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Volumn 38, Issue 2, 2008, Pages 132-160

The Immunobiology of Systemic Sclerosis

Author keywords

apoptosis; autoimmunity; collagen deposition; cytokine; fibrosis; systemic sclerosis

Indexed keywords

CHEMOKINE; COLLAGEN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT INTERLEUKIN 12; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

EID: 46849119322     PISSN: 00490172     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2007.10.010     Document Type: Article
Times cited : (145)

References (262)
  • 1
    • 0036839252 scopus 로고    scopus 로고
    • Murine animal models of systemic sclerosis
    • Jimenez S.A., and Christner P.J. Murine animal models of systemic sclerosis. Curr Opin Rheumatol 14 (2002) 671-680
    • (2002) Curr Opin Rheumatol , vol.14 , pp. 671-680
    • Jimenez, S.A.1    Christner, P.J.2
  • 2
    • 0029176118 scopus 로고
    • Animal models of scleroderma: contrasts and comparisons
    • Van de Water J., Jimenez S.A., and Gershwin M.E. Animal models of scleroderma: contrasts and comparisons. Int Rev Immunol 12 (1995) 201-216
    • (1995) Int Rev Immunol , vol.12 , pp. 201-216
    • Van de Water, J.1    Jimenez, S.A.2    Gershwin, M.E.3
  • 3
    • 0026604019 scopus 로고
    • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    • Prescott R.J., Freemont A.J., Jones C.J., Hoyland J., and Fielding P. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 166 (1992) 255-263
    • (1992) J Pathol , vol.166 , pp. 255-263
    • Prescott, R.J.1    Freemont, A.J.2    Jones, C.J.3    Hoyland, J.4    Fielding, P.5
  • 4
    • 0033758304 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95
    • Sgonc R., Gruschwitz M.S., Boeck G., Sepp N., Gruber J., and Wick G. Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum 43 (2000) 2550-2562
    • (2000) Arthritis Rheum , vol.43 , pp. 2550-2562
    • Sgonc, R.1    Gruschwitz, M.S.2    Boeck, G.3    Sepp, N.4    Gruber, J.5    Wick, G.6
  • 5
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R., Gruschwitz M.S., Dietrich H., Recheis H., Gershwin M.E., and Wick G. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest 98 (1996) 785-792
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3    Recheis, H.4    Gershwin, M.E.5    Wick, G.6
  • 7
    • 15644364960 scopus 로고    scopus 로고
    • Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis
    • Mavilia C., Scaletti C., Romagnani P., Carossino A.M., Pignone A., Emmi L., et al. Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis. Am J Pathol 151 (1997) 1751-1758
    • (1997) Am J Pathol , vol.151 , pp. 1751-1758
    • Mavilia, C.1    Scaletti, C.2    Romagnani, P.3    Carossino, A.M.4    Pignone, A.5    Emmi, L.6
  • 9
    • 0029048962 scopus 로고
    • Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages
    • Kräling B.M., Maul G.G., and Jimenez S.A. Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages. Pathobiology 63 (1995) 48-56
    • (1995) Pathobiology , vol.63 , pp. 48-56
    • Kräling, B.M.1    Maul, G.G.2    Jimenez, S.A.3
  • 10
    • 0025633516 scopus 로고
    • Dermal mast cell degranulation in systemic sclerosis
    • Seibold J.R., Giorno R.C., and Claman H.N. Dermal mast cell degranulation in systemic sclerosis. Arthritis Rheum 33 (1990) 1702-1709
    • (1990) Arthritis Rheum , vol.33 , pp. 1702-1709
    • Seibold, J.R.1    Giorno, R.C.2    Claman, H.N.3
  • 11
    • 0141928108 scopus 로고    scopus 로고
    • 3) and mast cells in the pathogenesis of scleroderma
    • 3) and mast cells in the pathogenesis of scleroderma. Clin Rheumatol 22 (2003) 189-195
    • (2003) Clin Rheumatol , vol.22 , pp. 189-195
    • Ozbilgin, M.K.1    Inan, S.2
  • 12
    • 0026316776 scopus 로고
    • Endothelial and fibroblastic activation in scleroderma. The myth of the "uninvolved skin"
    • Claman H.N., Giorno R.C., and Seibold J.R. Endothelial and fibroblastic activation in scleroderma. The myth of the "uninvolved skin". Arthritis Rheum 34 (1991) 1495-1501
    • (1991) Arthritis Rheum , vol.34 , pp. 1495-1501
    • Claman, H.N.1    Giorno, R.C.2    Seibold, J.R.3
  • 13
    • 0025949733 scopus 로고
    • Expression of intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic scleroderma
    • Majewski S., Hunzelmann N., Johnson J.P., Jung C., Mauch C., Ziegler-Heitbrock H.W., et al. Expression of intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic scleroderma. J Invest Dermatol 97 (1991) 667-671
    • (1991) J Invest Dermatol , vol.97 , pp. 667-671
    • Majewski, S.1    Hunzelmann, N.2    Johnson, J.P.3    Jung, C.4    Mauch, C.5    Ziegler-Heitbrock, H.W.6
  • 14
    • 0027717313 scopus 로고
    • In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease
    • Koch A.E., Kronfeld-Harrington L.B., Szekanecz Z., Cho M.M., Haines G.K., Harlow L.A., et al. In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease. Pathobiology 61 (1993) 239-246
    • (1993) Pathobiology , vol.61 , pp. 239-246
    • Koch, A.E.1    Kronfeld-Harrington, L.B.2    Szekanecz, Z.3    Cho, M.M.4    Haines, G.K.5    Harlow, L.A.6
  • 15
    • 0030936758 scopus 로고    scopus 로고
    • Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-γ and tumor necrosis factor α in the early disease stage
    • Gruschwitz M.S., and Vieth G. Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-γ and tumor necrosis factor α in the early disease stage. Arthritis Rheum 40 (1997) 540-550
    • (1997) Arthritis Rheum , vol.40 , pp. 540-550
    • Gruschwitz, M.S.1    Vieth, G.2
  • 17
    • 33745625865 scopus 로고    scopus 로고
    • Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients
    • Tan F.K., Zhou X., Mayes M.D., Gourh P., Guo X., Marcum C., et al. Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford) 45 (2006) 694-702
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 694-702
    • Tan, F.K.1    Zhou, X.2    Mayes, M.D.3    Gourh, P.4    Guo, X.5    Marcum, C.6
  • 18
    • 0031469085 scopus 로고    scopus 로고
    • Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines
    • Ihn H., Sato S., Fujimoto M., Kikuchi K., Kadono T., Tamaki K., et al. Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines. Br J Rheumatol 36 (1997) 1270-1275
    • (1997) Br J Rheumatol , vol.36 , pp. 1270-1275
    • Ihn, H.1    Sato, S.2    Fujimoto, M.3    Kikuchi, K.4    Kadono, T.5    Tamaki, K.6
  • 20
    • 0023885251 scopus 로고
    • Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization
    • Scharffetter K., Lankat-Buttgereit B., and Krieg T. Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur J Clin Invest 18 (1988) 9-17
    • (1988) Eur J Clin Invest , vol.18 , pp. 9-17
    • Scharffetter, K.1    Lankat-Buttgereit, B.2    Krieg, T.3
  • 22
    • 2342528447 scopus 로고    scopus 로고
    • Expression of pro-inflammatory markers by human dermal fibroblasts in a three-dimensional culture model is mediated by an autocrine interleukin-1 loop
    • Kessler-Becker D., Krieg T., and Eckes B. Expression of pro-inflammatory markers by human dermal fibroblasts in a three-dimensional culture model is mediated by an autocrine interleukin-1 loop. Biochem J 379 (2004) 351-358
    • (2004) Biochem J , vol.379 , pp. 351-358
    • Kessler-Becker, D.1    Krieg, T.2    Eckes, B.3
  • 23
    • 0035965308 scopus 로고    scopus 로고
    • Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype
    • Kessler D., Dethlefsen S., Haase I., Plomann M., Hirche F., Krieg T., et al. Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype. J Biol Chem 276 (2001) 36575-36585
    • (2001) J Biol Chem , vol.276 , pp. 36575-36585
    • Kessler, D.1    Dethlefsen, S.2    Haase, I.3    Plomann, M.4    Hirche, F.5    Krieg, T.6
  • 25
    • 0028861650 scopus 로고
    • Fibrosing alveolitis in systemic sclerosis: increase in memory T-cells in lung interstitium
    • Wells A.U., Lorimer S., Majumdar S., Harrison N.K., Corrin B., Black C.M., et al. Fibrosing alveolitis in systemic sclerosis: increase in memory T-cells in lung interstitium. Eur Respir J 8 (1995) 266-271
    • (1995) Eur Respir J , vol.8 , pp. 266-271
    • Wells, A.U.1    Lorimer, S.2    Majumdar, S.3    Harrison, N.K.4    Corrin, B.5    Black, C.M.6
  • 26
    • 0031732456 scopus 로고    scopus 로고
    • Interstitial lung disease in systemic sclerosis: comparison of BALF lymphocyte phenotype and DLCO impairment
    • Domagala-Kulawik J., Hoser G., Doboszynska A., Kawiak J., and Droszcz W. Interstitial lung disease in systemic sclerosis: comparison of BALF lymphocyte phenotype and DLCO impairment. Respir Med 92 (1998) 1295-1301
    • (1998) Respir Med , vol.92 , pp. 1295-1301
    • Domagala-Kulawik, J.1    Hoser, G.2    Doboszynska, A.3    Kawiak, J.4    Droszcz, W.5
  • 27
    • 13244272290 scopus 로고    scopus 로고
    • Alterations of mononuclear inflammatory cells. CD4/CD8+ T-cells, interleukin 1β, and tumour necrosis factor α in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis
