The amyloid-β rise and γ-secretase inhibitor potency depend on the level of substrate expression

Journal of Biological Chemistry

Volumn 283, Issue 34, 2008, Pages 22992-23003

  Burton, Catherine R ^a   Meredith, Jere E ^a   Barten, Donna M ^a   Goldstein, Margi E ^a   Krause, Carol M ^a   Kieras, Cathy J ^a   Sisk, Lisa ^a,c   Iben, Lawrence G ^a   Polson, Craig ^a   Thompson, Mark W ^a   Lin, Xu Alan ^a   Corsa, Jason ^a   Fiedler, Tracey ^a   Pierdomenico, Maria ^a   Cao, Yang ^a   Roach, Arthur H ^a,d   Cantone, Joseph L ^a   Ford, Michael J ^a   Drexler, Dieter M ^a   Olson, Richard E ^a   Yang, Michael G ^a   Bergstrom, Carl P ^a   McElhone, Kate E ^a,e   Bronson, Joanne J ^a   Macor, John E ^a   Blat, Yuval ^b   Grafstrom, Robert H ^b   Stern, Andrew M ^b,f   Seiffert, Dietmar A ^b   Zaczek, Robert ^a   Albright, Charles F ^a   Toyn, Jeremy H ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

^b BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

^c Brookside Clinical Laboratory Inc   (United States)

^d MERCK SERONO S A   (Switzerland)

^e JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GLYCOPROTEINS; PEPTIDES;

ALZHEIMER DISEASE; AMYLOID BETAS; C-TERMINAL FRAGMENTS; CELL CULTURE MODELS; HYPOTHETICAL MECHANISM; LOW CONCENTRATIONS; PRECURSOR PROTEINS; PROTEOLYTIC CLEAVAGE;

ANIMAL CELL CULTURE;

AMYLOID BETA PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; 4 (2 ((1R) 1 (((4 CHLOROPHENYL)SULFONYL) 2,5 DIFLUOROANILINO)ETHYL) 5 FLUOROPHENYL)BUTANOIC ACID; 4-(2-((1R)-1-(((4-CHLOROPHENYL)SULFONYL)-2,5-DIFLUOROANILINO)ETHYL)-5-FLUOROPHENYL)BUTANOIC ACID; BUTYRIC ACID DERIVATIVE; ENZYME INHIBITOR; HALOGENATED HYDROCARBON; SECRETASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; ANIMAL; BRAIN; CELL LINE; ENZYME SPECIFICITY; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALIA; RATTUS;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; BUTYRIC ACIDS; CELL LINE; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROCARBONS, HALOGENATED; MICE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SUBSTRATE SPECIFICITY;

EID: 53149091309     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804175200     Document Type: Article

References (53)

1. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
2. Selkoe, D. J., and Schenk, D. (2003) Annu. Rev. Pharmacol. Toxicol. 43, 545-584
3. Citron, M., Diehl, T. S., Gordon, G., Biere, A. L., Seubert, P., and Selkoe, D. J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13170-13175
4. Klafki, H.-W., Abramowski, D., Swoboda, R., Paganetti, P. A., and Staufenbiel, M. (1996) J. Biol. Chem. 271, 28655-28659
5. Durkin, J. T., Murthy, S., Husten, E. J., Trusko, S. P., Savage, M. J., Rotella, D. P., Greenberg, B. D., and Siman, R. (1999) J. Biol. Chem. 274, 20499-20504
6. Zhang, L., Song, L., Terracina, G., Liu, Y., Pramanik, B., and Parker, E. (2001) Biochemistry 40, 5049-5055
7. Yamazaki, T., Haass, C., Saido, T. C., Omura, S., and Ihara, Y. (1997) Biochemistry 36, 8377-8383
8. Higaki, J. N., Chakravarty, S., Bryant, C. M., Cowart, L. R., Harden, P., Scardina, J. M., Mavunkel, B., Luedtke, J. R., and Cordell, B. (1999) J. Med. Chem. 42, 3889-3898
9. Zhang, L., Song, L., and Parker, E. M. (1999) J. Biol. Chem. 274, 8966-8972
10. Dong, Y., Tan, J., Cui, M.-Z., Zhao, G., Mao, G., Singh, N., and Xu, X. (2006) FASEB J. 20, 331-333
11. Wolfe, M. S., Citron, M., Diehl, T. S., Xia, W., Donkor, I. O., and Selkoe, D. J. (1998) J. Med. Chem. 41, 6-9
12. Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewsky, B. L., Rahmati, T., Donkor, I. O., and Selkoe, D. J. (1999) Biochemistry 38, 4720-4727
13. Moore, C. L., Diehl, T. S., Selkoe, D. J., and Wolfe, M. S. (2000) Ann. N. Y. Acad. Sci. 920, 197-205
14. Lanz, T. A., Karmolowicz, M. J., Wood, K. M., Pozdnyakov, N., Du, P., Piotrowski, M. A., Brown, T. M., Nolan, C. E., Richter, K. E. G., Finley, J. E., Fei, Q., Ebbinghaus, C. F., Chen, Y. L., Spracklin, D. K., Tate, B., Geoghegan, K. F., Lau, L.-F., Auperin, D. D., and Schachter, J. B. (2006) J. Pharmacol. Exp. Ther. 319, 924-933
15. Siemers, E., Skinner, M., Dean, R. A., Gonzales, C., Satterwhite, J., Farlow, M., Ness, D., and May, P. C. (2005) Clin. Neuropharmacol. 28, 126-132
16. Seiffert, D., Bradley, J. D., Rominger, C. M., Rominger, D. H., Yang, F., Meredith, J. E., Wang, Q., Roach, A. H., Thompson, L. A., Spitz, S. M., Higaki, J. N., Prakash, S. R., Combs, A. P., Copeland, R. A., Arneric, S. P., Hartig, P. R., Robertson, D. W., Cordell, B., Stern, A. M., Olson, R. E., and Zaczek, R. (2000) J. Biol. Chem. 275, 34086-34091
17. Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., de Saint Andrieu, P., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E., Holsztynska, E. J., Hu, K. L., Johnson-Wood, K. L., Kennedy, S. L., Kholodenko, D., Knops, J. E., Latimer, L. H., Lee, M., Liao, Z., Lieberburg, I. M., Motter, R. N., Mutter, L. C., Nietz, J., Quinn, K. P., Sacchi, K. L., Seubert, P. A., Shopp, G. M., Thorsett, E. D., Tung, J. S., Wu, J., Yang, S., Yin, C. T., Schenk, D. B., May, P. C., Altstiel, L. D., Bender, M. H., Boggs, L. N., Britton, T. C., Clemens, J. C., Czilli, D. L., Dieckman-McGinty, D. K., Droste, J. J., Fuson, K. S., Gitter, B. D., Hyslop, P. A., Johnstone, E. M., Li, W.-Y., Little, S. P., Mabry, T. E., Miller, F. D., Ni, B., Nissen, J. S., Porter, W. J., Potts, B. D., Reel, J. K., Stephenson, D., Su, Y., Shipley, L. A., Whitesitt, C. A., Yin, T., and Audia, J. E. (2001) J. Neurochem. 76, 173-181
18. Li, Y.-M., Xu, M., Lai, M.-T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X.-P., Yin, K.-C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 681-694
19. Barten, D. M., Guss, V. L., Corsa, J. A., Loo, A., Hansel, S. B., Zheng, M., Munoz, B., Srinivasan, K., Wang, B., Roberts, S. B., Hendrick, J. P., Anderson, J. J., Loy, J. K., Denton, R., Verdoorn, T. A., Smith, D. W., and Felsenstein, K. M. (2005) J. Pharmacol. Exp. Ther. 312, 635-643
20. Prasad, C. V. C., Zheng, M., Vig, S., Bergstrom, C., Smith, D. W., Gao, Q., Yeola, S., Polson, C. T., Corsa, J. A., Guss, V. L., Loo, A., Wang, J., Sleczka, B. G., Dangler, C., Robertson, B. J., Hendrick, J. P., Roberts, S. B., and Barten, D. M. (2007) Bioorg. Med. Chem. Lett. 17, 4006-4011
21. Yang, M. G., Shi, J. L., Modi, D. P., Cochran, B. M., Wolf, M. A., Thompson, L. A., Ramanjulu, M. M., Roach, A. H., Zaczek, R., Robertson, D. W., Wexler, R. R., and Olson, R. E. (2007) Bioorg. Med. Chem. Lett. 17, 3910-3915
