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am. Rev. Respir. Dis. 147, 967-974 (1993).
    • (1993) Am. Rev. Respir. Dis , vol.147 , pp. 967-974
    • Renzi, P.M.1    Olivenstein, R.2    Martin, J.G.3
  • 33
    • 0028216832 scopus 로고
    • The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat
    • Rabb HA, Olivenstein R, Issekutz TB, Renzi PM, Martin JG. The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat. Am. J. Respir. Crit. Care Med. 149, 1186-1191 (1994).
    • (1994) Am. J. Respir. Crit. Care Med , vol.149 , pp. 1186-1191
    • Rabb, H.A.1    Olivenstein, R.2    Issekutz, T.B.3    Renzi, P.M.4    Martin, J.G.5
  • 34
    • 34250732585 scopus 로고    scopus 로고
    • Asthma
    • Morgan DW, Marshall LA Eds, Birkhauser Verlag, Basel, Switzerland
    • Selig WM, Chapman RW. Asthma. In: In Vivo Models of Inflammation. Morgan DW, Marshall LA (Eds). Birkhauser Verlag, Basel, Switzerland 111-135 (1999).
    • (1999) In Vivo Models of Inflammation , pp. 111-135
    • Selig, W.M.1    Chapman, R.W.2
  • 35
    • 0033785866 scopus 로고    scopus 로고
    • Absence of late airway response despite increased airway responsiveness and eosinophilia in a murine model of asthma
    • de Bie JJ, Kneepkens M, Kraneveld AD et al. Absence of late airway response despite increased airway responsiveness and eosinophilia in a murine model of asthma. Exp. Lung Res. 26, 491-507 (2000).
    • (2000) Exp. Lung Res , vol.26 , pp. 491-507
    • de Bie, J.J.1    Kneepkens, M.2    Kraneveld, A.D.3
  • 36
    • 0036038912 scopus 로고    scopus 로고
    • The strength of the OVA-induced airway inflammation in rats is strain dependent
    • Hylkema MN, Hoekstra MO, Luinge M, Timens W. The strength of the OVA-induced airway inflammation in rats is strain dependent. Clin. Exp. Immunol. 129, 390-396 (2002).
    • (2002) Clin. Exp. Immunol , vol.129 , pp. 390-396
    • Hylkema, M.N.1    Hoekstra, M.O.2    Luinge, M.3    Timens, W.4
  • 37
    • 0034529934 scopus 로고    scopus 로고
    • Time course of inflammatory and remodeling events in a murine model of asthma: Effect of steroid treatment
    • Trifilieff A, El-Hashim A, Bertrand C. Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment. Am. J. Physiol. Lung Cell Mol. Physiol. 279, L1120-L1128 (2000).
    • (2000) Am. J. Physiol. Lung Cell Mol. Physiol , vol.279
    • Trifilieff, A.1    El-Hashim, A.2    Bertrand, C.3
  • 38
    • 0024414345 scopus 로고
    • Autosomal recessive inhertiance of airway hyperreactivity to 5-hydroxytryptamine
    • Levitt RC, Mitzner W. Autosomal recessive inhertiance of airway hyperreactivity to 5-hydroxytryptamine. J. Appl. Physiol. 67, 1125-1132 (1989)
    • (1989) J. Appl. Physiol , vol.67 , pp. 1125-1132
    • Levitt, R.C.1    Mitzner, W.2
  • 39
    • 0004595652 scopus 로고    scopus 로고
    • Mouse IL-13 enhances antibody production in vivo and acts directly on B calls in vitro to increase survival and hence antibody production
    • Lai YH, Mosmann TR. Mouse IL-13 enhances antibody production in vivo and acts directly on B calls in vitro to increase survival and hence antibody production. J. Immunol. 162, 78-87 (1999).
    • (1999) J. Immunol , vol.162 , pp. 78-87
    • Lai, Y.H.1    Mosmann, T.R.2
  • 40
    • 0034930435 scopus 로고    scopus 로고
    • Chemokine receptors in airway disease: Which receptors to target?
    • Owen C. Chemokine receptors in airway disease: which receptors to target? Pulm. Pharmacol. Ther. 14, 193-202 (2001).
    • (2001) Pulm. Pharmacol. Ther , vol.14 , pp. 193-202
    • Owen, C.1
  • 41
    • 0036485214 scopus 로고    scopus 로고
    • Chemokine receptors: Multifaceted therapeutic targets
    • Proudfoot AE. Chemokine receptors: multifaceted therapeutic targets. Nat. Rev. Immunol. 2, 106-115 (2002).
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 106-115
    • Proudfoot, A.E.1
  • 42
    • 0028963908 scopus 로고
    • Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung
    • Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J. Exp. Med. 181, 1121-1216 (1995).
