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Volumn 15, Issue 4, 2008, Pages 305-313

Monoclonal antibody recognizing N-terminal epitope of hepatitis C virus nonstructural 5B inhibits viral RNA replication

Author keywords

Hepatitis C virus; Hepatocellular carcinoma; Monoclonal antibody; NS5B; RNA dependent RNA polymerase

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NONSTRUCTURAL PROTEIN 5B; RNA DIRECTED RNA POLYMERASE; VIRUS RNA;

EID: 40149103127     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2007.00945.x     Document Type: Article
Times cited : (5)

References (39)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989 244 : 359 362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 2
    • 0024511734 scopus 로고
    • An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
    • Kuo G, Choo QL, Alter HJ et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 1989 244 : 362 364.
    • (1989) Science , vol.244 , pp. 362-364
    • Kuo, G.1    Choo, Q.L.2    Alter, H.J.3
  • 3
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: Tales of a promiscuous protein
    • Macdonald A, Harris M. Hepatitis C virus NS5A: tales of a promiscuous protein. J Gen Virol 2004 85 : 2485 2502.
    • (2004) J Gen Virol , vol.85 , pp. 2485-2502
    • MacDonald, A.1    Harris, M.2
  • 4
    • 0025166005 scopus 로고
    • Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
    • Saito I, Miyamura T, Ohbayashi A et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 1990 87 : 6547 6549.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6547-6549
    • Saito, I.1    Miyamura, T.2    Ohbayashi, A.3
  • 5
    • 0028037825 scopus 로고
    • Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection
    • Di Bisceglie AM, Simpson LH, Lotze MT, Hoofnagle JH. Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection. J Clin Gastroenterol 1994 19 : 222 226.
    • (1994) J Clin Gastroenterol , vol.19 , pp. 222-226
    • Di Bisceglie, A.M.1    Simpson, L.H.2    Lotze, M.T.3    Hoofnagle, J.H.4
  • 6
    • 0029619825 scopus 로고
    • Hepatitis C virus as a causative agent of hepatocellular carcinoma
    • Shimotohno K. Hepatitis C virus as a causative agent of hepatocellular carcinoma. Intervirology 1995 38 : 162 169.
    • (1995) Intervirology , vol.38 , pp. 162-169
    • Shimotohno, K.1
  • 7
    • 15644380122 scopus 로고    scopus 로고
    • Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy
    • Marcellin P, Boyer N, Gervais A et al. Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy. Ann Intern Med 1997 127 : 875 881.
    • (1997) Ann Intern Med , vol.127 , pp. 875-881
    • Marcellin, P.1    Boyer, N.2    Gervais, A.3
  • 8
    • 0032501714 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. the Swedish Study Group
    • Reichard O, Norkrans G, Fryden A, Braconier JH, Sonnerborg A, Weiland O. Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group. Lancet 1998 351 : 83 87.
    • (1998) Lancet , vol.351 , pp. 83-87
    • Reichard, O.1    Norkrans, G.2    Fryden, A.3    Braconier, J.H.4    Sonnerborg, A.5    Weiland, O.6
  • 9
    • 0026767691 scopus 로고
    • Lack of protective immunity against reinfection with hepatitis C virus
    • Farci P, Alter HJ, Govindarajan S et al. Lack of protective immunity against reinfection with hepatitis C virus. Science 1992 258 : 135 140.
    • (1992) Science , vol.258 , pp. 135-140
    • Farci, P.1    Alter, H.J.2    Govindarajan, S.3
  • 10
    • 0031936597 scopus 로고    scopus 로고
    • Immunity in chimpanzees chronically infected with hepatitis C virus: Role of minor quasispecies in reinfection
    • Wyatt CA, Andrus L, Brotman B, Huang F, Lee DH, Prince AM. Immunity in chimpanzees chronically infected with hepatitis C virus: role of minor quasispecies in reinfection. J Virol 1998 72 : 1725 1730.
    • (1998) J Virol , vol.72 , pp. 1725-1730
    • Wyatt, C.A.1    Andrus, L.2    Brotman, B.3    Huang, F.4    Lee, D.H.5    Prince, A.M.6
  • 11
    • 0025685188 scopus 로고
    • Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis
    • Kato N, Hijikata M, Ootsuyama Y et al. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci USA 1990 87 : 9524 9528.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9524-9528
    • Kato, N.1    Hijikata, M.2    Ootsuyama, Y.3
  • 12
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with American and Japanese isolates
    • Inchauspe G, Zebedee S, Lee DH, Sugitani M, Nasoff M, Prince AM. Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci USA 1991 88 : 10292 10296.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10292-10296
