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Volumn 3, Issue 3, 2003, Pages 449-458

Non-viral gene transfer therapy for cystic fibrosis

Author keywords

Cystic fibrosis; DNA complexes; Gene transfer

Indexed keywords

DNA; LIPID; MACROGOL; NAKED DNA; PLASMID DNA; POLYCATION; POLYETHYLENEIMINE; POLYLYSINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 0038201998     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.3.449     Document Type: Review
Times cited : (29)

References (100)
  • 1
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: Cloning and characterization complimentary DNA
    • RIODAN JR, ROMMENS JM, KEREM B-S et al.: Identification of the cystic fibrosis gene: cloning and characterization complimentary DNA. Science (1989) 245:1066-1073.
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riodan, J.R.1    Rommens, J.M.2    Kerem, B.-S.3
  • 2
    • 0024988334 scopus 로고
    • Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • ROSENBERG SA, ABERSOLD P, CORNETTA K et al.: Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. (1990) 323:570-578.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 570-578
    • Rosenberg, S.A.1    Abersold, P.2    Cornetta, K.3
  • 3
    • 0033579358 scopus 로고    scopus 로고
    • Gene therapy death prompts review of adenovirus vector
    • MARSHALL E: Gene therapy death prompts review of adenovirus vector. Science (1999) 286(5448):2244-2245.
    • (1999) Science , vol.286 , Issue.5448 , pp. 2244-2245
    • Marshall, E.1
  • 4
    • 0026043883 scopus 로고
    • Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis
    • TRAPNELL BC, CHU CS, PAAKKO PK et al.: Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. USA (1991) 88(15):6565-6569.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , Issue.15 , pp. 6565-6569
    • Trapnell, B.C.1    Chu, C.S.2    Paakko, P.K.3
  • 5
    • 0034705105 scopus 로고    scopus 로고
    • A phage integrase directs efficient site-specific integration in human cells
    • GROTH AC, OLIVARES EC, THYAGARAJAN B, CALOS MP: A phage integrase directs efficient site-specific integration in human cells. Proc. Natl. Acad. Sci. USA (2000) 97(11):5995-6000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.11 , pp. 5995-6000
    • Groth, A.C.1    Olivares, E.C.2    Thyagarajan, B.3    Calos, M.P.4
  • 6
    • 0037122695 scopus 로고    scopus 로고
    • Development of nonviral vectors for systemic gene delivery
    • LIU F, HUANG L: Development of nonviral vectors for systemic gene delivery. J. Control Release. (2002) 78(1-3):259-266.
    • (2002) J. Control Release , vol.78 , Issue.1-3 , pp. 259-266
    • Liu, F.1    Huang, L.2
  • 7
    • 0035988755 scopus 로고    scopus 로고
    • Receptor-directed molecular conjugates for gene transfer
    • Morgan J (Ed.), Humana Press, Inc. Totowa, NJ, USA
    • ZIADY AG, DAVIS PB: Receptor-directed molecular conjugates for gene transfer. In: Methods In Molecular Medicine: Gene Therapy Protocols, vol. 69. Morgan J (Ed.), Humana Press, Inc. Totowa, NJ, USA (2001):25-48.
    • (2001) Methods In Molecular Medicine: Gene Therapy Protocols , vol.69 , pp. 25-48
    • Ziady, A.G.1    Davis, P.B.2
  • 8
    • 0032966457 scopus 로고    scopus 로고
    • Technology evaluation: Cystic fibrosis therapy, Genzyme
    • COCKETT MI: Technology evaluation: cystic fibrosis therapy, Genzyme. Curr. Opin. Mol. Ther. (1999) 1(2):279-283.
    • (1999) Curr. Opin. Mol. Ther. , vol.1 , Issue.2 , pp. 279-283
    • Cockett, M.I.1
  • 9
    • 0012417087 scopus 로고    scopus 로고
    • Molecular conjugates
    • Curiel DT, Douglas JT (Eds), John Wiley and Sons, Inc., Indianapolis, IN, USA
    • ZIADY AG, DAVIS PB: Molecular conjugates. In: Vector Targeting for Therapeutic Gene Delivery. Curiel DT, Douglas JT (Eds), John Wiley and Sons, Inc., Indianapolis, IN, USA (2002):63-86.
    • (2002) Vector Targeting for Therapeutic Gene Delivery , pp. 63-86
    • Ziady, A.G.1    Davis, P.B.2
  • 10
    • 0028199067 scopus 로고
    • The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems
    • PLANK C, OBERHAUSER B, MECHTLER K, KOCH C, WAGNER E: The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. (1994) 269:12918-12924.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12918-12924
    • Plank, C.1    Oberhauser, B.2    Mechtler, K.3    Koch, C.4    Wagner, E.5
  • 11
    • 0021269089 scopus 로고
    • Sequence requirements for nuclear location of simian virus 40 large-T antigen
    • KALDERON D, RICHARDSON WD, MARKHAM AF, SMITH AE: Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature (1984) 311:33-38.