    • Hussein M.R., Hassan H.I., Hofny E.R., Elkholy M., Fatehy N.A., Abd Elmoniem A.E., et al. Alterations of mononuclear inflammatory cells. CD4/CD8+ T-cells, interleukin 1β, and tumour necrosis factor α in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis. J Clin Pathol 58 (2005) 178-184
    • (2005) J Clin Pathol , vol.58 , pp. 178-184
    • Hussein, M.R.1    Hassan, H.I.2    Hofny, E.R.3    Elkholy, M.4    Fatehy, N.A.5    Abd Elmoniem, A.E.6
  • 28
    • 0043074624 scopus 로고    scopus 로고
    • Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T-cells from scleroderma patients
    • Luzina I.G., Atamas S.P., Wise R., Wigley F.M., Choi J., Xiao H.Q., et al. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T-cells from scleroderma patients. Arthritis Rheum 48 (2003) 2262-2274
    • (2003) Arthritis Rheum , vol.48 , pp. 2262-2274
    • Luzina, I.G.1    Atamas, S.P.2    Wise, R.3    Wigley, F.M.4    Choi, J.5    Xiao, H.Q.6
  • 31
    • 13444309109 scopus 로고    scopus 로고
    • Reduced circulating natural killer T-cells and γ/δ T-cells in patients with systemic sclerosis
    • Riccieri V., Parisi G., Spadaro A., Scrivo R., Barone F., Moretti T., et al. Reduced circulating natural killer T-cells and γ/δ T-cells in patients with systemic sclerosis. J Rheumatol 32 (2005) 283-286
    • (2005) J Rheumatol , vol.32 , pp. 283-286
    • Riccieri, V.1    Parisi, G.2    Spadaro, A.3    Scrivo, R.4    Barone, F.5    Moretti, T.6
  • 32
    • 0028797877 scopus 로고
    • Natural killer cells and γδ T-cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies
    • Holcombe R.F., Baethge B.A., Wolf R.E., Betzing K.W., and Stewart R.M. Natural killer cells and γδ T-cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies. Ann Rheum Dis 54 (1995) 69-72
    • (1995) Ann Rheum Dis , vol.54 , pp. 69-72
    • Holcombe, R.F.1    Baethge, B.A.2    Wolf, R.E.3    Betzing, K.W.4    Stewart, R.M.5
  • 33
    • 33646260917 scopus 로고    scopus 로고
    • Immunoregulation of autoimmunity by natural killer T-cells
    • Linsen L., Somers V., and Stinissen P. Immunoregulation of autoimmunity by natural killer T-cells. Hum Immunol 66 (2005) 1193-1202
    • (2005) Hum Immunol , vol.66 , pp. 1193-1202
    • Linsen, L.1    Somers, V.2    Stinissen, P.3
  • 34
    • 0035025559 scopus 로고    scopus 로고
    • Dysfunction of T-cell receptor AV24AJ18+. BV11+ double-negative regulatory natural killer T-cells in autoimmune diseases
    • Kojo S., Adachi Y., Keino H., Taniguchi M., and Sumida T. Dysfunction of T-cell receptor AV24AJ18+. BV11+ double-negative regulatory natural killer T-cells in autoimmune diseases. Arthritis Rheum 44 (2001) 1127-1138
    • (2001) Arthritis Rheum , vol.44 , pp. 1127-1138
    • Kojo, S.1    Adachi, Y.2    Keino, H.3    Taniguchi, M.4    Sumida, T.5
  • 36
    • 0036582288 scopus 로고    scopus 로고
    • γδ T-cells: functional plasticity and heterogeneity
    • Carding S.R., and Egan P.J. γδ T-cells: functional plasticity and heterogeneity. Nat Rev Immunol 2 (2002) 336-345
    • (2002) Nat Rev Immunol , vol.2 , pp. 336-345
    • Carding, S.R.1    Egan, P.J.2
  • 37
    • 0036883499 scopus 로고    scopus 로고
    • Emerging role of γδ T-cells in health and disease
    • Aljurf M., Ezzat A., and Om M. Emerging role of γδ T-cells in health and disease. Blood Rev 16 (2002) 203-206
    • (2002) Blood Rev , vol.16 , pp. 203-206
    • Aljurf, M.1    Ezzat, A.2    Om, M.3
  • 38
    • 0032587324 scopus 로고    scopus 로고
    • γδ receptor bearing T-cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro
    • Kahaleh M.B., Fan P.S., and Otsuka T. γδ receptor bearing T-cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro. Clin Immunol 91 (1999) 188-195
    • (1999) Clin Immunol , vol.91 , pp. 188-195
    • Kahaleh, M.B.1    Fan, P.S.2    Otsuka, T.3
  • 39
    • 0038651202 scopus 로고    scopus 로고
    • Evidence-based guidelines for the use of immunologic tests: anticentromere, Scl-70, and nucleolar antibodies
    • The American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines
    • Reveille J.D., Solomon D.H., and The American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. Evidence-based guidelines for the use of immunologic tests: anticentromere, Scl-70, and nucleolar antibodies. Arthritis Rheum 49 (2003) 399-412
    • (2003) Arthritis Rheum , vol.49 , pp. 399-412
    • Reveille, J.D.1    Solomon, D.H.2
  • 40
    • 0028222602 scopus 로고
    • Immunohistochemical localization of transforming growth factor-β1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders
    • Corrin B., Butcher D., McAnulty B.J., Dubois R.M., Black C.M., Laurent G.J., et al. Immunohistochemical localization of transforming growth factor-β1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders. Histopathology 24 (1994) 145-150
    • (1994) Histopathology , vol.24 , pp. 145-150
    • Corrin, B.1    Butcher, D.2    McAnulty, B.J.3    Dubois, R.M.4    Black, C.M.5    Laurent, G.J.6
  • 42
    • 33744535213 scopus 로고    scopus 로고
    • T-cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I
    • Hu P.Q., Oppenheim J.J., Medsger Jr. T.A., and Wright T.M. T-cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I. J Autoimmun 26 (2006) 258-267
    • (2006) J Autoimmun , vol.26 , pp. 258-267
    • Hu, P.Q.1    Oppenheim, J.J.2    Medsger Jr., T.A.3    Wright, T.M.4
  • 44
    • 0034121227 scopus 로고    scopus 로고
    • Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen
    • McKown K.M., Carbone L.D., Bustillo J., Seyer J.M., Kang A.H., and Postlethwaite A.E. Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen. Arthritis Rheum 43 (2000) 1054-1061
    • (2000) Arthritis Rheum , vol.43 , pp. 1054-1061
    • McKown, K.M.1    Carbone, L.D.2    Bustillo, J.3    Seyer, J.M.4    Kang, A.H.5    Postlethwaite, A.E.6
  • 45
    • 34547459403 scopus 로고    scopus 로고
    • Oral tolerance (OT) induction to type I collagen (CI) significantly reduces the skin score in patients with diffuse systemic sclerosis (SSc) with late-phase disease. Results of a NIAMS/NIAD multicenter phase II placebo-controlled double blind clinical trial
    • Postlethwaite A.E., Furst D.E., Wong W.K., and Clements P. Oral tolerance (OT) induction to type I collagen (CI) significantly reduces the skin score in patients with diffuse systemic sclerosis (SSc) with late-phase disease. Results of a NIAMS/NIAD multicenter phase II placebo-controlled double blind clinical trial. Arthritis Rheum 52 (2005) 109-128
    • (2005) Arthritis Rheum , vol.52 , pp. 109-128
    • Postlethwaite, A.E.1    Furst, D.E.2    Wong, W.K.3    Clements, P.4
  • 47
    • 33644890178 scopus 로고    scopus 로고
    • The presence of dominant T-cell clones in peripheral blood of patients with collagen vascular disorders: a prospective study of 97 cases
    • Dereure O., Gubler B., Bessis D., Guillot B., Guilhou J.J., Clot J., et al. The presence of dominant T-cell clones in peripheral blood of patients with collagen vascular disorders: a prospective study of 97 cases. Br J Dermatol 154 (2006) 445-449
    • (2006) Br J Dermatol , vol.154 , pp. 445-449
    • Dereure, O.1    Gubler, B.2    Bessis, D.3    Guillot, B.4    Guilhou, J.J.5    Clot, J.6
  • 48
    • 0036533681 scopus 로고    scopus 로고
    • Oligoclonal T-cell expansion in the skin of patients with systemic sclerosis
    • Sakkas L.I., Xu B., Artlett C.M., Lu S., Jimenez S.A., and Platsoucas C.D. Oligoclonal T-cell expansion in the skin of patients with systemic sclerosis. J Immunol 168 (2002) 3649-3659
    • (2002) J Immunol , vol.168 , pp. 3649-3659
    • Sakkas, L.I.1    Xu, B.2    Artlett, C.M.3    Lu, S.4    Jimenez, S.A.5    Platsoucas, C.D.6
  • 49
    • 33645106998 scopus 로고    scopus 로고
    • Peripheral T-lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin
    • De Palma R., Del Galdo F., Lupoli S., Altucci P., Abbate G., and Valentini G. Peripheral T-lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin. Clin Exp Immunol 144 (2006) 169-176
    • (2006) Clin Exp Immunol , vol.144 , pp. 169-176
    • De Palma, R.1    Del Galdo, F.2    Lupoli, S.3    Altucci, P.4    Abbate, G.5    Valentini, G.6
  • 50
    • 0030175638 scopus 로고    scopus 로고
    • Skewing of the CD8+ T-cell repertoire in the lungs of patients with systemic sclerosis
    • Yurovsky V.V., Wigley F.M., Wise R.A., and White B. Skewing of the CD8+ T-cell repertoire in the lungs of patients with systemic sclerosis. Hum Immunol 48 (1996) 84-97
    • (1996) Hum Immunol , vol.48 , pp. 84-97
    • Yurovsky, V.V.1    Wigley, F.M.2    Wise, R.A.3    White, B.4
  • 53
    • 0035892875 scopus 로고    scopus 로고
    • Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
    • Zhou X., Tan F.K., Xiong M., Milewicz D.M., Feghali C.A., Fritzler M.J., et al. Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. J Immunol 167 (2001) 7126-7133
