-
1
-
-
34248682403
-
RNAi therapeutics: Principles, prospects and challenges
-
Aagaard L, Rossi JJ. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev 2007;59(2-3):75-86
-
(2007)
Adv Drug Deliv Rev
, vol.59
, Issue.2-3
, pp. 75-86
-
-
Aagaard, L.1
Rossi, J.J.2
-
2
-
-
36849087968
-
Therapeutic application of RNAi: Is mRNA targeting finally ready for prime time?
-
Grimm D, Kay MA. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J Clin Invest 2007;117(12):3633-41
-
(2007)
J Clin Invest
, vol.117
, Issue.12
, pp. 3633-3641
-
-
Grimm, D.1
Kay, M.A.2
-
3
-
-
0023921083
-
Oligodeoxynucleotides as inhibitors of gene expression: A review
-
Stein CA, Cohen JS. Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res 1988;48(10):2659-68
-
(1988)
Cancer Res
, vol.48
, Issue.10
, pp. 2659-2668
-
-
Stein, C.A.1
Cohen, J.S.2
-
4
-
-
0026721173
-
Therapeutic applications of oligonucleotides
-
Crooke ST. Therapeutic applications of oligonucleotides. Ann Rev Pharmacol Toxicol 1992;32:329-76
-
(1992)
Ann Rev Pharmacol Toxicol
, vol.32
, pp. 329-376
-
-
Crooke, S.T.1
-
5
-
-
0032044068
-
An overview of progress in antisense therapeutics
-
Crooke ST. An overview of progress in antisense therapeutics. Antisense Nucleic Acid Drug Dev 1998;8:115-22
-
(1998)
Antisense Nucleic Acid Drug Dev
, vol.8
, pp. 115-122
-
-
Crooke, S.T.1
-
6
-
-
1542269161
-
Progress in antisense technology
-
Crooke ST. Progress in antisense technology. Ann Rev Med 2004;55:61-95
-
(2004)
Ann Rev Med
, vol.55
, pp. 61-95
-
-
Crooke, S.T.1
-
7
-
-
0000481424
-
Molecular mechanisms of antisense drugs: Human RNase H
-
Crooke ST. Molecular mechanisms of antisense drugs: human RNase H. Antisense Nucleic Acid Drug Dev 1999;9:377-9
-
(1999)
Antisense Nucleic Acid Drug Dev
, vol.9
, pp. 377-379
-
-
Crooke, S.T.1
-
8
-
-
3142514670
-
Progress in the development of nucleic acid therapeutics for cancer
-
Kalota A, Shetzline SE, Gewirtz AM. Progress in the development of nucleic acid therapeutics for cancer. Cancer Biol Ther 2004;3(1):4-12
-
(2004)
Cancer Biol Ther
, vol.3
, Issue.1
, pp. 4-12
-
-
Kalota, A.1
Shetzline, S.E.2
Gewirtz, A.M.3
-
9
-
-
0032817254
-
An antisense oligonucleotide primer. Antisense Nucleic Acid Drug Dev 1999
-
351-7, Table 1, clinical trials, updated
-
Hogrefe RI. An antisense oligonucleotide primer. Antisense Nucleic Acid Drug Dev 1999;9(4):351-7. (Table 1, clinical trials, updated 2007)
-
(2007)
, vol.9
, Issue.4
-
-
Hogrefe, R.I.1
-
10
-
-
0037046160
-
Novel antisense and peptide nucleic acid strategies for controlling gene expression
-
Braasch DA, Corey DR. Novel antisense and peptide nucleic acid strategies for controlling gene expression. Biochemistry 2002;41(14):4503-10
-
(2002)
Biochemistry
, vol.41
, Issue.14
, pp. 4503-4510
-
-
Braasch, D.A.1
Corey, D.R.2
-
11
-
-
36849042601
-
RNA interference against viruses: Strike and counterstrike
-
Haasnoot J, Westerhout EM, Berkhout B. RNA interference against viruses: strike and counterstrike. Nat Biotechnol 2007;25(12):1435-43
-
(2007)
Nat Biotechnol
, vol.25
, Issue.12
, pp. 1435-1443
-
-
Haasnoot, J.1
Westerhout, E.M.2
Berkhout, B.3
-
12
-
-
0032500293
-
First 'antisense' drug will treat CMV retinitis
-
Marwick C. First 'antisense' drug will treat CMV retinitis. JAMA 1998;280(10):871
-
(1998)
JAMA
, vol.280
, Issue.10
, pp. 871
-
-
Marwick, C.1
-
13
-
-
27244461714
-
Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs
-
Azad RF, Brown-Driver V, Buckheit RW Jr, Anderson KP. Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs. Antiviral Res 1995;28(2):101-11
-
(1995)
Antiviral Res
, vol.28
, Issue.2
, pp. 101-111
-
-
Azad, R.F.1
Brown-Driver, V.2
Buckheit Jr, R.W.3
Anderson, K.P.4
-
14
-
-
0035992688
-
Oblimersen Bcl-2 antisense: Facilitating apoptosis in anticancer treatment
-
Klasa RJ, Gillum AM, Klem RE, Frankel SR. Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment. Antisense Nucleic Acid Drug Dev 2002;12(3):193-213
-
(2002)
Antisense Nucleic Acid Drug Dev
, vol.12
, Issue.3
, pp. 193-213
-
-
Klasa, R.J.1
Gillum, A.M.2
Klem, R.E.3
Frankel, S.R.4
-
15
-
-
47649097577
-
Feasibility of administering oblimersen (G3139; Genasense) with imatinib mesilate in patients with imatinib resistant chronic myeloid leukemia - Cancer and leukemia group B study 10107
-
Wetzler M, Donohue KA, Odenike OM, et al. Feasibility of administering oblimersen (G3139; Genasense) with imatinib mesilate in patients with imatinib resistant chronic myeloid leukemia - Cancer and leukemia group B study 10107. Leuk Lymphoma 2008;49(7):1274-8
-
(2008)
Leuk Lymphoma
, vol.49
, Issue.7
, pp. 1274-1278
-
-
Wetzler, M.1