    • (1984) Nature , vol.311 , pp. 33-38
    • Kalderon, D.1    Richardson, W.D.2    Markham, A.F.3    Smith, A.E.4
  • 12
    • 13144275215 scopus 로고    scopus 로고
    • Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways
    • CHOW YH, O'BRODOVICH H, PLUMB J et al.: Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways. Proc. Natl. Acad. Sci. USA (1997) 94(26):14695-14700.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.26 , pp. 14695-14700
    • Chow, Y.H.1    O'Brodovich, H.2    Plumb, J.3
  • 13
    • 0036846329 scopus 로고    scopus 로고
    • Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis
    • RAMALHO AS, BECK S, MEYER M, PENQUE D, CUTTING GR, AMARAL MD: Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. (2002) 27(5):619-627.
    • (2002) Am. J. Respir. Cell Mol. Biol. , vol.27 , Issue.5 , pp. 619-627
    • Ramalho, A.S.1    Beck, S.2    Meyer, M.3    Penque, D.4    Cutting, G.R.5    Amaral, M.D.6
  • 14
    • 0031889465 scopus 로고    scopus 로고
    • Cellular heterogeneity of CFTR expression and function in the lung: Implications for gene therapy of cystic fibrosis
    • JIANG Q, ENGELHARDT JF: Cellular heterogeneity of CFTR expression and function in the lung: implications for gene therapy of cystic fibrosis. Eur. J. Hum. Genet. (1998)6(1):12-31.
    • (1998) Eur. J. Hum. Genet. , vol.6 , Issue.1 , pp. 12-31
    • Jiang, Q.1    Engelhardt, J.F.2
  • 15
    • 0026951303 scopus 로고
    • Submucosal glands are the predominant site of CFTR expression in the human bronchus
    • ENGELHARDT JF, YANKASKAS JR, ERNST SA et al.: Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. (1992) 2(3):240-248.
    • (1992) Nat. Genet. , vol.2 , Issue.3 , pp. 240-248
    • Engelhardt, J.F.1    Yankaskas, J.R.2    Ernst, S.A.3
  • 16
    • 0026918861 scopus 로고
    • Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis
    • JOHNSON LG, OLSEN JC, SARKADI B, MOORE KL, SWANSTROM R, BOUCHER RC: Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat. Genet. (1992)2(1):21-25.
    • (1992) Nat. Genet. , vol.2 , Issue.1 , pp. 21-25
    • Johnson, L.G.1    Olsen, J.C.2    Sarkadi, B.3    Moore, K.L.4    Swanstrom, R.5    Boucher, R.C.6
  • 17
    • 0032549553 scopus 로고    scopus 로고
    • Vector-specific complementation profiles of two independent primary defects in cystic fibrosis airways
    • ZHANG Y, JIANG Q, DUDUS L, YANKASKAS JR, ENGELHARDT JF: Vector-specific complementation profiles of two independent primary defects in cystic fibrosis airways. Hum. Gene Ther. (1998) 9(5):635-648.
    • (1998) Hum. Gene Ther. , vol.9 , Issue.5 , pp. 635-648
    • Zhang, Y.1    Jiang, Q.2    Dudus, L.3    Yankaskas, J.R.4    Engelhardt, J.F.5
  • 18
    • 0028912888 scopus 로고
    • Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells
    • JOHNSON LG, BOYLES SE, WILSON J, BOUCHER RC: Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. J. Clin. Invest. (1995) 95(3):1377-1382.
    • (1995) J. Clin. Invest. , vol.95 , Issue.3 , pp. 1377-1382
    • Johnson, L.G.1    Boyles, S.E.2    Wilson, J.3    Boucher, R.C.4
  • 19
    • 0029098922 scopus 로고
    • Sequences within the coding regions of dotting Factor VIII and CFTR block transcriptional elongation
    • KOEBERL DD, HALBERT CL, KRUMM A, MILLER AD: Sequences within the coding regions of dotting Factor VIII and CFTR block transcriptional elongation. Hum. Gene Ther. (1995) 6(4):469-479.
    • (1995) Hum. Gene Ther. , vol.6 , Issue.4 , pp. 469-479
    • Koeberl, D.D.1    Halbert, C.L.2    Krumm, A.3    Miller, A.D.4
  • 20
    • 0028991826 scopus 로고
    • In vivo nasal potential difference: Techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis
    • KNOWLES MR, PARADISO AM, BOUCHER RC: In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis. Hum. Gene Ther. (1995) 6(4):445-455.
    • (1995) Hum. Gene Ther. , vol.6 , Issue.4 , pp. 445-455
    • Knowles, M.R.1    Paradiso, A.M.2    Boucher, R.C.3
  • 21
    • 0033721158 scopus 로고    scopus 로고
    • Airway gene transfer in mouse nasal-airways: Importance of identification of epithelial type for assessment of gene transfer
    • PARSONS DW, HOPKINS PJ, BOURNE AJ, BOUCHER RC, MARTIN AJ: Airway gene transfer in mouse nasal-airways: importance of identification of epithelial type for assessment of gene transfer. Gene Ther. (2000) 7(21):1810-1815.
    • (2000) Gene Ther. , vol.7 , Issue.21 , pp. 1810-1815
    • Parsons, D.W.1    Hopkins, P.J.2    Bourne, A.J.3    Boucher, R.C.4    Martin, A.J.5
  • 22
    • 0029745771 scopus 로고    scopus 로고
    • A method for the rapid detection of recombinant CFTR during gene therapy in cystic fibrosis
    • DEMOLOMBE S, BARO I, BEBOK Z et al.: A method for the rapid detection of recombinant CFTR during gene therapy in cystic fibrosis. Gene Ther. (1996) 3(8):685-694.
