Human ABC transporters ABCG2 (BCRP) and ABCG4

Xenobiotica

Volumn 38, Issue 7-8, 2008, Pages 863-888

  Koshiba, S ^a   An, R ^a   Saito, H ^a   Wakabayashi, K ^a   Tamura, A ^a   Ishikawa, T ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

ABC transporter; Pharmacogenomics; Phototoxicity; Porphyrin; Protein kinase inhibitors

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ABC TRANSPORTER; ABC TRANSPORTER G4; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREAST CANCER RESISTANCE PROTEIN; CHOLESTEROL; CIMETIDINE; EKI 785; GEFITINIB; IMATINIB; IRINOTECAN; METHOTREXATE; N [4 [(3 BROMOPHENYL)AMINO] 6 QUINAZOLINYL] 2 BUTYNAMIDE; SEX HORMONE; TOPOTECAN; XENOBIOTIC AGENT;

ASTROCYTE; CHEMICAL STRUCTURE; DISULFIDE BOND; DRUG TRANSPORT; ENDOPLASMIC RETICULUM; GENETIC POLYMORPHISM; HUMAN; LIPID TRANSPORT; NERVE CELL; NONHUMAN; PHOTOSENSITIVITY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; STRUCTURE ACTIVITY RELATION; TESTIS; UBIQUITINATION;

ANIMALS; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; CHOLESTEROL; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MICE; NEOPLASM PROTEINS; NEURONS; PHOTOSENSITIVITY DISORDERS; POLYMORPHISM, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE HOMOLOGY, AMINO ACID; TESTIS; XENOBIOTICS;

EID: 48749090651     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250801986944     Document Type: Review

References (125)

