Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists

Journal of Medicinal Chemistry

Volumn 48, Issue 2, 2005, Pages 353-356

  Cole, Derek C ^a   Lennox, William J ^a   Lombardi, Sabrina ^a   Ellingboe, John W ^a   Bernotas, Ronald C ^b   Tawa, Gregory J ^b   Mazandarani, Hossein ^b   Smith, Deborah L ^b   Zhang, Guoming ^b   Coupet, Joseph ^b   Schechter, Lee E ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; SEROTONIN 6 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SULFONAMIDO 3 (PYRROLIDIN 2 YLMETHYL) 1H INDOLE DERIVATIVE; SULFONYLTRYPTAMINE DERIVATIVE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHOLINERGIC TRANSMISSION; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; NONHUMAN;

CYCLIC AMP; HELA CELLS; HUMANS; INDOLES; PYRROLIDINES; RECEPTORS, SEROTONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 19944430163     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049243i     Document Type: Article

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