    • (1996) Gene Ther. , vol.3 , Issue.8 , pp. 685-694
    • Demolombe, S.1    Baro, I.2    Bebok, Z.3
  • 23
    • 0036222250 scopus 로고    scopus 로고
    • Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor
    • ZIADY AG, KELLEY TJ, MILLIKEN E, FERKOL T, DAVIS PB: Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor. Mol. Ther. (2002) 5(4):413-419.
    • (2002) Mol. Ther. , vol.5 , Issue.4 , pp. 413-419
    • Ziady, A.G.1    Kelley, T.J.2    Milliken, E.3    Ferkol, T.4    Davis, P.B.5
  • 24
    • 0031156473 scopus 로고    scopus 로고
    • CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium
    • DAVIES JC, STERN M, DEWAR A et al.: CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium. Am. J. Respir. Cell Mol. Biol. (1997) 16(6):657-663.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.16 , Issue.6 , pp. 657-663
    • Davies, J.C.1    Stern, M.2    Dewar, A.3
  • 25
    • 0036377851 scopus 로고    scopus 로고
    • A Phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies
    • WAGNER JA, NEPOMUCENO IB, MESSNER AH et al.: A Phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum. Gene Ther. (2002) 13(11):1349-1359.
    • (2002) Hum. Gene Ther. , vol.13 , Issue.11 , pp. 1349-1359
    • Wagner, J.A.1    Nepomuceno, I.B.2    Messner, A.H.3
  • 26
    • 0037189522 scopus 로고    scopus 로고
    • Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5
    • WALTERS RW, PILEWSKI JM, CHIORINI JA, ZABNER J: Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. J. Biol. Chem. (2002) 277(26):23709-23713.
    • (2002) J. Biol. Chem. , vol.277 , Issue.26 , pp. 23709-23713
    • Walters, R.W.1    Pilewski, J.M.2    Chiorini, J.A.3    Zabner, J.4
  • 27
    • 0034820864 scopus 로고    scopus 로고
    • Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium
    • FERRARI S, KITSON C, FARLEY R et al.: Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium. Gene Ther. (2001) 8(18):1380-1386.
    • (2001) Gene Ther. , vol.8 , Issue.18 , pp. 1380-1386
    • Ferrari, S.1    Kitson, C.2    Farley, R.3
  • 28
    • 0346250724 scopus 로고    scopus 로고
    • Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant
    • ERNST N, ULRICHSKOTTER S, SCHMALIX WA et al.: Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant. J. Gene Med. (1999) 1(5):331-340.
    • (1999) J. Gene Med. , vol.1 , Issue.5 , pp. 331-340
    • Ernst, N.1    Ulrichskotter, S.2    Schmalix, W.A.3
  • 30
    • 0033586375 scopus 로고    scopus 로고
    • Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: A double-blind placebo-controlled trial
    • ALTON EW, STERN M, FARLEY R et al.: Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. Lancet (1999) 353:947-954.
    • (1999) Lancet , vol.353 , pp. 947-954
    • Alton, E.W.1    Stern, M.2    Farley, R.3
  • 31
    • 17344365059 scopus 로고    scopus 로고
    • A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis
    • KNOWLES MR, NOONE PG, HOHNEKER K et al.: A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis. Hum. Gene Ther. (1998) 9(2):249-269.
    • (1998) Hum. Gene Ther. , vol.9 , Issue.2 , pp. 249-269
    • Knowles, M.R.1    Noone, P.G.2    Hohneker, K.3
  • 32
    • 0034221077 scopus 로고    scopus 로고
    • Measure and interpretation of CF gene therapy trial results
    • ALTON E, GEDDES D, GILL D et al.: Measure and interpretation of CF gene therapy trial results. Mol. Ther. (2000) 2(1):34.
    • (2000) Mol. Ther. , vol.2 , Issue.1 , pp. 34
    • Alton, E.1    Geddes, D.2    Gill, D.3
  • 33
    • 0030759153 scopus 로고    scopus 로고
    • Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo
    • ZABNER J, CHENG SH, MEEKER D et al.: Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo. J. Clin. Invest. (1997) 100(6):1529-1537.
    • (1997) J. Clin. Invest. , vol.100 , Issue.6 , pp. 1529-1537
    • Zabner, J.1    Cheng, S.H.2    Meeker, D.3
  • 34
    • 19244363903 scopus 로고    scopus 로고
    • Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
    • LEE ER, MARSHALL J, SIEGEL CS et al.: Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum. Gene Ther. (1996) 7(14):1701-1717.
    • (1996) Hum. Gene Ther. , vol.7 , Issue.14 , pp. 1701-1717
    • Lee, E.R.1    Marshall, J.2    Siegel, C.S.3
  • 35
    • 19144363128 scopus 로고    scopus 로고
    • Intraluminal water increases expression of plasmid DNA in rat lung
    • SAWA T, MIYAZAKI H, PITTET JF et al.: Intraluminal water increases expression of plasmid DNA in rat lung. Hum. Gene Ther. (1996) 7:933-941.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 933-941
    • Sawa, T.1    Miyazaki, H.2    Pittet, J.F.3
  • 36
    • 0036579881 scopus 로고    scopus 로고
    • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor
    • GLASSPOOL-MALONE J, STEENLAND PR, MCDONALD RJ et al.: DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. J. Gene Med. (2002) 4:323-332.