1. Ahmed-Belkacem A, Pozza A, Munoz-Martinez F, Bates SE, Castanys S, Gamarro F, Di Pietro A, Perez-Victoria JM. 2005. Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Research 65:4852-4860.
2. Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M. 1998. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Research 58:5337-5339.
3. Annilo T, Tammur J, Hutchinson A, Rzhetsky A, Dean M, Allikmets R. 2001. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Cytogenetics and Cell Genetics 94:196-201.
4. Backstrom G, Taipalensuu J, Melhus H, Brandstrom H, Svensson AC, Artursson P, Kindmark A. 2003. Genetic variation in the ATP-binding cassette transporter gene ABCG2 (BCRP) in a Swedish population. European Journal of Pharmaceutical Science 18:359-364.
5. Bailey-Dell KJ, Hassel B, Doyle LA, Ross DD. 2001. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochimica et Biophysica Acta 1520:234-241.
6. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH. 2000. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290:1771-1775.
7. Borst P, Elferink RO. 2002. Mammalian ABC transporters in health and disease. Annual Review of Biochemistry 71:537-592.
8. Bosch TM, Kjellberg LM, Bouwers A, Koeleman BP, Schellens JH, Beijnen JH, Smits PH, Meijerman I. 2005. Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population. American Journal of Pharmacogenomics 5:123-131.
9. Bowers AG. 1999. Phytophotodermatitis. American Journal of Contact Dermatitis 10:89-93.
10. Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC. 2003. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22:8608-8618.
11. Brehmer D, Greff Z, Godl K, Blencke S, Kurtenbach A, Weber M, Muller S, Klebl B, Cotten M, Keri G, et al. 2005. Cellular targets of gefitinib. Cancer Research 65:379-382.
12. Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD. 2003. Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport. Cancer Research 63:4048-4054.
13. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654.
14. Cooray HC, Janvilisri T, Van Veen HW, Hladky SB, Barrand MA. 2004. Interaction of the breast cancer resistance protein with plant polyphenols. Biochemical and Biophysical Research Communications 317:269-275.
15. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. 1989. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proceedings of the National Academy of Sciences, USA 86:695-698.
16. Cserepes J, Szentpetery Z, Seres L, Özvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Varadi A, et al. 2004. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochemical and Biophysical Research Communications 320:860-867.
17. Cui Y, Konig J, Buchholz JK, Spring H, Leier I, Keppler D. 1999. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Molecular Pharmacology 55:929-937.
18. De Jong FA, Marsh S, Mathijssen RH, King C, Verweij J, Sparreboom A, McLeod HL. 2004. ABCG2 pharmacogenetics: Ethnic differences in allele frequency and assessment of influence on irinotecan disposition. Clinical Cancer Research 10:5889-5894.
19. Dean M, Rzhetsky A, Allikmets R. 2001. The human ATP-binding cassette (ABC) transporter superfamily. Genome Research 11:1156-1166.
20. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. 1998. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proceedings of the National Academy of Sciences, USA 95:15665-15670.
21. Elkind NB, Szentpetery Z, Apati A, Özvegy-Laczka C, Varady G, Ujhelly O, Szabo K, Homolya L, Varadi A, Buday L, et al. 2005. Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib). Cancer Research 65:1770-1777.
22. Engel T, Lorkowski S, Lueken A, Rust S, Schluter B, Berger G, Cullen P, Assmann G. 2001. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. Biochemical and Biophysical Research Communications 288:483-488.
23. Gottesman MM, Fojo T, Bates SE. 2002. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Reviews Cancer 2:48-58.
24. Graf GA, Yu L, Li WP, Gerard R, Tuma PL, Cohen JC, Hobbs HH. 2003. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. Journal of Biological Chemistry 278:48275-48282.
25. Henriksen U, Fog JU, Litman T, Gether U. 2005. Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2. Journal of Biological Chemistry 280:36926-36934.
26. Higgins CF. 1992. ABC transporters: From microorganisms to man. Annual Review of Cell Biology 8:67-113.
27. Hirano H, Kurata A, Onishi Y, Sakurai A, Saito H, Nakagawa H, Nagakura M, Tarui S, Kanamori Y, Kitajima M, et al. 2006. High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis. Molecular Pharmaceutics 3:252-265.
28. Honjo Y, Morisaki K, Huff LM, Robey RW, Hung J, Dean M, Bates SE. 2002. Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1). Cancer Biological Therapy 1:696-702.
29. Hwang C, Sinskey AJ, Lodish HF. 1992. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257:1496-1502.
30. Iida A, Saito S, Sekine A, Mishima C, Kitamura Y, Kondo K, Harigae S, Osawa S, Nakamura Y. 2002. Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. Journal of Human Genetics 47:285-310.
31. Imai Y, Nakane M, Kage K, Tsukahara S, Ishikawa E, Tsuruo T, Miki Y, Sugimoto Y. 2002. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Molecular Cancer Therapeutics 1:611-616.
32. Imai Y, Tsukahara S, Asada S, Sugimoto Y. 2004. Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Research 64:4346-4352.
