In vivo fate of phosphorothioate antisense oligodeoxynucleotides: Predominant uptake by scavenger receptors on endothelial liver cells

Nucleic Acids Research

Volumn 25, Issue 16, 1997, Pages 3290-3296

  Bijsterbosch, Martin K ^a   Manoharan, Muthiah ^b   Rump, Erik T ^a   De Vrueh, Remco L A ^a   Van Veghel, Richard ^a   Tivel, Kathleen L ^b   Biessen, Erik A L ^a   Bennett, C Frank ^b   Dan Cook, P ^b   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; INTERCELLULAR ADHESION MOLECULE 1; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; POLYADENYLIC ACID; POLYINOSINIC ACID; RECEPTOR; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL FRACTIONATION; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; HALF LIFE TIME; INTERNALIZATION; ISOTOPE LABELING; KUPFFER CELL; LIVER; LIVER CELL; LIVER PARENCHYMA; LYSOSOME; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SPLEEN;

ANIMALS; ENDOTHELIUM; INTERCELLULAR ADHESION MOLECULE-1; LIVER; MALE; MEMBRANE PROTEINS; METABOLIC CLEARANCE RATE; MICE; OLIGONUCLEOTIDES, ANTISENSE; POLYMERS; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; SUBCELLULAR FRACTIONS; THIONUCLEOTIDES; TISSUE DISTRIBUTION;

ANIMALIA; MURINAE; TRITIUM;

EID: 0030751852     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/25.16.3290     Document Type: Article

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