Donohue, K.A.2
Odenike, O.M.3
-
16
-
-
39749166555
-
Randomized phase II study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103
-
Rudin CM, Salgia R, Wang X, et al. Randomized phase II study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103. J Clin Oncol 2008;26(6):870-6
-
(2008)
J Clin Oncol
, vol.26
, Issue.6
, pp. 870-876
-
-
Rudin, C.M.1
Salgia, R.2
Wang, X.3
-
17
-
-
33645822110
-
G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice
-
Gekeler V, Gimmnich P, Hofmann H-P, et al. G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice. Oligonucleotides 2006;16(1):83-93
-
(2006)
Oligonucleotides
, vol.16
, Issue.1
, pp. 83-93
-
-
Gekeler, V.1
Gimmnich, P.2
Hofmann, H.-P.3
-
18
-
-
33845654040
-
Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy
-
Kim R, Emi M, Matsuura K, Tanabe K. Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy. Cancer Gene Ther 2007;14(1):1-11
-
(2007)
Cancer Gene Ther
, vol.14
, Issue.1
, pp. 1-11
-
-
Kim, R.1
Emi, M.2
Matsuura, K.3
Tanabe, K.4
-
19
-
-
37249074364
-
Bcl-2 antisense in thetreatment of human malignancies: A delusion in targeted therapy
-
Gjertsen BT, Bredholt T, Anensen N, Vintermyr OK. Bcl-2 antisense in thetreatment of human malignancies: a delusion in targeted therapy. Curt Pharm Biotechnol 2007;8(6):373-81
-
(2007)
Curt Pharm Biotechnol
, vol.8
, Issue.6
, pp. 373-381
-
-
Gjertsen, B.T.1
Bredholt, T.2
Anensen, N.3
Vintermyr, O.K.4
-
20
-
-
33645453677
-
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucteotide, in patients with advanced-stage non-small-cell lung cancer
-
Paz-Ares L, Douillard JY, Koralewski P, et al. Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucteotide, in patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2006;24(9):1428-34
-
(2006)
J Clin Oncol
, vol.24
, Issue.9
, pp. 1428-1434
-
-
Paz-Ares, L.1
Douillard, J.Y.2
Koralewski, P.3
-
21
-
-
14644438523
-
Efficacy and toxicity of the antisense oligonucleotide aprinacarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas
-
Grossman SA, Alavi JB, Supko JG, et al. Efficacy and toxicity of the antisense oligonucleotide aprinacarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. Neuro Oncol 2005;7(1):32-40
-
(2005)
Neuro Oncol
, vol.7
, Issue.1
, pp. 32-40
-
-
Grossman, S.A.1
Alavi, J.B.2
Supko, J.G.3
-
22
-
-
33846804162
-
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
-
Yacyshyn B, Chey WY, Wedel MK, et al. A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin Gastroenterol Hepatol 2007;5(2):215-20
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, Issue.2
, pp. 215-220
-
-
Yacyshyn, B.1
Chey, W.Y.2
Wedel, M.K.3
-
23
-
-
34248136340
-
Inflammatory bowel disease: Clinical aspects and established and evolving therapies
-
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007;369(9573):1641-57
-
(2007)
Lancet
, vol.369
, Issue.9573
, pp. 1641-1657
-
-
Baumgart, D.C.1
Sandborn, W.J.2
-
24
-
-
12444297637
-
Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
-
Davis AJ, Gelmon KA, Siu LL, et al. Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest New Drugs 2003;21(1):85-97
-
(2003)
Invest New Drugs
, vol.21
, Issue.1
, pp. 85-97
-
-
Davis, A.J.1
Gelmon, K.A.2
Siu, L.L.3
-
25
-
-
33646595937
-
Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: A National Cancer Institute of Canada Clinical Trials Group investigational new drug study
-
Winquist E, Knox J, Ayoub JP, et al. Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs 2006;24(2):159-67
-
(2006)
Invest New Drugs
, vol.24
, Issue.2
, pp. 159-167
-
-
Winquist, E.1
Knox, J.2
Ayoub, J.P.3
-
26
-
-
42249104213
-
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
-
Klisovic RB, Stock W Cataland S, et al. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin Cancer Res 2008;14(8):2444-9
-
(2008)
Clin Cancer Res
, vol.14
, Issue.8
, pp. 2444-2449
-
-
Klisovic, R.B.1
Stock, W.2
Cataland, S.3
-
27
-
-
0034798245
-
The experimental use of antisense oligonucleotides: A guide for the perplexed
-
Stein CA. The experimental use of antisense oligonucleotides: a guide for the perplexed. J Clin Invest 2001;108(5):641-4
-
(2001)
J Clin Invest
, vol.108
, Issue.5
, pp. 641-644
-
-
Stein, C.A.1
-
28
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
Scherer LJ, Rossi JJ. Approaches for the sequence-specific knockdown of mRNA. Nat Biotechnol 2003;21(12):1457-65
-
(2003)
Nat Biotechnol
, vol.21
, Issue.12
, pp. 1457-1465
-
-
Scherer, L.J.1
Rossi, J.J.2
-
29
-
-
19444375104
-
-
Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 2005;7(1):E61-77
-
Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 2005;7(1):E61-77