    • (1995) J. Exp. Med , vol.181 , pp. 1121-1216
    • Rothenberg, M.E.1    Luster, A.D.2    Lilly, C.M.3    Drazen, J.M.4    Leder, P.5
  • 43
    • 37349063414 scopus 로고    scopus 로고
    • Pulmonary inflammation in brown Norway rats: Possible association of environmental particles in the animal room environment
    • Noritake S, Ogawa K, Suzuki G, Ozawa K, Ikeda T. Pulmonary inflammation in brown Norway rats: possible association of environmental particles in the animal room environment. Exp. Anim. 56(5), 319-327 (2007).
    • (2007) Exp. Anim , vol.56 , Issue.5 , pp. 319-327
    • Noritake, S.1    Ogawa, K.2    Suzuki, G.3    Ozawa, K.4    Ikeda, T.5
  • 44
    • 0028837516 scopus 로고
    • Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice
    • Hessel EM, Van Oosterhout AJ, Hofstra CL et al. Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice. Eur. J. Pharmacol. 293, 401-412 (1995).
    • (1995) Eur. J. Pharmacol , vol.293 , pp. 401-412
    • Hessel, E.M.1    Van Oosterhout, A.J.2    Hofstra, C.L.3
  • 45
    • 0029969336 scopus 로고    scopus 로고
    • Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness
    • Lefort J, Bachelet CM, Leduc D, Vargaftig BB. Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 97, 788-799 (1996).
    • (1996) J. Allergy Clin. Immunol , vol.97 , pp. 788-799
    • Lefort, J.1    Bachelet, C.M.2    Leduc, D.3    Vargaftig, B.B.4
  • 47
    • 0035218049 scopus 로고    scopus 로고
    • A report from the International Eosinophil Society: Eosinophils in a tug of war
    • Lacy P, Weller PF, Moqbel R. A report from the International Eosinophil Society: eosinophils in a tug of war. J. Allergy Clin. Immunol. 108, 895-900 (2001).
    • (2001) J. Allergy Clin. Immunol , vol.108 , pp. 895-900
    • Lacy, P.1    Weller, P.F.2    Moqbel, R.3
  • 48
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, Ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3
  • 49
    • 0030068235 scopus 로고    scopus 로고
    • Corry DB, Folkesson HG, Warnock ML et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183(1), 109-117 (1996). Erratum in: J. Exp Med. 185(9), 1715 (1997).
    • Corry DB, Folkesson HG, Warnock ML et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183(1), 109-117 (1996). Erratum in: J. Exp Med. 185(9), 1715 (1997).
  • 50
    • 0027729739 scopus 로고
    • Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma
    • Mauser PJ, Pitman A, Witt A et al. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am. Rev. Respir. Dis. 148(6 Pt 1), 1623-1627 (1993).
    • (1993) Am. Rev. Respir. Dis , vol.148 , Issue.6 PART 1 , pp. 1623-1627
    • Mauser, P.J.1    Pitman, A.2    Witt, A.3
  • 51
    • 4544304222 scopus 로고    scopus 로고
    • Defining a link with asthma in mice congenitally deficient in eosinophils
    • Lee JJ, Dimina D, Macias MP, Ochkur SI et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305, 1773-1776 (2004).
    • (2004) Science , vol.305 , pp. 1773-1776
    • Lee, J.J.1    Dimina, D.2    Macias, M.P.3    Ochkur, S.I.4
  • 52
    • 4544274172 scopus 로고    scopus 로고
    • A critical role for eosinophils in allergic airways remodeling
    • Humbles AA, Lloyd CM, McMillan SJ et al. A critical role for eosinophils in allergic airways remodeling. Science 305, 1776-1779 (2004).
    • (2004) Science , vol.305 , pp. 1776-1779
    • Humbles, A.A.1    Lloyd, C.M.2    McMillan, S.J.3
  • 53
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183, 195-201 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 54
    • 0032145438 scopus 로고    scopus 로고
    • A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
    • Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, Foster PS. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 161, 1501-1509 (1998).
    • (1998) J. Immunol , vol.161 , pp. 1501-1509
    • Hogan, S.P.1    Matthaei, K.I.2    Young, J.M.3    Koskinen, A.4    Young, I.G.5    Foster, P.S.6
  • 55
    • 4544239885 scopus 로고    scopus 로고
    • Biomedicine. Eosinophils in asthma: Remodeling a tangled tale
    • Wills-Karp M, Karp CL. Biomedicine. Eosinophils in asthma: remodeling a tangled tale. Science 305, 1726-1729 (2004).
    • (2004) Science , vol.305 , pp. 1726-1729
    • Wills-Karp, M.1    Karp, C.L.2
  • 56
    • 0036739443 scopus 로고    scopus 로고
    • Underwood SL, Haddad el-B, Birrell MA et al. Functional characterization and biomarker identification in the brown Norway model of allergic airway inflammation. Br. J. Pharmacol. 137(2), 263-275 (2002).
    • Underwood SL, Haddad el-B, Birrell MA et al. Functional characterization and biomarker identification in the brown Norway model of allergic airway inflammation. Br. J. Pharmacol. 137(2), 263-275 (2002).
