A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor

Blood

Volumn 105, Issue 4, 2005, Pages 1652-1659

  Von Bubnoff, Nikolas ^c   Veach, Darren R ^c   Van Der Kuip, Heiko ^c   Aulitzky, Walter E ^c   Sänger, Jana ^c   Seipel, Petra ^c   Bornmann, William G ^c   Peschel, Christian ^c   Clarkson, Bayard ^b   Duyster, Justus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,6 DICHLOROPHENYL) 2 [3 (HYDROXYMETHYL)ANILINO] 8 METHYLPYRIDO[2,3 D]PYRIMIDIN 7(8H) ONE; ABELSON KINASE; ABELSON KINASE INHIBITOR; BCR ABL PROTEIN; IMATINIB; PROTEIN KINASE INHIBITOR; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; GENE MUTATION; HUMAN; IC 50; LEUKEMIA; MOUSE; NONHUMAN; PHILADELPHIA CHROMOSOME POSITIVE CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SCREENING;

EID: 20844448211     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-06-2445     Document Type: Article

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