Pulmonary inflammation in Brown Norway rats: Possible association of environmental particles in the animal room environment

Experimental Animals

Volumn 56, Issue 5, 2007, Pages 319-327

  Noritake, Shinobu ^a   Ogawa, Koji ^a   Suzuki, Go ^a   Ozawa, Kazunori ^a   Ikeda, Takuya ^a  

^a Development and Medical Affairs Division   (Japan)

Author keywords

Ambient particle; Brown Norway rat; Eosinophil; Granulomatous pneumonia

Indexed keywords

OVALBUMIN;

AIRBORNE PARTICLE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOLOGY; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; EOSINOPHIL COUNT; GRANULOMATOUS INFLAMMATION; HISTOPATHOLOGY; LUNG LAVAGE; LYMPHOCYTE; MALE; NEUTROPHIL; NONHUMAN; PARTICLE SIZE; PATHOGENESIS; PNEUMONIA; RAT; SCORING SYSTEM;

AIR POLLUTANTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILS; GRANULOMA; HOUSING, ANIMAL; LEUKOCYTE COUNT; MALE; PNEUMONIA; RATS; RATS, INBRED BN; RODENT DISEASES;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 37349063414     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.56.319     Document Type: Article

References (23)

1. Abadie, A. and Prouvost-Danon, A. 1980. Specific and IgE responses to antigenic stimuli in Brown-Norway, Lewis and Sprague-Dawley rats. Immunology 39: 561-569.
2. Adamis Z., Tatrai, E., Honma, K., and Ungvary, G. 1997. In vitro and in vivo assessment of the pulmonary toxicity of cellulose. J. Appl. Toxicol. 17: 137-141.
3. Albert, T.M. and Clifford, C.B. 2000. Eosinophilic granulomatous pneumonia: a strain-related lesion of high prevalence in the Brown Norway rat. AALAS Official Program Poster 39.
4. Arts, J.H.E., Kuper, C.F., Spoor, S.M., and Bloksma, N. 1998. Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals. Toxicol. Appl. Pharmacol. 152: 66-76.
5. Cook, R.M., Musgrove, N.R., and Smith, H. 1989. Eosinophils and the granulomatous reaction in rats injected with Sephadex particles. Pulm. Pharmacol. 2: 185-190.
6. Donaldson, K., Li, X.Y., and MacNee, W. 1998. Ultrafine (nanometre) particle mediated lung injury. J. Aerosol. Sci. 29: 553-560.
7. Ewaldsson, B., Fogelmark, B., Feinstein, R., Ewaldsson, L., and Rylander, R. 2002. Microbial cell wall product contamination of bedding may induce pulmonary inflammation in rats. Lab. Anim. 36: 282-290.
8. Ferin, J., Oberdorster, G., and Penney, D.P. 1992. Pulmonary retention of ultrafine and fine particles in rats. Am. J. Respir. Cell Mol. Biol. 6: 535-542.
9. Germann, P.G., Hafner, D., Hanauer, G., and Drommer, W. 1998. Incidence and severity of granulomatous pneumonia in Brown Norway (BN) rats: breeder related variations. J. Exp. Anim. Sci. 39: 22-33.
10. Howell, R.E., Jenkins, L.P., Fielding, L.E., and Grimes, D. 1995. Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats. Pulmo. Pharmacol. 8: 83-89.
11. Gripenbäck, S., Lundgren, L., Eklund, A., Liden, C., Skare, L., Tornling, G., and Grunewald, J. 2005. Accumulation of eosinophils and T-lymphocytes in the lungs after exposure to pinewood dust. Eur. Respir. J. 25: 118-124.
12. Kacergis, J.B., Jones, R.B., Reeb, C.K., Turner, W.A., Ohman, J.L., Ardman, M.R., and Paigen, B. 1996. Air quality in an animal facility: particulates, ammonia, and volatile organic compounds. Am. Ind. Hyg. Assoc. J. 57: 634-640.
13. Knippels, L.M.J. and Penninks, A.H. 2003. Assessment of the allergic potential of food protein extracts and proteins on oral application using the Brown Norway rat model. Environ. Health Perspect. 111: 233-238.
14. Kubin, R., Deschl, U., Linssen, M., and Wilhelms, O.H. 1992. Intratracheal application of Sephadex in rats leads to massive pulmonary eosinophilia without bronchial hyperreactivity to acetylcholine. Int. Arch. Allergy Immunol. 98: 266-272.
15. Michielsen, C.P.P.C., Leusink-Muis, A., Vos, J.G., and Bloksma, N. 2001. Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation is associated with in vivo airways hyperresponsiveness in the Brown Norway rat. Toxicol. Appl. Pharmacol. 172: 11-20.
16. Miller, F.J. 2000. Dosimetry of particles: critical factors having risk assessment implications. Inhal. Toxicol. 12 (Suppl. 3): 389-395.
17. Miyake, M., Morishita, M., Ito, K., Ito, A., Torii, S., and Sakamoto, T. 2004. Production of granulomatous inflammation in lungs of rat pups and adults by Sephadex beads. Pediatr. Res. 56: 205-211.
18. Namovic, M.T., Walsh, R.E., Goodfellow, C., Harris, R.R., Carter, G.W., and Bell, R.L. 1996. Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. Eur. J. Pharmacol. 315: 81-88.
19. Ohtsuka, R., Doi, K., and Itagaki, S. 1997. Histological characteristics of respiratory system in Brown Norway rat. Exp. Anim. 46: 127-133.
20. Pauwels, R., Bazin, H., Platteau, B., and van der Straeten, M. 1979. Relation between total serum IgE levels and IgE antibody production in rats. Int. Arch. Allergy Appl. Immunol. 58: 351-357.
21. Rice, T.M., Clarke, R.W., Godleski, J.J., Mutairi, E.Al, Jiang, N.F., Hauser, R., and Paulauskis, J.D. 2001. Differential ability of transition metals to induce pulmonary inflammation. Toxicol. Appl. Pharmacol. 177: 46-53.
22. Sakaguchi, M., Inouye, S., Miyazaki, H., Kamimura, H., Kimura, M., and Yamazaki, S. 1989. Particle size of airborne mouse crude and defined allergens. Lab. Anim. Sci. 39: 234-236.
23. Tatrai, E., Adamis, Z., Bohm, U., Meretey, K., and Ungvary, G. 1995. Role of cellulose in wood dust-induced fibrosing alveo-bronchiolitis in rat. J. Appl. Toxicol. 15: 45-48.