-
-
-
-
30
-
-
38049026252
-
A phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma
-
Stadler WM, Desai AA, Quinn DI, et al. A phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma. Cancer Chemother Pharmacol 2008;61(4):689-94
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.4
, pp. 689-694
-
-
Stadler, W.M.1
Desai, A.A.2
Quinn, D.I.3
-
31
-
-
0028114548
-
Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding
-
Brown DA, Kang S-H, Gryaznov SM, et al. Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J Biol Chem 1994;269:26801-5
-
(1994)
J Biol Chem
, vol.269
, pp. 26801-26805
-
-
Brown, D.A.1
Kang, S.-H.2
Gryaznov, S.M.3
-
32
-
-
12644302203
-
Pharmacokinetic properties of several novel oligonucleotide analogs in mice
-
Crooke ST Graham MJ, Zuckerman JE, et al. Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J Pharmacol Exp Ther 1996;277:923-37
-
(1996)
J Pharmacol Exp Ther
, vol.277
, pp. 923-937
-
-
Crooke ST Graham, M.J.1
Zuckerman, J.E.2
-
33
-
-
0037733977
-
Antisense technologies. Improvement through novel chemical modifications
-
Kurreck J. Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem 2003;270(8):1628-44
-
(2003)
Eur J Biochem
, vol.270
, Issue.8
, pp. 1628-1644
-
-
Kurreck, J.1
-
34
-
-
34247586674
-
2′-Modified oligonucleotides for antisense therapeutics
-
Prakash TP, Bhat B. 2′-Modified oligonucleotides for antisense therapeutics. Curt Top Med Chem 2007;7(7):641-9
-
(2007)
Curt Top Med Chem
, vol.7
, Issue.7
, pp. 641-649
-
-
Prakash, T.P.1
Bhat, B.2
-
35
-
-
0038578021
-
Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA
-
Grünweller A, Wyszko E, Bieber B, et al. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 2003;31(12):3185-93
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.12
, pp. 3185-3193
-
-
Grünweller, A.1
Wyszko, E.2
Bieber, B.3
-
36
-
-
33746334153
-
Promising nucleic acid analogs and mimics: Characteristic features and applications of PNA, LNA, and morpholino
-
Karkare S, Bhatnagar D. Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino. Appl Microbiol Biotechnol 2006;71(5):575-86
-
(2006)
Appl Microbiol Biotechnol
, vol.71
, Issue.5
, pp. 575-586
-
-
Karkare, S.1
Bhatnagar, D.2
-
37
-
-
34247566116
-
siRNA, and S-DNA compared: Impact of structure and mechanism of action on off-target effects and sequence specificity
-
Summerton JE. Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity. Curr Top Med Chem 2007;7(7):651-60
-
(2007)
Curr Top Med Chem
, vol.7
, Issue.7
, pp. 651-660
-
-
Morpholino, S.J.E.1
-
38
-
-
0033965192
-
Chemically modified oligonucleotides exhibit decreased immune stimulation in mice
-
Henry S, Stecker K, Brooks D, et al. Chemically modified oligonucleotides exhibit decreased immune stimulation in mice. J Pharmacol Exp Ther 2000;292(2):468-79
-
(2000)
J Pharmacol Exp Ther
, vol.292
, Issue.2
, pp. 468-479
-
-
Henry, S.1
Stecker, K.2
Brooks, D.3
-
39
-
-
0035119936
-
Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
-
Geary RS, Watanabe TA, Truong L, et al. Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats. Pharmacol Exp Ther 2001;296(3):890-7
-
(2001)
Pharmacol Exp Ther
, vol.296
, Issue.3
, pp. 890-897
-
-
Geary, R.S.1
Watanabe, T.A.2
Truong, L.3
-
40
-
-
12644302203
-
Pharmacokinetic properties of several novel oligonucleotide analogs in mice
-
Crooke ST, Graham MJ, Zuckerman JE, et al. Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J Pharmacol Exp Ther 1996;277(2):923-37
-
(1996)
J Pharmacol Exp Ther
, vol.277
, Issue.2
, pp. 923-937
-
-
Crooke, S.T.1
Graham, M.J.2
Zuckerman, J.E.3
-
41
-
-
0029761186
-
Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice
-
Rifai A, Brysch W, Fadden K, et al. Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice. Am J Pathol 1996;149(2):717-25
-
(1996)
Am J Pathol
, vol.149
, Issue.2
, pp. 717-725
-
-
Rifai, A.1
Brysch, W.2
Fadden, K.3
-
42
-
-
0030909609
-
Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies
-
Agrawall S, Jiang Z, Zhao Q, et al. Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies. Proc Natl Acad Sci USA 1997;94(6):2620-5
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.6
, pp. 2620-2625
-
-
Agrawall, S.1
Jiang, Z.2
Zhao, Q.3
-
43
-
-
0038578021
-
Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA
-
Grünweller A, Wyszko E, Bieber B, et al. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 2003;31(12):3185-93
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.12
, pp. 3185-3193
-
-
Grünweller, A.1
Wyszko, E.2
Bieber, B.3
-
44
-
-
34447300969
-
Antisense apolipoprotein B therapy: Where do we stand?
