Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

Journal of Biological Chemistry

Volumn 280, Issue 33, 2005, Pages 29765-29770

  Di Marco, Stefania ^a   Volpari, Cinzia ^a   Tomei, Licia ^a   Altamura, Sergio ^a   Harper, Steven ^a   Narjes, Frank ^a   Koch, Uwe ^a   Rowley, Michael ^a   De Francesco, Raffaele ^a   Migliaccio, Giovanni ^a   Carfí, Andrea ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMMUNICATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; GENETIC ENGINEERING; PROTEINS; RNA;

ALLOSTERIC INHIBITORS; HEPATITIS C VIRUS (HCV); POLYMERASE; THERAPEUTIC INTERVENTION;

VIRUSES;

3 CYCLOHEXYL 1 (2 MORPHOLIN 4 YL 2 OXOETHYL) 2 PHENYL 1H INDOLE 6 CARBOXYLIC ACID; 3 CYCLOHEXYL 1 [2 [METHYL[(1 METHYLPIPERIDIN 3 YL)METHYL]AMINO] 2 OXOETHYL] 2 PHENYL 1H INDOLE 6 CARBOXYLIC ACID; APOENZYME; ARGININE; BRIDGED COMPOUND; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; INDOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PHENYL GROUP; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA SYNTHESIS; VIRUS GENOME; VIRUS REPLICATION;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING SITES; ENZYME INHIBITORS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 23744452229     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505423200     Document Type: Article

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