33. Inanami O, Yoshito A, Takahashi K, Hiraoka W, Kuwabara M. 1999. Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells. Photochemistry and Photobiology 70:650-655.
34. 2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles. Journal of Biological Chemistry 264:17343-17348.
35. Ishikawa T. 1992. The ATP-dependent glutathione S-conjugate export pump. Trends in Biochemical Sciences 17:463-468.
36. Ishikawa T. 2003. Multidrug resistance: genetics of ABC transporters. In: Cooper DN, editor. Nature encyclopedia of the human genome. London: Nature Publishing Group. pp 154-160.
37. Ishikawa T, Hirano H, Onishi Y, Sakurai A, Tarui S. 2004a. Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: High-speed screening and structure-activity relationship analyses. Drug Metabolism and Pharmacokinetics 19:1-14.
38. Ishikawa T, Sakurai A, Kanamori Y, Nagakura M, Hirano H, Takarada Y, Yamada K, Fukushima K, Kitajima M. 2005a. High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: New strategies in pharmacogenomics. Methods in Enzymology 400:485-510.
39. Ishikawa T, Tamura A, Saito H, Wakabayashi K, Nakagawa H. 2005b. Pharmacogenomics of the human ABC transporter ABCG2: From functional evaluation to drug molecular design. Naturwissenschaften 92:451-463.
40. Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, Endou H, Sumino Y. 2004b. The genetic polymorphism of drug transporters: Functional analysis approaches. Pharmacogenomics 5:67-99.
41. Itoda M, Saito Y, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Suzuki H, Sugiyama Y, Ozawa S, Sawada J. 2003. Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan. Drug Metabolism and Pharmacokinetics 18:212-217.
42. Jitsukawa K, Suizu R, Hidano A. 1984. Chlorella photosensitization. New phytophotodermatosis. International Journal of Dermatology 23:263-268.
43. Johnston JA, Ward CL, Kopito RR. 1998. Aggresomes: A cellular response to misfolded proteins. Journal of Cell Biology 143:1883-1898.
44. Jonker JW, Buitelaar M, Wagenaar E, Van der Valk MA, Scheffer GL, Scheper RJ, Plosch T, Kuipers F, Elferink RP, Rosing H, et al. 2002. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proceedings of the National Academy of Sciences, USA 99:15649-15654.
45. Jonker JW, Merino G, Musters S, Van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH. 2005. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine 11:127-129.
46. Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JH, Schinkel AH. 2000. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. Journal of the National Cancer Institute 92:1651-1656.
47. Kage K, Fujita T, Sugimoto Y. 2005. Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2. Cancer Science 96:866-872.
48. Kage K, Tsukahara S, Sugiyama T, Asada S, Ishikawa E, Tsuruo T, Sugimoto Y. 2002. Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. International Journal of Cancer 97:626-630.
49. Kalow E, Meyer U, Tyndale RF. 2001. Pharmacogenomics. New York, NY: Marcel Dekker.
50. Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, Fukuoka M, Miyazawa T, Yana T, Matsui K, et al. 2003. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer 42:103-111.
51. Kim WS, Rahmanto AS, Kamili A, Rye KA, Guillemin GJ, Gelissen IC, Jessup W, Hill AF, Garner B. 2007. Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation. Journal of Biological Chemistry 282:2851-2861.
52. Kirov G, Lowry CA, Stephens M, Oldfield S, O'Donovan MC, Lightman SL, Owen MJ. 2001. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Molecular Psychiatry 6:671-677.
53. Klein I, Sarkadi B, Varadi A. 1999. An inventory of the human ABC proteins. Biochimica et Biophysica Acta 1461:237-262.
54. Klucken J, Buchler C, Orso E, Kaminski WE, Porsch-Ozcurumez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, et al. 2000. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proceedings of the National Academy of Sciences, USA 97:817-822.
55. Kobayashi D, Ieiri I, Hirota T, Takane H, Maegawa S, Kigawa J, Suzuki H, Nanba E, Oshimura M, Terakawa N, et al. 2005. Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta. Drug Metabolism and Disposition 33:94-101.
56. Kool M, De Haas M, Scheffer GL, Scheper RJ, Van Eijk MJ, Juijn JA, Baas F, Borst P. 1997. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Research 57:3537-3547.
57. Koshiba S, Ito T, Shiota A, Wakabayashi K, Ueda M, Ichinose H, Ishikawa T. 2007. Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: site-specific expression of mouse Abcg4 in brain. Journal of Experimental Therapeutics and Oncology 6:321-333.
58. Krasnovsky Jr AA, Neverov KV, Egorov S, Roeder B, Levald T. 1990. Photophysical studies of pheophorbide a and pheophytin a. Phosphorescence and photosensitized singlet oxygen luminescence. Journal of Photochemistry and Photobiology B 5:245-254.
59. Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. 2004. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. Journal of Biological Chemistry 279:24218-24225.
60. Kyte J, Doolittle RF. 1982. A simple method for displaying the hydropathic character of a protein. Journal of Molecular Biology 157:105-132.
61. Litman T, Jensen U, Hansen A, Covitz KM, Zhan Z, Fetsch P, Abati A, Hansen PR, Horn T, Skovsgaard T, et al. 2002. Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/ BCRP/ABCP/ABCG2. Biochimica et Biophysica Acta 1565:6-16.