    • (2001) J Immunol , vol.167 , pp. 7126-7133
    • Zhou, X.1    Tan, F.K.2    Xiong, M.3    Milewicz, D.M.4    Feghali, C.A.5    Fritzler, M.J.6
  • 54
    • 20144366026 scopus 로고    scopus 로고
    • Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease
    • Tan F.K., Hildebrand B.A., Lester M.S., Stivers D.N., Pounds S., Zhou X., et al. Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease. Arthritis Rheum 52 (2005) 865-876
    • (2005) Arthritis Rheum , vol.52 , pp. 865-876
    • Tan, F.K.1    Hildebrand, B.A.2    Lester, M.S.3    Stivers, D.N.4    Pounds, S.5    Zhou, X.6
  • 55
    • 5644247451 scopus 로고    scopus 로고
    • Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis
    • Hénault J., Tremblay M., Clément I., Raymond Y., and Senécal J.L. Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis. Arthritis Rheum 50 (2004) 3265-3274
    • (2004) Arthritis Rheum , vol.50 , pp. 3265-3274
    • Hénault, J.1    Tremblay, M.2    Clément, I.3    Raymond, Y.4    Senécal, J.L.5
  • 56
    • 0030641492 scopus 로고    scopus 로고
    • Highly restricted TCR-αβ usage by autoreactive human T-cell clones specific for DNA topoisomerase I: recognition of an immunodominant epitope
    • Kuwana M., Medsger Jr. T.A., and Wright T.M. Highly restricted TCR-αβ usage by autoreactive human T-cell clones specific for DNA topoisomerase I: recognition of an immunodominant epitope. J Immunol 158 (1997) 485-491
    • (1997) J Immunol , vol.158 , pp. 485-491
    • Kuwana, M.1    Medsger Jr., T.A.2    Wright, T.M.3
  • 57
    • 0141564934 scopus 로고    scopus 로고
    • Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor α
    • Chizzolini C., Parel Y., De Luca C., Tyndall A., Akesson A., Scheja A., et al. Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor α. Arthritis Rheum 48 (2003) 2593-2604
    • (2003) Arthritis Rheum , vol.48 , pp. 2593-2604
    • Chizzolini, C.1    Parel, Y.2    De Luca, C.3    Tyndall, A.4    Akesson, A.5    Scheja, A.6
  • 58
    • 0031734246 scopus 로고    scopus 로고
    • Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T-cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts
    • Chizzolini C., Rezzonico R., Ribbens C., Burger D., Wollheim F.A., and Dayer J.M. Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T-cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts. Arthritis Rheum 41 (1998) 2039-2047
    • (1998) Arthritis Rheum , vol.41 , pp. 2039-2047
    • Chizzolini, C.1    Rezzonico, R.2    Ribbens, C.3    Burger, D.4    Wollheim, F.A.5    Dayer, J.M.6
  • 59
    • 70350523842 scopus 로고    scopus 로고
    • Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts
    • Chizzolini C., Parel Y., Scheja A., and Dayer J.M. Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts. Arthritis Res Ther 8 (2005) R10
    • (2005) Arthritis Res Ther , vol.8
    • Chizzolini, C.1    Parel, Y.2    Scheja, A.3    Dayer, J.M.4
  • 61
    • 0242271835 scopus 로고    scopus 로고
    • Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts
    • Fukasawa C., Kawaguchi Y., Harigai M., Sugiura T., Takagi K., Kawamoto M., et al. Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts. Eur J Immunol 33 (2003) 2792-2800
    • (2003) Eur J Immunol , vol.33 , pp. 2792-2800
    • Fukasawa, C.1    Kawaguchi, Y.2    Harigai, M.3    Sugiura, T.4    Takagi, K.5    Kawamoto, M.6
  • 63
    • 14144253975 scopus 로고    scopus 로고
    • Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers
    • Allanore Y., Borderie D., Meune C., Lemaréchal H., Weber S., Ekindjian O.G., et al. Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers. Ann Rheum Dis 64 (2005) 481-483
    • (2005) Ann Rheum Dis , vol.64 , pp. 481-483
    • Allanore, Y.1    Borderie, D.2    Meune, C.3    Lemaréchal, H.4    Weber, S.5    Ekindjian, O.G.6
  • 64
    • 0036467531 scopus 로고    scopus 로고
    • Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling
    • Atamas S.P., Luzina I.G., Dai H., Wilt S.G., and White B. Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling. J Immunol 168 (2002) 1139-1145
    • (2002) J Immunol , vol.168 , pp. 1139-1145
    • Atamas, S.P.1    Luzina, I.G.2    Dai, H.3    Wilt, S.G.4    White, B.5
  • 65
    • 0031570120 scopus 로고    scopus 로고
    • CD40 is a functional activation antigen and B7-independent T-cell costimulatory molecule on normal human lung fibroblasts
    • Sempowski G.D., Chess P.R., and Phipps R.P. CD40 is a functional activation antigen and B7-independent T-cell costimulatory molecule on normal human lung fibroblasts. J Immunol 158 (1997) 4670-4677
    • (1997) J Immunol , vol.158 , pp. 4670-4677
    • Sempowski, G.D.1    Chess, P.R.2    Phipps, R.P.3
  • 67
    • 0026540461 scopus 로고
    • Selective upregulation of platelet-derived growth factor α receptors by transforming growth factor β in scleroderma fibroblasts
    • Yamakage A., Kikuchi K., Smith E.A., LeRoy E.C., and Trojanowska M. Selective upregulation of platelet-derived growth factor α receptors by transforming growth factor β in scleroderma fibroblasts. J Exp Med 175 (1992) 1227-1234
    • (1992) J Exp Med , vol.175 , pp. 1227-1234
    • Yamakage, A.1    Kikuchi, K.2    Smith, E.A.3    LeRoy, E.C.4    Trojanowska, M.5
  • 69
    • 0033788161 scopus 로고    scopus 로고
    • Role of apoptosis and transforming growth factor β1 in fibroblast selection and activation in systemic sclerosis
    • Jelaska A., and Korn J.H. Role of apoptosis and transforming growth factor β1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum 43 (2000) 2230-2239
    • (2000) Arthritis Rheum , vol.43 , pp. 2230-2239
    • Jelaska, A.1    Korn, J.H.2
  • 70
    • 20744455828 scopus 로고    scopus 로고
    • Diminished transforming growth factor β2 production leads to increased expression of a profibrotic procollagen α2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis
    • Prelog M., Scheidegger P., Peter S., Gershwin M.E., Wick G., and Sgonc R. Diminished transforming growth factor β2 production leads to increased expression of a profibrotic procollagen α2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis. Arthritis Rheum 52 (2005) 1804-1811
    • (2005) Arthritis Rheum , vol.52 , pp. 1804-1811
    • Prelog, M.1    Scheidegger, P.2    Peter, S.3    Gershwin, M.E.4    Wick, G.5    Sgonc, R.6
  • 71
    • 2642511623 scopus 로고    scopus 로고
    • Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B-cells and diminished but activated memory B-cells
    • Sato S., Fujimoto M., Hasegawa M., and Takehara K. Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B-cells and diminished but activated memory B-cells. Arthritis Rheum 50 (2004) 1918-1927
    • (2004) Arthritis Rheum , vol.50 , pp. 1918-1927
    • Sato, S.1    Fujimoto, M.2    Hasegawa, M.3    Takehara, K.4
  • 73
    • 7044253658 scopus 로고    scopus 로고
    • Autoantibodies in systemic sclerosis and fibrosing syndromes: clinical indications and relevance
    • Cepeda E.J., and Reveille J.D. Autoantibodies in systemic sclerosis and fibrosing syndromes: clinical indications and relevance. Curr Opin Rheumatol 16 (2004) 723-732
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 723-732
    • Cepeda, E.J.1    Reveille, J.D.2
  • 74
    • 0034544489 scopus 로고    scopus 로고
    • Quantitative genetic variation in CD19 expression correlates with autoimmunity
    • Sato S., Hasegawa M., Fujimoto M., Tedder T.F., and Takehara K. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 165 (2000) 6635-6643
    • (2000) J Immunol , vol.165 , pp. 6635-6643
    • Sato, S.1    Hasegawa, M.2    Fujimoto, M.3    Tedder, T.F.4    Takehara, K.5
  • 75
    • 0037379343 scopus 로고    scopus 로고
    • Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis
    • Sato S., Hayakawa I., Hasegawa M., Fujimoto M., and Takehara K. Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis. J Invest Dermatol 120 (2003) 542-547
    • (2003) J Invest Dermatol , vol.120 , pp. 542-547
    • Sato, S.1    Hayakawa, I.2    Hasegawa, M.3    Fujimoto, M.4    Takehara, K.5
  • 77
    • 27744474113 scopus 로고    scopus 로고
    • Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts
    • Svegliati S., Cancello R., Sambo P., Luchetti M., Paroncini P., Orlandini G., et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem 280 (2005) 36474-36482
    • (2005) J Biol Chem , vol.280 , pp. 36474-36482
    • Svegliati, S.1    Cancello, R.2    Sambo, P.3    Luchetti, M.4    Paroncini, P.5    Orlandini, G.6
  • 78
    • 0035149214 scopus 로고    scopus 로고
    • Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway
    • Sambo P., Baroni S.S., Luchetti M., Paroncini P., Dusi S., Orlandini G., et al. Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum 44 (2001) 2653-2664
    • (2001) Arthritis Rheum , vol.44 , pp. 2653-2664
    • Sambo, P.1    Baroni, S.S.2    Luchetti, M.3    Paroncini, P.4    Dusi, S.5    Orlandini, G.6
  • 79
