Phospatidylinositol 3-kinase expression in human breast cancer

Clinica Chimica Acta

Volumn 287, Issue 1-2, 1999, Pages 59-67

  Gershtein, Elena S ^a   Shatskaya, Valentina A ^b   Ermilova, Valeriya D ^a   Kushlinsky, Nicolai E ^a   Krasil'Nikov, Mikhail A ^b  

^a Oncology   (Russian Federation)

^b Institute of Carcinogenesis   (Russian Federation)

Author keywords

Breast cancer; Epidermal growth factor receptor; Mammary gland; Phospatidylinositol 3 kinase; Western blotting

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; STEROID RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MAMMARY GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; BREAST NEOPLASMS; ENZYME ACTIVATION; FEMALE; HUMANS; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 0032853715     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(99)00118-7     Document Type: Article

References (16)

1. Escobedo J., Navankasattusas S., Kavanaugh W., Milfay D., Freid V., Williams L. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of Pi3 kinase to the PDGF B-receptor. Cell. 65:1991;75-82.
2. Soltoff S., Rabin S., Cantley L., Kaplan D. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem. 267:1992;14472-14477.
3. Cantley L., Auger K., Carpenter C., et al. Oncogenes and signal transduction. Cell. 64:1991;281-302.
4. Kapeller R., Cantley L.C. Phosphatidylinositol 3-kinase. Bioessays. 16:1994;565-576.
5. Kapeller R., Chakrabarti R., Cantley L.C., Fay F., Corvera S. Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3 kinase complexes, potential interactions with the microtubule cytoskeleton. Mol Cell Biol. 13:1993;6052-6063.
6. Kundra V., Escobeda J., Kazlauskas A., et al. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature (London). 367:1994;474-476.
7. Kennedy S., Wagner A., Conzen S., et al. The Pi3kinase/Akt signalling pathway delivers an anti-apoptotic signal. Genes and Development. 11:1997;701-713.
8. Chang H., Aoki M., Fruman D., et al. Transformation of chicken cells by the gene encoding the catalytic subunit of Pi3kinase. Science. 276:1997;1848-1850.
9. Bassalyk L.S., Koposova T.L., Muravyeva N.I., et al. Trepanobiopsy as a tool for the study of the influence of presurgical treatment on the steroid receptor status of advanced breast cancer. Neoplasma. 33:1986;245-250.
10. Carter A., Downes C. Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J Biol Chem. 267:1992;14563-14567.
11. Kharbanda S., Saleem A., Shafman T., et al. Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase. J Biol Chem. 270:1995;18871-18874.
12. Amundadottirl L., Leder P. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene. 16:1998;737-746.
13. Dufourny B., Albas J., Hetty A., et al. Mitogenic signalling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem. 272:1997;31163-31171.
14. Klijn J., Berns P., Schmitz P., Foekens J. The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocrine Reviews. 13:1992;3-17.
15. Nicholson R., Mclelland R., Gee J., et al. Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Breast Cancer Res Treat. 29:1994;117-125.
16. Tan M., Grijalva R., Yu D. Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase. Cancer Res. 59:1999;1620-1625.