-
1
-
-
15244350902
-
Targeting the gatekeeper residue in phosphoinositide 3-kinases
-
Alaimo P.J., Knight Z.A., and Shokat K.M. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg. Med. Chem. 13 (2005) 2825-2836
-
(2005)
Bioorg. Med. Chem.
, vol.13
, pp. 2825-2836
-
-
Alaimo, P.J.1
Knight, Z.A.2
Shokat, K.M.3
-
2
-
-
0037459344
-
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
-
Azam M., Latek R.R., and Daley G.Q. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112 (2003) 831-843
-
(2003)
Cell
, vol.112
, pp. 831-843
-
-
Azam, M.1
Latek, R.R.2
Daley, G.Q.3
-
3
-
-
38949113725
-
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling
-
Balla A., Tuymetova G., Toth B., Szentpetery Z., Zhao X., Knight Z.A., Shokat K., Steinbach P.J., and Balla T. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry 47 (2008) 1599-1607
-
(2008)
Biochemistry
, vol.47
, pp. 1599-1607
-
-
Balla, A.1
Tuymetova, G.2
Toth, B.3
Szentpetery, Z.4
Zhao, X.5
Knight, Z.A.6
Shokat, K.7
Steinbach, P.J.8
Balla, T.9
-
4
-
-
0034699382
-
A chemical switch for inhibitor-sensitive alleles of any protein kinase
-
Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 (2000) 395-401
-
(2000)
Nature
, vol.407
, pp. 395-401
-
-
Bishop, A.C.1
Ubersax, J.A.2
Petsch, D.T.3
Matheos, D.P.4
Gray, N.S.5
Blethrow, J.6
Shimizu, E.7
Tsien, J.Z.8
Schultz, P.G.9
Rose, M.D.10
-
5
-
-
0035282974
-
Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles
-
Boschelli D.H., Wang Y.D., Ye F., Wu B., Zhang N., Dutia M., Powell D.W., Wissner A., Arndt K., Weber J.M., and Boschelli F. Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles. J. Med. Chem. 44 (2001) 822-833
-
(2001)
J. Med. Chem.
, vol.44
, pp. 822-833
-
-
Boschelli, D.H.1
Wang, Y.D.2
Ye, F.3
Wu, B.4
Zhang, N.5
Dutia, M.6
Powell, D.W.7
Wissner, A.8
Arndt, K.9
Weber, J.M.10
Boschelli, F.11
-
6
-
-
24944591333
-
Multi-kinase inhibitors create buzz at ASCO
-
Branca M.A. Multi-kinase inhibitors create buzz at ASCO. Nat. Biotechnol. 23 (2005) 639
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 639
-
-
Branca, M.A.1
-
7
-
-
34547574720
-
A new mutational AKTivation in the PI3K pathway
-
Brugge J., Hung M.C., and Mills G.B. A new mutational AKTivation in the PI3K pathway. Cancer Cell 12 (2007) 104-107
-
(2007)
Cancer Cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
Mills, G.B.3
-
8
-
-
0023353733
-
Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells
-
Brugge J.S., Jarosik G., Andersen J., Queral-Lustig A., Fedor-Chaiken M., and Broach J.R. Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells. Mol. Cell. Biol. 7 (1987) 2180-2187
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 2180-2187
-
-
Brugge, J.S.1
Jarosik, G.2
Andersen, J.3
Queral-Lustig, A.4
Fedor-Chaiken, M.5
Broach, J.R.6
-
9
-
-
0029831167
-
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
-
Brunn G.J., Williams J., Sabers C., Wiederrecht G., Lawrence Jr. J.C., and Abraham R.T. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15 (1996) 5256-5267
-
(1996)
EMBO J.
