The alliance of genes and environment in asthma and allergy

Nature

Volumn 402, Issue 6760 SUPPL. 1, 1999, Pages

  Cookson, William ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ARACHIDONATE 5 LIPOXYGENASE; FC RECEPTOR; HLA DR ANTIGEN; IMMUNOGLOBULIN E; LEUKOTRIENE C4 SYNTHASE; TUMOR NECROSIS FACTOR;

ALLERGY; ASTHMA; ATOPY; ECZEMA; EPIDEMIC; EXTRACHROMOSOMAL INHERITANCE; GENETIC LINKAGE; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW;

ALLERGENS; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ASTHMA; DISEASE OUTBREAKS; ECZEMA; ENVIRONMENT; GENOMIC IMPRINTING; HUMANS; HYPERSENSITIVITY; LINKAGE (GENETICS); MOTHERS;

EID: 0033604544     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35037002     Document Type: Review

References (92)

1. von Pirquet, C. Allergie. Münch. med. Wochenschr. 30, 1457 (1906).
2. Coca, A. F. & Cooke, R. A. On the phenomenon of hypersensitiveness. J. Immunol. 8, 163-182 (1923).
3. Smith, D. H. et al. A national estimate of the economic costs of asthma. Am. J. Respir. Crit. Care Med. 156, 787-793 (1997).
4. Nowak, D., Volmer, T. & Wettengel, R. Asthma bronchiale - eine Krankheitskostenanalyse. Pneumologie 50, 364-371 (1996).
5. National Asthma Campaign. Asthma Agenda (National Asthma Campaign, London, 1998).
6. Stuart, M. Start-up 12-20 (April 1999).
7. Sampson, H. A. Pathogenesis of eczema. Clin. Exp. Allergy 20, 459-467 (1990).
8. Schultz-Larsen, F. A genetic-epidemiologic study in a population-based twin sample. J. Am. Acad. Dermatol. 28, 719-723 (1993).
9. Cox, H. E. et al. Association of atopic dermatitis to the beta subunit of the high affinity Immunoglobulin E receptor. Br. J. Dermatol. 138, 182-187 (1998).
10. Moffatt, M. F. & Cookson, W. O. C. M. in Genetics of Asthma and Atopy (ed. Hall, I. P.) (Monogr. Allergy 33, 71-97) (Karger, Basel, 1996).
11. Larsen, J. N., Sparholt, S. H. & Ipsen, H. Epitope structure of recombinant isoallergens of Bet v 1. J. Adv. Exp. Med. Biol. 409, 243-249 (1996).
12. Mueller, G. A., Benjamin, D. C., Rule, G. S. & Beirne, B. Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies. Biochemistry 37, 12707-12714 (1998).
13. Sigurs, N. et al. Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years. J. Allergy Clin. Immunol. 94, 757-763 (1994).
14. Rona, R. J., Chinn, S. & Burney, P. G. Trends in the prevalence of asthma in Scottish and English primary school children 1982-92. Thorax 50, 992-993 (1995).
15. Aberg, N., Hesselmar, B., Aberg, B. & Eriksson, B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin. Exp. Allergy 25, 815-819 (1995).
16. Dubois, P., Degrave, E. & Vandenplas, O. Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91. Thorax 53, 101-105 (1998).
17. von Mutius, E., Fritzsch, C., Weiland, S. K., Roll, G. & Magnussen, H. Prevalence of asthma and allergic disorders among children in united Germany: a descriptive comparison. Brit. Med. J. 305, 1395-1399 (1992).
18. von Mutius, E. et al. Prevalence of asthma and atopy in two areas of West and East Germany. Am. J. Respir. Crit. Care Med. 149, 358-364 (1994).
19. Bjorksten, B. et al. Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe. Eur. Respir. J. 12, 432-437 (1998).
20. von Mutius, E., Weiland, S. K., Fritzsch, C., Duhme, H. & Keil, U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 351, 862-866 (1998).
21. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. Lancet 351, 1225-1232 (1998).
22. European Community Respiratory Health Survey (ECRHS). Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur. Respir. J. 9, 687-695 (1996).
23. Von Ehrenstein, O., von Mutius, E., Illi, S., Hachmeister, A. & von Kries, R. Reduced prevalence of atopic diseases in children living on a farm. Epidemiology 9, S118 (1998).
24. Godfrey, R. C. Asthma and IgE levels in rural and urban communities of The Gambia. Clin. Allergy 5, 201-207 (1975).
25. Braun-Fahrländer, C. et al. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. Clin. Exp. Allergy 29, 28-34 (1999).
26. Staines, C. Childhood factors and adult atopy: results from the European Community Respiratory Health Survey. Am. J. Respir. Crit. Care Med. 157, A11 (1998).
27. von Mutius, E. et al. Skin test reactivity and number of siblings. Br. Med. J. 308, 692-695 (1994).
