-
1
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science (Wash DC) 2002;296:1655-7.
-
(2002)
Science (Wash DC)
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
4
-
-
0036683691
-
Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases
-
Djordjevic S, Driscoll PC. Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases. Trends Biochem Sci 2002;27:426-32.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 426-432
-
-
Djordjevic, S.1
Driscoll, P.C.2
-
5
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (Lond) 1994;370:527-32.
-
(1994)
Nature (Lond)
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
-
6
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodriguez-Viciana P, Warne PH, Khwaja A, et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 1997;89:457-67.
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
-
7
-
-
18344380088
-
P53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas
-
Singh B, Reddy PG, Goberdhan A, et al. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev 2002;16:984-93.
-
(2002)
Genes Dev
, vol.16
, pp. 984-993
-
-
Singh, B.1
Reddy, P.G.2
Goberdhan, A.3
-
8
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
Chang HW, Aoki M, Fruman D, et al. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (Wash DC) 1997;276:1848-50.
-
(1997)
Science (Wash DC)
, vol.276
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
-
9
-
-
0031708412
-
Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
-
Klippel A, Escobedo MA, Wachowicz MS. et al. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol 1998;18:5699-711.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5699-5711
-
-
Klippel, A.1
Escobedo, M.A.2
Wachowicz, M.S.3
-
10
-
-
0032443803
-
The Akt kinase: Molecular determinants of oncogenicity
-
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK. The Akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci U S A 1998;95:14950-5.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14950-14955
-
-
Aoki, M.1
Batista, O.2
Bellacosa, A.3
Tsichlis, P.4
Vogt, P.K.5
-
11
-
-
0038168557
-
Differing roles of Akt and serum- And glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity
-
Sakoda H, Gotoh Y, Katagiri H, et al. Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 2003; 278:25802-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 25802-25807
-
-
Sakoda, H.1
Gotoh, Y.2
Katagiri, H.3
-
12
-
-
0035793086
-
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
-
Aoki M, Blazek E, Vogt PK. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc Natl Acad Sci U S A 2001;98: 136-41.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 136-141
-
-
Aoki, M.1
Blazek, E.2
Vogt, P.K.3
-
13
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I. Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
14
-
-
0142227019
-
Targeting the PI3K Akt pathway in human cancer: Rationale and promise
-
Luo J, Manning BD, Cantley LC. Targeting the PI3K Akt pathway in human cancer: rationale and promise. Cancer Cell 2003;4:257-62.
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
15
-
-
0035886016
-
The phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors
-
Philp AJ, Campbell IG, Leet C, et al. The phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors. Cancer Res 2001;61: 7426-9.
-
(2001)
Cancer Res
, vol.61
, pp. 7426-7429
-
-
Philp, A.J.1
Campbell, I.G.2
Leet, C.3
-
16
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999;21: 99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
-
17
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y. Wang Z, Bardelli A. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science (Wash DC) 2004;304:554.
-
(2004)
Science (Wash DC)
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
18
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell IG, Russell SE, Choong DYH, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004;64:7678-81.
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
-
19
-
-
2442660578
-
Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/ extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor κB pathway and cellular transformation
-
Ikenoue T, Hikiba Y, Kanai F, et al. Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/ extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor κB pathway and cellular transformation. Cancer Res 2004;64: 3428-35.
-
(2004)
Cancer Res
, vol.64
, pp. 3428-3435
-
-
Ikenoue, T.1
Hikiba, Y.2
Kanai, F.3
-
20
-
-
10744232660
-
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors
-
Ikenoue T, Hikiba Y, Kanai F, et al. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res 2003;63:8132-7.
-
(2003)
Cancer Res
, vol.63
, pp. 8132-8137
-
-
Ikenoue, T.1
Hikiba, Y.2
Kanai, F.3
-
21
-
-
0034928862
-
Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
-
McFall A, Ulku A, Lambert QT, Kusa A, Rogers-Graham K, Der CJ. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol 2001;21:5488-99.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5488-5499
-
-
McFall, A.1
Ulku, A.2
Lambert, Q.T.3
Kusa, A.4
Rogers-Graham, K.5
Der, C.J.6
-
22
-
-
0030860466
-
Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
-
Cheng JQ, Altomare DA, Klein MA, et al. Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 1997;14:2793-801.
-
(1997)
Oncogene
, vol.14
, pp. 2793-2801
-
-
Cheng, J.Q.1
Altomare, D.A.2
Klein, M.A.3
-
23
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
-
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J 1996;15:2442-51.
-
(1996)
EMBO J
, vol.15
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
Waterfield, M.D.4
Downward, J.5
-
24
-
-
0031887249
-
Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
-
Yu J, Zhang Y, McIlroy J, et al. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol Cell Biol 1998;18:1379-87.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1379-1387
-
-
Yu, J.1
Zhang, Y.2
McIlroy, J.3
-
25
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A 2005;102:802-7.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
26
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
27
-
-
1242307944
-
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
-
Khaleghpour K, Li Y, Banville D, Yu Z, Shen SH. Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 2004;25:241-8.
-
(2004)
Carcinogenesis
, vol.25
, pp. 241-248
-
-
Khaleghpour, K.1
Li, Y.2
Banville, D.3
Yu, Z.4
Shen, S.H.5
|