62. Loscher W, Potschka H. 2005. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Progress in Neurobiology 76:22-76.
63. Ma Y, Hendershot LM. 2004. ER chaperone functions during normal and stress conditions. Journal of Chemical Neuroanatomy 28:51-65.
64. Mayer U, Wagenaar E, Beijnen JH, Smit JW, Meijer DK, Van Asperen J, Borst P, Schinkel AH. 1996. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. British Journal of Pharmacology 119:1038-1044.
65. Meister A, Anderson ME. 1983. Glutathione. Annual Review of Biochemistry 52:711-760.
66. Millard TP, Hawk JL. 2002. Photosensitivity disorders: Cause, effect and management. American Journal of Clinical Dermatology 3:239-246.
67. Millard TP, Kirk A, Ratnavel R. 2004. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. Clinical and Experimental Dermatology 29:92-93.
68. Mitomo H, Kato R, Ito A, Kasamatsu S, Ikegami Y, Kii I, Kudo A, Kobatake E, Sumino Y, Ishikawa T. 2003. A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: Critical role of arginine-482 in methotrexate transport. Biochemical Journal 373:767-774.
69. Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Cristensen B, Brangi M, Greenberger L, Dean M, Fojo T, et al. 1999. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Research 59:8-13.
70. Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R. 2004. Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. Journal of Biological Chemistry 279:32667-32673.
71. Mori K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451-454.
72. Mottino AD, Hoffman T, Jennes L, Vore M. 2000. Expression and localization of multidrug resistant protein mrp2 in rat small intestine. Journal of Pharmacology and Experimental Therapeutics 293:717-723.
73. Nakagawa H, Tamura A, Wakabayashi K, Hoshijima K, Komada M, Yoshida T, Kometani S, Matsubara T, Mikuriya K, Ishikawa T. 2008. Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2. Biochemical Journal 411:623-631.
74. Nakatomi K, Yoshikawa M, Oka M, Ikegami Y, Hayasaka S, Sano K, Shiozawa K, Kawabata S, Soda H, Ishikawa T, et al. 2001. Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells. Biochemical and Biophysical Research Communications 288:827-832.
75. Noble ME, Endicott JA, Johnson LN. 2004. Protein kinase inhibitors: insights into drug design from structure. Science 303:1800-1805.
76. O'Gorman S, Fox DT, Wahl GM. 1991. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251:1351-1355.
77. Okura I. 2000. Charactarization of porphyrins and phthalocyanines. In: Okura I, editor. Photosensitization of porphyrins and phthalocyanines. Tokyo: Kodansha/Gordon & Breach. pp 45-62.
78. Özvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B. 2004. High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Molecular Pharmacology 65:1485-1495.
79. Pirmohamed M. 2001. Pharmacogenetics and pharmacogenomics. British Journal of Clinical Pharmacology 52:345-347.
80. Puglielli L, Tanzi RE, Kovacs DM. 2003. Alzheimer's disease: The cholesterol connection. Nature Neuroscience 6:345-351.
81. Rao RV, Ellerby HM, Bredesen DE. 2004. Coupling endoplasmic reticulum stress to the cell death program. Cell Death and Differentiation 11:372-380.
82. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D. 1999. Choroid plexus epithelial expression of MDR1P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proceedings of the National Academy of Sciences, USA 96:3900-3905.
83. Reed DJ. 1990. Glutathione: Toxicological implications. Annual Review of Pharmacology and Toxicology 30:603-631.
84. Robey RW, Steadman K, Polgar O, Bates SE. 2005. ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy. Cancer Biological Therapy 4:187-194.
85. Saito H, Hirano H, Nakagawa H, Fukami T, Oosumi K, Murakami K, Kimura H, Kouchi T, Konomi M, Tao E, et al. 2006. A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions. Journal of Pharmacology and Experimental Therapeutics 317:1114-1124.
86. Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, et al. 2007. Quantitative structure - activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1). Biochemistry 46:7678-7693.
87. Sakurai A, Tamura A, Onishi Y, Ishikawa T. 2005. Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications. Expert Opinion on Pharmacotherapy 6:2455-2473.
88. Sarkadi B, Özvegy-Laczka C, Nemet K, Varadi A. 2004. ABCG2 - a transporter for all seasons. FEBS Letters 567:116-120.
89. Sauer B. 1994. Site-specific recombination: Developments and applications. Current Opinion in Biotechnology 5:521-527.
90. Schinkel AH, Jonker JW. 2003. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview. Advanced Drug Delivery Reviews 55:3-29.
91. Schinkel AH, Smit JJ, Van Tellingen O, Beijnen JH, Wagenaar E, Van Deemter L, Molecular CA, Van der Valk MA, Robanus-Maandag EC, Te Riele HP, et al. 1994. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
92. Schinkel AH, Wagenaar E, Molecular CA, Van Deemter L. 1996. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. Journal of Clinical Investigation 97:2517-2524.
93. Schroder M, Kaufman RJ. 2005. ER stress and the unfolded protein response. Mutation Research 569:29-63.
94. Sesink AL, Arts IC, De Boer VC, Breedveld P, Schellens JH, Hollman PC, Russel FG. 2005. Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. Molecular Pharmacology 67:1999-2006.
