Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitized Brown-Norway rats

Immunology

Volumn 88, Issue 2, 1996, Pages 247-251

  Haczku, A ^a   Macary, P ^b   Haddad, E B ^a   Huang, T J ^a   Kemeny, D M ^b   Moqbel, R ^c   Chung, K F ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; IMMUNOMODULATION; INTERFERON PRODUCTION; LOEFFLER PNEUMONIA; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; PROVOCATION TEST; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0029890890     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.1996.tb00011.x     Document Type: Article

References (30)

1. AZZAWI M., BRADLEY B., JEFFREY P.K. et al. (1990) Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthmatics. Am Rev Respir Dis 142, 1407.
2. DJUKANOVIC R., ROCHE W.R., WILSON J.W., BEASLEY C.R.W., TWENTYMAN O.P. & HOWARTH PH. (1990) Mucosal inflammation in asthma. Am Rev Resp Dis 142, 434.
3. ROBINSON D.S., HAMID Q., YING S. et al. (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326, 298.
4. HAMID Q., AZZAWI M., YING S. et al. (1991) Expression of mRNA for interleukins in mucosal bronchial biopsies from asthma. J Clin Invest 87, 1541.
5. CHUNG K.F. (1995) Usefulness of animal models in asthma research. Eur Resp Rev 5, 184.
6. WASERMAN S., OLIVENSTEIN R., RENZI P., XU L. & MARTIN J.G. (1992) The relationship between late asthmatic responses and antigen-specific immunoglobulin. J Allergy Clin Immunol 90, 661.
7. HACZKU A., CHUNG K.F., BARNES P.J., KAY A.B. & MOQBEL R. (1995) Airway hyperresponsiveness, elevation of serum IgE and activation of T cells in Brown-Norway rats. Immunology 85, 598.
8. ELWOOD W., LOTVALL J.O., BARNES P.J. & CHUNG K.F. (1991) Characterisation of allergen-induced inflammation and bronchial hyperresponsiveness in sensitised Brown-Norway rats. J Allergy Clin Immunol 88, 951.
9. HACZKU A., MOQBEL R., SUN J. et al. (1995) T-cell subsets and activation in bronchial mucosa of sensitised Brown-Norway rats after single allergen exposure. Immunology 85, 598.
10. MOQBEL R., BARKANS J., BRADLEY B., DURHAM S.R. & KAY A.B. (1992) Application of monoclonal antibodies against major basic protein (BMK-13) and eosinophil cationic protein (EG1 and EG2) for quantifying eosinophils in bronchial biopsies for atopic asthma. Clin Exp Allergy 22, 265.
11. STAYNOV D.Z. & LEE T.H. (1992) Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in human peripheral blood mononuclear cells after activation with phorbol myristate acetate. Immunology 75, 196.
12. RENZI P.M., OLIVENSTEIN R. & MARTIN JG. (1993) Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Resp Dis 147, 967.
13. WATANABE A., MISHIMA H., RENZI P.M., XU L.J., HAMID Q. & MARTIN J.G. (1995) Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in Brown-Norway rats. J Clin Invest 96, 1303.
14. HACZKU A., MOQBEL R., SUN J. et al. (1995). T cells mediate eosinophilic inflammation and airway hyperresponsiveness in Brown-Norway rats. Am J Resp Crit Care Med 151, A347.
15. WANG J.M., RAMBALDI M., BIONDI A., CHEN Z.G., SANDERSON C.J. & MANTOVANI A. (1989) Recombinant human interleukin-5 is a selective eosinophil chemoattractant. Eur J Immunol 19, 701.
16. LOPEZ A.F., SANDERSON C.J., GAMBLE J.R., CAMPBELL H.D., YOUNG I.G. & VADAS M.A. (1988) Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 167, 219.
17. CLUTTERBUCK E.J., HIRST E.M. & SANDERSON C.J. (1989) Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6 and GM-CSF. Blood 73, 1504.
18. YAMAGUCHI Y., HAYASHI Y., SUGAMA Y. et al. (1988) Highly purified neurine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil factor. J Exp Med 167, 1737.
19. SCHLEIMER R.P., STERBINSKY C.A., KAISER C.A. et al. (1992) Interleukin-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1. J Immunol 148, 1086.
20. GAVETT S.H., CHEN X., FINKELMAN F. & WILLS-KARP M. (1994) Depletion of murine CD4 T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Resp Cell Mol Biol 10, 587.
21. VAN OOSTERHOUT A.J., LADENIUS A.R., SAVELKOUL H.F., VAN ARK I., DELSMAN K.C. & NIJKAMP F.P. (1993) Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am Rev Resp Dis 147, 548.
22. UCHIDA D.A., ACKERMAN S.J., COYLE A.J. et al. (1993) The effect of human granule major basic protein on airway responsiveness in the rat in vim. Am Rev Resp Dis 147, 982.
23. GAJEWSKI T.F., JOYCE J. & FITCH F.W. (1989) Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of Th1 and Th2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma. J Immunol 143, 15.
24. FERNANDEZ-BOTRAN R., SANDERS V.M., MOSSMAN T.R., UHR J.W. & VITETTA E.S. (1988) Lymphocyte-mediated regulation of the proliferative response of clones of Th1 and Th2 cells. J Exp Med 168, 543.
25. SWAIN S.L., WEINBERG A.D., ENGLISH M. & HUSTON G. (1990) IL-4 directs the development of Th2-like helper effectors. J Immunol 145, 3796.
26. SEDER A., PAUL W.E., DAVIS M.M. & FAZEKAS DE ST GROTH B. (1992) The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176, 1091.
27. GREENBAUM L.A., HOROWITZ J.B., WOODS A., PASQUALINI T., REICH E.P. & BOTTOMLY K. (1988) Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol 140, 1555.
28. NOBLE A., STAYNOV D.Z. & KEMENY D.M. (1993) Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ. Immunology 79, 562.
29. DIAZ-SANCHEZ D., NOBLE A., STAYNOV Z., LEE T.H. & KEMENY D.M. (1993) Elimination of IgE regulatory rat CD8+ T cells in vivo differentially modulates interleukin-4 and interferon-τ but not interleukin-2 production by splenic T cells. Immunology 78, 513.
30. ROBINSON D.S., HAMID Q., BENTLEY A.M., YING S., KAY A.B. & DURHAM S.R. (1993) Activation of CD4+ T cells and increased IL-4, IL-5 and GM-CSF mRNA positive cells in bronchoalveolar lavage fluid (BAL) 24 hours after allergen inhalation challenge of atopic asthmatic patients. J Allergy Clin Immunol 92, 313.