  • 57
    • 0029558250 scopus 로고
    • Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin-5-dependent bronchial hyperresponsiveness
    • Eum S-Y, Hailé S, Lefort J, Huerre M, Vargaftig BB. Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin-5-dependent bronchial hyperresponsiveness. Proc. Natl Acad. Sci. USA 92, 12290-12294 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 12290-12294
    • Eum, S.-Y.1    Hailé, S.2    Lefort, J.3    Huerre, M.4    Vargaftig, B.B.5
  • 60
    • 20444423863 scopus 로고    scopus 로고
    • IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    • Fish SC, Donaldson DD, Goldman SJ, Williams CMM, Kasaian MT. IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13. J. Immunol. 174, 7716-7724 (2005).
    • (2005) J. Immunol , vol.174 , pp. 7716-7724
    • Fish, S.C.1    Donaldson, D.D.2    Goldman, S.J.3    Williams, C.M.M.4    Kasaian, M.T.5
  • 61
    • 0031781163 scopus 로고    scopus 로고
    • An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen
    • Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 53, 849-856 (1998).
    • (1998) Thorax , vol.53 , pp. 849-856
    • Temelkovski, J.1    Hogan, S.P.2    Shepherd, D.P.3    Foster, P.S.4    Kumar, R.K.5
  • 62
    • 9144267663 scopus 로고    scopus 로고
    • Continuous exposure to house dust mice elicits chronic airway inflammation and structural remodeling
    • Johnson JR, Wiley RE, Fattouh R et al. Continuous exposure to house dust mice elicits chronic airway inflammation and structural remodeling. Am. J. Respir. Crit. Care Med. 169, 378-385 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.169 , pp. 378-385
    • Johnson, J.R.1    Wiley, R.E.2    Fattouh, R.3
  • 64
    • 34250763237 scopus 로고    scopus 로고
    • Animal models of asthma
    • Zosky GR, Sly PD. Animal models of asthma. Clin. Exp. Allergy 37(7), 973-988 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , Issue.7 , pp. 973-988
    • Zosky, G.R.1    Sly, P.D.2
  • 65
    • 33644842209 scopus 로고    scopus 로고
    • Building a better mouse model: Experimental models of chronic asthma
    • Fulkerson PC, Rothenberg ME, Hogan SP. Building a better mouse model: experimental models of chronic asthma. Clin. Exp. Allergy. 35, 1251-1253 (2005).
    • (2005) Clin. Exp. Allergy , vol.35 , pp. 1251-1253
    • Fulkerson, P.C.1    Rothenberg, M.E.2    Hogan, S.P.3
  • 66
    • 3242754344 scopus 로고    scopus 로고
    • Tolerance induced by inhaled antigen involves CD4 (1) T cells expressing membrane-bound TGF-β and Foxp3
    • Ostroukhova M, Seguin-Devaux C, Oriss TB et al. Tolerance induced by inhaled antigen involves CD4 (1) T cells expressing membrane-bound TGF-β and Foxp3. J. Clin. Invest. 114, 28-38 (2004).
    • (2004) J. Clin. Invest , vol.114 , pp. 28-38
    • Ostroukhova, M.1    Seguin-Devaux, C.2    Oriss, T.B.3
  • 67
    • 0036038968 scopus 로고    scopus 로고
    • Maternal allergen immunization during pregnancy in a mouse model reduces adult allergy-related antibody responses in the offspring
    • Melkild I, Groeng EC, Leikvold RB, Granum B, Lovik M. Maternal allergen immunization during pregnancy in a mouse model reduces adult allergy-related antibody responses in the offspring. Clin. Exp. Allergy 32, 1370-1376 (2002).
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 1370-1376
    • Melkild, I.1    Groeng, E.C.2    Leikvold, R.B.3    Granum, B.4    Lovik, M.5
  • 68
    • 33748508415 scopus 로고    scopus 로고
    • Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults
    • You D, Becnel D, Wang K, Ripple M, Daly M, Cormier SA. Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults. Respir. Res. 7, 107 (2006).
    • (2006) Respir. Res , vol.7 , pp. 107
    • You, D.1    Becnel, D.2    Wang, K.3    Ripple, M.4    Daly, M.5    Cormier, S.A.6
  • 69
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653 (2004).
    • (2004) N. Engl. J. Med , vol.350 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3
  • 70
    • 0035035768 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease
    • Pauwels RA, Buist S, Calverley PMA, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 163, 1256-1276 (2001).
    • (2001) Am. J. Respir. Crit. Care Med , vol.163 , pp. 1256-1276
    • Pauwels, R.A.1    Buist, S.2    Calverley, P.M.A.3    Jenkins, C.R.4    Hurd, S.S.5
  • 71
    • 0028852752 scopus 로고
    • Effects of air pollution on symptoms and peak expiratory flow measurements in subjects with obstructive airways disease
    • Higgins BG, Francis HC, Yates CJ et al. Effects of air pollution on symptoms and peak expiratory flow measurements in subjects with obstructive airways disease. Thorax 50, 149-155 (1995).