, vol.15
, pp. 5256-5267
-
-
Brunn, G.J.1
Williams, J.2
Sabers, C.3
Wiederrecht, G.4
Lawrence Jr., J.C.5
Abraham, R.T.6
-
10
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
11
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter T.A., Wodicka L.M., Shah N.P., Velasco A.M., Fabian M.A., Treiber D.K., Milanov Z.V., Atteridge C.E., Biggs III W.H., Edeen P.T., et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc. Natl. Acad. Sci. USA 102 (2005) 11011-11016
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
Velasco, A.M.4
Fabian, M.A.5
Treiber, D.K.6
Milanov, Z.V.7
Atteridge, C.E.8
Biggs III, W.H.9
Edeen, P.T.10
-
12
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
Chang H.W., Aoki M., Fruman D., Auger K.R., Bellacosa A., Tsichlis P.N., Cantley L.C., Roberts T.M., and Vogt P.K. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276 (1997) 1848-1850
-
(1997)
Science
, vol.276
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
Auger, K.R.4
Bellacosa, A.5
Tsichlis, P.N.6
Cantley, L.C.7
Roberts, T.M.8
Vogt, P.K.9
-
13
-
-
34247174760
-
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis
-
Cosker K.E., and Eickholt B.J. Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis. Biochem. Soc. Trans. 35 (2007) 207-210
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 207-210
-
-
Cosker, K.E.1
Eickholt, B.J.2
-
14
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M., You H., Levine A.J., and Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6 (2006) 184-192
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
15
-
-
0030783253
-
STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae
-
Cutler N.S., Heitman J., and Cardenas M.E. STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. J. Biol. Chem. 272 (1997) 27671-27677
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27671-27677
-
-
Cutler, N.S.1
Heitman, J.2
Cardenas, M.E.3
-
16
-
-
10444280878
-
Strategies to overcome resistance to targeted protein kinase inhibitors
-
Daub H., Specht K., and Ullrich A. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat. Rev. Drug Discov. 3 (2004) 1001-1010
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 1001-1010
-
-
Daub, H.1
Specht, K.2
Ullrich, A.3
-
17
-
-
0037603113
-
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
-
Debnath J., Muthuswamy S.K., and Brugge J.S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30 (2003) 256-268
-
(2003)
Methods
, vol.30
, pp. 256-268
-
-
Debnath, J.1
Muthuswamy, S.K.2
Brugge, J.S.3
-
18
-
-
33749435816
-
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
-
Engelman J.A., Mukohara T., Zejnullahu K., Lifshits E., Borras A.M., Gale C.M., Naumov G.N., Yeap B.Y., Jarrell E., Sun J., et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J. Clin. Invest. 116 (2006) 2695-2706
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2695-2706
-
-
Engelman, J.A.1
Mukohara, T.2
Zejnullahu, K.3
Lifshits, E.4
Borras, A.M.5
Gale, C.M.6
Naumov, G.N.7
Yeap, B.Y.8
Jarrell, E.9
Sun, J.10
-
19
-
-
33646382364
-
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
-
Fan Q.W., Knight Z.A., Goldenberg D.D., Yu W., Mostov K.E., Stokoe D., Shokat K.M., and Weiss W.A. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9 (2006) 341-349
-
(2006)
Cancer Cell
, vol.9
, pp. 341-349
-
-
Fan, Q.W.1
Knight, Z.A.2
Goldenberg, D.D.3
Yu, W.4
Mostov, K.E.5
Stokoe, D.6
Shokat, K.M.7
Weiss, W.A.8
-
21
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N., and Sawyers C.L. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293 (2001) 876-880
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Rao, P.N.6
Sawyers, C.L.7
-
22
-
-
0032563315
-
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
-
Gray N.S., Wodicka L., Thunnissen A.M., Norman T.C., Kwon S., Espinoza F.H., Morgan D.O., Barnes G., LeClerc S., Meijer L., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 (1998) 533-538
