-
1
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
-
Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39 (2005) 359-407
-
(2005)
Annu Rev Genet
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
2
-
-
38549145044
-
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
-
Letai A.G. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 8 (2008) 121-132
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 121-132
-
-
Letai, A.G.1
-
3
-
-
34249941116
-
The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies
-
Nguyen D.M., and Hussain M. The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies. J Bioenerg Biomembr 39 (2007) 13-21
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 13-21
-
-
Nguyen, D.M.1
Hussain, M.2
-
4
-
-
34249944782
-
Alteration of mitochondrial function and cell sensitization to death
-
Gogvadze V., and Zhivotovsky B. Alteration of mitochondrial function and cell sensitization to death. J Bioenerg Biomembr 39 (2007) 23-30
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 23-30
-
-
Gogvadze, V.1
Zhivotovsky, B.2
-
5
-
-
26444468146
-
Mitochondria: pharmacological manipulation of cell death
-
Bouchier-Hayes L., Lartigue L., and Newmeyer D.D. Mitochondria: pharmacological manipulation of cell death. J Clin Invest 115 (2005) 2640-2647
-
(2005)
J Clin Invest
, vol.115
, pp. 2640-2647
-
-
Bouchier-Hayes, L.1
Lartigue, L.2
Newmeyer, D.D.3
-
6
-
-
34547877924
-
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
-
An excellent recent review of various approaches to targeting mitochondria for therapeutic benefit.
-
Armstong J.S. Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br J Pharmacol 151 (2007) 1154-1165. An excellent recent review of various approaches to targeting mitochondria for therapeutic benefit.
-
(2007)
Br J Pharmacol
, vol.151
, pp. 1154-1165
-
-
Armstong, J.S.1
-
7
-
-
34547785566
-
Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signaling
-
Hagland H., Nikolaisen J., Hodneland L.I., Gjertsen B.T., Bruserud O., and Tronstad K.J. Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signaling. Expert Opin Therapeut Targets 11 (2007) 1055-1069
-
(2007)
Expert Opin Therapeut Targets
, vol.11
, pp. 1055-1069
-
-
Hagland, H.1
Nikolaisen, J.2
Hodneland, L.I.3
Gjertsen, B.T.4
Bruserud, O.5
Tronstad, K.J.6
-
8
-
-
33746895175
-
Mitochondria as therapeutic targets for cancer chemotherapy
-
Galluzzi L., Larochette N., Zamzami N., and Kroemer G. Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25 (2006) 4812-4830
-
(2006)
Oncogene
, vol.25
, pp. 4812-4830
-
-
Galluzzi, L.1
Larochette, N.2
Zamzami, N.3
Kroemer, G.4
-
9
-
-
33746888993
-
Mitochondriotoxic compounds for cancer therapy
-
Fantin V.R., and Leder P. Mitochondriotoxic compounds for cancer therapy. Oncogene 25 (2006) 4787-4797
-
(2006)
Oncogene
, vol.25
, pp. 4787-4797
-
-
Fantin, V.R.1
Leder, P.2
-
10
-
-
20444429105
-
Drugs targeting mitochondrial functions to control tumor cell growth
-
Dias N., and Bailly C. Drugs targeting mitochondrial functions to control tumor cell growth. Biochem Pharmacol 70 (2005) 1-12
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1-12
-
-
Dias, N.1
Bailly, C.2
-
11
-
-
34249945104
-
The cancer cell's 'power plants' as promising therapeutic targets: an overview
-
Pedersen P.L. The cancer cell's 'power plants' as promising therapeutic targets: an overview. J Bioenerg Biomembr 39 (2007) 1-12
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 1-12
-
-
Pedersen, P.L.1
-
12
-
-
33751072935
-
Bioenergetics and the formation of mitochondrial reactive oxygen species
-
Adam-Vizi V., and Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27 (2006) 639-645
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 639-645
-
-
Adam-Vizi, V.1
Chinopoulos, C.2
-
13
-
-
33847349283
-
Reactive oxygen species: a breath of life or death?
