메뉴 건너뛰기




Volumn 15, Issue 12, 2003, Pages 1495-1504

Transforming growth factor-β inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response

Author keywords

CD25; IL 10; Immunosuppression; Smad protein; Tolerance

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CYTOKINE; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SIGNAL PEPTIDE; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 0347407823     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxg147     Document Type: Article
Times cited : (63)

References (41)
  • 1
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • Friedman, A. and Weiner, H. L. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl Acad. Sci. USA 91:6688.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6688
    • Friedman, A.1    Weiner, H.L.2
  • 2
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389
    • Shevach, E.M.1
  • 3
    • 0032403091 scopus 로고    scopus 로고
    • T cell immunity to oral allergens
    • MacDonald, T. T. 1998. T cell immunity to oral allergens. Curr. Opin. Immunol. 10:620.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 620
    • MacDonald, T.T.1
  • 4
    • 0036724011 scopus 로고    scopus 로고
    • T-cell tolerance in allergic response
    • Schmidt-Weber, C. B. and Blaser, K. 2002. T-cell tolerance in allergic response. Allergy 57:762.
    • (2002) Allergy , vol.57 , pp. 762
    • Schmidt-Weber, C.B.1    Blaser, K.2
  • 6
    • 0034844841 scopus 로고    scopus 로고
    • h3-type TGF-beta-secreting regulatory cells
    • h3-type TGF-beta-secreting regulatory cells. Microbes Infect. 3:947.
    • (2001) Microbes Infect. , vol.3 , pp. 947
    • Weiner, H.L.1
  • 7
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio, J. J. and Roberts, A. B. 1998. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16:137.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 137
    • Letterio, J.J.1    Roberts, A.B.2
  • 9
    • 0025695183 scopus 로고
    • Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: Comparison of active and latent TGF-beta 1
    • Wallick, S. C., Figari, I. S., Morris, R. E., Levinson, A. D. and Palladino, M. A. 1990. Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1. J. Exp. Med. 172:1777.
    • (1990) J. Exp. Med. , vol.172 , pp. 1777
    • Wallick, S.C.1    Figari, I.S.2    Morris, R.E.3    Levinson, A.D.4    Palladino, M.A.5
  • 12
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague, J. 2000. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:169.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 169
    • Massague, J.1
  • 13
    • 0034679703 scopus 로고    scopus 로고
    • Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity
    • Nakao, A., Miike, S., Hatano, M., Okumura, K., Tokuhisa, T., Ra, C. and Iwamoto, I. 2000. Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J. Exp. Med. 192:151.
    • (2000) J. Exp. Med. , vol.192 , pp. 151
    • Nakao, A.1    Miike, S.2    Hatano, M.3    Okumura, K.4    Tokuhisa, T.5    Ra, C.6    Iwamoto, I.7
  • 15
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik, L. and Flavell, R. A. 2000. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12:171.
    • (2000) Immunity , vol.12 , pp. 171
    • Gorelik, L.1    Flavell, R.A.2
  • 16
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor
    • Lucas, P. J., Kim, S. J., Melby, S. J. and Gress, R. E. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J. Exp. Med. 191:1187.
    • (2000) J. Exp. Med. , vol.191 , pp. 1187
    • Lucas, P.J.1    Kim, S.J.2    Melby, S.J.3    Gress, R.E.4
  • 17
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signaling in the intestine contributes to tissue injury in inflammatory bowel disease
    • Hahm, K. B., Im, Y. H., Parks, T. W., Park, S. H., Markowitz, S., Jung, H. Y., Green, J. and Kim, S. J. 2001. Loss of transforming growth factor beta signaling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 49:190.
    • (2001) Gut , vol.49 , pp. 190
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3    Park, S.H.4    Markowitz, S.5    Jung, H.Y.6    Green, J.7    Kim, S.J.8
  • 18
    • 0035879091 scopus 로고    scopus 로고
    • Regulation of TGF-beta response during T cell activation is modulated by IL-10
    • Cottrez, F. and Groux, H. 2001. Regulation of TGF-beta response during T cell activation is modulated by IL-10. J. Immunol. 167:773.
    • (2001) J. Immunol. , vol.167 , pp. 773
    • Cottrez, F.1    Groux, H.2
  • 20
    • 0022465625 scopus 로고
    • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M. B. and Fauci, A. S. 1986. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037.
    • (1986) J. Exp. Med. , vol.163 , pp. 1037
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3    Jakowlew, S.4    Alvarez-Mon, M.5    Derynck, R.6    Sporn, M.B.7    Fauci, A.S.8
  • 21
    • 0027241250 scopus 로고
    • Effect of transforming growth factor-beta on early and late activation events in human T cells
    • Ahuja, S. S., Paliogianni, F., Yamada, H., Balow, J. E. and Boumpas, D. T. 1993. Effect of transforming growth factor-beta on early and late activation events in human T cells. J. Immunol. 150:3109.
    • (1993) J. Immunol. , vol.150 , pp. 3109
    • Ahuja, S.S.1    Paliogianni, F.2    Yamada, H.3    Balow, J.E.4    Boumpas, D.T.5
  • 23
    • 0021253159 scopus 로고
    • Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones
    • Yssel, H., de Vries, J. E., Koken, M., Van Blitterswijk, W. and Spits, H. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219.
    • (1984) J. Immunol. Methods , vol.72 , pp. 219
    • Yssel, H.1    de Vries, J.E.2    Koken, M.3    Van Blitterswijk, W.4    Spits, H.5
  • 25
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik, L. and Flavell, R. A. 2002. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2:46.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 46
    • Gorelik, L.1    Flavell, R.A.2
  • 27
    • 0033797107 scopus 로고    scopus 로고
    • A transforming growth factor-beta1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura
    • Andersson, P. O., Stockelberg, D., Jacobsson, S. and Wadenvik, H. 2000. A transforming growth factor-beta1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura. Ann. Hematol 79:507.
    • (2000) Ann. Hematol , vol.79 , pp. 507
    • Andersson, P.O.1    Stockelberg, D.2    Jacobsson, S.3    Wadenvik, H.4
  • 28
    • 0035985790 scopus 로고    scopus 로고
    • The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases
    • Horwitz, D. A., Gray, J. D. and Zheng, S. G. 2002. The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res. 4:241.
    • (2002) Arthritis Res. , vol.4 , pp. 241
    • Horwitz, D.A.1    Gray, J.D.2    Zheng, S.G.3
  • 29
    • 0036151568 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor enhances the expression of transforming growth factor-beta mRNA in CD4-positive peripheral blood lymphocytes in the donors for allogeneic peripheral blood stem cell transplantation
    • Hirayama, Y., Sakamaki, S., Matsunaga, T., Kuroda, H., Kusakabe, T., Akiyama, T., Kato, J., Kogawa, K., Koyama, R., Nagai, T., Ohta, H. and Niitsu, Y. 2002. Granulocyte-colony stimulating factor enhances the expression of transforming growth factor-beta mRNA in CD4-positive peripheral blood lymphocytes in the donors for allogeneic peripheral blood stem cell transplantation. Am. J. Hematol. 69:138.
    • (2002) Am. J. Hematol. , vol.69 , pp. 138
    • Hirayama, Y.1    Sakamaki, S.2    Matsunaga, T.3    Kuroda, H.4    Kusakabe, T.5    Akiyama, T.6    Kato, J.7    Kogawa, K.8    Koyama, R.9    Nagai, T.10    Ohta, H.11    Niitsu, Y.12
  • 33
    • 0030030037 scopus 로고    scopus 로고
    • Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1
    • Cerwenka, A., Kovar, H., Majdic, O. and Holter, W. 1996. Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1. J. Immunol. 156:459.
    • (1996) J. Immunol. , vol.156 , pp. 459
    • Cerwenka, A.1    Kovar, H.2    Majdic, O.3    Holter, W.4
  • 34
    • 0029149596 scopus 로고
    • Control of CD4 effector fate: Transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion
    • Zhang, X., Giangreco, L., Broome, H. E., Dargan, C. M. and Swain, S. L. 1995. Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J. Exp. Med. 182:699.
    • (1995) J. Exp. Med. , vol.182 , pp. 699
    • Zhang, X.1    Giangreco, L.2    Broome, H.E.3    Dargan, C.M.4    Swain, S.L.5
  • 35
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y. and Wang, X. F. 1995. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl Acad. Sci. USA 92:5545.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 36
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak, K., Kato, J. Y., Solomon, M. J., Sherr, C. J., Massague, J., Roberts, J. M. and Koff, A. 1994. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9.
    • (1994) Genes Dev. , vol.8 , pp. 9
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6    Koff, A.7
  • 37
    • 0027392761 scopus 로고
    • Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site
    • Brabletz, T., Pfeuffer, I., Schorr, E., Siebelt, F., Wirth, T. and Serfling, E. 1993. Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site. Mol. Cell. Biol. 13:1155.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 1155
    • Brabletz, T.1    Pfeuffer, I.2    Schorr, E.3    Siebelt, F.4    Wirth, T.5    Serfling, E.6
  • 38
    • 0035071186 scopus 로고    scopus 로고
    • Transforming growth factor-beta promotes 'death by neglect' in post-activated human T cells
    • Sillett, H. K., Cruickshank, S. M., Southgate, J. and Trejdosiewicz, L. K. 2001. Transforming growth factor-beta promotes 'death by neglect' in post-activated human T cells. Immunology 102:310.
    • (2001) Immunology , vol.102 , pp. 310
    • Sillett, H.K.1    Cruickshank, S.M.2    Southgate, J.3    Trejdosiewicz, L.K.4
  • 39
    • 0033563273 scopus 로고    scopus 로고
    • Antigen-specific T cell activation and proliferation during oral tolerance induction
    • Sun, J., Dirden-Kramer, B., Ito, K., Ernst, P. B. and Van Houten, N. 1999. Antigen-specific T cell activation and proliferation during oral tolerance induction. J. Immunol. 162:5868.
    • (1999) J. Immunol. , vol.162 , pp. 5868
    • Sun, J.1    Dirden-Kramer, B.2    Ito, K.3    Ernst, P.B.4    Van Houten, N.5
  • 40
    • 0032519412 scopus 로고    scopus 로고
    • TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells
    • Takeuchi, M., Alard, P. and Streilein, J. W. 1998. TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 160:1589.
    • (1998) J. Immunol. , vol.160 , pp. 1589
    • Takeuchi, M.1    Alard, P.2    Streilein, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.