28. Holt, P. G., McMenamin, C. & Nelson, D. Primary sensitisation to inhalant allergens during infancy. Pediatr. Allergy Immunol. 1, 3-15 (1990).
29. Sporik, R., Holgate, S., Platts-Mills, T. A. E. & Cogswells, J. J. Exposure to house dust mite allergen Der p I and the development of asthma in children. N. Engl. J. Med. 323, 502-507 (1990).
30. Bjorksten, B. Allergy priming early in life. Lancet 353, 167-168 (1999).
31. Rook, G. A. & Stanford, J. L. Give us this day our daily germs. Immunol. Today 19, 113-116 (1998).
32. Anto, J. M. & Sunyer, J. A point-source asthma outbreak. Lancet 1, 900-903 (1986).
33. Duffy, D. L., Martin, N. G., Battistutta, D., Hopper, J. L. & Mathews, J. D. Genetics of asthma and hay fever in Australian twins. Am. Rev. Respir. Dis. 142, 1351-1358 (1990).
34. Lawrence, S. et al. Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies. Ann. Hum. Genet. 58, 359-368 (1994).
35. Holberg, C. et al. Segregation analysis of physician-diagnosed asthma in hispanic and non-hispanic white families. Am. J. Respir. Crit. Care Med. 154, 144-150 (1996).
36. Jenkins, M., Hopper, J. & Giles, G. Regressive logistic modelling of familial aggregation for asthma in 7,394 population-based nuclear families. Genet. Epidemiol. 14, 317-332 (1997).
37. Schultz Larsen, F., Hohn, N. V. & Henningsen, K. Atopic dermatitis. A genetic epidemiologic study in a population-based twin sample, J. Am. Acad. Derm. 15, 487-494 (1986).
38. Dold, S. et al. Genetic risk for asthma, allergic rhinitis and atopic dermatitis. Arch. Dis. Child. 67, 1018-1022 (1992).
39. Blumenthal, M. N., Namborrdiri, K., Mendell, N., Gleich, C. & Elston, R. C. Genetic transmission of serum IgE levels. Am. J. Med. Genet. 10, 219-228 (1981).
40. Borecki, I., Rao, D. C., Lalouel, J. M., McGue, L. & Gerrard, J. W. Demonstration of a common major gene with pleiotrophic effects on Immunoglobulin E and allergy. Genet. Epidemiol. 2, 327-338 (1985).
41. Collins, F. S. Positional cloning moves from perditional to traditional. Nature Genet. 9, 347-350 (1995).
42. Cookson, W. O. C. M., Sharp, P. A., Faux, J. A. & Hopkin, J. M. Linkage between Immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 8650, 1292-1295 (1989).
43. Watson, M. et al. Exclusion from proximal 11q of a common gene with megaphenic effect on atopy. Ann. Hum. Genet. 59, 403-411 (1995).
44. Hill, M. R. & Cookson, W. O. C. M. A new variant of the β subunit of the high-affinity receptor for Immunoglobulin E (Fc∈RI-β E237G): associations with measures of atopy and bronchial hyperresponsiveness. Hum. Mol. Genet. 5, 959-962 (1996).
45. Shirakawa, T. et al. Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum. Mol. Genet. 5, 1129-1130 (1996).
46. van Herwerden, L. et al. Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet 346, 1262-1265 (1995).
47. Palmer, L. J. et al. Fc∈RI-β polymorphism and total serum IgE levels in endemically parasitised Australian Aboriginies. Am. J. Hum. Genet. 61, 182-188 (1997).
48. Shirakawa, T. S. et al. Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nature Genet. 7, 125-129 (1994).
49. Rosenwasser, L. J. Genetics of atopy and asthma: promoter-based candidate gene studies for IL-4. Int. Arch. Allergy Immunol 113, 61-64 (1997).
50. Baldini, M. et al. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD 14 levels and with total serum immunoglobulin E. Am. J. Respir. Cell Mol. Biol. 20, 976-983 (1999).
51. Hershey, G. K., Friedrich, M. F., Esswein, L. A., Thomas, M. L. & Chatila, T. A. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med. 337, 1720-1725 (1997).
52. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33, 9414-9419 (1994).
53. Hall, I. P. Beta 2 adrenoceptor polymorphisms: are they clinically important? Thorax 51, 351-353 (1996).
54. Moffatt, M. F. & Cookson, W. O. C. M. Tumour necrosis factor haplotypes and asthma. Hum. Molec. Genet. 6, 551-554 (1997).
55. Shirakawa, T. et al. Linkage between severe atopy and chromosome 11q in Japanese families. Clin. Genet. 46, 125-129 (1994).
56. Yandava, C. N. et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet. 22, 168-170 (1999).
57. Sanak, M., Simon, H. U. & Szczeklik, A. Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet 350, 1599-1600 (1997).
58. Gyapay, G. et al. The 1993-94 Genethon human genetic linkage map. Nature Genet. 7, 246-339 (1994).
59. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
60. Cookson, W. O. & Palmer, L. J. Investigating the asthma phenotype. Clin. Exp. Allergy 28(Suppl. 1), 88-89 (discussion 108-110) (1998).
61. Risch, N. & Zhang, H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268, 1584-1589 (1995).
62. Marsh, D. G. et al. Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum IgE concentrations. Science 264, 1152-1156 (1994).
63. Meyers, D. A. et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 23, 464-470 (1994).
64. Barnes, K. C. et al. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics 37, 41-50 (1996).
65. Nickel, R. et al. Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study. Genomics 46, 159-162 (1997).
66. Moffatt, M. F. et al. Genetic linkage of the TCR-α/δ region to specific Immunoglobulin E responses. Lancet 343, 1597-1600 (1994).
67. Daniels, S. E. et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 383, 247-250 (1996).
68. Eiberg, H., Lind, P., Mohr, J. & Nielsen, L. S. Linkage relationship between the human immunoglobulin-E polymorphism and ESD marker. Cytogen. Cell. Genet. 40, 622 (1985).
69. Kimura, K. et al. Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population. Hum. Molec. Genet. 8, 1487-1490 (1999).
70. Ober, C. et al. [The Collaborative Study on the Genetics of Asthma.] Genome-wide search for asthma susceptibility loci in a founder population. Hum. Mol. Genet. 7, 1393-1398 (1998).
71. Wjst, M. et al. [German Asthma Genetics Group.] A genome-wide search for linkage to asthma. Genomics 58, 1-8 (1999).
72. Hizawa, N. et al. [The Collaborative Study on the Genetics of Asthma (CSGA).] Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. J. Allergy Clin. Immunol. 102, 436-442 (1998).
73. The Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genet. 15, 389-392 (1997).
74. Dizier, M. H. et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am. J. Respir. Crit. Care Med. 159, A649 (1999).
75. Satsangi, J. et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genet. 14, 199-202 (1996).
76. Hugot, J. P. et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379, 821-823 (1996).
77. Duerr, R. H. et al. Linkage and association between inflammatory bowel disease and a locus on chromosome 12. Am. J. Hum. Genet. 63, 95-100 (1998).
78. Mansfield, J. C. et al. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 106, 637-642 (1994).
79. Hardwick, L. J. et al. Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis. J. Rheumatol. 24, 197-198 (1997).
80. Nakagawa, Y. et al. Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. Am. J. Hum. Genet. 63, 547-556 (1998).
81. Ramsay, G. DNA chips: state-of-the art. Nature Biotechnol. 16, 40-44 (1998).
82. Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
83. Moffatt, M. F. & Cookson, W. O. The genetics of asthma. Maternal effects in atopic disease. Clin. Exp. Allergy 28(Suppl 1), 56-61 (discussion 65-66) (1998).
84. Warram, J. H., Krolewski, A. S., Gottlieb, M. S. & Kahn, C. R. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med. 311, 149-152 (1984).
85. Akolkar, P. N. et al. Differences in risk of Crohn's disease in offspring of mothers and fathers with inflammatory bowel disease. Am. J. Gastroenterol. 92, 2241-2244 (1997).
86. Koumantaki, Y. et al. Family history as a risk factor for rheumatoid arthritis: a case-control study. J. Rheumatol. 24, 1522-1526 (1997).
87. Vorechovsky, I., Webster, A. D. B., Plebani, A. & Hammarstrom, L. Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of IgA antibodies in disease predisposition. Am. J. Hum. Genet. 64, 1096-1109 (1999).
88. Hall, J. G. Genomic imprinting. Arch. Dis. Child. 65, 1013-1016 (1990).
89. Moffatt, M. F. et al. Factors confounding genetic linkage between atopy and chromosome 11q. Clin. Exp. Allergy 22, 1046-1051 (1992).
90. Moffatt, M. F., Abecasis, G., James, A., Musk, A. W. & Cookson, W. O. C. M. Association of parental atopy phenotype with linkage to Fc∈RI-β. Am. J. Respir. Crit. Care Med. 159, A648 (1999).
91. Bennett, S. T. & Todd, J. A. Human type I diabetes and the insulin gene: principles of mapping polygenes. Annu. Rev. Genet. 30, 343-370 (1996).
92. Chess, A. Expansion of the allelic exclusion principle? Science 279, 2067-2068 (1998).