    • (1995) Thorax , vol.50 , pp. 149-155
    • Higgins, B.G.1    Francis, H.C.2    Yates, C.J.3
  • 72
    • 0026346077 scopus 로고
    • Mucin gene expression in rat airways following infection and irritation
    • Jany B, Gallup M, Tsuda T, Basbaum C. Mucin gene expression in rat airways following infection and irritation. Biochem. Biophys. Res. Commun. 181, 1-8 (1991).
    • (1991) Biochem. Biophys. Res. Commun , vol.181 , pp. 1-8
    • Jany, B.1    Gallup, M.2    Tsuda, T.3    Basbaum, C.4
  • 73
    • 0028979938 scopus 로고
    • Mechanisms and modulation of airway plasma exudation after direct inhalation of cigarette smoke
    • Lei YH, Barnes PJ, Rogers DF. Mechanisms and modulation of airway plasma exudation after direct inhalation of cigarette smoke. Am. J. Respir. Crit. Care Med. 151, 1752-1762 (1995).
    • (1995) Am. J. Respir. Crit. Care Med , vol.151 , pp. 1752-1762
    • Lei, Y.H.1    Barnes, P.J.2    Rogers, D.F.3
  • 74
    • 0024455518 scopus 로고
    • Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals
    • Dusser DJ, Djokic TD, Borson DB, Nadel JA. Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals. J. Clin. Invest. 84, 900-906 (1989).
    • (1989) J. Clin. Invest , vol.84 , pp. 900-906
    • Dusser, D.J.1    Djokic, T.D.2    Borson, D.B.3    Nadel, J.A.4
  • 75
    • 4344675455 scopus 로고    scopus 로고
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    • Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364, 709-721 (2004).
    • (2004) Lancet , vol.364 , pp. 709-721
    • Hogg, J.C.1
  • 80
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 25, 1645-1648 (1977).
    • (1977) Br. Med. J , vol.25 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 81
    • 0345701470 scopus 로고    scopus 로고
    • Obstructive lung disease in northern sweden studies. Not 15 but 50% of smokers develop COPD? - Report from the obstructive lung disease in northern sweden studies
    • Lundback B, Lindberg A, Lindstrom M et al. Obstructive lung disease in northern sweden studies. Not 15 but 50% of smokers develop COPD? - Report from the obstructive lung disease in northern sweden studies. Respir. Med. 97, 115-122 (2003).
    • (2003) Respir. Med , vol.97 , pp. 115-122
    • Lundback, B.1    Lindberg, A.2    Lindstrom, M.3
  • 82
    • 0013828812 scopus 로고
    • Studies in 1-antitrypsin deficiency
    • Eriksson S. Studies in 1-antitrypsin deficiency. Acta Med. Scand. 432(Suppl.), 1-85 (1965).
    • (1965) Acta Med. Scand , vol.432 , Issue.SUPPL. , pp. 1-85
    • Eriksson, S.1
  • 83
    • 84907041622 scopus 로고
    • The electrophoretic 1-globulin pattern of serum in α1-antitrypsin deficiency
    • Laurell C-B, Eriksson S. The electrophoretic 1-globulin pattern of serum in α1-antitrypsin deficiency. Scand. J. Clin. Lab. Invest. 15, 132-140 (1963).
    • (1963) Scand. J. Clin. Lab. Invest , vol.15 , pp. 132-140
    • Laurell, C.-B.1    Eriksson, S.2
  • 85
    • 0026447203 scopus 로고
    • Emphysema: The first two centuries and beyond. A historical overview, with suggestions for future research: part 2
    • Snider GL. Emphysema: the first two centuries and beyond. A historical overview, with suggestions for future research: part 2. Am. Rev. Respir. Dis. 146, 1615-1622 (1992).
    • (1992) Am. Rev. Respir. Dis , vol.146 , pp. 1615-1622
    • Snider, G.L.1
  • 87
    • 0023747488 scopus 로고
    • An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase
    • Lucey EC, Stone PJ, Christensen TG, Breuer R, Snider GL. An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase. Exp. Lung Res. 14, 671-686 (1988).
    • (1988) Exp. Lung Res , vol.14 , pp. 671-686
    • Lucey, E.C.1    Stone, P.J.2    Christensen, T.G.3    Breuer, R.4    Snider, G.L.5
  • 88
    • 55149122609 scopus 로고    scopus 로고
    • Asthma
    • Volume2, Stevenson CS, Marshall LM, Morgan DW Eds, Birkhauser Verlag, Basel, Switzerland
    • Stevenson CS, Underwood DC. Asthma. In: In Vivo Models of Inflammation (Volume2). Stevenson CS, Marshall LM, Morgan DW (Eds). Birkhauser Verlag, Basel, Switzerland 29-57 (2006).
    • (2006) In Vivo Models of Inflammation , pp. 29-57
    • Stevenson, C.S.1    Underwood, D.C.2
  • 89
    • 0014783109 scopus 로고
    • Demonstration of the chemotactic properties of collagen
    • Chang C, Houck JC. Demonstration of the chemotactic properties of collagen. Proc. Soc. Exp. Biol. Med. 134, 22-26 (1970).