    • (2002) J. Gene Med. , vol.4 , pp. 323-332
    • Glasspool-Malone, J.1    Steenland, P.R.2    Mcdonald, R.J.3
  • 37
    • 0029815814 scopus 로고    scopus 로고
    • Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation
    • CROOK K, MCLACHLAN G, STEVENSON BJ, PORTEOUS DJ: Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation. Gene Ther. (1996) 3:834-839.
    • (1996) Gene Ther. , vol.3 , pp. 834-839
    • Crook, K.1    Mclachlan, G.2    Stevenson, B.J.3    Porteous, D.J.4
  • 38
    • 0028245537 scopus 로고
    • Cationic liposomes for direct gene transfer in therapy of cancer and other diseases
    • FARHOOD H, GAO X, SON K et al.: Cationic liposomes for direct gene transfer in therapy of cancer and other diseases. Ann. NY Acad. Sci. (1994) 716:23-35.
    • (1994) Ann. NY Acad. Sci. , vol.716 , pp. 23-35
    • Farhood, H.1    Gao, X.2    Son, K.3
  • 39
    • 0032551589 scopus 로고    scopus 로고
    • Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo
    • JIANG C, O'CONNOR SP, FANG SL et al.: Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo. Hum. Gene Ther. (1998) 9(11):1531-1542.
    • (1998) Hum. Gene Ther. , vol.9 , Issue.11 , pp. 1531-1542
    • Jiang, C.1    O'Connor, S.P.2    Fang, S.L.3
  • 40
    • 0033924663 scopus 로고    scopus 로고
    • Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis
    • HYDE SC, SOUTHERN KW, GILEADI U et al.: Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis. Gene Ther. (2000) 7:1156-1165.
    • (2000) Gene Ther. , vol.7 , pp. 1156-1165
    • Hyde, S.C.1    Southern, K.W.2    Gileadi, U.3
  • 41
    • 0037103750 scopus 로고    scopus 로고
    • Interference of poly(ethylene glycol)-lipid analogues with cationic-lipid-mediated delivery of oligonucleotides; role of lipid exchangeability and non-lamellar transitions
    • SHI F, WASUNGU L, NOMDEN A et al.: Interference of poly(ethylene glycol)-lipid analogues with cationic-lipid-mediated delivery of oligonucleotides; role of lipid exchangeability and non-lamellar transitions. Biochem. J. (2002) 366(Pt 1):333-341.
    • (2002) Biochem. J. , vol.366 , Issue.PART 1 , pp. 333-341
    • Shi, F.1    Wasungu, L.2    Nomden, A.3
  • 42
    • 0036230134 scopus 로고    scopus 로고
    • Role of intracellular cationic liposome-DNA complex dissociation in transfection mediated by cationic lipids
    • CORNELIS S, VANDENBRANDEN M, RUYSSCHAERT JM, ELOUAHABI A: Role of intracellular cationic liposome-DNA complex dissociation in transfection mediated by cationic lipids. DNA Cell Biol. (2002) 21:91-97.
    • (2002) DNA Cell Biol. , vol.21 , pp. 91-97
    • Cornelis, S.1    Vandenbranden, M.2    Ruysschaert, J.M.3    Elouahabi, A.4
  • 44
    • 0032571392 scopus 로고    scopus 로고
    • Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells
    • POLLARD H, REMY JS, LOUSSOUARN G, DEMOLOMBE S, BEHR JP, ESCANDE D: Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J. Biol. Chem. (1998) 273:7507-7511.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7507-7511
    • Pollard, H.1    Remy, J.S.2    Loussouarn, G.3    Demolombe, S.4    Behr, J.P.5    Escande, D.6
  • 45
    • 0030866645 scopus 로고    scopus 로고
    • In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
    • LI S, HUANG L: In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther. (1997) 4(9):891-900.
    • (1997) Gene Ther. , vol.4 , Issue.9 , pp. 891-900
    • Li, S.1    Huang, L.2
  • 46
    • 0033585425 scopus 로고    scopus 로고
    • Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes
    • YEW NS, WANG KX, PRZYBYLSKA M et al.: Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes. Hum. Gene Ther. (1999) 10:223-234.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 223-234
    • Yew, N.S.1    Wang, K.X.2    Przybylska, M.3
  • 47
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • KRIEG AM: CpG motifs in bacterial DNA and their immune effects. Ann. Rev. Immunol. (2002) 20:709-760.
    • (2002) Ann. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 48
    • 0034149827 scopus 로고    scopus 로고
    • Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs
    • YEW NS, ZHAO H, WU IH et al.: Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs. Mol. Ther. (2000) 1(3):255-262.
    • (2000) Mol. Ther. , vol.1 , Issue.3 , pp. 255-262
    • Yew, N.S.1    Zhao, H.2    Wu, I.H.3
  • 49
    • 0035989006 scopus 로고    scopus 로고
    • CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo
    • YEW NS, ZHAO H, PRZYBYLSKA M et al.: CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol. Ther. (2002) 5:731-738.
