α-tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function

Journal of Biological Chemistry

Volumn 281, Issue 17, 2006, Pages 11819-11825

  Shiau, Chung Wai ^a   Huang, Jui Wen ^a   Wang, Da Sheng ^a   Weng, Jing Ru ^b   Yang, Chih Cheng ^a   Lin, Chia Hui ^a   Li, Chenglong ^a   Chen, Ching Shih ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; CONFORMATIONS; ENZYME INHIBITION; MOLECULAR STRUCTURE; POLYPEPTIDES; VITAMINS;

APOPTOSIS; BCL-XL/BCL-2 INHIBITOR; PROSTATE CANCER CELL; TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE);

CELLS;

[2 (4,8 DIMETHYLNONYL) 2,5,7,8 TETRAMETHYL CHROMAN 6 OL]; [3 [2,5,7,8 TETRAMETHYL 2 (4,8 DIMETHYLNONYL)CHROMAN 6 YLOXY]PROPIONIC ACID; [SUCCINIC ACID MONO(2,2,5,7,8 PENTAMETHYLCHROMAN 6 YL)ESTER]; [SUCCINIC ACID MONO[2 (4,8 DIMETHYLNONYL) 2,5,7,8 TETRAMETHYL CHROMAN 6 YL]ESTER]; [SUCCINIC ACID MONO[2,5,7,8 TETRAMETHYL 2 (4 METHYLPENTYL)CHROMAN 6 YL]ESTER]; ALPHA TOCOPHEROL SUCCINATE; CASPASE; CYTOCHROME C; HETERODIMER; LIGAND; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL STRAIN LNCAP; CELL VIABILITY; COMPUTER MODEL; CONFORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BCL-X PROTEIN; CELL PROLIFERATION; CYTOCHROMES C; HUMANS; MALE; MODELS, MOLECULAR; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; VITAMIN E;

EID: 33744959427     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511015200     Document Type: Article

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