    • (1970) Proc. Soc. Exp. Biol. Med , vol.134 , pp. 22-26
    • Chang, C.1    Houck, J.C.2
  • 90
    • 85012405294 scopus 로고
    • Collagen and collagen peptide-induced chemotaxis of human blood monocytes
    • Postlethwaite AE, Kang AH. Collagen and collagen peptide-induced chemotaxis of human blood monocytes. J. Exp. Med. 143, 1299-1307 (1976).
    • (1976) J. Exp. Med , vol.143 , pp. 1299-1307
    • Postlethwaite, A.E.1    Kang, A.H.2
  • 91
    • 0018893350 scopus 로고
    • Chemotactic activity of elastin-derived peptides
    • Senior RM, Griffin GL, Mecham RP. Chemotactic activity of elastin-derived peptides. J. Clin. Invest. 66, 859-862 (1980).
    • (1980) J. Clin. Invest , vol.66 , pp. 859-862
    • Senior, R.M.1    Griffin, G.L.2    Mecham, R.P.3
  • 92
    • 21544474123 scopus 로고    scopus 로고
    • Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-κB pathway activation
    • Birrell MA, Wong S, Hele DJ, McCluskie K, Hardaker E, Belvisi MG. Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-κB pathway activation. Am. J. Respir. Crit. Care Med. 172, 74-84 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.172 , pp. 74-84
    • Birrell, M.A.1    Wong, S.2    Hele, D.J.3    McCluskie, K.4    Hardaker, E.5    Belvisi, M.G.6
  • 93
    • 33644643244 scopus 로고    scopus 로고
    • Elastin fragments drive disease progression in a murine model of emphysema
    • Houghton AM, Quintero PA, Perkins DL et al. Elastin fragments drive disease progression in a murine model of emphysema. J. Clin. Invest. 116, 753-759 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 753-759
    • Houghton, A.M.1    Quintero, P.A.2    Perkins, D.L.3
  • 94
    • 0015903352 scopus 로고
    • The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum
    • Kaplan PD, Kuhn C, Pierce JA. The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum. J. Lab. Clin. Med. 82, 349-356 (1973).
    • (1973) J. Lab. Clin. Med , vol.82 , pp. 349-356
    • Kaplan, P.D.1    Kuhn, C.2    Pierce, J.A.3
  • 95
    • 0017127862 scopus 로고
    • The induction of emphysema with elastase. II. Changes in connective tissue
    • Kuhn C, Yu SY, Chraplyvy M, Linder HE, Senior RM. The induction of emphysema with elastase. II. Changes in connective tissue. Lab. Invest. 34, 372-380 (1976).
    • (1976) Lab. Invest , vol.34 , pp. 372-380
    • Kuhn, C.1    Yu, S.Y.2    Chraplyvy, M.3    Linder, H.E.4    Senior, R.M.5
  • 96
    • 16944366965 scopus 로고    scopus 로고
    • Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats
    • Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat. Med. 3, 675-677 (1997).
    • (1997) Nat. Med , vol.3 , pp. 675-677
    • Massaro, G.D.1    Massaro, D.2
  • 97
    • 1542405173 scopus 로고    scopus 로고
    • Retinoic acid fails to reverse emphysema in adult mouse models
    • Fujita M, Ye Q, Ouchi H et al. Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 59, 224-230 (2004).
    • (2004) Thorax , vol.59 , pp. 224-230
    • Fujita, M.1    Ye, Q.2    Ouchi, H.3
  • 98
    • 0038751985 scopus 로고    scopus 로고
    • Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysemea
    • Lucey EC, Goldstein RH, Breuer R, Rexer BN, Ong DE, Snider GL. Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysemea. Respiration 70, 200-205 (2003).
    • (2003) Respiration , vol.70 , pp. 200-205
    • Lucey, E.C.1    Goldstein, R.H.2    Breuer, R.3    Rexer, B.N.4    Ong, D.E.5    Snider, G.L.6
  • 99
    • 3142692403 scopus 로고    scopus 로고
    • Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats
    • March TH, Cossey PY, Esparza DC, Dix KJ, McDonald JD, Bowen LE. Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats. Exp. Lung Res. 30, 383-404 (2004).
    • (2004) Exp. Lung Res , vol.30 , pp. 383-404
    • March, T.H.1    Cossey, P.Y.2    Esparza, D.C.3    Dix, K.J.4    McDonald, J.D.5    Bowen, L.E.6
  • 100
    • 55149095108 scopus 로고    scopus 로고
    • IκB kinase-2 independent and dependent inflammation in airway disease models: Relevance of IKK-2 inhibition to the clinic
    • Birrell MA, Wong S, Hardaker E et al. IκB kinase-2 independent and dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol. Pharmacol. 282(44), 31882-31890 (2006).
    • (2006) Mol. Pharmacol , vol.282 , Issue.44 , pp. 31882-31890
    • Birrell, M.A.1    Wong, S.2    Hardaker, E.3
  • 101
    • 33751241164 scopus 로고    scopus 로고
    • Feasibility of retinoids for the treatment of emphysema study
    • Roth MD, Connett JE, D'Armiento JM et al. Feasibility of retinoids for the treatment of emphysema study. Chest 130(5), 1334-1345 (2006).