    • 33746056036 scopus 로고    scopus 로고
    • Anti-endothelial cell antibodies from patients with limited cutaneous systemic sclerosis bind to centromeric protein B (CENP-B)
    • Servettaz A., Tamby M.C., Guilpain P., Reinbolt J., Garcia de la Peña-Lefebvre P., Allanore Y., et al. Anti-endothelial cell antibodies from patients with limited cutaneous systemic sclerosis bind to centromeric protein B (CENP-B). Clin Immunol 120 (2006) 212-219
    • (2006) Clin Immunol , vol.120 , pp. 212-219
    • Servettaz, A.1    Tamby, M.C.2    Guilpain, P.3    Reinbolt, J.4    Garcia de la Peña-Lefebvre, P.5    Allanore, Y.6
  • 80
    • 0141676369 scopus 로고    scopus 로고
    • In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay
    • Worda M., Sgonc R., Dietrich H., Niederegger H., Sundick R.S., Gershwin M.E., et al. In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay. Arthritis Rheum 48 (2003) 2605-2614
    • (2003) Arthritis Rheum , vol.48 , pp. 2605-2614
    • Worda, M.1    Sgonc, R.2    Dietrich, H.3    Niederegger, H.4    Sundick, R.S.5    Gershwin, M.E.6
  • 81
    • 0033621643 scopus 로고    scopus 로고
    • Endothelial injury in internal organs of University of California at Davis line 200 (UCD 200) chickens, an animal model for systemic sclerosis (Scleroderma)
    • Nguyen V.A., Sgonc R., Dietrich H., and Wick G. Endothelial injury in internal organs of University of California at Davis line 200 (UCD 200) chickens, an animal model for systemic sclerosis (Scleroderma). J Autoimmun 14 (2000) 143-149
    • (2000) J Autoimmun , vol.14 , pp. 143-149
    • Nguyen, V.A.1    Sgonc, R.2    Dietrich, H.3    Wick, G.4
  • 82
    • 0030031147 scopus 로고    scopus 로고
    • IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines
    • Carvalho D., Savage C.O., Black C.M., and Pearson J.D. IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J Clin Invest 97 (1996) 111-119
    • (1996) J Clin Invest , vol.97 , pp. 111-119
    • Carvalho, D.1    Savage, C.O.2    Black, C.M.3    Pearson, J.D.4
  • 83
    • 0036269002 scopus 로고    scopus 로고
    • Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis
    • Chizzolini C., Raschi E., Rezzonico R., Testoni C., Mallone R., Gabrielli A., et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. Arthritis Rheum 46 (2002) 1602-1613
    • (2002) Arthritis Rheum , vol.46 , pp. 1602-1613
    • Chizzolini, C.1    Raschi, E.2    Rezzonico, R.3    Testoni, C.4    Mallone, R.5    Gabrielli, A.6
  • 84
    • 0036272386 scopus 로고    scopus 로고
    • Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway
    • Ronda N., Gatti R., Giacosa R., Raschi E., Testoni C., Meroni P.L., et al. Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway. Arthritis Rheum 46 (2002) 1595-1601
    • (2002) Arthritis Rheum , vol.46 , pp. 1595-1601
    • Ronda, N.1    Gatti, R.2    Giacosa, R.3    Raschi, E.4    Testoni, C.5    Meroni, P.L.6
  • 85
    • 3242810358 scopus 로고    scopus 로고
    • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    • Asano N., Fujimoto M., Yazawa N., Shirasawa S., Hasegawa M., Okochi H., et al. B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol 165 (2004) 641-650
    • (2004) Am J Pathol , vol.165 , pp. 641-650
    • Asano, N.1    Fujimoto, M.2    Yazawa, N.3    Shirasawa, S.4    Hasegawa, M.5    Okochi, H.6
  • 86
    • 0036262665 scopus 로고    scopus 로고
    • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    • Saito E., Fujimoto M., Hasegawa M., Komura K., Hamaguchi Y., Kaburagi Y., et al. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest 109 (2002) 1453-1462
    • (2002) J Clin Invest , vol.109 , pp. 1453-1462
    • Saito, E.1    Fujimoto, M.2    Hasegawa, M.3    Komura, K.4    Hamaguchi, Y.5    Kaburagi, Y.6
  • 87
    • 33748788266 scopus 로고    scopus 로고
    • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    • Hasegawa M., Hamaguchi Y., Yanaba K., Bouaziz J.D., Uchida J., Fujimoto M., et al. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol 169 (2006) 954-966
    • (2006) Am J Pathol , vol.169 , pp. 954-966
    • Hasegawa, M.1    Hamaguchi, Y.2    Yanaba, K.3    Bouaziz, J.D.4    Uchida, J.5    Fujimoto, M.6
  • 88
    • 0031438573 scopus 로고    scopus 로고
    • B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene
    • Kasturi K.N., Hatakeyama A., Murai C., Gordon R., Phelps R.G., and Bona C.A. B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene. J Autoimmun 10 (1997) 505-517
    • (1997) J Autoimmun , vol.10 , pp. 505-517
    • Kasturi, K.N.1    Hatakeyama, A.2    Murai, C.3    Gordon, R.4    Phelps, R.G.5    Bona, C.A.6
  • 89
    • 0037675809 scopus 로고    scopus 로고
    • Distinct immune profiles characterize patients with diffuse or limited systemic sclerosis
    • Ingegnoli F., Trabattoni D., Saresella M., Fantini F., and Clerici M. Distinct immune profiles characterize patients with diffuse or limited systemic sclerosis. Clin Immunol 108 (2003) 21-28
    • (2003) Clin Immunol , vol.108 , pp. 21-28
    • Ingegnoli, F.1    Trabattoni, D.2    Saresella, M.3    Fantini, F.4    Clerici, M.5
  • 90
    • 33749992315 scopus 로고    scopus 로고
    • Resistance to apoptosis in circulating α/β and γ/δ T-lymphocytes from patients with systemic sclerosis
    • Cipriani P., Fulminis A., Pingiotti E., Marrelli A., Liakouli V., Perricone R., et al. Resistance to apoptosis in circulating α/β and γ/δ T-lymphocytes from patients with systemic sclerosis. J Rheumatol 33 (2006) 2003-2014
    • (2006) J Rheumatol , vol.33 , pp. 2003-2014
    • Cipriani, P.1    Fulminis, A.2    Pingiotti, E.3    Marrelli, A.4    Liakouli, V.5    Perricone, R.6
  • 91
    • 1642376385 scopus 로고    scopus 로고
    • Increased CD8+ T-cell apoptosis in scleroderma is associated with low levels of NF-κB
    • Kessel A., Rosner I., Rozenbaum M., Zisman D., Sagiv A., Shmuel Z., et al. Increased CD8+ T-cell apoptosis in scleroderma is associated with low levels of NF-κB. J Clin Immunol 24 (2004) 30-36
    • (2004) J Clin Immunol , vol.24 , pp. 30-36
    • Kessel, A.1    Rosner, I.2    Rozenbaum, M.3    Zisman, D.4    Sagiv, A.5    Shmuel, Z.6
  • 92
    • 0032523920 scopus 로고    scopus 로고
    • The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis
    • Bordron A., Dueymes M., Levy Y., Jamin C., Leroy J.P., Piette J.C., et al. The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis. J Clin Invest 101 (1998) 2029-2035
    • (1998) J Clin Invest , vol.101 , pp. 2029-2035
    • Bordron, A.1    Dueymes, M.2    Levy, Y.3    Jamin, C.4    Leroy, J.P.5    Piette, J.C.6
  • 93
    • 0032717522 scopus 로고    scopus 로고
    • Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
    • Kuwano K., Hagimoto N., Kawasaki M., Yatomi T., Nakamura N., Nagata S., et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 104 (1999) 13-19
    • (1999) J Clin Invest , vol.104 , pp. 13-19
    • Kuwano, K.1    Hagimoto, N.2    Kawasaki, M.3    Yatomi, T.4    Nakamura, N.5    Nagata, S.6
  • 94
    • 17844367321 scopus 로고    scopus 로고
    • Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis
    • Maeyama T., Kuwano K., Kawasaki M., Kunitake R., Hagimoto N., Matsuba T., et al. Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis. Eur Respir J 17 (2001) 180-189
    • (2001) Eur Respir J , vol.17 , pp. 180-189
    • Maeyama, T.1    Kuwano, K.2    Kawasaki, M.3    Kunitake, R.4    Hagimoto, N.5    Matsuba, T.6
  • 95
    • 0030638505 scopus 로고    scopus 로고
    • Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice
    • Hagimoto N., Kuwano K., Nomoto Y., Kunitake R., and Hara N. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 16 (1997) 91-101
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 91-101
    • Hagimoto, N.1    Kuwano, K.2    Nomoto, Y.3    Kunitake, R.4    Hara, N.5
  • 98
    • 0033846131 scopus 로고    scopus 로고
    • The Fas/Fas-ligand system is not required for bleomycin-induced pulmonary fibrosis in mice
    • Aoshiba K., Yasui S., Tamaoki J., and Nagai A. The Fas/Fas-ligand system is not required for bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 162 (2000) 695-700
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 695-700
    • Aoshiba, K.1    Yasui, S.2    Tamaoki, J.3    Nagai, A.4
  • 99
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-β in T-cell biology
    • Gorelik L., and Flavell R.A. Transforming growth factor-β in T-cell biology. Nat Rev Immunol 2 (2002) 46-53
    • (2002) Nat Rev Immunol , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 100
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-β. Annu Rev Immunol 16 (1998) 137-161
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 101
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425 (2003) 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 102
    • 0025092082 scopus 로고
    • Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: a mediator of fibrosis?
