Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver

Gene Therapy

Volumn 8, Issue 11, 2001, Pages 874-881

  Robaczewska, M ^a,b   Guerret, S ^c   Remy, J S ^d   Chemin, I ^a   Offensperger, W B ^e   Chevallier, M ^f   Behr, J P ^d   Podhajska, A J ^b   Blum, H E ^e   Trepo, C ^a   Cova, L ^a  

^a INSERM   (France)

^b UNIVERSITY OF GDA SK   (Poland)

^c UNIVERSITÉ LYON 1   (France)

^d Faculty of Pharmacy   (France)

^e UNIVERSITY OF FREIBURG   (Germany)

^f Labaratoire Marcel Merieux   (France)

Author keywords

Antisense oligonucleotides; Antiviral therapy; Cell uptake; Hepatitis B virus; Polyethylenimine

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTISENSE PHOSPHODIESTER OLIGODEOXYNUCLEOTIDE; ANTIVIRUS AGENT; PHOSPHOROTHIOIC ACID DERIVATIVE; POLYETHYLENEIMINE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOMETRY; CYTOTOXICITY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DUCK; GENE TRANSFER; GROWTH INHIBITION; HEPADNAVIRUS; HEPATITIS B; HEPATITIS B VIRUS; IN VIVO STUDY; INJECTION; LIVER; LIVER LEVEL; NONHUMAN; PREVENTION; PRIORITY JOURNAL; START CODON; VIRUS REPLICATION;

ANIMALS; GENE THERAPY; HEPADNAVIRIDAE INFECTIONS; HEPATITIS B VIRUS, DUCK; IMMUNOBLOTTING; KIDNEY; LIVER; LUNG; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, ANIMAL; OLIGONUCLEOTIDES, ANTISENSE; POLYETHYLENEIMINE; SPLEEN; VIRUS REPLICATION;

EID: 0034968241     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301464     Document Type: Article

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