    • (2006) Chest , vol.130 , Issue.5 , pp. 1334-1345
    • Roth, M.D.1    Connett, J.E.2    D'Armiento, J.M.3
  • 102
    • 16344393319 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lungs attenuates elastase-induced pulmonary emphysema in mice
    • Shinohara T, Kaneko T, Nagashima Y, Ueda A, Tagawa A, Ishigatsubo Y. Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lungs attenuates elastase-induced pulmonary emphysema in mice. Hum. Gene Ther. 16, 318-327 (2005).
    • (2005) Hum. Gene Ther , vol.16 , pp. 318-327
    • Shinohara, T.1    Kaneko, T.2    Nagashima, Y.3    Ueda, A.4    Tagawa, A.5    Ishigatsubo, Y.6
  • 103
    • 0032193237 scopus 로고    scopus 로고
    • Oxidant stress incites spreading of macrophages via extracellular signal-regulated kinases and p38 mitogen-activated protein kinase
    • Ogura M, Kitamura M. Oxidant stress incites spreading of macrophages via extracellular signal-regulated kinases and p38 mitogen-activated protein kinase. J. Immunol. 161, 3569-3574 (1998).
    • (1998) J. Immunol , vol.161 , pp. 3569-3574
    • Ogura, M.1    Kitamura, M.2
  • 104
    • 0036141863 scopus 로고    scopus 로고
    • Severity of elastase-induced emphysema is decreased in tumor necrosis factor-α and interleukin-1β receptor-deficient mice
    • Lucey EC, Keane J, Kuang PP, Snider GL, Goldstein RH. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-α and interleukin-1β receptor-deficient mice. Lab. Invest. 82, 79-85 (2002).
    • (2002) Lab. Invest , vol.82 , pp. 79-85
    • Lucey, E.C.1    Keane, J.2    Kuang, P.P.3    Snider, G.L.4    Goldstein, R.H.5
  • 105
    • 0036943648 scopus 로고    scopus 로고
    • Animal models of cigarette smoke-induced COPD
    • Wright JL, Churg A. Animal models of cigarette smoke-induced COPD. Chest 122, 301S-306S (2002).
    • (2002) Chest , vol.122
    • Wright, J.L.1    Churg, A.2
  • 106
    • 0032726815 scopus 로고    scopus 로고
    • Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 rats
    • March TH, Barr EB, Finch GL et al. Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 rats. Toxicol. Sci. 51, 289-299 (1999).
    • (1999) Toxicol. Sci , vol.51 , pp. 289-299
    • March, T.H.1    Barr, E.B.2    Finch, G.L.3
  • 107
    • 13444256632 scopus 로고    scopus 로고
    • Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants
    • Bartalesi B, Cavarra E, Fineschi S et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur. Respir. J. 25, 15-22 (2005).
    • (2005) Eur. Respir. J , vol.25 , pp. 15-22
    • Bartalesi, B.1    Cavarra, E.2    Fineschi, S.3
  • 108
    • 7044229899 scopus 로고    scopus 로고
    • The development of emphysema in cigarette smoke-exposed mice is strain dependent
    • Guerassimov A, Hoshino Y, Takubo Y et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am. J. Respir. Crit. Care Med. 170, 974-980 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.170 , pp. 974-980
    • Guerassimov, A.1    Hoshino, Y.2    Takubo, Y.3
  • 109
    • 0037447184 scopus 로고    scopus 로고
    • Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release
    • Churg A, Wang RD, Tai H et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release. Am. J. Respir. Crit. Care Med. 167, 1083-1089 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , pp. 1083-1089
    • Churg, A.1    Wang, R.D.2    Tai, H.3
  • 110
    • 33750725415 scopus 로고    scopus 로고
    • Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice
    • Leclerc O, Lagente V, Planquois JM et al. Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice. Eur. Respir. J. 27(6), 1102-1109 (2006).
    • (2006) Eur. Respir. J , vol.27 , Issue.6 , pp. 1102-1109
    • Leclerc, O.1    Lagente, V.2    Planquois, J.M.3
  • 112
    • 4444322565 scopus 로고    scopus 로고
    • Tumor necrosis factor-α. drives 70% of cigarette smoke-induced emphysema in the mouse
    • Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. Tumor necrosis factor-α. drives 70% of cigarette smoke-induced emphysema in the mouse. Am. J. Respir. Crit. Care Med. 170 (5), 492-498 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.170 , Issue.5 , pp. 492-498
    • Churg, A.1    Wang, R.D.2    Tai, H.3    Wang, X.4    Xie, C.5    Wright, J.L.6
  • 113
    • 0035446905 scopus 로고    scopus 로고
    • Effects of cigarette smoke in mice with different levels of α1-proteinase inhibitor and sensitivity to oxidants
    • Cavarra E, Bartalesi B, Lucattelli M et al. Effects of cigarette smoke in mice with different levels of α1-proteinase inhibitor and sensitivity to oxidants. Am. J. Respir. Crit. Care Med. 164, 886-890 (2001).