-
Fruehauf J.P., and Meyskens Jr. F.L. Reactive oxygen species: a breath of life or death?. Clin Cancer Res 13 (2007) 789-794
-
(2007)
Clin Cancer Res
, vol.13
, pp. 789-794
-
-
Fruehauf, J.P.1
Meyskens Jr., F.L.2
-
14
-
-
34548213103
-
A common mechanism of cellular death induced by bactericidal antibiotics
-
Kohanski M.A., Dwyer D.J., Hayete B., Lawrence C.A., and Collins J.J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130 (2007) 797-810
-
(2007)
Cell
, vol.130
, pp. 797-810
-
-
Kohanski, M.A.1
Dwyer, D.J.2
Hayete, B.3
Lawrence, C.A.4
Collins, J.J.5
-
15
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
-/- cells that are unable to undergo a metabolic conversion to glycolysis in response to inhibition of mitochondrial electron transport.
-
-/- cells that are unable to undergo a metabolic conversion to glycolysis in response to inhibition of mitochondrial electron transport.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.L.4
DeBerardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
16
-
-
34247511558
-
Vitamin E analogs, a novel group of 'mitocans,' as anticancer agents: the importance of being redox-silent
-
Neuzil J., Tomasetti M., Zhao Y., Dong L.F., Birringer M., Wang X.F., Low P., Wu K., Salvatore B.A., and Ralph S.J. Vitamin E analogs, a novel group of 'mitocans,' as anticancer agents: the importance of being redox-silent. Mol Pharmacol 71 (2007) 1185-1199
-
(2007)
Mol Pharmacol
, vol.71
, pp. 1185-1199
-
-
Neuzil, J.1
Tomasetti, M.2
Zhao, Y.3
Dong, L.F.4
Birringer, M.5
Wang, X.F.6
Low, P.7
Wu, K.8
Salvatore, B.A.9
Ralph, S.J.10
-
17
-
-
34249934598
-
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
-
Neuzil J., Dyason J.C., Freeman R., Dong L.F., Prochazka L., Wang X.F., Scheffler I., and Ralph S.J. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr 39 (2007) 65-72
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 65-72
-
-
Neuzil, J.1
Dyason, J.C.2
Freeman, R.3
Dong, L.F.4
Prochazka, L.5
Wang, X.F.6
Scheffler, I.7
Ralph, S.J.8
-
18
-
-
33748788835
-
Molecular mechanism of 'mitocan' -induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
-
Neuzil J., Wang X.F., Dong L.F., Low P., and Ralph S.J. Molecular mechanism of 'mitocan' -induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett 580 (2006) 5125-5129
-
(2006)
FEBS Lett
, vol.580
, pp. 5125-5129
-
-
Neuzil, J.1
Wang, X.F.2
Dong, L.F.3
Low, P.4
Ralph, S.J.5
-
19
-
-
33744959427
-
α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function
-
Shiau C.W., Huang J.W., Wang D.S., Weng J.R., Yang C.C., Lin C.H., Li C., and Chen C.S. α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. J Biol Chem 281 (2006) 11819-11825
-
(2006)
J Biol Chem
, vol.281
, pp. 11819-11825
-
-
Shiau, C.W.1
Huang, J.W.2
Wang, D.S.3
Weng, J.R.4
Yang, C.C.5
Lin, C.H.6
Li, C.7
Chen, C.S.8
-
21
-
-
32044434388
-
Apoptolidin: induction of apoptosis by a natural product
-
Daniel P.T., Koert U., and Schuppan J. Apoptolidin: induction of apoptosis by a natural product. Angew Chem Int Ed 45 (2006) 872-893
-
(2006)
Angew Chem Int Ed
, vol.45
, pp. 872-893
-
-
Daniel, P.T.1
Koert, U.2
Schuppan, J.3
-
26
-
-
33751294565
-
Inhibitors of the catalytic domain of mitochondrial ATP synthase
-