-
(1998)
Science
, vol.281
, pp. 533-538
-
-
Gray, N.S.1
Wodicka, L.2
Thunnissen, A.M.3
Norman, T.C.4
Kwon, S.5
Espinoza, F.H.6
Morgan, D.O.7
Barnes, G.8
LeClerc, S.9
Meijer, L.10
-
23
-
-
34249026448
-
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
-
Gupta S., Ramjaun A.R., Haiko P., Wang Y., Warne P.H., Nicke B., Nye E., Stamp G., Alitalo K., and Downward J. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129 (2007) 957-968
-
(2007)
Cell
, vol.129
, pp. 957-968
-
-
Gupta, S.1
Ramjaun, A.R.2
Haiko, P.3
Wang, Y.4
Warne, P.H.5
Nicke, B.6
Nye, E.7
Stamp, G.8
Alitalo, K.9
Downward, J.10
-
24
-
-
34247105759
-
PI3K signalling during influenza A virus infections
-
Hale B.G., and Randall R.E. PI3K signalling during influenza A virus infections. Biochem. Soc. Trans. 35 (2007) 186-187
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 186-187
-
-
Hale, B.G.1
Randall, R.E.2
-
25
-
-
33750953816
-
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors
-
Hayakawa M., Kaizawa H., Kawaguchi K., Ishikawa N., Koizumi T., Ohishi T., Yamano M., Okada M., Ohta M., Tsukamoto S., et al. Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors. Bioorg. Med. Chem. 15 (2007) 403-412
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 403-412
-
-
Hayakawa, M.1
Kaizawa, H.2
Kawaguchi, K.3
Ishikawa, N.4
Koizumi, T.5
Ohishi, T.6
Yamano, M.7
Okada, M.8
Ohta, M.9
Tsukamoto, S.10
-
26
-
-
33947730475
-
Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors
-
Hayakawa M., Kaizawa H., Moritomo H., Koizumi T., Ohishi T., Yamano M., Okada M., Ohta M., Tsukamoto S., Raynaud F.I., et al. Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors. Bioorg. Med. Chem. Lett. 17 (2007) 2438-2442
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 2438-2442
-
-
Hayakawa, M.1
Kaizawa, H.2
Moritomo, H.3
Koizumi, T.4
Ohishi, T.5
Yamano, M.6
Okada, M.7
Ohta, M.8
Tsukamoto, S.9
Raynaud, F.I.10
-
27
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy B.T., Smith D.L., Ram P.T., Lu Y., and Mills G.B. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4 (2005) 988-1004
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
28
-
-
37249056471
-
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
-
Huang C.H., Mandelker D., Schmidt-Kittler O., Samuels Y., Velculescu V.E., Kinzler K.W., Vogelstein B., Gabelli S.B., and Amzel L.M. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 318 (2007) 1744-1748
-
(2007)
Science
, vol.318
, pp. 1744-1748
-
-
Huang, C.H.1
Mandelker, D.2
Schmidt-Kittler, O.3
Samuels, Y.4
Velculescu, V.E.5
Kinzler, K.W.6
Vogelstein, B.7
Gabelli, S.B.8
Amzel, L.M.9
-
29
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
Ikenoue T., Kanai F., Hikiba Y., Obata T., Tanaka Y., Imamura J., Ohta M., Jazag A., Guleng B., Tateishi K., et al. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res. 65 (2005) 4562-4567
-
(2005)
Cancer Res.
, vol.65
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
Obata, T.4
Tanaka, Y.5
Imamura, J.6
Ohta, M.7
Jazag, A.8
Guleng, B.9
Tateishi, K.10
-
30
-
-
28244479028
-
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
-
Isakoff S.J., Engelman J.A., Irie H.Y., Luo J., Brachmann S.M., Pearline R.V., Cantley L.C., and Brugge J.S. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 65 (2005) 10992-11000
-
(2005)
Cancer Res.
, vol.65
, pp. 10992-11000
-
-
Isakoff, S.J.1
Engelman, J.A.2
Irie, H.Y.3
Luo, J.4
Brachmann, S.M.5
Pearline, R.V.6
Cantley, L.C.7
Brugge, J.S.8
-
31
-
-
33746232407
-
Multitargeted therapy: can promiscuity be praised in an era of political correctness?
-
Jimeno A., and Hidalgo M. Multitargeted therapy: can promiscuity be praised in an era of political correctness?. Crit. Rev. Oncol. Hematol. 59 (2006) 150-158
-
(2006)
Crit. Rev. Oncol. Hematol.
