High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA

Journal of Biological Chemistry

Volumn 282, Issue 23, 2007, Pages 16907-16916

  Deval, Jérôme ^a   D'Abramo, Claudia M ^a   Zhao, Zhuojun ^b   McCormick, Suzanne ^a   Coutsinos, Dimitrios ^a   Hess, Sonja ^c   Kvaratskhelia, Mamuka ^b   Götte, Matthias ^a  

^a MCGILL UNIVERSITY   (Canada)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CHANNELS; CONFORMATIONAL REARRANGEMENTS; INTRADOMAIN CONTACTS; LYSINES; RNA BINDING;

AMINO ACIDS; BINDING SITES; CHEMICAL MODIFICATION; CONFORMATIONS; RNA; VIRUSES;

ENZYME ACTIVITY;

ARGININE; LYSINE; NONSTRUCTURAL PROTEIN 5B; RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; RIBONUCLEASE H; VIRUS RNA;

ARTICLE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; DNA FOOTPRINTING; ENZYME BINDING; HEPATITIS C VIRUS; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA BINDING; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HYDROLYSIS; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION;

HEPATITIS C VIRUS;

AMINO ACID SEQUENCE; ARGININE; BASE SEQUENCE; ESCHERICHIA COLI; HEPACIVIRUS; HYDROLYSIS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RIBONUCLEASE H, CALF THYMUS; RNA, VIRAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 34447117574     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701973200     Document Type: Article

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