Quantitative structure-activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1)

Biochemistry

Volumn 46, Issue 26, 2007, Pages 7678-7693

  Sakurai, Aki ^a   Onishi, Yuko ^a   Hirano, Hiroyuki ^a   Seigneuret, Michel ^b   Obanayama, Kazuya ^a   Kim, Gunwoo ^a   Ei, Leen Liew ^a   Sakaeda, Toshiyuki ^c   Yoshiura, Koh Ichiro ^d,e   Niikawa, Norio ^d,e   Sakurai, Minora ^a   Ishikawa, Toshihisa ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b INSTITUT COCHIN   (France)

^c KYOTO UNIVERSITY   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; COMPUTER SIMULATION; DATA ACQUISITION; MOLECULAR DYNAMICS; POLYMORPHISM;

INTRACELLULAR LOOP; KINETIC PROPERTIES; TRANSMEMBRANE;

GLYCOPROTEINS;

ADENOSINE TRIPHOSPHATASE; GLYCOPROTEIN P; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DNA POLYMORPHISM; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE EXPRESSION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; KINETICS; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; THREE DIMENSIONAL IMAGING;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; GENE FREQUENCY; HUMANS; KINETICS; NICARDIPINE; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SEQUENCE HOMOLOGY, AMINO ACID; SPODOPTERA; SUBSTRATE SPECIFICITY; VERAPAMIL;

EID: 34347363131     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700330b     Document Type: Article

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