Gledhill J.R., and Walker J.E. Inhibitors of the catalytic domain of mitochondrial ATP synthase. Biochem Soc Trans 34 (2006) 989-992
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 989-992
-
-
Gledhill, J.R.1
Walker, J.E.2
-
28
-
-
0036802423
-
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility
-
Blatt N.B., Bednarski J.J., Warner R.E., Leonetti F., Johnson K.M., Boitano A., Yung R., Richardson B.C., Johnson K.J., Ellman J.A., et al. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J Clin Invest 110 (2002) 1123-1132
-
(2002)
J Clin Invest
, vol.110
, pp. 1123-1132
-
-
Blatt, N.B.1
Bednarski, J.J.2
Warner, R.E.3
Leonetti, F.4
Johnson, K.M.5
Boitano, A.6
Yung, R.7
Richardson, B.C.8
Johnson, K.J.9
Ellman, J.A.10
-
29
-
-
0037333995
-
Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine
-
Bednarski J.J., Warner R.E., Rao T., Leonetti F., Yung R., Richardson B.C., Johnson K.J., Ellman J.A., Opipari Jr. A.W., and Glick G.D. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis Rheum 48 (2003) 757-766
-
(2003)
Arthritis Rheum
, vol.48
, pp. 757-766
-
-
Bednarski, J.J.1
Warner, R.E.2
Rao, T.3
Leonetti, F.4
Yung, R.5
Richardson, B.C.6
Johnson, K.J.7
Ellman, J.A.8
Opipari Jr., A.W.9
Glick, G.D.10
-
30
-
-
20144375716
-
A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin
-
Varani J., Bhagavathula N., Nerusu K.C., Sherzer H., Fay K., Boitano A.E., Glick G.D., Johnson K., Kang S., and Opipari Jr. A.W. A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin. J Pharm Exp Therapeut 313 (2005) 56-63
-
(2005)
J Pharm Exp Therapeut
, vol.313
, pp. 56-63
-
-
Varani, J.1
Bhagavathula, N.2
Nerusu, K.C.3
Sherzer, H.4
Fay, K.5
Boitano, A.E.6
Glick, G.D.7
Johnson, K.8
Kang, S.9
Opipari Jr., A.W.10
-
31
-
-
40849142357
-
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalene-2-ylmethyl)-3,4-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423) a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model
-
Bhagavathula N., Nerusu K.C., Hanosh A., Aslam M.N., Sundberg T.B., Opipari Jr. A.W., Johnson K., Kang S., Glick G.D., and Varani J. 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalene-2-ylmethyl)-3,4-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423) a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model. J Pharmacol Exp Therapeut 324 (2008) 938-947
-
(2008)
J Pharmacol Exp Therapeut
, vol.324
, pp. 938-947
-
-
Bhagavathula, N.1
Nerusu, K.C.2
Hanosh, A.3
Aslam, M.N.4
Sundberg, T.B.5
Opipari Jr., A.W.6
Johnson, K.7
Kang, S.8
Glick, G.D.9
Varani, J.10
-
32
-
-
32944455992
-
The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation
-
The anti-proliferative effects of Bz-423 in B cells are mediated through a superoxide-dependent decrease in c-myc levels.
-
Sundberg T.B., Ney G.M., Subramanian C., Opipari Jr. A.W., and Glick G.D. The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation. Cancer Res 66 (2006) 1775-1782. The anti-proliferative effects of Bz-423 in B cells are mediated through a superoxide-dependent decrease in c-myc levels.
-
(2006)
Cancer Res
, vol.66
, pp. 1775-1782
-
-
Sundberg, T.B.1
Ney, G.M.2
Subramanian, C.3
Opipari Jr., A.W.4
Glick, G.D.5
-
33
-
-
35548958999
-
0-ATPase
-
A detailed mechanistic study establishing the kinetics of ATPase inhibition by this novel uncompetitive inhibitor.