, vol.59
, pp. 150-158
-
-
Jimeno, A.1
Hidalgo, M.2
-
32
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
Kang S., Bader A.G., and Vogt P.K. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc. Natl. Acad. Sci. USA 102 (2005) 802-807
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
33
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight Z.A., Gonzalez B., Feldman M.E., Zunder E.R., Goldenberg D.D., Williams O., Loewith R., Stokoe D., Balla A., Toth B., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125 (2006) 733-747
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
Loewith, R.7
Stokoe, D.8
Balla, A.9
Toth, B.10
-
34
-
-
38449095987
-
A membrane capture assay for lipid kinase activity
-
Knight Z.A., Feldman M.E., Balla A., Balla T., and Shokat K.M. A membrane capture assay for lipid kinase activity. Nat. Protoc. 2 (2007) 2459-2466
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2459-2466
-
-
Knight, Z.A.1
Feldman, M.E.2
Balla, A.3
Balla, T.4
Shokat, K.M.5
-
35
-
-
33646142995
-
Pten regulates neuronal arborization and social interaction in mice
-
Kwon C.H., Luikart B.W., Powell C.M., Zhou J., Matheny S.A., Zhang W., Li Y., Baker S.J., and Parada L.F. Pten regulates neuronal arborization and social interaction in mice. Neuron 50 (2006) 377-388
-
(2006)
Neuron
, vol.50
, pp. 377-388
-
-
Kwon, C.H.1
Luikart, B.W.2
Powell, C.M.3
Zhou, J.4
Matheny, S.A.5
Zhang, W.6
Li, Y.7
Baker, S.J.8
Parada, L.F.9
-
36
-
-
27644556527
-
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance
-
Lim K.H., and Counter C.M. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell 8 (2005) 381-392
-
(2005)
Cancer Cell
, vol.8
, pp. 381-392
-
-
Lim, K.H.1
Counter, C.M.2
-
37
-
-
0031709073
-
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src
-
Liu Y., Shah K., Yang F., Witucki L., and Shokat K.M. A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorg. Med. Chem. 6 (1998) 1219-1226
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1219-1226
-
-
Liu, Y.1
Shah, K.2
Yang, F.3
Witucki, L.4
Shokat, K.M.5
-
38
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
-
Luo J., Manning B.D., and Cantley L.C. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4 (2003) 257-262
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
39
-
-
0034254368
-
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance
-
Mahon F.X., Deininger M.W., Schultheis B., Chabrol J., Reiffers J., Goldman J.M., and Melo J.V. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 96 (2000) 1070-1079
-
(2000)
Blood
, vol.96
, pp. 1070-1079
-
-
Mahon, F.X.1
Deininger, M.W.2
Schultheis, B.3
Chabrol, J.4
Reiffers, J.5
Goldman, J.M.6
Melo, J.V.7
-
41
-
-
0034194152
-
Phosphoinositide signaling and the regulation of membrane trafficking in yeast
-
Odorizzi G., Babst M., and Emr S.D. Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem. Sci. 25 (2000) 229-235
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 229-235
-
-
Odorizzi, G.1
Babst, M.2
Emr, S.D.3
-
42
-
-
9144239955
-
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
-
Paling N.R., Wheadon H., Bone H.K., and Welham M.J. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem. 279 (2004) 48063-48070
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48063-48070
-
-
Paling, N.R.1
Wheadon, H.2
Bone, H.K.3
Welham, M.J.4
-
44
-
-
34250823572
-
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
-
Raynaud F.I., Eccles S., Clarke P.A., Hayes A., Nutley B., Alix S., Henley A., Di-Stefano F., Ahmad Z., Guillard S., et al. Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res. 67 (2007) 5840-5850
-
(2007)
Cancer Res.
, vol.67
, pp. 5840-5850
-
-
Raynaud, F.I.1
Eccles, S.2
Clarke, P.A.3
Hayes, A.4
Nutley, B.5
Alix, S.6
Henley, A.7
Di-Stefano, F.8
Ahmad, Z.9
Guillard, S.10
-
45
-
-
0035986856
-
Functions of PI 3-kinase in development of the nervous system
-
Rodgers E.E., and Theibert A.B. Functions of PI 3-kinase in development of the nervous system. Int. J. Dev. Neurosci. 20 (2002) 187-197
-
(2002)
Int. J. Dev. Neurosci.