    • Gruschwitz M., Müller P.U., Sepp N., Hofer E., Fontana A., and Wick G. Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: a mediator of fibrosis?. J Invest Dermatol 94 (1990) 197-203
    • (1990) J Invest Dermatol , vol.94 , pp. 197-203
    • Gruschwitz, M.1    Müller, P.U.2    Sepp, N.3    Hofer, E.4    Fontana, A.5    Wick, G.6
  • 103
    • 0032769817 scopus 로고    scopus 로고
    • Expression of TGF-β1, -β2 and -β3 in localized and systemic scleroderma
    • Querfeld C., Eckes B., Huerkamp C., Krieg T., and Sollberg S. Expression of TGF-β1, -β2 and -β3 in localized and systemic scleroderma. J Dermatol Sci 21 (1999) 13-22
    • (1999) J Dermatol Sci , vol.21 , pp. 13-22
    • Querfeld, C.1    Eckes, B.2    Huerkamp, C.3    Krieg, T.4    Sollberg, S.5
  • 104
    • 0025145174 scopus 로고
    • Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis
    • Kulozik M., Hogg A., Lankat-Buttgereit B., and Krieg T. Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest 86 (1990) 917-922
    • (1990) J Clin Invest , vol.86 , pp. 917-922
    • Kulozik, M.1    Hogg, A.2    Lankat-Buttgereit, B.3    Krieg, T.4
  • 105
    • 0036894848 scopus 로고    scopus 로고
    • Upregulated expression of transforming growth factor-β receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis
    • Kubo M., Ihn H., Yamane K., and Tamaki K. Upregulated expression of transforming growth factor-β receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis. J Rheumatol 29 (2002) 2558-2564
    • (2002) J Rheumatol , vol.29 , pp. 2558-2564
    • Kubo, M.1    Ihn, H.2    Yamane, K.3    Tamaki, K.4
  • 106
    • 2342547687 scopus 로고    scopus 로고
    • An increased transforming growth factor β receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma
    • Pannu J., Gore-Hyer E., Yamanaka M., Smith E.A., Rubinchik S., Dong J.Y., et al. An increased transforming growth factor β receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma. Arthritis Rheum 50 (2004) 1566-1577
    • (2004) Arthritis Rheum , vol.50 , pp. 1566-1577
    • Pannu, J.1    Gore-Hyer, E.2    Yamanaka, M.3    Smith, E.A.4    Rubinchik, S.5    Dong, J.Y.6
  • 108
    • 0028973641 scopus 로고
    • Elevated levels of platelet derived growth factor and transforming growth factor-β1 in bronchoalveolar lavage fluid from patients with scleroderma
    • Ludwicka A., Ohba T., Trojanowska M., Yamakage A., Strange C., Smith E.A., et al. Elevated levels of platelet derived growth factor and transforming growth factor-β1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol 22 (1995) 1876-1883
    • (1995) J Rheumatol , vol.22 , pp. 1876-1883
    • Ludwicka, A.1    Ohba, T.2    Trojanowska, M.3    Yamakage, A.4    Strange, C.5    Smith, E.A.6
  • 110
    • 9644258488 scopus 로고    scopus 로고
    • Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement
    • Scala E., Pallotta S., Frezzolini A., Abeni D., Barbieri C., Sampogna F., et al. Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement. Clin Exp Immunol 138 (2004) 540-546
    • (2004) Clin Exp Immunol , vol.138 , pp. 540-546
    • Scala, E.1    Pallotta, S.2    Frezzolini, A.3    Abeni, D.4    Barbieri, C.5    Sampogna, F.6
  • 111
    • 0034856397 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
    • Sato S., Hasegawa M., and Takehara K. Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci 27 (2001) 140-146
    • (2001) J Dermatol Sci , vol.27 , pp. 140-146
    • Sato, S.1    Hasegawa, M.2    Takehara, K.3
  • 112
    • 0142085920 scopus 로고    scopus 로고
    • Cytokine regulation of pulmonary fibrosis in scleroderma
    • Atamas S.P., and White B. Cytokine regulation of pulmonary fibrosis in scleroderma. Cytokine Growth Factor Rev 14 (2003) 537-550
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 537-550
    • Atamas, S.P.1    White, B.2
  • 113
    • 0031945628 scopus 로고    scopus 로고
    • Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts
    • Mattila L., Airola K., Ahonen M., Hietarinta M., Black C., Saarialho-Kere U., et al. Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts. J Invest Dermatol 110 (1998) 416-421
    • (1998) J Invest Dermatol , vol.110 , pp. 416-421
    • Mattila, L.1    Airola, K.2    Ahonen, M.3    Hietarinta, M.4    Black, C.5    Saarialho-Kere, U.6
  • 114
    • 0141955064 scopus 로고    scopus 로고
    • Antagonistic effects of TNF-α on TGF-β signaling through down-regulation of TGF-β receptor type II in human dermal fibroblasts
    • Yamane K., Ihn H., Asano Y., Jinnin M., and Tamaki K. Antagonistic effects of TNF-α on TGF-β signaling through down-regulation of TGF-β receptor type II in human dermal fibroblasts. J Immunol 171 (2003) 3855-3862
    • (2003) J Immunol , vol.171 , pp. 3855-3862
    • Yamane, K.1    Ihn, H.2    Asano, Y.3    Jinnin, M.4    Tamaki, K.5
  • 115
    • 0031661468 scopus 로고    scopus 로고
    • IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts
    • Doucet C., Brouty-Boyé D., Pottin-Clemenceau C., Jasmin C., Canonica G.W., and Azzarone B. IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. Int Immunol 10 (1998) 1421-1433
    • (1998) Int Immunol , vol.10 , pp. 1421-1433
    • Doucet, C.1    Brouty-Boyé, D.2    Pottin-Clemenceau, C.3    Jasmin, C.4    Canonica, G.W.5    Azzarone, B.6
  • 116
    • 0030014832 scopus 로고    scopus 로고
    • 1 gene expression by monocyte chemoattractant protein-1 via specific receptors
    • 1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271 (1996) 17779-17784
    • (1996) J Biol Chem , vol.271 , pp. 17779-17784
    • Gharaee-Kermani, M.1    Denholm, E.M.2    Phan, S.H.3
  • 117
    • 0036745067 scopus 로고    scopus 로고
    • Increased transcriptional activities of transforming growth factor β receptors in scleroderma fibroblasts
    • Yamane K., Ihn H., Kubo M., and Tamaki K. Increased transcriptional activities of transforming growth factor β receptors in scleroderma fibroblasts. Arthritis Rheum 46 (2002) 2421-2428
    • (2002) Arthritis Rheum , vol.46 , pp. 2421-2428
    • Yamane, K.1    Ihn, H.2    Kubo, M.3    Tamaki, K.4
  • 118
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors
    • Ihn H., Yamane K., Kubo M., and Tamaki K. Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors. Arthritis Rheum 44 (2001) 474-480
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 119
    • 0029100211 scopus 로고
    • Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-β1
    • Kikuchi K., Kadono T., Ihn H., Sato S., Igarashi A., Nakagawa H., et al. Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-β1. J Invest Dermatol 105 (1995) 128-132
    • (1995) J Invest Dermatol , vol.105 , pp. 128-132
    • Kikuchi, K.1    Kadono, T.2    Ihn, H.3    Sato, S.4    Igarashi, A.5    Nakagawa, H.6
  • 120
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., Mimura Y., and Tamaki K. Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts. Arthritis Rheum 52 (2005) 2897-2905
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 121
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., and Tamaki K. Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol 168 (2006) 499-510
    • (2006) Am J Pathol , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 122
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung
    • Sime P.J., Xing Z., Graham F.L., Csaky K.G., and Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100 (1997) 768-776
    • (1997) J Clin Invest , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 124
    • 0035138260 scopus 로고    scopus 로고
    • Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4Rα and transforming growth factor-β genes
    • McGaha T., Saito S., Phelps R.G., Gordon R., Noben-Trauth N., Paul W.E., et al. Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4Rα and transforming growth factor-β genes. J Invest Dermatol 116 (2001) 136-143
    • (2001) J Invest Dermatol , vol.116 , pp. 136-143
    • McGaha, T.1    Saito, S.2    Phelps, R.G.3    Gordon, R.4    Noben-Trauth, N.5    Paul, W.E.6
  • 125
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G., Takagawa S., Chen S.J., Ferreira A.M., Han G., Masuda K., et al. Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 165 (2004) 203-217
    • (2004) Am J Pathol , vol.165 , pp. 203-217
    • Lakos, G.1    Takagawa, S.2    Chen, S.J.3    Ferreira, A.M.4    Han, G.5    Masuda, K.6
  • 126
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • Lee C.G., Homer R.J., Zhu Z., Lanone S., Wang X., Koteliansky V., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 194 (2001) 809-821
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3    Lanone, S.4    Wang, X.5    Koteliansky, V.6
  • 127
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-β treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma
    • McCormick L.L., Zhang Y., Tootell E., and Gilliam A.C. Anti-TGF-β treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol 163 (1999) 5693-5699
    • (1999) J Immunol , vol.163 , pp. 5693-5699
    • McCormick, L.L.1    Zhang, Y.2    Tootell, E.3    Gilliam, A.C.4
  • 128
    • 0141887528 scopus 로고    scopus 로고
    • Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma
    • Zhang Y., McCormick L.L., and Gilliam A.C. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol 121 (2003) 713-719
