A combinatorial approach to the identification of dipeptide aldehyde inhibitors of β-amyloid production

Journal of Medicinal Chemistry

Volumn 42, Issue 19, 1999, Pages 3889-3898

  Higaki, Jeffrey N ^a   Chakravarty, Sarvajit ^a   Bryant, Carmen M ^a   Cowart, Lisa R ^a   Harden, Paul ^a   Scardina, Jan Marian ^a   Mavunkel, Babu ^a   Luedtke, Gregory R ^a   Cordell, Barbara ^a  

^a SCIOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHOXYCINNAMAMIDE ISOLEUCINYLLEUCINAL; ALDEHYDE DERIVATIVE; AMYLOID BETA PROTEIN; DIPEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION;

ALDEHYDES; AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; DIPEPTIDES; HUMANS; IMMUNOENZYME TECHNIQUES; MASS SPECTROMETRY; MODELS, CHEMICAL; PEPTIDE LIBRARY;

EID: 0033598365     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990009f     Document Type: Article

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