Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine β cells and pancreatic islets

American Journal of Transplantation

Volumn 3, Issue 10, 2003, Pages 1230-1241

  Zhang, Nan ^a   Schröppel, Bernd ^a   Chen, Dongmei ^a   Fu, Shuang ^a   Hudkins, Kelly L ^b   Zhang, Haojiang ^a   Murphy, Barbara M ^a   Sung, Randall S ^a   Bromberg, Jonathan S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Adenovirus; Chemokine; Islet; Transplantation

Indexed keywords

ADENOVIRUS VECTOR; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE TRANSFER; IMMUNE RESPONSE; IN SITU HYBRIDIZATION; INFLAMMATION; INSULIN RELEASE; ISOGRAFT; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL;

ADENOVIRIDAE; ANIMALS; CHEMOKINE CCL2; CHEMOKINES; DNA, COMPLEMENTARY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLUCOSE; IN SITU HYBRIDIZATION; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RANTES; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TIME FACTORS;

EID: 0141446327     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-6143.2003.00215.x     Document Type: Article

References (42)

1. Verma IM, Somia N. Gene therapy - promises, problems and prospects. Nature 1997; 389: 239-242.
2. Monahan PE, Samulski RJ. AAV vectors: is clinical success on the horizon? Gene Ther 2000; 7: 24-30.
3. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33-40.
4. Schnell MA, Zhang Y, Tazelaar J et al. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 2001; 3: 708-722.
5. Ruzek MC, Kavanagh BF, Scaria A, Richards SM, Garman RD. Adenoviral vectors stimulate murine natural killer cell responses and demonstrate antitumor activities in the absence of transgene expression. Mol Ther 2002; 2: 115-124.
6. Sung RS, Qin L, Bromberg JS. TNFα and IFNγ induced by innate anti-adenoviral immune responses inhibit adenovirus mediated transgene expression. Mol Ther 2001; 3: 757-767.
7. Zhang Y, Chirmule N, Gao GP et al. Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages. Mol Ther 2001; 3: 697-707.
8. Guidotti LG. Chisari FVNoncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001; 19: 65-91.
9. Schluger NW, Rom WN. Early responses to infection: chemokines as mediators of inflammation. Curr Opin Immunol 1997; 9: 504-508.
10. Segerer S, Cui Y, Hudkins KL et al. Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis. J Am Soc Nephrol 2000; 11: 2231-2242.
11. Piemonti L, Leone BE, Nano R et al. Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes 2002; 51: 55-65.
12. Saiura A, Kohro T, Yamamoto T et al. Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray. Transplantation 2002; 73: 1480-1486.
13. Luster AD. The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 2002; 14: 129-135.
14. Deng S, Ketchum RJ, Kucher T, Weber M, Naji A, Brayman KL. Primary nonfunction of islet xenografts in rat recipients results from non-T-cell-mediated immune responses. Transplant Proc 1997; 29: 1726-1727.
15. Kenmochi T, Miyamoto M, Mullen Y. Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin. Cell Transplant 1996; 5: 41-47.
16. Kaufman DB, Platt JL, Rabe FL, Dunn DL, Bach FH, Sutherland DE. Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med 1990; 172: 291-302.
17. Kaufman DB, Gores PF, Field MJ et al. Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass. Diabetes 1994; 43: 778-783.
18. Borgland SL, Bowen GP, Wong NC, Libermann TA, Muruve DA. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-B. J Virol 2000; 74: 3941-3947.
19. Muruve DA, Barnes MJ, Stillman IE, Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 1999; 10: 965-976.
20. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.
21. Segerer S, Cui Y, Eitner F et al. Expression of chemokines and chemokine receptors during human renal transplant rejection. Am J Kidney Dis 2001; 37: 518-531.
22. Wittwer CT, Ririe KM, Andrew RV, David DA, Gundry RA, Balis UJ. The LightCycler: a microvolume multisample fluorimeter with rapid temperature control. Biotechniques 1997; 22: 176-181.
23. Bowen GP, Borgland SL, Lam M, Libermann TA, Wong NCW, Muruve DA. Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-κB. Hum Gene Therapy 2002; 13: 367-379.
24. Andoh A, Takaya H, Saotome T et al. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 2000; 119: 211-219.
25. Sigalla J, David A, Anegon I et al. Adenovirus-mediated gene transfer into isolated mouse adult pancreatic islets: normal beta-cell function despite induction of an anti-adenovirus immune response. Hum Gene Ther 1997; 8: 1625-1634.
26. Barrou B, Bertry-Coussot L, Morin S et al. Prolonged islet allograft survival by adenovirus-mediated transfer of sICAM-1/Ig immunoadhensin gene. Hum Gene Ther 2002; 13: 1441-1450.
27. Giannoukakis N, Rudert WA, Robbins PD, Trucco M. Targeting autoimmune diabetes with gene therapy. Diabetes 1999; 48: 2107-2121.
28. Kapturczak MH, Flotte T, Atkinson MA. Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes. Curr Mol Med 2001; 1: 245-258.
29. Tibbles LA, Spurrell JCL, Bowen GP et al. Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10. J Virol 2002; 76: 1559-1568.
30. Zaiss AK, Liu Q, Bowen GP, Wang NCW, Bartlett JS, Muruve DA. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. J Virol 2002; 76: 4580-4590.
31. Frigerio S, Junt T, Lu B et al. B cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med 2002; 8: 1414-1420.
32. Cameron MJ, Arreaza GA, Grattan M et al. Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type i diabetes. J Immunol 2000; 165: 1102-1110.
33. Karpus WJ, Kennedy KJ. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis. J Leukocyte Biol 1997; 62: 681-687.
34. Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD. An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 1995; 155: 5003-5010.
35. Kunkel SL. Th1- and Th2-type cytokines regulate chemokine expression. Biol Signals 1996; 5: 197-202.
36. Lohmann T, Laue S, Nietzschmann U etal. Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes 2002; 51: 2474-2480.
37. Bottino R, Fernandez LA, Ricordi C et al. Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998; 47: 316-323.
38. Jansen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA. Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes 1994; 43: 667-675.
39. Bradley LM, Asensio VC, Schioetz LK et al. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 1999; 162: 2511-2520.
40. Wu Y, Prystowsky MB, Orlofsky A. Sustained high-level production of murine chemokine C10 during chronic inflammation. Cytokine 1999; 11: 523-530.
41. Mattsson G, Jansson L, Carlsson PO. Decreased vascular density in mouse pancreatic islets after transplantation. Diabetes 2002; 51: 1362-1366.
42. Chirmule N, Propert K, Magosin S, Qian Y, Qian R, Wilson J. Immune response to adenovirus and adeno-associated virus in humans. Gene Therapy 1999; 6: 1574-1583.