95. Shen X, Zhang K, Kaufman RJ. 2004. The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum. Journal of Chemical Neuroanatomy 28:79-92.
96. Sies H, Menck CF. 1992. Singlet oxygen induced DNA damage. Mutation Research 275:367-375.
97. Sparreboom A, Van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DK, Borst P, Nooijen WJ, Beijnen JH, Van Tellingen O. 1997. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proceedings of the National Academy of Sciences, USA 94:2031-2035.
98. Stewart CF, Leggas M, Schuetz JD, Panetta JC, Cheshire PJ, Peterson J, Daw N, Jenkins III JJ, Gilbertson R, Germain GS, et al. 2004. Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice. Cancer Research 64:7491-7499.
99. Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashima T, Terasaki T. 2005. Distinct spatiotemporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. Journal of Neurochemistry 95:294-304.
100. Tamura A, Onishi Y, An R, Koshiba S, Wakabayashi K, Hoshijima K, Priebe W, Yoshida T, Kometani S, Matsubara T, et al. 2007. In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs. Drug Metabolism and Pharmacokinetics 22:428-440.
101. Tamura A, Watanabe M, Saito H, Nakagawa H, Kamachi T, Okura I, Ishikawa T. 2006. Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: Identification of alleles that are defective in porphyrin transport. Molecular Pharmacology 70:287-296.
102. Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, et al. 2007. The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. Journal of Lipid Research 48:1022-1034.
103. Tarr PT, Edwards PA. 2008. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. Journal of Lipid Research 49:169-182.
104. Taylor JG, Choi EH, Foster CB, Chanock SJ. 2001. Using genetic variation to study human disease. Trends in Molecular Medicine 7:507-512.
105. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. 1987. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proceedings of the National Academy of Sciences, USA 84:7735-7738.
106. Tu BP, Weissman JS. 2004. Oxidative protein folding in eukaryotes: Mechanisms and consequences. Journal of Cell Biology 164:341-346.
107. Van Herwaarden AE, Schinkel AH. 2006. The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends in Pharmacological Sciences 27:10-16.
108. Vance JE, Hayashi H, Karten B. 2005. Cholesterol homeostasis in neurons and glial cells. Seminars in Cell and Developmental Biology 16:193-212.
109. Varadi A, Tusnady GE, Sarkadi B. 2003. Membrane topology the human ABC transporter proteins. In: Holland IB, Cole SPC, Kuchler K, Higgins CF, editors. ABC proteins: From bacteria to man. London: Academic Press. pp 37-46.
110. Volk EL, Schneider E. 2003. Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Research 63:5538-5543.
111. Wakabayashi K, Nakagawa H, Adachi T, Kii I, Kobatake E, Kudo A, Ishikawa T. 2006. Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: A new approach using the flp recombinase system. Journal of Experimental Therapeutics and Oncology 5:205-222.
112. Wakabayashi K, Nakagawa H, Tamura A, Koshiba S, Hoshijima K, Komada M, Ishikawa T. 2007. Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein. Journal of Biological Chemistry 282:27841-27846.
113. Wang N, Lan D, Chen W, Matsuura F, Tall AR. 2004. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proceedings of the National Academy of Sciences, USA 101:9774-9779.
114. Wirth D, Hauser H. 2004. Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells. Methods in Molecular Biology 267:467-476.
115. Xu C, Bailly-Maitre B, Reed JC. 2005. Endoplasmic reticulum stress: cell life and death decisions. Journal of Clinical Investigation 115:2656-2664.
116. Yanase K, Tsukahara S, Asada S, Ishikawa E, Imai Y, Sugimoto Y. 2004. Gefitinib reverses breast cancer resistance protein-mediated drug resistance. Molecular Cancer Therapeutics 3:1119-1125.
117. Ye Y, Shibata Y, Kikkert M, Van Voorden S, Wiertz E, Rapoport TA. 2005. Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proceedings of the National Academy of Sciences, USA 102:14132-14138.
118. Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, et al. 2004a. Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. International Journal of Cancer 110:921-927.
119. Yoshikawa M, Ikegami Y, Sano K, Yoshida H, Mitomo H, Sawada S, Ishikawa T. 2004b. Transport of SN-38 by the wild-type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid. Journal of Experimental Therapeutics and Oncology 4:25-35.
120. Yoshikawa M, Yabuuchi H, Kuroiwa A, Ikegami Y, Sai Y, Tamai I, Tsuji A, Matsuda Y, Yoshida H, Ishikawa T. 2002. Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. Gene 293:67-75.
121. Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. 2003. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics 13:19-28.
122. Zhang S, Yang X, Morris ME. 2004. Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharmaceutical Research 21:1263-1273.
123. Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP. 2002. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proceedings of the National Academy of Sciences, USA 99:12339-12344.
124. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, et al. 2001. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature Medicine 7:1028-1034.
125. Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP. 2005. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood 105:2571-2576.