    • (2003) J Invest Dermatol , vol.121 , pp. 713-719
    • Zhang, Y.1    McCormick, L.L.2    Gilliam, A.C.3
  • 129
    • 33846250366 scopus 로고    scopus 로고
    • Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
    • Denton C.P., Merkel P.A., Furst D.E., Khanna D., Emery P., Hsu V.M., et al. Recombinant human anti-transforming growth factor β1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 56 (2007) 323-333
    • (2007) Arthritis Rheum , vol.56 , pp. 323-333
    • Denton, C.P.1    Merkel, P.A.2    Furst, D.E.3    Khanna, D.4    Emery, P.5    Hsu, V.M.6
  • 130
    • 0029941568 scopus 로고    scopus 로고
    • Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis
    • Salmon-Ehr V., Serpier H., Nawrocki B., Gillery P., Clavel C., Kalis B., et al. Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis. Arch Dermatol 132 (1996) 802-806
    • (1996) Arch Dermatol , vol.132 , pp. 802-806
    • Salmon-Ehr, V.1    Serpier, H.2    Nawrocki, B.3    Gillery, P.4    Clavel, C.5    Kalis, B.6
  • 131
    • 0030847892 scopus 로고    scopus 로고
    • In situ expression and serum levels of tumor necrosis factor-α receptors in patients with early stages of systemic sclerosis
    • Gruschwitz M.S., Albrecht M., Vieth G., and Haustein U.F. In situ expression and serum levels of tumor necrosis factor-α receptors in patients with early stages of systemic sclerosis. J Rheumatol 24 (1997) 1936-1943
    • (1997) J Rheumatol , vol.24 , pp. 1936-1943
    • Gruschwitz, M.S.1    Albrecht, M.2    Vieth, G.3    Haustein, U.F.4
  • 132
    • 0025174196 scopus 로고
    • Functional and phenotypic analysis of T-lymphocytes cloned from the skin of patients with systemic sclerosis
    • Ferrarini M., Steen V., Medsger Jr. T.A., and Whiteside T.L. Functional and phenotypic analysis of T-lymphocytes cloned from the skin of patients with systemic sclerosis. Clin Exp Immunol 79 (1990) 346-352
    • (1990) Clin Exp Immunol , vol.79 , pp. 346-352
    • Ferrarini, M.1    Steen, V.2    Medsger Jr., T.A.3    Whiteside, T.L.4
  • 133
    • 0032824790 scopus 로고    scopus 로고
    • Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a quantitative study of open lung biopsies
    • Majumdar S., Li D., Ansari T., Pantelidis P., Black C.M., Gizycki M., et al. Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a quantitative study of open lung biopsies. Eur Respir J 14 (1999) 251-257
    • (1999) Eur Respir J , vol.14 , pp. 251-257
    • Majumdar, S.1    Li, D.2    Ansari, T.3    Pantelidis, P.4    Black, C.M.5    Gizycki, M.6
  • 134
    • 0031606459 scopus 로고    scopus 로고
    • Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung
    • Hancock A., Armstrong L., Gama R., and Millar A. Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol 18 (1998) 60-65
    • (1998) Am J Respir Cell Mol Biol , vol.18 , pp. 60-65
    • Hancock, A.1    Armstrong, L.2    Gama, R.3    Millar, A.4
  • 135
    • 0030904129 scopus 로고    scopus 로고
    • Cytokine concentrations in bronchoalveolar lavage fluid of patients with systemic sclerosis
    • Bolster M.B., Ludwicka A., Sutherland S.E., Strange C., and Silver R.M. Cytokine concentrations in bronchoalveolar lavage fluid of patients with systemic sclerosis. Arthritis Rheum 40 (1997) 743-751
    • (1997) Arthritis Rheum , vol.40 , pp. 743-751
    • Bolster, M.B.1    Ludwicka, A.2    Sutherland, S.E.3    Strange, C.4    Silver, R.M.5
  • 136
    • 0033000530 scopus 로고    scopus 로고
    • Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis
    • Atamas S.P., Yurovsky V.V., Wise R., Wigley F.M., Goter Robinson C.J., Henry P., et al. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum 42 (1999) 1168-1178
    • (1999) Arthritis Rheum , vol.42 , pp. 1168-1178
    • Atamas, S.P.1    Yurovsky, V.V.2    Wise, R.3    Wigley, F.M.4    Goter Robinson, C.J.5    Henry, P.6
  • 137
    • 0035039581 scopus 로고    scopus 로고
    • Peripheral blood T-lymphocytes from systemic sclerosis patients show both Th1 and Th2 activation
    • Valentini G., Baroni A., Esposito K., Naclerio C., Buommino E., Farzati A., et al. Peripheral blood T-lymphocytes from systemic sclerosis patients show both Th1 and Th2 activation. J Clin Immunol 21 (2001) 210-217
    • (2001) J Clin Immunol , vol.21 , pp. 210-217
    • Valentini, G.1    Baroni, A.2    Esposito, K.3    Naclerio, C.4    Buommino, E.5    Farzati, A.6
  • 138
    • 0036446301 scopus 로고    scopus 로고
    • Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T-lymphocytes from patients with systemic sclerosis
    • Fujii H., Hasegawa M., Takehara K., Mukaida N., and Sato S. Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T-lymphocytes from patients with systemic sclerosis. Clin Exp Immunol 130 (2002) 548-556
    • (2002) Clin Exp Immunol , vol.130 , pp. 548-556
    • Fujii, H.1    Hasegawa, M.2    Takehara, K.3    Mukaida, N.4    Sato, S.5
  • 139
    • 0034990164 scopus 로고    scopus 로고
    • Increased frequency of interleukin 4 producing CD4+ and CD8+ cells in peripheral blood from patients with systemic sclerosis
    • Tsuji-Yamada J., Nakazawa M., Minami M., and Sasaki T. Increased frequency of interleukin 4 producing CD4+ and CD8+ cells in peripheral blood from patients with systemic sclerosis. J Rheumatol 28 (2001) 1252-1258
    • (2001) J Rheumatol , vol.28 , pp. 1252-1258
    • Tsuji-Yamada, J.1    Nakazawa, M.2    Minami, M.3    Sasaki, T.4
  • 140
    • 0034887359 scopus 로고    scopus 로고
    • Circulating γ/δ T-lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization
    • Giacomelli R., Cipriani P., Fulminis A., Barattelli G., Matucci-Cerinic M., D'Alò S., et al. Circulating γ/δ T-lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization. Clin Exp Immunol 125 (2001) 310-315
    • (2001) Clin Exp Immunol , vol.125 , pp. 310-315
    • Giacomelli, R.1    Cipriani, P.2    Fulminis, A.3    Barattelli, G.4    Matucci-Cerinic, M.5    D'Alò, S.6
  • 141
    • 8044257704 scopus 로고    scopus 로고
    • A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
    • Black R.A., Rauch C.T., Kozlosky C.J., Peschon J.J., Slack J.L., Wolfson M.F., et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 385 (1997) 729-733
    • (1997) Nature , vol.385 , pp. 729-733
    • Black, R.A.1    Rauch, C.T.2    Kozlosky, C.J.3    Peschon, J.J.4    Slack, J.L.5    Wolfson, M.F.6
  • 143
    • 0032869964 scopus 로고    scopus 로고
    • Investigation of the alveolar macrophages and T-lymphocytes in 15 patients with systemic sclerosis
    • Czirják L., Koncz A., Varga I., Dévényi K., Kumánovics G., and Szücs G. Investigation of the alveolar macrophages and T-lymphocytes in 15 patients with systemic sclerosis. Clin Rheumatol 18 (1999) 357-363
    • (1999) Clin Rheumatol , vol.18 , pp. 357-363
    • Czirják, L.1    Koncz, A.2    Varga, I.3    Dévényi, K.4    Kumánovics, G.5    Szücs, G.6
  • 145
    • 0024322543 scopus 로고
    • Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-α and β and tumor necrosis factor-α and β
    • Duncan M.R., and Berman B. Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-α and β and tumor necrosis factor-α and β. J Invest Dermatol 92 (1989) 699-706
    • (1989) J Invest Dermatol , vol.92 , pp. 699-706
    • Duncan, M.R.1    Berman, B.2
  • 146
    • 0025302767 scopus 로고
    • Regulation of human lung fibroblast collagen production by recombinant interleukin-1, tumor necrosis factor, and interferon-γ
    • Elias J.A., Freundlich B., Adams S., and Rosenbloom J. Regulation of human lung fibroblast collagen production by recombinant interleukin-1, tumor necrosis factor, and interferon-γ. Ann NY Acad Sci 580 (1990) 233-244
    • (1990) Ann NY Acad Sci , vol.580 , pp. 233-244
    • Elias, J.A.1    Freundlich, B.2    Adams, S.3    Rosenbloom, J.4
  • 147
    • 26444515531 scopus 로고    scopus 로고
    • Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts
    • Hetzel M., Bachem M., Anders D., Trischler G., and Faehling M. Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung 183 (2005) 225-237
    • (2005) Lung , vol.183 , pp. 225-237
    • Hetzel, M.1    Bachem, M.2    Anders, D.3    Trischler, G.4    Faehling, M.5
  • 148
    • 0032733697 scopus 로고    scopus 로고
    • Interferon-γ and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts
    • Spoelstra F.M., Postma D.S., Hovenga H., Noordhoek J.A., and Kauffman H.F. Interferon-γ and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts. Eur Respir J 14 (1999) 759-766
    • (1999) Eur Respir J , vol.14 , pp. 759-766
    • Spoelstra, F.M.1    Postma, D.S.2    Hovenga, H.3    Noordhoek, J.A.4    Kauffman, H.F.5
  • 149
    • 0033108957 scopus 로고    scopus 로고
    • Upregulation of the p75 but not the p55 TNF-α receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice
    • Ortiz L.A., Lasky J., Lungarella G., Cavarra E., Martorana P., Banks W.A., et al. Upregulation of the p75 but not the p55 TNF-α receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol 20 (1999) 825-833
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 825-833
    • Ortiz, L.A.1    Lasky, J.2    Lungarella, G.3    Cavarra, E.4    Martorana, P.5    Banks, W.A.6
  • 150
    • 31344473454 scopus 로고    scopus 로고
    • The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?