22. Tian, G., Ghanekar, S. V., Aharony, D., Shenvi, A. B., Jacobs, R. T., Liu, X., and Greenberg, B. D. (2003) J. Biol. Chem. 278, 28968-28975
23. Clarke, E. E., Churcher, I., Ellis, S., Wrigley, J. D. J., Lewis, H. D., Harrison, T., Shearman, M. S., and Beher, D. (2006) J. Biol. Chem. 281, 31279-31289
24. Herreman, A., Serneels, L., Annaert, W., Collen, D., Schoonjans, L., and De Strooper, B. (2000) Nat. Cell Biol. 2, 461-462
25. Zhang, Z., Nadeau, P., Song, W., Donoviel, D., Yuan, M., Bernstein, A., and Yankner, B. A. (2000) Nat. Cell Biol. 2, 463-464
26. Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E. A., Lee, G., Fritz, L. C., and Oltersdorf, T. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7341-7345
27. Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., and Selkoe, D. J. (1993) J. Biol. Chem. 268, 22959-22962
28. Tian, G., Sobotka-Briner, C. D., Zysk, J., Liu, X., Birr, C., Sylvester, M. A., Edwards, P. D., Scott, C. D., and Greenberg, B. D. (2002) J. Biol. Chem. 277, 31499-31505
29. Wahrle, S., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2002) Neurobiol. Dis. 9, 11-23
30. Goldstein, M. E., Cao, Y., Fiedler, T., Toyn, J., Iben, L., Barten, D. M., Pierdomenico, M., Corsa, J., Prasad, C. V. C., Olson, R. E., Li, Y.-W., Zaczek, R., and Albright, C. F. (2007) J. Pharmacol. Exp. Ther. 323, 102-108
31. Bateman, R. J., Munsell, L. Y., Chen, X., Holtzman, D. M., and Yarasheski, K. E. (2007) J. Am. Soc. Mass Spectrom. 18, 997-1006
32. Iben, L. G., Olson, R. E., Balanda, L. A., Jayachandra, S., Robertson, B. J., Hay, V., Corradi, J., Prasad, C. V. C., Zaczek, R., Albright, C. F., and Toyn, J. H. (2007) J. Biol. Chem. 282, 36829-36836
33. Kaether, C., and Haass, C. (2004) J. Cell Biol. 167, 809-812
34. Funamoto, S., Morishima-Kawashima, M., Tanimura, Y., Hirotani, N., Saido, T. C., and Ihara, Y. (2004) Biochemistry 43, 13532-13540
35. Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G., Hirotani, N., Horikoshi, Y., Kametani, F., Maeda, M., Saido, T. C., Wang, R., and Ihara, Y. (2005) J. Neurosci. 25, 436-445
36. Sato, T., Tanimura, Y., Hirotani, N., Saido, T. C., Morishima-Kawashima, M., and Ihara, Y. (2005) FEBS Lett. 579, 2907-2912
37. Kakuda, N., Funamoto, S., Yagishita, S., Takami, M., Osawa, S., Dohmae, N., and Ihara, Y. (2006) J. Biol. Chem. 281, 14776-14786
38. Yagishita, S., Morishima-Kawashima, M., Tanimura, Y., Ishiura, S., and Ihara, Y. (2006) Biochemistry 45, 3952-3960
39. Zhao, G., Mao, G., Tan, J., Dong, Y., Cui, M.-Z., Kim, S.-H., and Xu, X. (2004) J. Biol. Chem. 279, 50647-50650
40. Zhao, G., Cui, M.-Z., Mao, G., Dong, Y., Tan, J., Sun, L., and Xu, X. (2005) J. Biol. Chem. 280, 37689-37697
41. Zhao, G., Tan, J., Mao, G., Cui, M.-Z., and Xu, X. (2007) J. Neurochem. 100, 1234-1246
42. Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., and De Strooper, B. (2006) J. Neurochem. 96, 732-742
43. Wolfe, M. S. (2007) EMBO Rep. 8, 136-140
44. Lleó, A., Berezovska, O., Herl, L., Raju, S., Deng, A., Bacskai, B. J., Frosch, M. P., Irizarry, M., and Hyman, B. T. (2004) Nat. Med. 10, 1065-1066
45. Berezovska, O., Lleó, A., Herl, L. D., Frosch, M. P., Stern, E. A., Bacskai, B. J., and Hyman, B. T. (2005) J. Neurosci. 25, 3009-3017
46. Kuentzel, S. L., Ali, S. M., Altman, R. A., Greenberg, B. D., and Raub, T. J. (1993) Biochem. J. 295, 367-378
47. Haass, C., Lemere, C. A., Capell, A., Citron, M., Seubert, P., Schenk, D., Lannfelt, L., and Selkoe, D. J. (1995) Nat. Med. 1, 1291-1296
48. Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., and Sisodia, S. S. (1996) J. Biol. Chem. 271, 9390-9397
49. Steinhilb, M. L., Turner, R. S., and Gaut, J. R. (2002) J. Neurochem. 80, 1019-1028
50. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
51. Koo, E. H., Squazzo, S. L., Selkoe, D. J., and Koo, E. H. (1996) J. Cell Sci. 109, 991-998
52. Zhang, M., Haapasalo, A., Kim, D. Y., Ingano, L. A. M., Pettingell, W. H., and Kovacs, D. M. (2006) FASEB J. 20, 1176-1178
53. Barten, D. M., Meredith, J. E., Zaczek, R., Houston, J. G., and Albright, C. F. (2006) Drugs Res. Dev. 7, 87-97