    • Inchauspe, G.1    Zebedee, S.2    Lee, D.H.3    Sugitani, M.4    Nasoff, M.5    Prince, A.M.6
  • 13
    • 0025968921 scopus 로고
    • Genetic organization and diversity of the hepatitis C virus
    • Choo QL, Richman KH, Han JH et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci USA 1991 88 : 2451 2455.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2451-2455
    • Choo, Q.L.1    Richman, K.H.2    Han, J.H.3
  • 14
    • 0025249362 scopus 로고
    • Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups
    • Miller RH, Purcell RH. Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci USA 1990 87 : 2057 2061.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2057-2061
    • Miller, R.H.1    Purcell, R.H.2
  • 15
    • 0026084948 scopus 로고
    • Structure and organization of the hepatitis C virus genome isolated from human carriers
    • Takamizawa A, Mori C, Fuke I et al. Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol 1991 65 : 1105 1113.
    • (1991) J Virol , vol.65 , pp. 1105-1113
    • Takamizawa, A.1    Mori, C.2    Fuke, I.3
  • 16
    • 0026674719 scopus 로고
    • Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs
    • Brown EA, Zhang H, Ping LH, Lemon SM. Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 1992 20 : 5041 5045.
    • (1992) Nucleic Acids Res , vol.20 , pp. 5041-5045
    • Brown, E.A.1    Zhang, H.2    Ping, L.H.3    Lemon, S.M.4
  • 17
    • 0026632752 scopus 로고
    • The Taiwanese hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA
    • Chen PJ, Lin MH, Tai KF, Liu PC, Lin CJ, Chen DS. The Taiwanese hepatitis C virus genome: sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA. Virology 1992 188 : 102 113.
    • (1992) Virology , vol.188 , pp. 102-113
    • Chen, P.J.1    Lin, M.H.2    Tai, K.F.3    Liu, P.C.4    Lin, C.J.5    Chen, D.S.6
  • 18
    • 0029938477 scopus 로고    scopus 로고
    • Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
    • Kolykhalov AA, Feinstone SM, Rice CM. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J Virol 1996 70 : 3363 3371.
    • (1996) J Virol , vol.70 , pp. 3363-3371
    • Kolykhalov, A.A.1    Feinstone, S.M.2    Rice, C.M.3
  • 19
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3′ terminus of the hepatitis C virus genome
    • Tanaka T, Kato N, Cho MJ, Sugiyama K, Shimotohno K. Structure of the 3′ terminus of the hepatitis C virus genome. J Virol 1996 70 : 3307 3312.
    • (1996) J Virol , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Sugiyama, K.4    Shimotohno, K.5
  • 20
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
    • Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Shimotohno K. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci USA 1991 88 : 5547 5551.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4    Shimotohno, K.5
  • 21
    • 0028151708 scopus 로고
    • Processing of E1 and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells
    • Matsuura Y, Suzuki T, Suzuki R et al. Processing of E1 and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells. Virology 1994 205 : 141 150.
    • (1994) Virology , vol.205 , pp. 141-150
    • Matsuura, Y.1    Suzuki, T.2    Suzuki, R.3
  • 22
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin C, Lindenbach BD, Pragai BM, McCourt DW, Rice CM. Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J Virol 1994 68 : 5063 5073.
    • (1994) J Virol , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 24
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol 1993 67 : 3835 3844.
    • (1993) J Virol , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 25
    • 0027176287 scopus 로고
    • NS3 is a serine protease required for processing of hepatitis C virus polyprotein
    • Tomei L, Failla C, Santolini E, De Francesco R, La Monica N. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol 1993 67 : 4017 4026.
    • (1993) J Virol , vol.67 , pp. 4017-4026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    De Francesco, R.4    La Monica, N.5
  • 26
    • 0031579246 scopus 로고    scopus 로고
    • Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization
    • Hwang SB, Park KJ, Kim YS, Sung YC, Lai MM. Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization. Virology 1997 227 : 439 446.
    • (1997) Virology , vol.227 , pp. 439-446
    • Hwang, S.B.1    Park, K.J.2    Kim, Y.S.3    Sung, Y.C.4    Lai, M.M.5
  • 27
    • 1842289764 scopus 로고    scopus 로고
    • Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