-
0-ATPase. ACS Chem Biol 1 (2006) 304-308. A detailed mechanistic study establishing the kinetics of ATPase inhibition by this novel uncompetitive inhibitor.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 304-308
-
-
Johnson, K.M.1
Cleary, J.2
Fierke, C.A.3
Opipari Jr., A.W.4
Glick, G.D.5
-
34
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
-
35
-
-
33745962138
-
Therapeutic potential of resveratrol: the in vivo evidence
-
Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Disc 5 (2006) 493-506
-
(2006)
Nat Rev Drug Disc
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
36
-
-
4444267291
-
Crystal structure of quinone reductase 2 in complex with resveratrol
-
Buryanovskyy L., Fu Y., Boyd M., Ma Y., Hsieh T.C., Wu J.M., and Zhang Z. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 43 (2004) 11417-11426
-
(2004)
Biochemistry
, vol.43
, pp. 11417-11426
-
-
Buryanovskyy, L.1
Fu, Y.2
Boyd, M.3
Ma, Y.4
Hsieh, T.C.5
Wu, J.M.6
Zhang, Z.7
-
37
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.-L., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.-L.10
-
38
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein M., McDonagh T., Heltweg B., Hixon J., Westman E.A., Caldwell S.D., Napper A., Curtis R., DiStefano P.S., Fields S., et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 280 (2005) 17038-17045
-
(2005)
J Biol Chem
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
McDonagh, T.2
Heltweg, B.3
Hixon, J.4
Westman, E.A.5
Caldwell, S.D.6
Napper, A.7
Curtis, R.8
DiStefano, P.S.9
Fields, S.10
-
39
-
-
10744231564
-
0 ATP hydrolase
-
0 ATP hydrolase. Bioorg Med Chem Lett 14 (2004) 1027-1030
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1027-1030
-
-
Atwal, K.S.1
Ahmad, S.2
Ding, C.Z.3
Stein, P.D.4
Lloyd, J.5
Hamann, L.G.6
Green, D.W.7
Ferrara, F.N.8
Wang, P.9
Rogers, W.L.10
-
40
-
-
10744223887
-
0 ATP hydrolase
-
0 ATP hydrolase. Bioorg Med Chem Lett 14 (2004) 1031-1034
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1031-1034
-
-
Hamann, L.G.1
Ding, C.Z.2
Miller, A.V.3
Madsen, C.S.4
Wang, P.5
Stein, P.D.6
Pudzianowski, A.T.7
Green, D.W.8
Monshizadegan, H.9
Atwal, K.S.10
-
41
-
-
1242296328
-
0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors
-
0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. J Med Chem 47 (2004) 1081-1084
-
(2004)
J Med Chem
, vol.47
, pp. 1081-1084
-
-
Atwal, K.S.1
Wang, P.2
Rogers, W.L.3
Sleph, P.4
Monshizadegan, H.5
Ferrara, F.N.6
Traeger, S.7
Green, D.W.8
Grover, G.J.9
-
42
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
Koul A., Dendouga N., Vergauwen K., Molenberghs B., Vranckx L., Willebrords R., Ristic Z., Lill H., Dorange I., Guillemont J., et al. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat Chem Biol 3 (2007) 323-324
-
(2007)
Nat Chem Biol
, vol.3
, pp. 323-324
-
-
Koul, A.1
Dendouga, N.2
Vergauwen, K.3
Molenberghs, B.4
Vranckx, L.5
Willebrords, R.6
Ristic, Z.7
Lill, H.8
Dorange, I.9
Guillemont, J.10
-
43
-
-
33745950626
-
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
-
Chipuk J.E., Bouchier-Hayes L., and Green D.R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 13 (2006) 1396-1402
-
(2006)
Cell Death Differ
, vol.13
, pp. 1396-1402
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Green, D.R.3
-
44
-
-
33745745762
-
Development of ligands for the peripheral benzodiazepine receptor
-
James M.L., Selleri S., and Kassiou M. Development of ligands for the peripheral benzodiazepine receptor. Curr Med Chem 13 (2006) 1991-2001
-
(2006)
Curr Med Chem
, vol.13
, pp. 1991-2001
-
-
James, M.L.1
Selleri, S.2
Kassiou, M.3
-
45
-
-
34548238745
-
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
-
Veenman L., Papadopoulous V., and Gavish M. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharmaceutical Des 13 (2007) 2385-2405
-
(2007)
Curr Pharmaceutical Des
, vol.13
, pp. 2385-2405
-
-
Veenman, L.1
Papadopoulous, V.2
Gavish, M.3
-
46
-
-
34250372956
-
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels
-
Erastin is selectively cytotoxic toward tumor cells harboring an oncogenic ras protein.
-
Yagoda N., von Rechenburg M., Zaganjor E., Bauer A.J., Yang W.S., Fridman D.J., Wolpaw A.J., Smukste I., Peltier J.M., Boniface J.J., et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 (2007) 864-868. Erastin is selectively cytotoxic toward tumor cells harboring an oncogenic ras protein.
