Emphysema: An autoimmune vascular disease?

Proceedings of the American Thoracic Society

Volumn 2, Issue 1, 2005, Pages 23-25

  Voelkel, Norbert ^a,b   Taraseviciene Stewart, Laima ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Division of Pulmonary Sciences and Critical Care Medicine   (United States)

Author keywords

Autoimmune disease; Emphysema; Metalloproteinase 9; Methylprednisolone; Vascular endothelial growth factor

Indexed keywords

ACETYLCYSTEINE; CYTOCHROME P450; ILOMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; METHYLPREDNISOLONE; SEMAXANIB; SUPEROXIDE DISMUTASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

APOPTOSIS; AUTOIMMUNE DISEASE; CONFERENCE PAPER; EMPHYSEMA; ENZYME INDUCTION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CELL PROLIFERATION; ENDOTHELIAL GROWTH FACTORS; GLUCOCORTICOIDS; INDOLES; METHYLPREDNISOLONE; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; PULMONARY EMPHYSEMA; PYRROLES; RATS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR;

EID: 17644373104     PISSN: 15463222     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1513/pats.200405-033MS     Document Type: Conference Paper

References (30)

1. Voelkel NF, Cool C, Taraseviciene-Stewart L, Geraci MW, Yeager M, Bull T, Kasper M, Tuder RM. Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit Care Med 2002;30 (Suppl.):S251-S256.
2. Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest 2001;108:957-962.
3. Vandivier RW, Tuder RM, Morimoto K, Voelkel NF, Henson PM. Vascular endothelial growth factor (VEGF) regulates clearance of apoptotic complications in emphysema [abstract]. Am J Respir Crit Care Med 2004;169:A503.
4. Voelkel NF, Tuder RM. Hypoxia-induced pulmonary vascular remodeling: a model for what human disease? J Clin Invest 2000;106:733-738.
5. Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart LO, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003;29:88-97.
6. Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 2003;28:555-562.
7. Mahadeva R, Shapiro SD. Chronic obstructive pulmonary disease: 3. Experimental animal models of pulmonary emphysema. Thorax 2002;57:908-914.
8. Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, et al. SU-5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (FIk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59:99-106.
9. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000;106:1311-1319.
10. Demura Y, Taraseviciene-Stewart L, Scerbavicius R, Tuder RM, Voelkel NF. 4 A.D. N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema. J COPD 2004;1:1-8.
11. Tschanz SA, Damke BM, Burri PH. Influence of postnatally administered glucocorticoids on rat lung growth. Biol Neonate 1995;68:229-245.
12. Ionescu AA, Schoon E. Osteoporosis in chronic obstructive pulmonary disease. Eur Respir J 2003;46 (Suppl.):64s-75s.
13. Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Gera L, Tuder RM, Voelkel NF. Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult rats. Am J Respir Crit Care Med 2003;167:1516-1521.
14. Segura-Valdez L, Pardo A, Gaxiola M, Uhal BD, Becerril C, Selman M. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 2000;117:684-694.
15. Wenzel SE, Balzar S, Cundall M, Che HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase-9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 2003;111:1345-1352.
16. Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci USA 2001;98:12485-12490.
17. Wei YQ, Wang QR, Zhao X, Yang L, Tian L, Lu Y, Kang B, Lu CJ, Huang MJ, Lou YY, et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nat Med 2000;6:1160-1166.
18. Niethammer AG, Xiang R, Becker JC, Wodrich H, Pertl U, Karsten G, Eliceiri BP, Reisfeld RA. A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth. Nat Med 2002;8:1369-1375.
19. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Tuder RM, Voelkel NF. Immunization with xenogeneic endothelial cells causes emphysema in rats [abstract]. Am J Respir Crit Care Med 2002;165:B5.
20. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001;163:737-744.
21. Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:490-495.
22. Santos S, Peinado VI, Ramirez R, Melgosa T, Roca J, Rodriguez-Roisin R, Barbera JA. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 2002;19:632-638.
23. Yamato H, Sun JP, Churg A, Wright JL. Cigarette smoke-induced emphysema in guinea pigs is associated with diffusely decreased capillary density and capillary narrowing. Lab Invest 1996;75:211-219.
24. Voelkel NF, Cool CD. Pulmonary vascular involvement in chronic obstructive pulmonary disease. Eur Respir J 2003;46 (Suppl.):28s-32s.
25. Raymond MA, Desormeaux A, Laplante P, Vigneault N, Filep JG, Landry K, Pshezhetsky AV, Hebert MJ. Apoptosis of endothelial cells triggers a caspase-dependent anti-apoptotic paracrine loop active on VSMC. FASEB J 2004;18:705-707.
26. Majo J, Ghezzo H, Cosio MG. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J 2001;17:946-953.
27. Amaral SL, Papanek PE, Greene AS. Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training. Am J Physiol Heart Circ Physiol 2001;281:H1163-H1169.
28. Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee ME, Haber E. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J Clin Invest 1996;98:490-496.
29. Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc Natl Acad Sci USA 2001;98:6390-6395.
30. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001;163:737-744.