    • Lohmann V, Korner F, Herian U, Bartenschlager R. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol 1997 71 : 8416 8428.
    • (1997) J Virol , vol.71 , pp. 8416-8428
    • Lohmann, V.1    Korner, F.2    Herian, U.3    Bartenschlager, R.4
  • 28
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
    • Lesburg CA, Cable MB, Ferrari E, Hong Z, Mannarino AF, Weber PC. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 1999 6 : 937 943.
    • (1999) Nat Struct Biol , vol.6 , pp. 937-943
    • Lesburg, C.A.1    Cable, M.B.2    Ferrari, E.3    Hong, Z.4    Mannarino, A.F.5    Weber, P.C.6
  • 29
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens SE, Tomei L, De Francesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996 15 : 12 22.
    • (1996) EMBO J , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De Francesco, R.3
  • 30
    • 0032902564 scopus 로고    scopus 로고
    • Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
    • Ferrari E, Wright-Minogue J, Fang JW, Baroudy BM, Lau JY, Hong Z. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol 1999 73 : 1649 1654.
    • (1999) J Virol , vol.73 , pp. 1649-1654
    • Ferrari, E.1    Wright-Minogue, J.2    Fang, J.W.3    Baroudy, B.M.4    Lau, J.Y.5    Hong, Z.6
  • 31
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005 11 : 791 796.
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3
  • 32
    • 0000639845 scopus 로고
    • Full genome cloning and nucleotide sequence analysis of hepatitis C virus from sera of chronic hepatitis patients in Korea
    • Cho YG, Yoon JW, Jang KL, Kim CM, Sung YC. Full genome cloning and nucleotide sequence analysis of hepatitis C virus from sera of chronic hepatitis patients in Korea. Mol Cells 1993 3 : 195 202.
    • (1993) Mol Cells , vol.3 , pp. 195-202
    • Cho, Y.G.1    Yoon, J.W.2    Jang, K.L.3    Kim, C.M.4    Sung, Y.C.5
  • 33
    • 0026801487 scopus 로고
    • Hepatitis delta antigen expressed by recombinant baculoviruses: Comparison of biochemical properties and post-translational modifications between the large and small forms
    • Hwang SB, Lee CZ, Lai MM. Hepatitis delta antigen expressed by recombinant baculoviruses: comparison of biochemical properties and post-translational modifications between the large and small forms. Virology 1992 190 : 413 422.
    • (1992) Virology , vol.190 , pp. 413-422
    • Hwang, S.B.1    Lee, C.Z.2    Lai, M.M.3
  • 34
    • 0032816079 scopus 로고    scopus 로고
    • A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA
    • Oh JW, Ito T, Lai MM. A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J Virol 1999 73 : 7694 7702.
    • (1999) J Virol , vol.73 , pp. 7694-7702
    • Oh, J.W.1    Ito, T.2    Lai, M.M.3
  • 35
    • 0035941344 scopus 로고    scopus 로고
    • Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase
    • Schmidt-Mende J, Bieck E, Hugle T et al. Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem 2001 276 : 44052 44063.
    • (2001) J Biol Chem , vol.276 , pp. 44052-44063
    • Schmidt-Mende, J.1    Bieck, E.2    Hugle, T.3
  • 36
    • 0032546963 scopus 로고    scopus 로고
    • RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region
    • Yamashita T, Kaneko S, Shirota Y et al. RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. J Biol Chem 1998 273 : 15479 15486.
    • (1998) J Biol Chem , vol.273 , pp. 15479-15486
    • Yamashita, T.1    Kaneko, S.2    Shirota, Y.3
  • 37
    • 1842562346 scopus 로고    scopus 로고
    • The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo
    • Lee KJ, Choi J, Ou JH, Lai MM. The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo. J Virol 2004 78 : 3797 3802.
    • (2004) J Virol , vol.78 , pp. 3797-3802
    • Lee, K.J.1    Choi, J.2    Ou, J.H.3    Lai, M.M.4
  • 38
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo
    • Kolykhalov AA, Mihalik K, Feinstone SM, Rice CM. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo. J Virol 2000 74 : 2046 2051.
    • (2000) J Virol , vol.74 , pp. 2046-2051
    • Kolykhalov, A.A.1    Mihalik, K.2    Feinstone, S.M.3    Rice, C.M.4
  • 39
    • 0036305913 scopus 로고    scopus 로고
    • Mutations in NS5B polymerase of hepatitis C virus: Impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture
    • Cheney IW, Naim S, Lai VC et al. Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture. Virology 2002 297 : 298 306.
    • (2002) Virology , vol.297 , pp. 298-306
    • Cheney, I.W.1    Naim, S.2    Lai, V.C.3


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