-
(2007)
Nature
, vol.447
, pp. 864-868
-
-
Yagoda, N.1
von Rechenburg, M.2
Zaganjor, E.3
Bauer, A.J.4
Yang, W.S.5
Fridman, D.J.6
Wolpaw, A.J.7
Smukste, I.8
Peltier, J.M.9
Boniface, J.J.10
-
48
-
-
33846856501
-
Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
-
Elesclomol™ (formerly STA-4783) is a pro-oxidant drug with clinical activity against metastatic melanoma.
-
Berkenblit A., Eder Jr. J.P., Ryan D.P., Seiden M.V., Tatsuta N., Sherman M.L., Dahl T.A., Dezube B.J., and Supko J.G. Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors. Clin Cancer Res 13 (2007) 584-590. Elesclomol™ (formerly STA-4783) is a pro-oxidant drug with clinical activity against metastatic melanoma.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 584-590
-
-
Berkenblit, A.1
Eder Jr., J.P.2
Ryan, D.P.3
Seiden, M.V.4
Tatsuta, N.5
Sherman, M.L.6
Dahl, T.A.7
Dezube, B.J.8
Supko, J.G.9
-
49
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang P., Feng L., Oldham E.A., Keating M.J., and Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407 (2000) 390-395
-
(2000)
Nature
, vol.407
, pp. 390-395
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
50
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban R.S., Nemoto S., and Finkel T. Mitochondria, oxidants, and aging. Cell 120 (2005) 483-495
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
51
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440 (2006) 944-948
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
52
-
-
34247096170
-
Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays
-
Nadanaciva S., Bernal A., Aggeler R., Capaldi R., and Will Y. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Tox In Vitro 21 (2007) 902-911
-
(2007)
Tox In Vitro
, vol.21
, pp. 902-911
-
-
Nadanaciva, S.1
Bernal, A.2
Aggeler, R.3
Capaldi, R.4
Will, Y.5
-
53
-
-
0242363266
-
Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective
-
Lewis W., Day B.J., and Copeland W.C. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nature 2 (2003) 812-822
-
(2003)
Nature
, vol.2
, pp. 812-822
-
-
Lewis, W.1
Day, B.J.2
Copeland, W.C.3
-
54
-
-
34548379435
-
The significance of mitochondrial toxicity testing in drug development
-
Dykens J.A., and Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Disc Today 12 (2007) 777-785
-
(2007)
Drug Disc Today
, vol.12
, pp. 777-785
-
-
Dykens, J.A.1
Will, Y.2
-
55
-
-
0037444769
-
Mitochondrial threshold effects
-
Rossignol R., Faustin B., Rocher C., Malgat M., Mazat J.P., and Letellier T. Mitochondrial threshold effects. Biochem J 370 (2003) 751-762
-
(2003)
Biochem J
, vol.370
, pp. 751-762
-
-
Rossignol, R.1
Faustin, B.2
Rocher, C.3
Malgat, M.4
Mazat, J.P.5
Letellier, T.6
-
56
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
An analysis of the bioenergetic states of progressively transformed cells links cancer causing genes to an increasing dependence on glycolysis.
-
Ramanathan A., Wang C., and Schreiber S.L. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A 102 (2005) 5992-5997. An analysis of the bioenergetic states of progressively transformed cells links cancer causing genes to an increasing dependence on glycolysis.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
Wang, C.2
Schreiber, S.L.3
-
57
-
-
37449024702
-
The Biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
A summary of metabolic changes associated with tumorigenesis including an increase in aerobic glycolysis.