    • (2002) Mol. Ther. , vol.5 , pp. 731-738
    • Yew, N.S.1    Zhao, H.2    Przybylska, M.3
  • 50
    • 0034915570 scopus 로고    scopus 로고
    • A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis
    • RUIZ FE, CLANCY JP, PERRICONE MA et al.: A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis. Hum. Gene Ther. (2001) 12(7):751-761.
    • (2001) Hum. Gene Ther. , vol.12 , Issue.7 , pp. 751-761
    • Ruiz, F.E.1    Clancy, J.P.2    Perricone, M.A.3
  • 51
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethytenimine
    • BOUSSIF O, LEZOUALC'H F, ZANTA MA et al.: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethytenimine. Proc. Natl. Acad. Sci. USA (1995) 92:7297-7301.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7297-7301
    • Boussif, O.1    Lezoualc'h, F.2    Zanta, M.A.3
  • 52
    • 0032811354 scopus 로고    scopus 로고
    • Poly(ethylenimine) and its role in gene delivery
    • GODBEY WT, WU KK, MIKOS AG: Poly(ethylenimine) and its role in gene delivery. J. Control Release. (1999) 60:149-160.
    • (1999) J. Control Release , vol.60 , pp. 149-160
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 53
    • 0028618172 scopus 로고
    • Enhanced resistance to nudease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers
    • CHIOU HC, TANGCO MV, LEVINE SM et al.: Enhanced resistance to nudease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers. Nucleic Acids Res. (1994) 22:5439-5446.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5439-5446
    • Chiou, H.C.1    Tangco, M.V.2    Levine, S.M.3
  • 54
    • 0033582456 scopus 로고    scopus 로고
    • Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo
    • ZIADY AG, FERKOL T, DAWSON DV, PERLMUTTER DH, DAVIS PB: Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo. J. Biol. Chem. (1999) 274(8):4908-4916.
    • (1999) J. Biol. Chem. , vol.274 , Issue.8 , pp. 4908-4916
    • Ziady, A.G.1    Ferkol, T.2    Dawson, D.V.3    Perlmutter, D.H.4    Davis, P.B.5
  • 55
    • 0002988379 scopus 로고    scopus 로고
    • Nanoparticles of compacted DNA transfect post-mitotic cells
    • LIU G, LI D, PASUMARTHY M et al.: Nanoparticles of compacted DNA transfect post-mitotic cells. Mol. Ther. (2001) 3(Suppl.):S14.
    • (2001) Mol. Ther. , vol.3 , Issue.SUPPL.
    • Liu, G.1    Li, D.2    Pasumarthy, M.3
  • 56
    • 0010588660 scopus 로고
    • Antigenicity of polypeptides (poly-alpha amino acids)
    • MAURER PH: Antigenicity of polypeptides (poly-alpha amino acids). J. Immunol. (1962) 88:330-345.
    • (1962) J. Immunol. , vol.88 , pp. 330-345
    • Maurer, P.H.1
  • 57
    • 0002010107 scopus 로고
    • Studies on artificial antigens: Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in Guinea pigs
    • KANTOR FS, OJEDA A, BENACERRAF B: Studies on artificial antigens: antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in Guinea pigs. Hum. Exp. Med. (1962) 117:55-69.
    • (1962) Hum. Exp. Med. , vol.117 , pp. 55-69
    • Kantor, F.S.1    Ojeda, A.2    Benacerraf, B.3
  • 58
    • 0023212742 scopus 로고
    • Receptor-mediated in vitro gene transformation by a soluble DNA carrier system
    • WU GY, WU CH: Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. (1987) 262:4429-4432.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4429-4432
    • Wu, G.Y.1    Wu, C.H.2
  • 59
    • 0027076361 scopus 로고
    • Transferrinfection: A highly efficient way to express gene constructs in eukaryotic cells
    • ZATOUKAL K, WAGNER E, COTTEN M et al.: Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells. Ann. NY Acad Sci. (1992) 660:136-153.
    • (1992) Ann. NY Acad Sci. , vol.660 , pp. 136-153
    • Zatoukal, K.1    Wagner, E.2    Cotten, M.3
  • 60
    • 0027365343 scopus 로고
    • Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor
    • FERKOL T, KAETZEL CS, DAVIS PB: Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor. J. Clin. Invest (1993) 92:2394-2400.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2394-2400
    • Ferkol, T.1    Kaetzel, C.S.2    Davis, P.B.3
  • 61
    • 0027217646 scopus 로고
    • Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells
    • MIDOUX P, MENDES C, LEGRAND A et al.: Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Res. (1993) 21:871-878.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 871-878
    • Midoux, P.1    Mendes, C.2    Legrand, A.3
  • 62
    • 0028414109 scopus 로고
    • Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes
    • MONSIGNY M, ROCHE AC, MIDOUX P, MAYER R: Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes. Adv. Drug. Delivery Rev. (1994) 14:1-24.
    • (1994) Adv. Drug. Delivery Rev. , vol.14 , pp. 1-24
    • Monsigny, M.1    Roche, A.C.2    Midoux, P.3    Mayer, R.4
  • 63
    • 0028168773 scopus 로고
    • Galactosylated histone-mediated gene transfer and expression
    • CHEN J, STICKLES RJ, DAISCENDT KA: Galactosylated histone-mediated gene transfer and expression. Hum. Gene Ther. (1994) 5:429-435.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 429-435
    • Chen, J.1    Stickles, R.J.2    Daiscendt, K.A.3
  • 64
    • 0028079888 scopus 로고
    • An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes
    • PERALES JC, FERKOL T, MOLAS M, HANSON RW: An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur. J. Biochem. (1994) 226:255-266.