-
Akdim F, Stroes ES, Kastelein JJ. Antisense apolipoprotein B therapy: where do we stand? Curr Opin Lipidol 2007;18(4):397-400
-
(2007)
Curr Opin Lipidol
, vol.18
, Issue.4
, pp. 397-400
-
-
Akdim, F.1
Stroes, E.S.2
Kastelein, J.J.3
-
45
-
-
35148815698
-
Apolipoproteins A-I and B: Biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease
-
Olofsson SO, Wiklund O, Borén J. Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease. Vasc Health Risk Manag 2007;3(4):491-502
-
(2007)
Vasc Health Risk Manag
, vol.3
, Issue.4
, pp. 491-502
-
-
Olofsson, S.O.1
Wiklund, O.2
Borén, J.3
-
46
-
-
35348908391
-
Apolipoprotein polymorphisms and familial hypercholesterolemia
-
Dedoussis GV. Apolipoprotein polymorphisms and familial hypercholesterolemia. Pharmacogenomics 2007;8(9):1179-89
-
(2007)
Pharmacogenomics
, vol.8
, Issue.9
, pp. 1179-1189
-
-
Dedoussis, G.V.1
-
47
-
-
33750207033
-
Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
-
Kastelein JJ, Wedel MK, Baker BF, et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006;114(16):1729-35
-
(2006)
Circulation
, vol.114
, Issue.16
, pp. 1729-1735
-
-
Kastelein, J.J.1
Wedel, M.K.2
Baker, B.F.3
-
48
-
-
34748859659
-
ISIS 301012 gene therapy for hypercholesterolemia: Sense, antisense, or nonsense?
-
Ito MK. ISIS 301012 gene therapy for hypercholesterolemia: sense, antisense, or nonsense? Ann Pharmacother 2007;41(10):1669-78
-
(2007)
Ann Pharmacother
, vol.41
, Issue.10
, pp. 1669-1678
-
-
Ito, M.K.1
-
49
-
-
33847338002
-
Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100
-
Yu RZ, Kim TW, Hong A, et al. Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100. Drug Metab Dispos 2007;35(3):460-8
-
(2007)
Drug Metab Dispos
, vol.35
, Issue.3
, pp. 460-468
-
-
Yu, R.Z.1
Kim, T.W.2
Hong, A.3
-
50
-
-
33646456336
-
The potential of clusterin inhibiting antisense oligodeoxynucleotide therapy for prostate cancer
-
Miyake H, Hara I, Fujisawa M, Gleave ME. The potential of clusterin inhibiting antisense oligodeoxynucleotide therapy for prostate cancer. Expert Opin Investig Drugs 2006;15(5):507-17
-
(2006)
Expert Opin Investig Drugs
, vol.15
, Issue.5
, pp. 507-517
-
-
Miyake, H.1
Hara, I.2
Fujisawa, M.3
Gleave, M.E.4
-
51
-
-
38949153810
-
A Phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
Chi KN, Siu LL, Hirte H, et al. A Phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res 2008;14(3):833-952
-
(2008)
Clin Cancer Res
, vol.14
, Issue.3
, pp. 833-952
-
-
Chi, K.N.1
Siu, L.L.2
Hirte, H.3
-
52
-
-
0036329620
-
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis
-
Rondinone CM, Trevillyan JM, Clampit J, et al. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes 2002;51(8):2405-11
-
(2002)
Diabetes
, vol.51
, Issue.8
, pp. 2405-2411
-
-
Rondinone, C.M.1
Trevillyan, J.M.2
Clampit, J.3
-
53
-
-
13844251786
-
Antisense oligonucleotide blockade of alpha 4 integrin prevents and reverses clinical symptoms in murine experimental autoimmune encephalomyelitis
-
Myers KJ, Witchell DR, Graham MJ, et al. Antisense oligonucleotide blockade of alpha 4 integrin prevents and reverses clinical symptoms in murine experimental autoimmune encephalomyelitis. J Neuroimmunol 2005;160(1-2):12-24
-
(2005)
J Neuroimmunol
, vol.160
, Issue.1-2
, pp. 12-24
-
-
Myers, K.J.1
Witchell, D.R.2
Graham, M.J.3
-
54
-
-
30944443047
-
Antisense- and RNA interference-based therapeutic strategies in allergy
-
Popescu FD. Antisense- and RNA interference-based therapeutic strategies in allergy. J Cell Mol Med 2005;9(4):840-53
-
(2005)
J Cell Mol Med
, vol.9
, Issue.4
, pp. 840-853
-
-
Popescu, F.D.1
-
55
-
-
22044456529
-
Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothicate oligonucleotide AP 12009 in rabbits and primates: Toxicology and safety
-
Schlingensiepen R, Goldbrunner M, Szyrach MN, et al. Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothicate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety. Oligonucleotides 2005;15(2):94-104
-
(2005)
Oligonucleotides
, vol.15
, Issue.2
, pp. 94-104
-
-
Schlingensiepen, R.1
Goldbrunner, M.2
Szyrach, M.N.3
-
56
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S. Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 2008;177:137-50
-
(2008)
Recent Results Cancer Res
, vol.177
, pp. 137-150
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
57
-
-
0038615898
-
GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors
-
Lee Y, Vassilakos A, Feng N, et al. GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors. Cancer Res 2003;63(11):2802-11
-
(2003)
Cancer Res
, vol.63
, Issue.11
, pp. 2802-2811
-
-
Lee, Y.1
Vassilakos, A.2
Feng, N.3
-
58
-
-
0036567147
-
Design of antisense oligonucleotides stabilized by locked nucleic acids
-
Kurreck J, Wyszko E, Gillen C, Erdmann VA. Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res 2002;30(9):1911-8
-
(2002)
Nucleic Acids Res
, vol.30
