Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme

Journal of Virology

Volumn 77, Issue 13, 2003, Pages 7575-7581

  Love, Robert A ^a   Parge, Hans E ^a   Yu, Xiu ^a   Hickey, Michael J ^a   Diehl, Wade ^a   Gao, Jingjin ^a   Wriggers, Hilary ^a   Ekker, Anne ^a   Wang, Liann ^a   Thomson, James A ^a   Dragovich, Peter S ^a   Fuhrman, Shella A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE; RNA POLYMERASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; GENE DISRUPTION; GENOTYPE; HEPATITIS C VIRUS; MOLECULAR DYNAMICS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RNA BINDING; SEQUENCE ANALYSIS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0038467627     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.13.7575-7581.2003     Document Type: Article

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