, vol.20
, pp. 187-197
-
-
Rodgers, E.E.1
Theibert, A.B.2
-
46
-
-
25144492129
-
Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast
-
Rodriguez-Escudero I., Roelants F.M., Thorner J., Nombela C., Molina M., and Cid V.J. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem. J. 390 (2005) 613-623
-
(2005)
Biochem. J.
, vol.390
, pp. 613-623
-
-
Rodriguez-Escudero, I.1
Roelants, F.M.2
Thorner, J.3
Nombela, C.4
Molina, M.5
Cid, V.J.6
-
47
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y., Wang Z., Bardelli A., Silliman N., Ptak J., Szabo S., Yan H., Gazdar A., Powell S.M., Riggins G.J., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 (2004) 554
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
-
48
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels Y., Diaz Jr. L.A., Schmidt-Kittler O., Cummins J.M., Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7 (2005) 561-573
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
-
49
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
50
-
-
0345688603
-
Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias
-
Shah N.P., and Sawyers C.L. Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias. Oncogene 22 (2003) 7389-7395
-
(2003)
Oncogene
, vol.22
, pp. 7389-7395
-
-
Shah, N.P.1
Sawyers, C.L.2
-
51
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah N.P., Nicoll J.M., Nagar B., Gorre M.E., Paquette R.L., Kuriyan J., and Sawyers C.L. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2 (2002) 117-125
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Sawyers, C.L.7
-
52
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah N.P., Tran C., Lee F.Y., Chen P., Norris D., and Sawyers C.L. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305 (2004) 399-401
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
53
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw R.J., and Cantley L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441 (2006) 424-430
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
54
-
-
38849180154
-
Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway
-
Stauffer F., Maira S.M., Furet P., and Garcia-Echeverria C. Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg. Med. Chem. Lett. 18 (2008) 1027-1030
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 1027-1030
-
-
Stauffer, F.1
Maira, S.M.2
Furet, P.3
Garcia-Echeverria, C.4
-
56
-
-
0035189738
-
A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays
-
Tugendreich S., Perkins E., Couto J., Barthmaier P., Sun D., Tang S., Tulac S., Nguyen A., Yeh E., Mays A., et al. A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays. Genome Res. 11 (2001) 1899-1912
-
(2001)
Genome Res.
, vol.11
, pp. 1899-1912
-
-
Tugendreich, S.1
Perkins, E.2
Couto, J.3
Barthmaier, P.4
Sun, D.5
Tang, S.6
Tulac, S.7
Nguyen, A.8
Yeh, E.9
Mays, A.10
-
57
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos C.J., Matter W.F., Hui K.Y., and Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269 (1994) 5241-5248
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
58
-
-
20844448211
-
A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor
-
von Bubnoff N., Veach D.R., van der Kuip H., Aulitzky W.E., Sanger J., Seipel P., Bornmann W.G., Peschel C., Clarkson B., and Duyster J. A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood 105 (2005) 1652-1659
-
(2005)
Blood
, vol.105
, pp. 1652-1659
-
-
von Bubnoff, N.1
Veach, D.R.2
van der Kuip, H.3
Aulitzky, W.E.4
Sanger, J.5
Seipel, P.6
Bornmann, W.G.7
Peschel, C.8
Clarkson, B.9
Duyster, J.10
-
59
-
-
0033581886
-
Structural insights into phosphoinositide 3-kinase catalysis and signalling
-
Walker E.H., Perisic O., Ried C., Stephens L., and Williams R.L. Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402 (1999) 313-320
-
(1999)
Nature
, vol.402
, pp. 313-320
-
-
Walker, E.H.1
Perisic, O.2
Ried, C.3
Stephens, L.4
Williams, R.L.5
-
60
-
-
0041802784
-
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
-
Ward S.G., and Finan P. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents. Curr. Opin. Pharmacol. 3 (2003) 426-434
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 426-434
-
-
Ward, S.G.1
Finan, P.2
-
61
-
-
29444449785
-
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
-
Zhao J.J., Liu Z., Wang L., Shin E., Loda M.F., and Roberts T.M. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc. Natl. Acad. Sci. USA 102 (2005) 18443-18448
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18443-18448
-
-
Zhao, J.J.1
Liu, Z.2
Wang, L.3
Shin, E.4
Loda, M.F.5
Roberts, T.M.6
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