, Issue.9
, pp. 1911-1918
-
-
Kurreck, J.1
Wyszko, E.2
Gillen, C.3
Erdmann, V.A.4
-
59
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmén J, Thonberg H, Ljungberg K, et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res 2005;33(1):439-47
-
(2005)
Nucleic Acids Res
, vol.33
, Issue.1
, pp. 439-447
-
-
Elmén, J.1
Thonberg, H.2
Ljungberg, K.3
-
60
-
-
33846902312
-
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
-
Swayze EE, Siwkowski AM, Wancewicz EV, et al. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res 2007;35(2):687-700
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.2
, pp. 687-700
-
-
Swayze, E.E.1
Siwkowski, A.M.2
Wancewicz, E.V.3
-
61
-
-
40249106014
-
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to upregulation of a large set of predicted target mRNAs in the liver
-
Elmén J, Lindow M, Silahtaroglu A, et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to upregulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008;36(4):1153-62
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.4
, pp. 1153-1162
-
-
Elmén, J.1
Lindow, M.2
Silahtaroglu, A.3
-
62
-
-
0034078048
-
Peptide nucleic acid (PNA): Its medical and biotechnical applications and promise for the future
-
Ray A, Nordén B. Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J 2000;14(9):1041-60
-
(2000)
FASEB J
, vol.14
, Issue.9
, pp. 1041-1060
-
-
Ray, A.1
Nordén, B.2
-
63
-
-
0034777151
-
Peptide-nucleic acids (PNAs): A tool for the development of gene expression modifiers
-
Gambari R. Peptide-nucleic acids (PNAs): a tool for the development of gene expression modifiers. Curr Pharm Des 2001;7(17):1839-62
-
(2001)
Curr Pharm Des
, vol.7
, Issue.17
, pp. 1839-1862
-
-
Gambari, R.1
-
64
-
-
24344485512
-
Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers
-
Amantana A, Iversen PL. Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers. Curr Opin Pharmacol 2005;5(5):550-5
-
(2005)
Curr Opin Pharmacol
, vol.5
, Issue.5
, pp. 550-555
-
-
Amantana, A.1
Iversen, P.L.2
-
65
-
-
4544361386
-
The peptide nucleic acids: A new way for chromosomal investigation on isolated cells?
-
Pellestor F. Paulasova P, Macek M, Hamamah S. The peptide nucleic acids: a new way for chromosomal investigation on isolated cells? Hum Reprod 2004;19(9):1946-51
-
(2004)
Hum Reprod
, vol.19
, Issue.9
, pp. 1946-1951
-
-
Pellestor, F.1
Paulasova, P.2
Macek, M.3
Hamamah, S.4
-
66
-
-
19344375743
-
RNAi Therapeutics: How Likely, How Soon?
-
Doi:10.1371/journal.pbio.0020028
-
Robinson R. RNAi Therapeutics: How Likely, How Soon? PLoS Biol 2004;2(1):e28. Doi:10.1371/journal.pbio.0020028
-
(2004)
PLoS Biol
, vol.2
, Issue.1
-
-
Robinson, R.1
-
67
-
-
0041331496
-
siRNA function in RNAi: A chemical modification analysis
-
Chiu Y-L, Rana TM. siRNA function in RNAi: a chemical modification analysis. RNA 2003;9:1034-48
-
(2003)
RNA
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.-L.1
Rana, T.M.2
-
68
-
-
0038606999
-
Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
-
Czauderna F, Fechtner M, Dames S, et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res 2003;31(11):2705-16
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.11
, pp. 2705-2716
-
-
Czauderna, F.1
Fechtner, M.2
Dames, S.3
-
69
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey DV, Lockridge JA, Shaw L, et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechtiol 2005;23:1002-7
-
(2005)
Nat Biotechtiol
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
-
70
-
-
24344478782
-
2-5A antisense treatment of respiratory syncytial virus
-
Leaman DW. 2-5A antisense treatment of respiratory syncytial virus. Curr Opin Pharmacol 2005;5(5):502-7
-
(2005)
Curr Opin Pharmacol
, vol.5
, Issue.5
, pp. 502-507
-
-
Leaman, D.W.1
-
71
-
-
13444262170
-
Inhibition of respiratory viruses by nasally administered siRNA
-
Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005;11(1):50-5
-
(2005)
Nat Med
, vol.11
, Issue.1
, pp. 50-55
-
-
Bitko, V.1
Musiyenko, A.2
Shulyayeva, O.3
Barik, S.4
-
72
-
-
39749160560
-
Antibody-targeted liposomes in cancer therapy and imaging
-
Sofou S, Sgouros G. Antibody-targeted liposomes in cancer therapy and imaging. Expert Opin Drug Deliv 2008;5(2):189-204
-
(2008)
Expert Opin Drug Deliv
, vol.5
, Issue.2
, pp. 189-204
-
-
Sofou, S.1
Sgouros, G.2
-
73
-
-
33846199148
-
Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL
-
Hussain S, Plückthun A, Allen TM, Zangemeister-Wittke U. Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL. Mol Cancer Ther 2006;5(12):3170-80
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.12
, pp. 3170-3180
-
-
Hussain, S.1
Plückthun, A.2
Allen, T.M.3
Zangemeister-Wittke, U.4
-
74
-
-
6444244496
-
Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol)
-
Allen C, Dos Santos N, Gallagher R, et al. Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol). Biosci Rep 2002;22(2):225-50
