Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase

Journal of Biological Chemistry

Volumn 283, Issue 35, 2008, Pages 24089-24102

  Nikonov, Andrei ^a   Juronen, Erkki ^a   Ustav, Mart ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANTIBODIES; BIOCHEMISTRY; FUNCTIONAL POLYMERS; HYPERSONIC AERODYNAMICS; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; RNA; SURFACE PLASMON RESONANCE; VIRUSES;

AMINO ACID RESIDUES; ANTIVIRAL DRUGS; FUNCTIONAL CHARACTERIZATIONS; FUNCTIONAL PROPERTIES; IN VITRO; LINEAR EPITOPES; MECHANISM OF ACTIONS; MUTATION EFFECTS; NONSTRUCTURAL PROTEINS; RNA POLYMERASES; RNA SYNTHESIS; SUB DOMAINS; VIRAL REPLICATIONS;

NUCLEIC ACIDS;

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 7G8; NONSTRUCTURAL PROTEIN 5B; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN; VIRUS RNA;

ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITOPE MAPPING; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PURIFICATION; RNA BINDING; RNA SYNTHESIS; SITE DIRECTED MUTAGENESIS; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; VIRUS REPLICATION;

HEPATITIS C VIRUS;

AMINO ACID MOTIFS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIVIRAL AGENTS; CELL LINE; EPITOPES; HEPACIVIRUS; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 53049106343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803422200     Document Type: Article

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