Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase: Crystal structures and mechanism of inhibition

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9489-9495

  Wang, Meitian ^a   Ng, Kenneth K S ^a   Cherney, Maia M ^a   Chan, Laval ^b   Yannopoulos, Constantin G ^b   Bedard, Jean ^b   Morin, Nicolas ^b   Nguyen Ba, Nghe ^b   Alaoui Ismaili, Moulay H ^b   Bethell, Richard C ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; RNA; VIRUSES;

INHIBITOR-BINDING;

ENZYMES;

NON NUCLEOSIDE ANALOG INHIBITOR; NUCLEOSIDE ANALOG; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; NITROGEN; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; NUCLEOSIDE; OXYGEN; RECOMBINANT PROTEIN; SERINE; TYROSINE; VIRUS PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; HEPATITIS C VIRUS; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; X RAY ANALYSIS; AMINO ACID SEQUENCE; BINDING COMPETITION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; IC 50; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS; RNA VIRUSES;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITROGEN; NUCLEOSIDES; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE; TYROSINE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0038322074     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209397200     Document Type: Article

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