-
DeBerardinis R.J., Lum J.J., Hatzivassiliou G., and Thompson C.B. The Biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7 (2008) 11-20. A summary of metabolic changes associated with tumorigenesis including an increase in aerobic glycolysis.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
58
-
-
34548014737
-
Revving the engine: signal transduction fuels T cell activation
-
Jones R.G., and Thompson C.B. Revving the engine: signal transduction fuels T cell activation. Cell Immunity 27 (2007) 173-178
-
(2007)
Cell Immunity
, vol.27
, pp. 173-178
-
-
Jones, R.G.1
Thompson, C.B.2
-
59
-
-
27744519400
-
Fuel feeds function: energy metabolism and the T-cell response
-
Fox C.J., Hammerman P.S., and Thompson C.B. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 5 (2005) 844-852
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
60
-
-
0141509869
-
Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism
-
Pelicano H., Feng L., Zhou Y., Carew J.S., Hileman E.O., Plunkett W., Keating M.J., and Huang P. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278 (2003) 37832-37839
-
(2003)
J Biol Chem
, vol.278
, pp. 37832-37839
-
-
Pelicano, H.1
Feng, L.2
Zhou, Y.3
Carew, J.S.4
Hileman, E.O.5
Plunkett, W.6
Keating, M.J.7
Huang, P.8
-
61
-
-
0036016917
-
The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide
-
Yi J., Gao F., Shi G., Li H., Wang Z., Shi X., and Tang X. The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide. Apoptosis 7 (2002) 209-215
-
(2002)
Apoptosis
, vol.7
, pp. 209-215
-
-
Yi, J.1
Gao, F.2
Shi, G.3
Li, H.4
Wang, Z.5
Shi, X.6
Tang, X.7
-
62
-
-
33748165596
-
Reactive oxygen species in cancer cells: live by the sword, die by the sword
-
Schumacher P.T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10 (2006) 175-176
-
(2006)
Cancer Cell
, vol.10
, pp. 175-176
-
-
Schumacher, P.T.1
-
63
-
-
40449112930
-
Large-scale chemical dissection of mitochondrial function
-
High throughput screens of cell viability, mitochondrial physiology, and gene expression are used to interrogate mitochondrial biology and toxicity as well as to identify novel therapeutics.
-
Wagner B.K., Kitami T., Gilbert T.J., Peck D., Ramanathan A., Schreiber S.L., Golub T.R., and Mootha V.K. Large-scale chemical dissection of mitochondrial function. Nat Biotech 26 (2008) 343-351. High throughput screens of cell viability, mitochondrial physiology, and gene expression are used to interrogate mitochondrial biology and toxicity as well as to identify novel therapeutics.
-
(2008)
Nat Biotech
, vol.26
, pp. 343-351
-
-
Wagner, B.K.1
Kitami, T.2
Gilbert, T.J.3
Peck, D.4
Ramanathan, A.5
Schreiber, S.L.6
Golub, T.R.7
Mootha, V.K.8
-
64
-
-
45549099294
-
Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B
-
10.1021/pr700742h
-
Huang T.C., Chang H.Y., Hsu C.H., Kuo W.H., Chang K.J., and Juan H.F. Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B. J Proteome Res (2008) 10.1021/pr700742h
-
(2008)
J Proteome Res
-
-
Huang, T.C.1
Chang, H.Y.2
Hsu, C.H.3
Kuo, W.H.4
Chang, K.J.5
Juan, H.F.6
-
65
-
-
33847618832
-
Mitochondrial drug delivery and mitochondrial disease therapy-an approach to liposome-based delivery targeted to mitochondria
-
Yamada Y., Akita H., Kogure K., Kamiya H., and Harashima H. Mitochondrial drug delivery and mitochondrial disease therapy-an approach to liposome-based delivery targeted to mitochondria. Mitochondrion 7 (2007) 63-71
-
(2007)
Mitochondrion
, vol.7
, pp. 63-71
-
-
Yamada, Y.1
Akita, H.2
Kogure, K.3
Kamiya, H.4
Harashima, H.5
-
66
-
-
0141459148
-
Total synthesis of the (+)-antimycin A3 family; structure elucidation of (+)-antimycin A3a
-
Nishii T., Suzuki S., Yoshida K., Arakaki K., and Tsunoda T. Total synthesis of the (+)-antimycin A3 family; structure elucidation of (+)-antimycin A3a. Tetrahedron Lett 44 (2003) 7829-7832
-
(2003)
Tetrahedron Lett
, vol.44
, pp. 7829-7832
-
-
Nishii, T.1
Suzuki, S.2
Yoshida, K.3
Arakaki, K.4
Tsunoda, T.5
-
67
-
-
40249105812
-
X-Ray structures and absolute configurations of the antibiotics oligomycins A, B and C: inhibitors of ATP synthase
-
Palmer R.A., and Potter B.S. X-Ray structures and absolute configurations of the antibiotics oligomycins A, B and C: inhibitors of ATP synthase. J Chem Cryst 38 (2008) 243-253
-
(2008)
J Chem Cryst
, vol.38
, pp. 243-253
-
-
Palmer, R.A.1
Potter, B.S.2
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