    • (2001) Am. J. Respir. Crit. Care Med , vol.164 , pp. 886-890
    • Cavarra, E.1    Bartalesi, B.2    Lucattelli, M.3
  • 114
    • 0037106511 scopus 로고    scopus 로고
    • Tumor necrosis factor-α is central to acute cigarette smoke-induced inflammation and connective tissue breakdown
    • Churg A, Dai J, Tai H, Xie C, Wright JL. Tumor necrosis factor-α is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am. J. Respir. Crit. Care Med. 166, 849-854 (2002).
    • (2002) Am. J. Respir. Crit. Care Med , vol.166 , pp. 849-854
    • Churg, A.1    Dai, J.2    Tai, H.3    Xie, C.4    Wright, J.L.5
  • 115
    • 13644267621 scopus 로고    scopus 로고
    • Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect
    • Stevenson CS, Coote K, Webster R et al. Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am. J. Physiol. Lung Cell Mol. Physiol. 288, L514-L522 (2005).
    • (2005) Am. J. Physiol. Lung Cell Mol. Physiol , vol.288
    • Stevenson, C.S.1    Coote, K.2    Webster, R.3
  • 117
    • 13644263315 scopus 로고    scopus 로고
    • A chronic rat model of smoke-induced lung injury and comparison with an acute 24 h screening model
    • Stevenson CS, Winny C, Coote K et al. A chronic rat model of smoke-induced lung injury and comparison with an acute 24 h screening model. Am. J. Respir. Crit. Care Med. 169, A205 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.169
    • Stevenson, C.S.1    Winny, C.2    Coote, K.3
  • 118
    • 0036727064 scopus 로고    scopus 로고
    • cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice
    • Churg A, Zay K, Shay S, Xie C et al. cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am. J. Respir. Cell Mol. Biol. 27, 368-374 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , pp. 368-374
    • Churg, A.1    Zay, K.2    Shay, S.3    Xie, C.4
  • 119
    • 9744220302 scopus 로고    scopus 로고
    • Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    • Marwick JA, Kirkham PA, Stevenson CS et al. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J. Respir. Cell Mol. Biol. 31, 633-642 (2004).
    • (2004) Am J. Respir. Cell Mol. Biol , vol.31 , pp. 633-642
    • Marwick, J.A.1    Kirkham, P.A.2    Stevenson, C.S.3
  • 120
    • 0027514051 scopus 로고
    • Cigarette smoke causes rapid lipid peroxidation of rat tracheal epithelium
    • Churg A, Cherukupalli K. Cigarette smoke causes rapid lipid peroxidation of rat tracheal epithelium. Int. J. Exp. Pathol. 74, 127-132 (1993).
    • (1993) Int. J. Exp. Pathol , vol.74 , pp. 127-132
    • Churg, A.1    Cherukupalli, K.2
  • 121
    • 33644839261 scopus 로고    scopus 로고
    • Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice
    • Foronjy RF, Mirochnitchenko O, Propokenko O et al. Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am. J. Respir. Crit. Care Med. 173, 623-631 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.173 , pp. 623-631
    • Foronjy, R.F.1    Mirochnitchenko, O.2    Propokenko, O.3
  • 122
    • 0022623634 scopus 로고
    • Inhibition by oral N-acetylcysteine of cigarette smoke-induced "bronchitis" in the rat
    • Rogers DF, Jeffery PK. Inhibition by oral N-acetylcysteine of cigarette smoke-induced "bronchitis" in the rat. Exp. Lung Res. 10, 267-283 (1986).
    • (1986) Exp. Lung Res , vol.10 , pp. 267-283
    • Rogers, D.F.1    Jeffery, P.K.2
  • 124
    • 36348981219 scopus 로고    scopus 로고
    • Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation
    • Stevenson CS, Docx C, Webster R et al. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. Am. J. Physiol. Lung Cell Mol. Physiol. 293, L1183-L1193 (2007).
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol , vol.293
    • Stevenson, C.S.1    Docx, C.2    Webster, R.3
  • 125
    • 21044458874 scopus 로고    scopus 로고
    • Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    • Ito K, Ito M, Elliott WM et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 352, 1967-1976 (2005).
    • (2005) N. Engl. J. Med , vol.352 , pp. 1967-1976
    • Ito, K.1    Ito, M.2    Elliott, W.M.3
  • 126
    • 33646671144 scopus 로고    scopus 로고
    • An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse
    • Pemberton PA, Cantwell JS, Kim KM et al. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 2(3), 303-310 (2005).
    • (2005) COPD , vol.2 , Issue.3 , pp. 303-310
    • Pemberton, P.A.1    Cantwell, J.S.2    Kim, K.M.3
  • 127
    • 0034883830 scopus 로고    scopus 로고
    • α-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    • Churg AJ, Dai K, Zay A et al. α-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab. Invest. 81, 1119-1131 (2001).
