Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays

Toxicology in Vitro

Volumn 21, Issue 5, 2007, Pages 902-911

  Nadanaciva, Sashi ^a   Bernal, Autumn ^a   Aggeler, Robert ^a   Capaldi, Roderick ^a   Will, Yvonne ^b  

^a MitoSciences Inc   (United States)

^b PFIZER INC   (United States)

Author keywords

Drug; HTS; Mitochondria; OXPHOS; Toxicity

Indexed keywords

AMIODARONE; BENOXAPROFEN; BEZAFIBRATE; CHLORPROMAZINE; CYTOCHROME C OXIDASE; DANTROLENE; DICLOFENAC; FLUCONAZOLE; GEFITINIB; LINEZOLID; METFORMIN; NEFAZODONE; PAROXETINE; PRAVASTATIN; PRIMAQUINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RADICICOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROSIGLITAZONE; SIMVASTATIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); TAMOXIFEN; TRAZODONE; TROVAFLOXACIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG IDENTIFICATION; DRUG INFORMATION; DRUG SCREENING; DRUG TARGETING; ENZYME IMMUNOASSAY; ENZYME INHIBITION; MITOCHONDRIAL TOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ENZYME INHIBITORS; IMMUNOCHEMISTRY; MITOCHONDRIA, HEART; OLIGOMYCINS; OXIDATIVE PHOSPHORYLATION; POTASSIUM CYANIDE; PROTON-TRANSLOCATING ATPASES; ROTENONE; SUCCINATE CYTOCHROME C OXIDOREDUCTASE; THENOYLTRIFLUOROACETONE; UNCOUPLING AGENTS;

EID: 34247096170     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.01.011     Document Type: Article

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