Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Cell

Volumn 77, Issue 4, 1994, Pages 491-502

  Schinkel, A H ^a   Smit, J J M ^a   van Tellingen, O ^a   Beijnen, J H ^a   Wagenaar, E ^a   van Deemter, L ^a   Mol, C A A M ^a   van der Valk, M A ^b   Robanus Maandag, E C ^b   te Riele, H P J ^b   Berns, A J M ^b   Borst, P ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLYCOPROTEIN P; IVERMECTIN; RNA; VINBLASTINE SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG SENSITIVITY; DRUG TISSUE LEVEL; FEMALE; GENE DISRUPTION; GENE STRUCTURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BLOOD-BRAIN BARRIER; CAPILLARIES; CARRIER PROTEINS; DRUG RESISTANCE; EPITHELIAL CELLS; FEMALE; INTESTINE, SMALL; IVERMECTIN; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; P-GLYCOPROTEIN; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION; VINBLASTINE;

ANIMALIA;

EID: 0028229150     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90212-7     Document Type: Article

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