    • Yamamoto T. The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?. Arch Dermatol Res 297 (2006) 333-344
    • (2006) Arch Dermatol Res , vol.297 , pp. 333-344
    • Yamamoto, T.1
  • 153
    • 33744499180 scopus 로고    scopus 로고
    • Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumab
    • Allanore Y., Devos-François G., Caramella C., Boumier P., Jounieaux V., and Kahan A. Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumab. Ann Rheum Dis 65 (2006) 834-835
    • (2006) Ann Rheum Dis , vol.65 , pp. 834-835
    • Allanore, Y.1    Devos-François, G.2    Caramella, C.3    Boumier, P.4    Jounieaux, V.5    Kahan, A.6
  • 155
    • 0037184698 scopus 로고    scopus 로고
    • Complex cytokine regulation of tissue fibrosis
    • Atamas S.P. Complex cytokine regulation of tissue fibrosis. Life Sci 72 (2002) 631-643
    • (2002) Life Sci , vol.72 , pp. 631-643
    • Atamas, S.P.1
  • 156
    • 0024520959 scopus 로고
    • Synergistic effect of tumor necrosis factor-α and interferon-γ on collagen synthesis of human skin fibroblasts in vitro
    • Scharffetter K., Heckmann M., Hatamochi A., Mauch C., Stein B., Riethmüller G., et al. Synergistic effect of tumor necrosis factor-α and interferon-γ on collagen synthesis of human skin fibroblasts in vitro. Exp Cell Res 181 (1989) 409-419
    • (1989) Exp Cell Res , vol.181 , pp. 409-419
    • Scharffetter, K.1    Heckmann, M.2    Hatamochi, A.3    Mauch, C.4    Stein, B.5    Riethmüller, G.6
  • 158
    • 0034467817 scopus 로고    scopus 로고
    • Differential in vitro effects of IL-4. IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium
    • Morita Y., Yamamura M., Kawashima M., Aita T., Harada S., Okamoto H., et al. Differential in vitro effects of IL-4. IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheumatol Int 20 (2001) 49-54
    • (2001) Rheumatol Int , vol.20 , pp. 49-54
    • Morita, Y.1    Yamamura, M.2    Kawashima, M.3    Aita, T.4    Harada, S.5    Okamoto, H.6
  • 161
    • 0030992808 scopus 로고    scopus 로고
    • Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma
    • Hunzelmann N., Anders S., Fierlbeck G., Hein R., Herrmann K., Albrecht M., et al. Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma. Arch Dermatol 133 (1997) 609-613
    • (1997) Arch Dermatol , vol.133 , pp. 609-613
    • Hunzelmann, N.1    Anders, S.2    Fierlbeck, G.3    Hein, R.4    Herrmann, K.5    Albrecht, M.6
  • 163
    • 0033121274 scopus 로고    scopus 로고
    • Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
    • Kawaguchi Y., Hara M., and Wright T.M. Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A. J Clin Invest 103 (1999) 1253-1260
    • (1999) J Clin Invest , vol.103 , pp. 1253-1260
    • Kawaguchi, Y.1    Hara, M.2    Wright, T.M.3
  • 164
    • 0029670244 scopus 로고    scopus 로고
    • Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis
    • Szegedi A., Czirjak L., Unkeless J.C., and Boros P. Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis. Acta Derm Venereol 76 (1996) 21-23
    • (1996) Acta Derm Venereol , vol.76 , pp. 21-23
    • Szegedi, A.1    Czirjak, L.2    Unkeless, J.C.3    Boros, P.4
  • 165
    • 0033669058 scopus 로고    scopus 로고
    • Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1β and TNF-α
    • Sasaki M., Kashima M., Ito T., Watanabe A., Izumiyama N., Sano M., et al. Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1β and TNF-α. Mediators Inflamm 9 (2000) 155-160
    • (2000) Mediators Inflamm , vol.9 , pp. 155-160
    • Sasaki, M.1    Kashima, M.2    Ito, T.3    Watanabe, A.4    Izumiyama, N.5    Sano, M.6
  • 166
    • 0031689268 scopus 로고    scopus 로고
    • Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T-lymphocytes: involvement of membrane-associated cytokines
    • Burger D., Rezzonico R., Li J.M., Modoux C., Pierce R.A., Welgus H.G., et al. Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T-lymphocytes: involvement of membrane-associated cytokines. Arthritis Rheum 41 (1998) 1748-1759
    • (1998) Arthritis Rheum , vol.41 , pp. 1748-1759
    • Burger, D.1    Rezzonico, R.2    Li, J.M.3    Modoux, C.4    Pierce, R.A.5    Welgus, H.G.6
  • 167
    • 5044232255 scopus 로고    scopus 로고
    • Autocrine activation by interleukin 1α induces the fibrogenic phenotype of systemic sclerosis fibroblasts
    • Kawaguchi Y., McCarthy S.A., Watkins S.C., and Wright T.M. Autocrine activation by interleukin 1α induces the fibrogenic phenotype of systemic sclerosis fibroblasts. J Rheumatol 31 (2004) 1946-1954
    • (2004) J Rheumatol , vol.31 , pp. 1946-1954
    • Kawaguchi, Y.1    McCarthy, S.A.2    Watkins, S.C.3    Wright, T.M.4
  • 168
    • 0027280170 scopus 로고
    • Interleukin 1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin 1β
    • Kawaguchi Y., Harigai M., Suzuki K., Hara M., Kobayashi K., Ishizuka T., et al. Interleukin 1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin 1β. Biochem Biophys Res Commun 190 (1993) 154-161
    • (1993) Biochem Biophys Res Commun , vol.190 , pp. 154-161
    • Kawaguchi, Y.1    Harigai, M.2    Suzuki, K.3    Hara, M.4    Kobayashi, K.5    Ishizuka, T.6
  • 169
    • 0034659812 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1α loop
    • Yamamoto T., Eckes B., Mauch C., Hartmann K., and Krieg T. Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1α loop. J Immunol 164 (2000) 6174-6179
    • (2000) J Immunol , vol.164 , pp. 6174-6179
    • Yamamoto, T.1    Eckes, B.2    Mauch, C.3    Hartmann, K.4    Krieg, T.5
  • 170
    • 0030045122 scopus 로고    scopus 로고
    • IL-6 cytokine family and signal transduction: a model of the cytokine system
    • Hibi M., Nakajima K., and Hirano T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med 74 (1996) 1-12
    • (1996) J Mol Med , vol.74 , pp. 1-12
    • Hibi, M.1    Nakajima, K.2    Hirano, T.3
  • 171
    • 0031911610 scopus 로고    scopus 로고
    • Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis
    • Hasegawa M., Sato S., Fujimoto M., Ihn H., Kikuchi K., and Takehara K. Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis. J Rheumatol 25 (1998) 308-313
    • (1998) J Rheumatol , vol.25 , pp. 308-313
    • Hasegawa, M.1    Sato, S.2    Fujimoto, M.3    Ihn, H.4    Kikuchi, K.5    Takehara, K.6
  • 172
    • 0031935542 scopus 로고    scopus 로고
    • Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts
    • Kadono T., Kikuchi K., Ihn H., Takehara K., and Tamaki K. Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts. J Rheumatol 25 (1998) 296-301
    • (1998) J Rheumatol , vol.25 , pp. 296-301
    • Kadono, T.1    Kikuchi, K.2    Ihn, H.3    Takehara, K.4    Tamaki, K.5
  • 173
    • 0031880752 scopus 로고    scopus 로고
    • Enhanced interleukin 6 production by cultured fibroblasts from patients with systemic sclerosis in response to platelet derived growth factor
    • Takemura H., Suzuki H., Fujisawa H., Yuhara T., Akama T., Yamane K., et al. Enhanced interleukin 6 production by cultured fibroblasts from patients with systemic sclerosis in response to platelet derived growth factor. J Rheumatol 25 (1998) 1534-1539
    • (1998) J Rheumatol , vol.25 , pp. 1534-1539
    • Takemura, H.1    Suzuki, H.2    Fujisawa, H.3    Yuhara, T.4    Akama, T.5    Yamane, K.6
  • 174
    • 0029611002 scopus 로고
    • Regulatory effects of γ-interferon on IL-6 and IL-8 secretion by cultured human keratinocytes and dermal fibroblasts
    • Maruyama K., Zhang J.Z., Nihei Y., Ono I., and Kaneko F. Regulatory effects of γ-interferon on IL-6 and IL-8 secretion by cultured human keratinocytes and dermal fibroblasts. J Dermatol 22 (1995) 901-906
    • (1995) J Dermatol , vol.22 , pp. 901-906
    • Maruyama, K.1    Zhang, J.Z.2    Nihei, Y.3    Ono, I.4    Kaneko, F.5
  • 175
    • 0031943618 scopus 로고    scopus 로고
    • The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses
    • Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 16 (1998) 495-521
    • (1998) Annu Rev Immunol , vol.16 , pp. 495-521
    • Gately, M.K.1    Renzetti, L.M.2    Magram, J.3    Stern, A.S.4    Adorini, L.5    Gubler, U.6
  • 179
    • 0036721628 scopus 로고    scopus 로고
    • A profibrotic function of IL-12p40 in experimental pulmonary fibrosis
    • Huaux F., Arras M., Tomasi D., Barbarin V., Delos M., Coutelier J.P., et al. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 169 (2002) 2653-2661
    • (2002) J Immunol , vol.169 , pp. 2653-2661
    • Huaux, F.1    Arras, M.2    Tomasi, D.3    Barbarin, V.4    Delos, M.5    Coutelier, J.P.6
  • 180
    • 0000155803 scopus 로고    scopus 로고
    • A novel function of IL-12p40 as a chemotactic molecule for macrophages
    • Ha S.J., Lee C.H., Lee S.B., Kim C.M., Jang K.L., Shin H.S., et al. A novel function of IL-12p40 as a chemotactic molecule for macrophages. J Immunol 163 (1999) 2902-2908
