-
1
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu
-
Katso, R. et aL Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biot. 17, 615-675 (2001).
-
(2001)
Rev. Cell Dev. Biot
, vol.17
, pp. 615-675
-
-
Katso, R.1
-
2
-
-
0032577699
-
Thetumorsuppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
-
Maehama, T. & Dixon, J.E. Thetumorsuppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 273, 13375-13378 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
3
-
-
34249026448
-
Binding ofras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
-
Gupta, S. et al. Binding ofras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129, 957-968 (2007).
-
(2007)
Cell
, vol.129
, pp. 957-968
-
-
Gupta, S.1
-
4
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodriguez-Viciana, P. et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457-467 (1997).
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
-
5
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana, P. et aL. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532 (1994).
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
-
6
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels, Y. et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004).
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
-
7
-
-
33344462540
-
Mutation of the PIK3CA oncogene in human cancers
-
Karakas, B., Bachman, K.E. & Park, B.H. Mutation of the PIK3CA oncogene in human cancers. Br. J. Cancer 94, 455-459 (2006).
-
(2006)
Br. J. Cancer
, vol.94
, pp. 455-459
-
-
Karakas, B.1
Bachman, K.E.2
Park, B.H.3
-
8
-
-
33745888913
-
PTEN function in normal and neoplastic growth
-
Chow, L.M. & Baker, S.J. PTEN function in normal and neoplastic growth. Cancer Lett. 241, 184-196 (2006).
-
(2006)
Cancer Lett
, vol.241
, pp. 184-196
-
-
Chow, L.M.1
Baker, S.J.2
-
9
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated inhuman brain, breast, and prostate cancer
-
Li, J. et al. PTEN, a putative protein tyrosine phosphatase gene mutated inhuman brain, breast, and prostate cancer. Science 275, 1943-1947 (1997).
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
-
10
-
-
0037047590
-
Impaired B and Tcellantigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug, K. et al. Impaired B and Tcellantigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297, 1031-1034 (2002).
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
-
11
-
-
7244232917
-
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
-
Ali, K. et aL. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 431, 1007-1011 (2004).
-
(2004)
Nature
, vol.431
, pp. 1007-1011
-
-
Ali, K.1
-
12
-
-
0037323892
-
Phosphoinositide 3-kinase gamma: A key modulator in inflammation and allergy. Biochem. Soc
-
Wymann, M.P. et al. Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. Biochem. Soc. Trans. 31, 275-280 (2003).
-
(2003)
Trans
, vol.31
, pp. 275-280
-
-
Wymann, M.P.1
-
13
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch, E. et al. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287, 1049-1053 (2000).
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
-
14
-
-
84984757784
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps, M. et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11, 924-955 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 924-955
-
-
Camps, M.1
-
15
-
-
24744449495
-
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
Barber, D.F. et al. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. 11, 933-935 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 933-935
-
-
Barber, D.F.1
-
16
-
-
34247163550
-
Chemically targeting the PI3K family
-
Knight, Z.A. & Shokat, K.M. Chemically targeting the PI3K family. Biochem. Soc. Trans. 35, 245-249 (2007).
-
(2007)
Biochem. Soc. Trans
, vol.35
, pp. 245-249
-
-
Knight, Z.A.1
Shokat, K.M.2
-
17
-
-
0037442448
-
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
-
Gray, A., Olsson, H., Batty, I.H., Priganica, L. & Peter Downes, C. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. AnaL. Biochem. 313, 234-245 (2003).
-
(2003)
Anal. Biochem
, vol.313
, pp. 234-245
-
-
Gray, A.1
Olsson, H.2
Batty, I.H.3
Priganica, L.4
Peter Downes, C.5
-
18
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight, Z.A. et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. CeLL 125, 733-747 (2006).
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
-
19
-
-
3843135141
-
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
-
Knight, Z.A. et al. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg. Med. Chem. 12, 4749-4759 (2004).
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 4749-4759
-
-
Knight, Z.A.1
-
20
-
-
0030802292
-
Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases
-
Balla, T. et al. Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases. J. BioL. Chem. 272, 18358-18366 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 18358-18366
-
-
Balla, T.1
-
21
-
-
0031054245
-
Cloning and characterization ofawortmannin-sensitive human phosphatidylinositol 4-kinase
-
Meyers, R. & Cantley, L.C. Cloning and characterization ofawortmannin-sensitive human phosphatidylinositol 4-kinase. J. BioL. Chem. 272, 4384-4390 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 4384-4390
-
-
Meyers, R.1
Cantley, L.C.2
-
22
-
-
0029954611
-
Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase
-
Nakagawa, T., Goto, K. & Kondo, H. Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase. Biochem. J. 320 (Part 2): 643-649 (1996).
-
(1996)
Biochem. J
, vol.320
, pp. 643-649
-
-
Nakagawa, T.1
Goto, K.2
Kondo, H.3
-
23
-
-
0029892506
-
Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase
-
Nakagawa, T., Goto, K. & Kondo, H. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. J. BioL. Chem. 271, 12088-12094 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 12088-12094
-
-
Nakagawa, T.1
Goto, K.2
Kondo, H.3
-
24
-
-
0032502721
-
Phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family
-
Ishihara, H. etai Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. BioL Chem. 273, 8741-8748 (1998).
-
(1998)
J. Biol Chem
, vol.273
, pp. 8741-8748
-
-
Ishihara, H.1
-
25
-
-
0029795811
-
Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase
-
Ishihara, H. et al. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J. BioL. Chem. 271, 23611-23614
-
J. Biol. Chem
, vol.271
, pp. 23611-23614
-
-
Ishihara, H.1
-
26
-
-
0030721527
-
A new pathway for synthesis of phosphatidylinositol-4, 5-bisphosphate
-
Rameh, L.E., Tolias, K.F., Duckworth, B.C. & Cantley, L.C. A new pathway for synthesis of phosphatidylinositol-4, 5-bisphosphate. Nature 390, 192-196
-
Nature
, vol.390
, pp. 192-196
-
-
Rameh, L.E.1
Tolias, K.F.2
Duckworth, B.C.3
Cantley, L.C.4
-
27
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
Carpenter, C.L. et aL. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biot. Chem. 265, 19704-19711 (1990).
-
(1990)
J. Biot. Chem
, vol.265
, pp. 19704-19711
-
-
Carpenter, C.L.1
-
28
-
-
24944497371
-
Features of selective kinase inhibitors
-
Knight, Z.A. & Shokat, K.M. Features of selective kinase inhibitors. Chem. BioL. 12, 621-637 (2005).
-
(2005)
Chem. Biol
, vol.12
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
29
-
-
0015861774
-
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
-
Cheng, Y. & Prusoff, W.H.: Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108 (1973).
-
(1973)
Biochem. Pharmacol
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
30
-
-
0028143584
-
Physiological concentrations of purines and pyrimidines
-
Traut, T.W.: Physiological concentrations of purines and pyrimidines. Mot. Celt. Biochem. 140, 1-22 (1994).
-
(1994)
Mot. Celt. Biochem
, vol.140
, pp. 1-22
-
-
Traut, T.W.1
-
31
-
-
0034730616
-
A novel method for measurement of submembrane ATP concentration
-
Gribble, F.M. et al. A novel method for measurement of submembrane ATP concentration. J. Biot. Chem. 275, 30046-30049 (2000).
-
(2000)
J. Biot. Chem
, vol.275
, pp. 30046-30049
-
-
Gribble, F.M.1
|