    • (1994) Eur. J. Biochem. , vol.226 , pp. 255-266
    • Perales, J.C.1    Ferkol, T.2    Molas, M.3    Hanson, R.W.4
  • 65
    • 0030003605 scopus 로고    scopus 로고
    • Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte derived macrophages
    • ERBACHER P, BOUSSER MT, RAIMOND J, MONSIGNY M, MIDOUX P, ROCHE AC: Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte derived macrophages. Hum. Gene Ther. (1996) 7:721-729.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 721-729
    • Erbacher, P.1    Bousser, M.T.2    Raimond, J.3    Monsigny, M.4    Midoux, P.5    Roche, A.C.6
  • 66
    • 0030858180 scopus 로고    scopus 로고
    • Gene transfer into hepatocyte cell lines via the serpin enzyme complex (SEC) receptor
    • ZIADY AG, PERALES JC, FERKOL T et al.: Gene transfer into hepatocyte cell lines via the serpin enzyme complex (SEC) receptor. Am. J. Physiol. (1997) 273:G545-G552.
    • (1997) Am. J. Physiol. , vol.273
    • Ziady, A.G.1    Perales, J.C.2    Ferkol, T.3
  • 67
    • 0032416587 scopus 로고    scopus 로고
    • Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells
    • ZIADY AG, FERKOL T, GERKEN T, DAWSON DV, PERLMUTTER DH, DAVIS PB: Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells. Gene Ther. (1998) 5(12):1685-1697.
    • (1998) Gene Ther. , vol.5 , Issue.12 , pp. 1685-1697
    • Ziady, A.G.1    Ferkol, T.2    Gerken, T.3    Dawson, D.V.4    Perlmutter, D.H.5    Davis, P.B.6
  • 68
    • 0033540649 scopus 로고    scopus 로고
    • Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells
    • FAJAC I, BRIAND P, MONSIGNY M, MIDOUX P: Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells. Hum. Gene Ther. (1999) 10(3):395-406.
    • (1999) Hum. Gene Ther. , vol.10 , Issue.3 , pp. 395-406
    • Fajac, I.1    Briand, P.2    Monsigny, M.3    Midoux, P.4
  • 69
    • 0035470184 scopus 로고    scopus 로고
    • Gene therapy of cystic fibrosis (CF) airways: A review emphasizing targeting with lactose
    • KLINK DT, GLICK MC, SCANLIN TF: Gene therapy of cystic fibrosis (CF) airways: a review emphasizing targeting with lactose. Glycocenj. J. (2001) 18(9):731-740.
    • (2001) Glycocenj. J. , vol.18 , Issue.9 , pp. 731-740
    • Klink, D.T.1    Glick, M.C.2    Scanlin, T.F.3
  • 70
    • 0034952813 scopus 로고    scopus 로고
    • Nuclear translocation of lactosylated poly-L-lysine/cDNA complex in cystic fibrosis airway epithelial cells
    • KLINK DT, CHAO S, GLICK MC, SCANLIN TF: Nuclear translocation of lactosylated poly-L-lysine/cDNA complex in cystic fibrosis airway epithelial cells. Mol. Ther. (2001) 3(6):831-841.
    • (2001) Mol. Ther. , vol.3 , Issue.6 , pp. 831-841
    • Klink, D.T.1    Chao, S.2    Glick, M.C.3    Scanlin, T.F.4
  • 71
    • 0023811723 scopus 로고
    • Receptor-mediated gene delivery and expression in vivo
    • WU GY, WU CH: Receptor-mediated gene delivery and expression in vivo. J. Biol. Chem. (1988) 263:14621-14624.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14621-14624
    • Wu, G.Y.1    Wu, C.H.2
  • 72
    • 0026502766 scopus 로고
    • Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in lipoprotein receptor-deficient rabbits
    • WILSON JM, GROSSMAN M, WU CH, CHOWDHURY NR, WU GY, CHOWDHURY JR: Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in lipoprotein receptor-deficient rabbits. J. Biol. Chem. (1992) 267:963-967.
    • (1992) J. Biol. Chem. , vol.267 , pp. 963-967
    • Wilson, J.M.1    Grossman, M.2    Wu, C.H.3    Chowdhury, N.R.4    Wu, G.Y.5    Chowdhury, J.R.6
  • 74
    • 0027215910 scopus 로고
    • Chicken adenovirus (CELO) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants
    • COTTEN M, WAGNER E, ZATLOUKAL K, BIRNSTIEL ML: Chicken adenovirus (CELO) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants. J. Virol. (1993) 67:3777-3785.
    • (1993) J. Virol. , vol.67 , pp. 3777-3785
    • Cotten, M.1    Wagner, E.2    Zatloukal, K.3    Birnstiel, M.L.4
  • 75
    • 0027447460 scopus 로고
    • Hepatic gene therapy: Adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes
    • CHRISTIANO RJ, SMITH LC, WOO SL: Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. Proc. Natl. Acad. Sci. USA (1993) 90:2122-2126.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2122-2126
    • Christiano, R.J.1    Smith, L.C.2    Woo, S.L.3
  • 77
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression and regulation of genes introduced into the livers by receptor targeted uptake
    • PERALES JC, FERKOL T, BEEGEN H, RATNOFF OD, HANSON RW: Gene transfer in vivo: sustained expression and regulation of genes introduced into the livers by receptor targeted uptake. Proc. Natl. Acad. Sci. USA (1994) 91:4086-4090.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 78
    • 0037057855 scopus 로고    scopus 로고
    • Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
    • RUDOLPH C, SCHILLINGER U, PLANK C et al.: Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine. Biochim. Biophys. Acta. (2002) 1573(1):75-83.
