PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis

Science

Volumn 318, Issue 5847, 2007, Pages 64-66

  Hawkins, Phillip T ^a   Stephens, Len R ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RANTES; CHEMOKINE; GUANOSINE TRIPHOSPHATASE; ISOENZYME; LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3-KINASE GAMMA; POLYPHOSPHOINOSITIDE; PROTEIN KINASE; UNCLASSIFIED DRUG;

CELL ORGANELLE; ENZYME; HOMEOSTASIS; LIPID; PROTEIN;

APOPTOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELL ADHESION; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL MOTION; CELL SECRETION; CELL SURVIVAL; ENZYME ACTIVATION; HOMEOSTASIS; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SHORT SURVEY; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; ANIMAL; ARTICLE; CARDIOVASCULAR FUNCTION; CELL MEMBRANE; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; HUMAN; METABOLISM; NEUTROPHIL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARDIOVASCULAR PHYSIOLOGY; CELL MEMBRANE; CELL MOVEMENT; CHEMOKINES; DIMERIZATION; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; HOMEOSTASIS; HUMANS; INFLAMMATION; ISOENZYMES; LIGANDS; NEUTROPHILS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN KINASES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 35148839928     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145420     Document Type: Short Survey

References (16)

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16. We thank members of the Inositide Laboratory at the Babraham Institute for help and advice in the preparation of this article. Work in the author's laboratory is currently supported by grants from the Biotechnology and Biological Science Research Council, the Medical Research Council, and the British Lung Foundation.