-
(2002)
Biosci Rep
, vol.22
, Issue.2
, pp. 225-250
-
-
Allen, C.1
Dos Santos, N.2
Gallagher, R.3
-
75
-
-
0036083609
-
Pegylation: Engineering improved pharmaceuticals for enhanced therapy
-
Molineux G. Pegylation: engineering improved pharmaceuticals for enhanced therapy. Cancer Treat Rev 2002;28(Suppl A): 13-6
-
(2002)
Cancer Treat Rev
, vol.28
, Issue.SUPPL. A
, pp. 13-16
-
-
Molineux, G.1
-
76
-
-
10744233586
-
Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models
-
Pastorino F, Brignole C, Marimpietri D, et al. Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models. Clin Cancer Res 2003;9(12):4595-605
-
(2003)
Clin Cancer Res
, vol.9
, Issue.12
, pp. 4595-4605
-
-
Pastorino, F.1
Brignole, C.2
Marimpietri, D.3
-
77
-
-
38549126565
-
-
Pastorino F, Mumbengegwi DR, Ribatti D, et al. Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin. J Control Release 2008;126(1):85-94
-
Pastorino F, Mumbengegwi DR, Ribatti D, et al. Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin. J Control Release 2008;126(1):85-94
-
-
-
-
78
-
-
0034594649
-
Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: Antitumor effects
-
Pagnan G, Stuart DD, Pastorino F, et al. Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects. J Natl Cancer Inst 2000;92(3):253-61
-
(2000)
J Natl Cancer Inst
, vol.92
, Issue.3
, pp. 253-261
-
-
Pagnan, G.1
Stuart, D.D.2
Pastorino, F.3
-
79
-
-
40149097015
-
Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles
-
Spänkuch B, Steinhauser I, Wartlick H, et al. Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles. Neoplasia 2008;10(3):223-34
-
(2008)
Neoplasia
, vol.10
, Issue.3
, pp. 223-234
-
-
Spänkuch, B.1
Steinhauser, I.2
Wartlick, H.3
-
80
-
-
43349103903
-
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
-
Alam MR, Dixit V, Kang H, et al. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res 2008;36(8):2764-76
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.8
, pp. 2764-2776
-
-
Alam, M.R.1
Dixit, V.2
Kang, H.3
-
81
-
-
0030751852
-
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: Predominant uptake by scavenger receptors on endothelial liver cells
-
Bijsterbosch MK, Manoharan M, Rump ET, et al. In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells. Nucleic Acids Res 1997;25(16):3290-6
-
(1997)
Nucleic Acids Res
, vol.25
, Issue.16
, pp. 3290-3296
-
-
Bijsterbosch, M.K.1
Manoharan, M.2
Rump, E.T.3
-
83
-
-
0033856775
-
Viral vectors for gene transfer: A review of their use in the treatment of human diseases
-
Walther W, Stein U. Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 2000;60(2):249-71
-
(2000)
Drugs
, vol.60
, Issue.2
, pp. 249-271
-
-
Walther, W.1
Stein, U.2
-
84
-
-
0035914989
-
Intracellular trafficking and transgene expression of viral and non-viral gene vectors
-
Kamiya H, Tsuchiya H, Yamazaki J, Harashima H. Intracellular trafficking and transgene expression of viral and non-viral gene vectors. Adv Drug Deliv Rev 2001;52:153-64
-
(2001)
Adv Drug Deliv Rev
, vol.52
, pp. 153-164
-
-
Kamiya, H.1
Tsuchiya, H.2
Yamazaki, J.3
Harashima, H.4
-
86
-
-
0041808932
-
Gene therapy progress and prospects: Adenoviral vectors
-
St George JA. Gene therapy progress and prospects: adenoviral vectors. Gene Ther 2003;10(14):1135-41
-
(2003)
Gene Ther
, vol.10
, Issue.14
, pp. 1135-1141
-
-
St George, J.A.1
-
87
-
-
33845388144
-
Micellar nanocarriers: Pharmaceutical perspectives
-
Tarchilin VP. Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 2007;24(1):1-16
-
(2007)
Pharm Res
, vol.24
, Issue.1
, pp. 1-16
-
-
Tarchilin, V.P.1
-
88
-
-
0031795974
-
Liver directed gene transfer: A linear polyethlenimine derivative mediates highly efficient DNA delivery to primary hepatocytes in vitro and in vivo
-
Chemin I, Moradpour D, Wieland S, et al. Liver directed gene transfer: a linear polyethlenimine derivative mediates highly efficient DNA delivery to primary hepatocytes in vitro and in vivo. J Viral Hepat 1998;5:369-75
-
(1998)
J Viral Hepat
, vol.5
, pp. 369-375
-
-
Chemin, I.1
Moradpour, D.2
Wieland, S.3
-
89
-
-
0033537836
-
Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor
-
Bandyopadhyay P, Ma X, Linehan-Stieers C, et al. Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor. J Biol Chem 1999;274:10163-72
-
(1999)
J Biol Chem
, vol.274
, pp. 10163-10172
-
-
Bandyopadhyay, P.1
Ma, X.2
Linehan-Stieers, C.3
-
90
-
-
0034968241
-
Inhibition of hepadnaviral replication by polyethylenimine based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver
-
Robaczewska M, Guerret S, Remy JS, et al. Inhibition of hepadnaviral replication by polyethylenimine based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver. Gene Ther 2001;8:874-81
-
(2001)
Gene Ther
, vol.8
, pp. 874-881
-
-
Robaczewska, M.1
Guerret, S.2
Remy, J.S.3
-
91
-
-
0033427317
-