    • (2002) Biochim. Biophys. Acta , vol.1573 , Issue.1 , pp. 75-83
    • Rudolph, C.1    Schillinger, U.2    Plank, C.3
  • 79
    • 0033582456 scopus 로고    scopus 로고
    • Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo
    • ZIADY AG, FERKOL T, DAWSON DV, PERLMUTTER DH, DAVIS PB: Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo. J. Biol. Chem. (1999) 274(8):4908-4916.
    • (1999) J. Biol. Chem. , vol.274 , Issue.8 , pp. 4908-4916
    • Ziady, A.G.1    Ferkol, T.2    Dawson, D.V.3    Perlmutter, D.H.4    Davis, P.B.5
  • 81
    • 0032531160 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells
    • KELLEY TJ, DRUMM ML: Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells. J. Clin. Invest. (1998) 102:1200-1207.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1200-1207
    • Kelley, T.J.1    Drumm, M.L.2
  • 82
    • 0031023264 scopus 로고    scopus 로고
    • Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery
    • HONG K, ZHENG W, BAKER A, PAPAHADJOPOULOS D: Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery. FEBS Lett. (1997) 400:233-237.
    • (1997) FEBS Lett. , vol.400 , pp. 233-237
    • Hong, K.1    Zheng, W.2    Baker, A.3    Papahadjopoulos, D.4
  • 83
    • 0032938324 scopus 로고    scopus 로고
    • PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
    • OGRIS M, BRUNNER S, SCHULLER S, KIRCHEIS R. WAGNER E: PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. (1999) 6:595-605.
    • (1999) Gene Ther. , vol.6 , pp. 595-605
    • Ogris, M.1    Brunner, S.2    Schuller, S.3    Kircheis, R.4    Wagner, E.5
  • 84
    • 0026352832 scopus 로고
    • Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
    • PAPAHADJOPOULOS D, ALLEN TM, GABIZON A et al.: Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA (1991) 88:11460-11464.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 11460-11464
    • Papahadjopoulos, D.1    Allen, T.M.2    Gabizon, A.3
  • 85
    • 0003013339 scopus 로고    scopus 로고
    • High-level expression of compacted DNA complexes following intratracheal administration
    • GEDEON C, ZIADY AG, MILLER TJ et al.: High-level expression of compacted DNA complexes following intratracheal administration. Mol. Ther. (2000) 1(Suppl.):S78.
    • (2000) Mol. Ther. , vol.1 , Issue.SUPPL.
    • Gedeon, C.1    Ziady, A.G.2    Miller, T.J.3
  • 86
    • 4244128576 scopus 로고    scopus 로고
    • Stabilized PLASmin complexes deliver exogenous genes to the nasal epithelia of cystic fibrosis (CF) knockout mice and confer partial physiological correction of CFTR-mediated chloride transport
    • ZIADY AG, GEDEON C, PAYNE JM et al.: Stabilized PLASmin complexes deliver exogenous genes to the nasal epithelia of cystic fibrosis (CF) knockout mice and confer partial physiological correction of CFTR-mediated chloride transport. Mol. Ther. (2002) 5(Suppl.):S463.
    • (2002) Mol. Ther. , vol.5 , Issue.SUPPL.
    • Ziady, A.G.1    Gedeon, C.2    Payne, J.M.3
  • 87
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • PLANK C, MECHTLER K, SZOKA F, WAGNER E: Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther. (1996) 7(12):1437-1446.
    • (1996) Hum. Gene Ther. , vol.7 , Issue.12 , pp. 1437-1446
    • Plank, C.1    Mechtler, K.2    Szoka, F.3    Wagner, E.4
  • 88
    • 0033585470 scopus 로고    scopus 로고
    • Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes
    • PLANK C, TANG MX, WOLFE AR, SZOKA FC JR: Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum. Gene Ther. (1999) 10(2):319-332.
    • (1999) Hum. Gene Ther. , vol.10 , Issue.2 , pp. 319-332
    • Plank, C.1    Tang, M.X.2    Wolfe, A.R.3    Szoka F.C., Jr.4
  • 89
    • 4243628889 scopus 로고    scopus 로고
    • Lack of typical inflammatory responses to CpG sequences following intrapulmonary administration of plasmid DNA compacted with PEG-substituted polylysine
    • ZIADY AG, GEDEON C, PAYNE JM et al.: Lack of typical inflammatory responses to CpG sequences following intrapulmonary administration of plasmid DNA compacted with PEG-substituted polylysine. Mol. Ther. (2002) 5(Suppl.):S463.
    • (2002) Mol. Ther. , vol.5 , Issue.SUPPL.
