High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: New strategies in pharmacogenomics

Methods in Enzymology

Volumn 400, Issue , 2005, Pages 485-510

  Ishikawa, Toshihisa ^a   Sakurai, Aki ^a   Kanamori, Yoichi ^b   Nagakura, Makoto ^c   Hirano, Hiroyuki ^d   Takarada, Yutaka ^e   Yamada, Kazunari ^f   Fukushima, Kazuhisa ^g   Kitajima, Masato ^h  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Nosan Corporation   (Japan)

^c BioTec Co Ltd   (Japan)

^d GS PlatZ Co Ltd   (Japan)

^e TOYOBO CO LTD   (Japan)

^f NGK INSULATORS LTD   (Japan)

^g YOKOGAWA ELECTRIC CORPORATION   (Japan)

^h FUJITSU LABORATORIES LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ACEMETACIN; BEPRIDIL; BREAST CANCER RESISTANCE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CORTISONE; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; EPIRIZOLE; ETOPOSIDE; FENDILINE; FLUOROURACIL; HISTAMINE; IBUPROFEN; INDOMETACIN; MELATONIN; METHOTREXATE; NAPROXEN; NICARDIPINE; NICORANDIL; NORADRENALIN; PACLITAXEL; PINACIDIL; PRENYLAMINE; QUINIDINE; TACROLIMUS; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG TRANSPORT; GENETIC POLYMORPHISM; HUMAN; MEMBRANE VESICLE; PHARMACOGENOMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 28244477160     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)00027-3     Document Type: Review

References (39)