Polyethylenimine but not cationic lipid improves antisense activity of 3′-capped phosphodiester oligonucleotides
-
Dheur S, Dias N, van Aerschot A, et al. Polyethylenimine but not cationic lipid improves antisense activity of 3′-capped phosphodiester oligonucleotides. Antisense Nucleic Acid Drug Dev 1999; 9:515-25
-
(1999)
Antisense Nucleic Acid Drug Dev
, vol.9
, pp. 515-525
-
-
Dheur, S.1
Dias, N.2
van Aerschot, A.3
-
92
-
-
0033991001
-
Polyethyleneimine-mediated transfection to improve antisense activity of 3′-capped phosphodiester oligonucleotides
-
Dheur S, Saison-Behmoaras TE. Polyethyleneimine-mediated transfection to improve antisense activity of 3′-capped phosphodiester oligonucleotides. Methods Enzymol 2000;313:56-73
-
(2000)
Methods Enzymol
, vol.313
, pp. 56-73
-
-
Dheur, S.1
Saison-Behmoaras, T.E.2
-
93
-
-
0033834587
-
Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies
-
Jen KY, Gewirtz AM. Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies. Stem Cells 2000;18(5):307-19
-
(2000)
Stem Cells
, vol.18
, Issue.5
, pp. 307-319
-
-
Jen, K.Y.1
Gewirtz, A.M.2
-
94
-
-
0036371914
-
Side effects of a systemic injection of linear polyethylenimine-DNA complexes
-
Chollet P, Favrot MC, Hurbin A, Coll JL. Side effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med 2002;4:84-91
-
(2002)
J Gene Med
, vol.4
, pp. 84-91
-
-
Chollet, P.1
Favrot, M.C.2
Hurbin, A.3
Coll, J.L.4
-
95
-
-
34548150237
-
Cell-penetrating-peptide-based delivery of oligonucleotides: An overview
-
Abes R, Arzumanov AA, Moulton HM, et al. Cell-penetrating-peptide-based delivery of oligonucleotides: an overview. Biochem Soc Trans 2007;35(Pt 4):775-9
-
(2007)
Biochem Soc Trans
, vol.35
, Issue.PART 4
, pp. 775-779
-
-
Abes, R.1
Arzumanov, A.A.2
Moulton, H.M.3
-
96
-
-
3843092828
-
Chances and pitfalls of cell penetrating peptides for cellular drug delivery
-
Tréhin R, Merkle HP. Chances and pitfalls of cell penetrating peptides for cellular drug delivery. Eur J Pharm Biopharm 2004;58(2):209-23
-
(2004)
Eur J Pharm Biopharm
, vol.58
, Issue.2
, pp. 209-223
-
-
Tréhin, R.1
Merkle, H.P.2
-
97
-
-
0037600638
-
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogs
-
Gait MJ. Peptide-mediated cellular delivery of antisense oligonucleotides and their analogs. Cell Mol Life Sci 2003;60(5):844-53
-
(2003)
Cell Mol Life Sci
, vol.60
, Issue.5
, pp. 844-853
-
-
Gait, M.J.1
-
98
-
-
39049130647
-
Cell-penetrating peptides for drug delivery across membrane barriers
-
Foged C, Nielsen HM. Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opin Drug Deliv 2008;5(1):105-17
-
(2008)
Expert Opin Drug Deliv
, vol.5
, Issue.1
, pp. 105-117
-
-
Foged, C.1
Nielsen, H.M.2
-
99
-
-
34548157008
-
Cell-penetrating peptide-morpholino conjugates alter premRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo
-
Moulton HM, Fletcher S, Neuman BW, et al. Cell-penetrating peptide-morpholino conjugates alter premRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans 2007;35(Pt 4):826-8
-
(2007)
Biochem Soc Trans
, vol.35
, Issue.PART 4
, pp. 826-828
-
-
Moulton, H.M.1
Fletcher, S.2
Neuman, B.W.3
-
100
-
-
13744259834
-
Synthesis, cellular uptake and HIV-1 Tat-dependent transactivation inhibition activity of oligonucleotide analogs disulfide-conjugated to cell-penetrating peptides
-
Turner JJ, Arzumanov AA, Gait MJ. Synthesis, cellular uptake and HIV-1 Tat-dependent transactivation inhibition activity of oligonucleotide analogs disulfide-conjugated to cell-penetrating peptides. Nucleic Acids Res 2005;33(1):27-42
-
(2005)
Nucleic Acids Res
, vol.33
, Issue.1
, pp. 27-42
-
-
Turner, J.J.1
Arzumanov, A.A.2
Gait, M.J.3
-
101
-
-
38949206876
-
Cell penetrating peptide conjugates of steric block oligonucleotides
-
Lebleu B, Moulton HM, Abes R, et al. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv Drug Deliv Rev 2008;60(4-5):517-29
-
(2008)
Adv Drug Deliv Rev
, vol.60
, Issue.4-5
, pp. 517-529
-
-
Lebleu, B.1
Moulton, H.M.2
Abes, R.3
-
102
-
-
0033779762
-
The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
-
Weiner GJ. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J Leukoc Biol 2000;68(4):455-63
-
(2000)
J Leukoc Biol
, vol.68
, Issue.4
, pp. 455-463
-
-
Weiner, G.J.1
-
103
-
-
33644850350
-
Nucleic acid aptamers for target validation and therapeutic applications
-
Pendergrast PS, Marsh HN, Grate D, et al. Nucleic acid aptamers for target validation and therapeutic applications. J Biomol Tech 2005;16(3):224-34
-
(2005)
J Biomol Tech
, vol.16
, Issue.3
, pp. 224-234
-
-
Pendergrast, P.S.1
Marsh, H.N.2
Grate, D.3
-
105
-
-
0005620475
-
Aptamers as therapeutic and diagnostic agents
-
Brody EN, Gold L. Aptamers as therapeutic and diagnostic agents. J Biotechnol 2000;74(1):5-13
-
(2000)
J Biotechnol
, vol.74
, Issue.1
, pp. 5-13
-
-
Brody, E.N.1
Gold, L.2
-
106
-
-
17644399512
-
Pharmacokinetics and biodistribution of novel aptamer compositions