    • Ziady, A.G.1    Gedeon, C.2    Payne, J.M.3
  • 90
    • 0034219238 scopus 로고    scopus 로고
    • In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers
    • RUDOLPH C, LAUSIER J, NAUNDORF S, MULLER RH, ROSENECKER J: In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers. J. Gene Med. (2000) 2(4):269-278.
    • (2000) J. Gene Med. , vol.2 , Issue.4 , pp. 269-278
    • Rudolph, C.1    Lausier, J.2    Naundorf, S.3    Muller, R.H.4    Rosenecker, J.5
  • 91
    • 0036371914 scopus 로고    scopus 로고
    • Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
    • CHOLLET P, FAVROT MC, HURBIN A, COLL JL: Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J. Gene Med. (2002) 4:84-91.
    • (2002) J. Gene Med. , vol.4 , pp. 84-91
    • Chollet, P.1    Favrot, M.C.2    Hurbin, A.3    Coll, J.L.4
  • 92
    • 0034980741 scopus 로고    scopus 로고
    • Transgene expression in mouse airway epithelium by aerosol gene therapy with PEI-DNA complexes
    • GAUTAM A, DENSMORE CL, GOLUNSKI E, XU B, WALDREP JC: Transgene expression in mouse airway epithelium by aerosol gene therapy with PEI-DNA complexes. Mol. Ther. (2001) 3(4):551-556.
    • (2001) Mol. Ther. , vol.3 , Issue.4 , pp. 551-556
    • Gautam, A.1    Densmore, C.L.2    Golunski, E.3    Xu, B.4    Waldrep, J.C.5
  • 93
    • 0035850212 scopus 로고    scopus 로고
    • Evaluation of polyplexes as gene transfer agents
    • GEBHART CL, KABANOV AV: Evaluation of polyplexes as gene transfer agents. J. Control Release (2001) 73:401-416.
    • (2001) J. Control Release , vol.73 , pp. 401-416
    • Gebhart, C.L.1    Kabanov, A.V.2
  • 94
    • 0035114195 scopus 로고    scopus 로고
    • Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy
    • GAUTAM A, DENSMORE CL, WALDREP JC: Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther. (2001) 8(3):254-257.
    • (2001) Gene Ther. , vol.8 , Issue.3 , pp. 254-257
    • Gautam, A.1    Densmore, C.L.2    Waldrep, J.C.3
  • 95
    • 0034924240 scopus 로고    scopus 로고
    • Effects of linear polyethylenimine and polyethylenimine/DNA on lung function after airway instillation to rat lungs
    • UDUEHI AN, STAMMBERGER U, KUBISA B, GUGGER M, BUEHLER TA, SCHMID RA: Effects of linear polyethylenimine and polyethylenimine/DNA on lung function after airway instillation to rat lungs. Mol. Ther. (2001) 4(1):52-57.
    • (2001) Mol. Ther. , vol.4 , Issue.1 , pp. 52-57
    • Uduehi, A.N.1    Stammberger, U.2    Kubisa, B.3    Gugger, M.4    Buehler, T.A.5    Schmid, R.A.6
  • 96
    • 0036632956 scopus 로고    scopus 로고
    • Evaluation of a porcine model for pulmonary gene transfer using a novel synthenic vector
    • CUNNINGHAM S, MENG QH, KLEIN N, MCANULTY RJ, HART SL: Evaluation of a porcine model for pulmonary gene transfer using a novel synthenic vector. J. Gene Med. (2002) 4(4):438-446.
    • (2002) J. Gene Med. , vol.4 , Issue.4 , pp. 438-446
    • Cunningham, S.1    Meng, Q.H.2    Klein, N.3    Mcanulty, R.J.4    Hart, S.L.5
  • 97
    • 85047697141 scopus 로고    scopus 로고
    • Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus
    • SANDERS NN, DE SMEDT SC, CHENG SH, DEMEESTER J: Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus. Gene Ther. (2002) 9(6):363-371.
    • (2002) Gene Ther. , vol.9 , Issue.6 , pp. 363-371
    • Sanders, N.N.1    De Smedt, S.C.2    Cheng, S.H.3    Demeester, J.4
  • 98
    • 7844249025 scopus 로고    scopus 로고
    • Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells
    • COLIN M, HARBOTTLE RP, KNIGHT A et al.: Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells. Gene Ther. (1998) 5(11):1488-1498.
    • (1998) Gene Ther. , vol.5 , Issue.11 , pp. 1488-1498
    • Colin, M.1    Harbottle, R.P.2    Knight, A.3
  • 99
    • 0034920977 scopus 로고    scopus 로고
    • Targeting transgene expression for cystic fibrosis gene therapy
    • KOEHLER DR, HANNAM V, BELCASTRO R et al.: Targeting transgene expression for cystic fibrosis gene therapy. Mol. Ther. (2001) 4(1):58-65.
    • (2001) Mol. Ther. , vol.4 , Issue.1 , pp. 58-65
    • Koehler, D.R.1    Hannam, V.2    Belcastro, R.3
  • 100
    • 0035166381 scopus 로고    scopus 로고
    • Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1 alpha promoter
    • GILL DR, SMYTH SE, GODDARD CA et al.: Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1 alpha promoter. Gene Ther. (2001) 8(20):1539-1546.
    • (2001) Gene Ther. , vol.8 , Issue.20 , pp. 1539-1546
    • Gill, D.R.1    Smyth, S.E.2    Goddard, C.A.3


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