1. Allikmets R., Schriml L.M., Hutchinson A., Romano-Spica V., and Dean M. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance Cancer Res. 58 1998 5337 5339
2. Ambudkar S.V., Dey S., Hrycyna C.A., Ramachandra M., Pastan I., and Gottesman M.M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter Annu. Rev. Pharmacol. Toxicol. 39 1999 361 398
3. Bailey-Dell K.J., Hassel B., Doyle L.A., and Ross D.D. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene Biochim. Biophys. Acta. 1520 2001 234 241
4. Borst P., and Elferink R.O. Mammalian ABC transporters in health and disease Annu. Rev. Biochem. 71 2002 537 592
5. Carter S.G., and Karl D.W. Inorganic phosphate assay with malachite green: An improvement and evaluation J. Biochem. Biophys. Methods 7 1982 7 13
6. Cervenak J., Andrikovics H., Özvegy-Laczka C., Tordai A., Német K., Vásadi A., and Sarkadi B. The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology Cancer Lett 2005
7. Dean M., Rzhetsky A., and Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily Genome Res. 11 2001 1156 1166
8. Doyle L.A., Yang W., Abruzzo L.V., Krogmann T., Gao Y., Rishi A.K., and Ross D.D. A multidrug resistance transporter from human MCF-7 breast cancer cells Proc. Natl. Acad. Sci. USA 95 1998 15665 15670
9. Garrigues A., Nugier J., Orlowski S., and Ezan E. A high-throughput screening microplate test for the interaction of drugs with P-glycoprotein Anal. Biochem. 305 2002 106 114
10. Holland I.B., Cole S.P.C., Kuchler K., and Higgins C.F. "ABC Proteins: From Bacteria to Man." 2003 Academic Press Amsterdam
11. Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M., and Bates S.E. Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1) Cancer Biol. Ther. 1 2002 696 702
12. Imai Y., Nakane M., Kage K., Tsukahara S., Ishikawa E., Tsuruo T., Miki Y., and Sugimoto Y. C421A polymorphism in human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance Mol. Cancer Ther. 1 2002 611 616
13. 2+-dependent cardiac transport system for glutathione S-conjugates: A study using rat heart sarcolemma vesicles J. Biol. Chem. 264 1989 17343 17348
14. Ishikawa T. The ATP-dependent glutathione S-conjugate export pump Trends Biochem. Sci. 17 1992 433 468
15. Ishikawa T. Multidrug resistance: Genomics of ABC transporters D.N. Cooper "Nature Encyclopedia of the Human Genome" Vol. 4 2003 Nature Publishing Group London 154 160
16. Ishikawa T., Kasamtsu S., Hagiwara Y., Mitomo H., Kato R., and Sumino Y. Expression and functional characterization of human ABC transporter ABCG2 variants in insect cells Drug Metab. Pharamcokin. 18 2003 194 202
17. Ishikawa T., Müller M., Klünemann C., Schaub T., and Keppler D. ATP-dependent primary active transport of cysteinyl leukotrienes across rat liver canalicular membrane: The role of glutathione S-conjugate carrier J. Biol. Chem. 265 1990 19279 19286
18. Ishikawa T., Onishi Y., Hirano H., Oosumi K., Nagakura M., and Tarui S. Pharmacogenomics of drug transporters: A new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1) Bio. Pharm. Bull. 27 2004 939 948
19. Ishikawa T., Tsuji A., Inui K., Sai Y., Anzai N., Wada M., Endou H., and Sumino Y. The genetic polymorphism of drug transporters: Functional analysis approaches Pharmacogenomics 5 2004 67 99
20. Jonker J.W., Buitelaar M., Wagenaar E., Van der Valk M.A., Scheffer G.L., Scheper R.J., Plosch T., Kuipers F., Elferink R.P., Rosing H., Beijinen J.H., and Schinkel A.H. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria Proc. Natl. Acad. Sci. USA 99 2002 15649 15654
21. Kalow W., Meyer U.A., and Tyndale R.F. "Pharmacogenomics." 2001 Dekker New York
22. Keppler D., Jedlitschky G.., and Leier I. Transport function and substrate specificity of multidrug resistance protein Methods Enzymol. 292 1998 607 616
23. Kerb R., Hoffmeyer S., and Brinkmann U. ABC drug transporters: Hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2 Pharmacogenomics 2 2001 51 64
24. Klein I., Sarkadi B., and Váradi A. An inventory of the human ABC proteins Biochim. Biophys. Acta 1461 1999 237 262
25. Ling V. Multidrug resistance: Molecular mechanisms and clinical relevance Cancer Chemother. Pharmacol. 40 1997 S3 S8
26. Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A., Pijnenborg A.C., Schinkel A.H., van De Vijver M.J., Scheper R.J., and Schellens J.H. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues Cancer Res. 61 2001 3458 3464
27. Mitomo H., Kato R., Ito A., Kasamatsu S., Ikegami Y., Kii I., Kudo A., Kobatake E., Sumino Y., and Ishikawa T. A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: Critical role of Arg-482 in methotrexate transport Biochem. J. 373 2003 767 774
28. Miyake K., Mickley L., Litman T., Zhan Z., Robey R., Cristensen B., Brangi M., Greenberger L., Dean M., Fojo T., and Bates S.E. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes Cancer Res. 59 1999 8 13
29. Nakatomi K., Yoshikawa M., Oka M., Ikegami Y., Hayasaka S., Sano K., Shiozawa K., Kawabata S., Soda H., Ishikawa T., Tanabe S., and Kohno S. Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells Biochem. Biophys. Res. Commun. 288 2001 827 832
30. Onishi Y., Hirano H., Nakata K., Oosumi K., Nagakura M., Tarui S., and Ishikawa T. High-speed screening and structure-activity relationship analysis for the substrate specificity of P-glycoprotein (ABCB1) Chem.-Biol. Inform. J. 3 2003 175 193
31. O'Reilly D.R., Miller L.K., and Luckow V.A. "Baculovirus Expression Vectors, a Laboratory Manual." 1994 Oxford Univ. Press New York
32. Sarkadi B., Price E.M., Boucher R.C., Germann U.A., and Scarborough G.A. Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase J. Biol. Chem. 267 1992 4854 4858
33. Sauna Z.E., and Ambudkar S.V. Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein Proc. Natl. Acad. Sci. USA 97 2000 2515 2520
34. Schinkel A.H., and Jonker J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview Adv. Drug Deliv. Rev. 55 2003 3 29
35. Senior A.E., Al-Shawi M.K., and Urbatsch I.L. The catalytic cycle of P-glycoprotein FEBS Lett. 377 1995 285 289
36. Sparreboom A., Danesi R., and Ando Y. Pharmacogenomics of ABC transporters and its role in cancer chemotherapy Drug Resistance Update 6 2003 71 84
37. Summers M.D., and Smith G.E. A manual of methods for baculovirus vectors and insect cell culture procedures Texas Agric. Exp. Stat. Bull. 1555 1987 1 57
38. Yoshikawa M., Ikegami Y., Sano K., Yoshida H., Mitomo H., Sawada S., and Ishikawa T. Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid J. Exp. Ther. Oncol. 4 2004 25 35
39. Zhou S., Schuetz J.D., Bunting K.D., Colapietro A.M., Sampath J., Morris J.J., Lagutina I., Grosveld G.C., Osawa M., Nakauchi H., and Sorrentino B.P. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Nat. Med. 7 2001 1028 1034