-
Healy JM, Lewis SD, Kurz M, et al. Pharmacokinetics and biodistribution of novel aptamer compositions. Pharm Res 2004;21(12):2234-46
-
(2004)
Pharm Res
, vol.21
, Issue.12
, pp. 2234-2246
-
-
Healy, J.M.1
Lewis, S.D.2
Kurz, M.3
-
107
-
-
39049142223
-
Pegaptanib sodium for the treatment of age-related macular degeneration
-
Apte RS. Pegaptanib sodium for the treatment of age-related macular degeneration. Expert Opin Pharmacother 2008;9(3):499-508
-
(2008)
Expert Opin Pharmacother
, vol.9
, Issue.3
, pp. 499-508
-
-
Apte, R.S.1
-
108
-
-
32544435129
-
Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor
-
McCauley TG, Kurz JC, Merlino PG, et al. Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor. Pharm Res 2006;23(2):303-11
-
(2006)
Pharm Res
, vol.23
, Issue.2
, pp. 303-311
-
-
McCauley, T.G.1
Kurz, J.C.2
Merlino, P.G.3
-
109
-
-
35348911812
-
Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies
-
Bhindi R, Fahmy RG, Lowe HC, et al. Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies. Am J Pathol 2007;171(4):1079-88
-
(2007)
Am J Pathol
, vol.171
, Issue.4
, pp. 1079-1088
-
-
Bhindi, R.1
Fahmy, R.G.2
Lowe, H.C.3
-
110
-
-
84884581309
-
Toll-Like receptors (TLRs) and their ligands
-
Uematsu S, Akira S. Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol 2008;183:1-20
-
(2008)
Handb Exp Pharmacol
, vol.183
, pp. 1-20
-
-
Uematsu, S.1
Akira, S.2
-
111
-
-
36749069393
-
Interferons at age 50: Past, current and future impact on biomedicine
-
Borden EC, Sen GC, Uze G, et al. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007;6(12):975-90
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.12
, pp. 975-990
-
-
Borden, E.C.1
Sen, G.C.2
Uze, G.3
-
112
-
-
38649123396
-
The future of toll-like receptor therapeutics
-
Parkinson T. The future of toll-like receptor therapeutics. Curr Opin Mol Ther 2008;10(1):21-31
-
(2008)
Curr Opin Mol Ther
, vol.10
, Issue.1
, pp. 21-31
-
-
Parkinson, T.1
-
113
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B cell activation
-
Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B cell activation. Nature 1995;374(6522):546-9
-
(1995)
Nature
, vol.374
, Issue.6522
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
-
114
-
-
0038330766
-
DNA as a vaccine adjuvant
-
Klinman DM. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines 2003;2(2):305-15
-
(2003)
Expert Rev Vaccines
, vol.2
, Issue.2
, pp. 305-315
-
-
Klinman, D.C.1
-
115
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006;5(6):471-84
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.6
, pp. 471-484
-
-
Krieg, A.M.1
-
116
-
-
37849002321
-
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
-
Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008;27(2):161-167
-
(2008)
Oncogene
, vol.27
, Issue.2
, pp. 161-167
-
-
Krieg, A.M.1
-
117
-
-
38649089811
-
Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators
-
Dorn A, Kippenberger S. Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators. Curr Opin Mol Ther 2008;10(1):10-20
-
(2008)
Curr Opin Mol Ther
, vol.10
, Issue.1
, pp. 10-20
-
-
Dorn, A.1
Kippenberger, S.2
-
118
-
-
35948987594
-
Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma
-
Leonard JP, Link BK, Emmanouilides C, et al. Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma. Clin Cancer Res 2007;13(20):6168-74
-
(2007)
Clin Cancer Res
, vol.13
, Issue.20
, pp. 6168-6174
-
-
Leonard, J.P.1
Link, B.K.2
Emmanouilides, C.3
-
119
-
-
33750542135
-
Toll' gates for future immunotherapy
-
Ishii KJ, Uematsu S, Akira S. 'Toll' gates for future immunotherapy. Curr Pharm Des 2006;12(32):4135-42
-
(2006)
Curr Pharm Des
, vol.12
, Issue.32
, pp. 4135-4142
-
-
Ishii, K.J.1
Uematsu, S.2
Akira, S.3
-
120
-
-
33744539798
-
Toll-like receptors and RNA helicases: Two parallel ways to trigger antiviral responses
-
Meylan E, Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 2006;22(5):561-9
-
(2006)
Mol Cell
, vol.22
, Issue.5
, pp. 561-569
-
-
Meylan, E.1
Tschopp, J.2
-
121
-
-
40649097299
-
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
-
Trumpfheller C, Caskey M, Nchinda G, et al. The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci USA 2008;105(7):2574-9
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.7
, pp. 2574-2579
-
-
Trumpfheller, C.1
Caskey, M.2
Nchinda, G.3
-
122
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz CA, Holko M, de Veer MJ, et al. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003;5(9):834-9
-
(2003)
Nat Cell Biol
, vol.5
, Issue.9
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
-
123
-
-
33646561864
-
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
-
Marques JT, Devosse T, Wang D, et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol 2006;24(5):559-65
-
(2006)
Nat Biotechnol
, vol.24
, Issue.5
, pp. 559-565
-
-
Marques, J.T.1
Devosse, T.2
Wang, D.3
|