    • (2001) Lab. Invest , vol.81 , pp. 1119-1131
    • Churg, A.J.1    Dai, K.2    Zay, A.3
  • 128
    • 40849119969 scopus 로고    scopus 로고
    • p38α-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation
    • Medicherla S, Fitzgerald MF, Spicer D et al. p38α-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. J. Pharmacol. Exp. Ther. 324, 921-929 (2008).
    • (2008) J. Pharmacol. Exp. Ther , vol.324 , pp. 921-929
    • Medicherla, S.1    Fitzgerald, M.F.2    Spicer, D.3
  • 130
    • 0026051652 scopus 로고
    • Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
    • Wright JL, Churg A. Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig. Exp. Lung Res. 17, 997-1009 (1991).
    • (1991) Exp. Lung Res , vol.17 , pp. 997-1009
    • Wright, J.L.1    Churg, A.2
  • 132
    • 42049101172 scopus 로고    scopus 로고
    • Mechanisms of cigarette smoke-induced COPD: Insights from animal models
    • Churg A, Cosio M, Wright JL. Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am. J. Physiol. Lung Cell Mol. Physiol. 294(4), L612-L631 (2008).
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol , vol.294 , Issue.4
    • Churg, A.1    Cosio, M.2    Wright, J.L.3
  • 133
    • 0034103172 scopus 로고    scopus 로고
    • Rubio ML, Sanchez-Cifuentes MV, Ortega M et al. N-acetylcysteine prevents cigarette smoke induced small airways alterations in rats. Eur. Respir. J. 15, 505-511 (2000).
    • Rubio ML, Sanchez-Cifuentes MV, Ortega M et al. N-acetylcysteine prevents cigarette smoke induced small airways alterations in rats. Eur. Respir. J. 15, 505-511 (2000).
  • 134
    • 55149120876 scopus 로고    scopus 로고
    • Videomicroscopy of small airway function in precision cut lung slices prepared from tobacco smoke exposed rats
    • Cooper PR, Stevenson CS, Poll CT, Barnes PJ, Sturton RG. Videomicroscopy of small airway function in precision cut lung slices prepared from tobacco smoke exposed rats. Proc. Am. Thorac. Soc. 2, A652 (2005).
    • (2005) Proc. Am. Thorac. Soc , vol.2
    • Cooper, P.R.1    Stevenson, C.S.2    Poll, C.T.3    Barnes, P.J.4    Sturton, R.G.5
  • 135
    • 0032720871 scopus 로고    scopus 로고
    • Cigarette smoke exposure causes constriction of rat lung
    • Wright JL, Sun JP, Churg A. Cigarette smoke exposure causes constriction of rat lung. Eur. Respir. J. 14, 1095-1099 (1999).
    • (1999) Eur. Respir. J , vol.14 , pp. 1095-1099
    • Wright, J.L.1    Sun, J.P.2    Churg, A.3
  • 137
    • 33749155173 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice
    • Bracke KR, D'hulst AI, Maes T et al. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J. Immunol. 177, 4350-4359 (2006).
    • (2006) J. Immunol , vol.177 , pp. 4350-4359
    • Bracke, K.R.1    D'hulst, A.I.2    Maes, T.3
  • 138
    • 33845473487 scopus 로고    scopus 로고
    • Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall
    • Churg A, Tai H, Coulthard T, Wang R, Wright JL. Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am. J. Respir. Crit. Care Med. 174, 1327-1334 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.174 , pp. 1327-1334
    • Churg, A.1    Tai, H.2    Coulthard, T.3    Wang, R.4    Wright, J.L.5
  • 139
    • 0025609659 scopus 로고
    • Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig
    • Wright JL, Churg A. Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig. Am. Rev. Respir. Dis. 142, 1422-1428 (1990).
    • (1990) Am. Rev. Respir. Dis , vol.142 , pp. 1422-1428
    • Wright, J.L.1    Churg, A.2
  • 140
    • 34047227238 scopus 로고    scopus 로고
    • Animal models of cough: Literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig
    • Lewis CA, Ambrose C, Banner K et al. Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulm. Pharmacol. Ther. 20 (4), 325-333 (2007).
    • (2007) Pulm. Pharmacol. Ther , vol.20 , Issue.4 , pp. 325-333
    • Lewis, C.A.1    Ambrose, C.2    Banner, K.3
  • 142
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103, 779-788 (1999).
    • (1999) J. Clin. Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3
  • 143
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grünig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263 (1998).
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grünig, G.1    Warnock, M.2    Wakil, A.E.3
  • 144
    • 0030823772 scopus 로고    scopus 로고
    • Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    • Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277, 2002-2004 (1997).
    • (1997) Science , vol.277 , pp. 2002-2004
    • Hautamaki, R.D.1    Kobayashi, D.K.2    Senior, R.M.3    Shapiro, S.D.4
  • 146
    • 38949170602 scopus 로고    scopus 로고
    • Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    • Bartlett NW, Walton RP, Edwards MR et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat. Med. 14(2), 199-204 (2008).
    • (2008) Nat. Med , vol.14 , Issue.2 , pp. 199-204
    • Bartlett, N.W.1    Walton, R.P.2    Edwards, M.R.3


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