    • (1999) J Immunol , vol.163 , pp. 2902-2908
    • Ha, S.J.1    Lee, C.H.2    Lee, S.B.3    Kim, C.M.4    Jang, K.L.5    Shin, H.S.6
  • 181
    • 0031014560 scopus 로고    scopus 로고
    • Functions of IL-4 and control of its expression
    • Brown M.A., and Hural J. Functions of IL-4 and control of its expression. Crit Rev Immunol 17 (1997) 1-32
    • (1997) Crit Rev Immunol , vol.17 , pp. 1-32
    • Brown, M.A.1    Hural, J.2
  • 182
    • 1642333177 scopus 로고    scopus 로고
    • Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    • Kolodsick J.E., Toews G.B., Jakubzick C., Hogaboam C., Moore T.A., McKenzie A., et al. Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol 172 (2004) 4068-4076
    • (2004) J Immunol , vol.172 , pp. 4068-4076
    • Kolodsick, J.E.1    Toews, G.B.2    Jakubzick, C.3    Hogaboam, C.4    Moore, T.A.5    McKenzie, A.6
  • 185
    • 12144264841 scopus 로고    scopus 로고
    • Interleukin-13 augments transforming growth factor-β1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts
    • Zhou X., Trudeau J.B., Schoonover K.J., Lundin J.I., Barnes S.M., Cundall M.J., et al. Interleukin-13 augments transforming growth factor-β1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts. Am J Physiol Cell Physiol 288 (2005) C435-C442
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Zhou, X.1    Trudeau, J.B.2    Schoonover, K.J.3    Lundin, J.I.4    Barnes, S.M.5    Cundall, M.J.6
  • 186
    • 0032822463 scopus 로고    scopus 로고
    • Increased levels of alternatively spliced interleukin 4 (IL-4δ2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis
    • Sakkas L.I., Tourtellotte C., Berney S., Myers A.R., and Platsoucas C.D. Increased levels of alternatively spliced interleukin 4 (IL-4δ2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis. Clin Diagn Lab Immunol 6 (1999) 660-664
    • (1999) Clin Diagn Lab Immunol , vol.6 , pp. 660-664
    • Sakkas, L.I.1    Tourtellotte, C.2    Berney, S.3    Myers, A.R.4    Platsoucas, C.D.5
  • 187
    • 0032850329 scopus 로고    scopus 로고
    • Interleukin 4 in systemic sclerosis: not just an increase
    • Atamas S.P., and White B. Interleukin 4 in systemic sclerosis: not just an increase. Clin Diagn Lab Immunol 6 (1999) 658-659
    • (1999) Clin Diagn Lab Immunol , vol.6 , pp. 658-659
    • Atamas, S.P.1    White, B.2
  • 188
    • 0037133611 scopus 로고    scopus 로고
    • Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts
    • Kodera T., McGaha T.L., Phelps R., Paul W.E., and Bona C.A. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts. Proc Natl Acad Sci USA 99 (2002) 3800-3805
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3800-3805
    • Kodera, T.1    McGaha, T.L.2    Phelps, R.3    Paul, W.E.4    Bona, C.A.5
  • 189
    • 0031712891 scopus 로고    scopus 로고
    • Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma
    • Ong C., Wong C., Roberts C.R., Teh H.S., and Jirik F.R. Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma. Eur J Immunol 28 (1998) 2619-2629
    • (1998) Eur J Immunol , vol.28 , pp. 2619-2629
    • Ong, C.1    Wong, C.2    Roberts, C.R.3    Teh, H.S.4    Jirik, F.R.5
  • 191
    • 0036787916 scopus 로고    scopus 로고
    • Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    • Belperio J.A., Dy M., Burdick M.D., Xue Y.Y., Li K., Elias J.A., et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 27 (2002) 419-427
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 419-427
    • Belperio, J.A.1    Dy, M.2    Burdick, M.D.3    Xue, Y.Y.4    Li, K.5    Elias, J.A.6
  • 192
    • 0031056613 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin 4 (IL-4). IL-10, and IL-13 in patients with systemic sclerosis
    • Hasegawa M., Fujimoto M., Kikuchi K., and Takehara K. Elevated serum levels of interleukin 4 (IL-4). IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol 24 (1997) 328-332
    • (1997) J Rheumatol , vol.24 , pp. 328-332
    • Hasegawa, M.1    Fujimoto, M.2    Kikuchi, K.3    Takehara, K.4
  • 193
    • 0027943188 scopus 로고
    • Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts
    • Reitamo S., Remitz A., Tamai K., and Uitto J. Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts. J Clin Invest 94 (1994) 2489-2492
    • (1994) J Clin Invest , vol.94 , pp. 2489-2492
    • Reitamo, S.1    Remitz, A.2    Tamai, K.3    Uitto, J.4
  • 194
    • 0034810226 scopus 로고    scopus 로고
    • Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-β and monocyte chemoattractant protein-1
    • Yamamoto T., Eckes B., and Krieg T. Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-β and monocyte chemoattractant protein-1. Biochem Biophys Res Commun 281 (2001) 200-205
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 200-205
    • Yamamoto, T.1    Eckes, B.2    Krieg, T.3
  • 196
    • 17444393936 scopus 로고    scopus 로고
    • Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles
    • Barbarin V., Xing Z., Delos M., Lison D., and Huaux F. Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am J Physiol Lung Cell Mol Physiol 288 (2005) L841-L848
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Barbarin, V.1    Xing, Z.2    Delos, M.3    Lison, D.4    Huaux, F.5
  • 197
    • 0034945450 scopus 로고    scopus 로고
    • Role of cytokines and cytokine therapy in wound healing and fibrotic diseases
    • Gharaee-Kermani M., and Phan S.H. Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Curr Pharm Des 7 (2001) 1083-1103
    • (2001) Curr Pharm Des , vol.7 , pp. 1083-1103
    • Gharaee-Kermani, M.1    Phan, S.H.2
  • 198
    • 11144347711 scopus 로고    scopus 로고
    • Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts
    • Jinnin M., Ihn H., Mimura Y., Asano Y., Yamane K., and Tamaki K. Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts. J Cell Physiol 202 (2005) 510-517
    • (2005) J Cell Physiol , vol.202 , pp. 510-517
    • Jinnin, M.1    Ihn, H.2    Mimura, Y.3    Asano, Y.4    Yamane, K.5    Tamaki, K.6
  • 199
    • 0024539072 scopus 로고
    • Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma
    • Gay S., Jones Jr. R.E., Huang G.Q., and Gay R.E. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma. J Invest Dermatol 92 (1989) 301-303
    • (1989) J Invest Dermatol , vol.92 , pp. 301-303
    • Gay, S.1    Jones Jr., R.E.2    Huang, G.Q.3    Gay, R.E.4
  • 200
    • 0025014021 scopus 로고
    • Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis
    • Klareskog L., Gustafsson R., Scheynius A., and Hällgren R. Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis. Arthritis Rheum 33 (1990) 1534-1541
    • (1990) Arthritis Rheum , vol.33 , pp. 1534-1541
    • Klareskog, L.1    Gustafsson, R.2    Scheynius, A.3    Hällgren, R.4
  • 202
    • 33644525604 scopus 로고    scopus 로고
    • Differential effects of PDGF-BB on matrix metalloproteases and cytokine release in fibroblasts of Type 2 diabetic patients and normal controls in vitro
    • Lobmann R., Pap T., Ambrosch A., Waldmann K., König W., and Lehnert H. Differential effects of PDGF-BB on matrix metalloproteases and cytokine release in fibroblasts of Type 2 diabetic patients and normal controls in vitro. J Diabetes Complications 20 (2006) 105-112
    • (2006) J Diabetes Complications , vol.20 , pp. 105-112
    • Lobmann, R.1    Pap, T.2    Ambrosch, A.3    Waldmann, K.4    König, W.5    Lehnert, H.6
  • 203
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of PDGF and its receptors in fibrotic diseases
    • Bonner J.C. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15 (2004) 255-273
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 255-273
    • Bonner, J.C.1
  • 204
    • 0032974438 scopus 로고    scopus 로고
    • Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1α) and MIP-1β) in patients with systemic sclerosis: MCP-1 and MIP-1α may be involved in the development of pulmonary fibrosis
    • Hasegawa M., Sato S., and Takehara K. Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1α) and MIP-1β) in patients with systemic sclerosis: MCP-1 and MIP-1α may be involved in the development of pulmonary fibrosis. Clin Exp Immunol 117 (1999) 159-165
    • (1999) Clin Exp Immunol , vol.117 , pp. 159-165
    • Hasegawa, M.1    Sato, S.2    Takehara, K.3
  • 205
    • 0033396567 scopus 로고    scopus 로고
    • Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis
    • Distler O., Rinkes B., Hohenleutner U., Schölmerich J., Landthaler M., Lang B., et al. Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis. Rheumatol Int 19 (1999) 39-46
    • (1999) Rheumatol Int , vol.19 , pp. 39-46
    • Distler, O.1    Rinkes, B.2    Hohenleutner, U.3    Schölmerich, J.4    Landthaler, M.5    Lang, B.6
  • 206
    • 0038004791 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse
    • Ong V.H., Evans L.A., Shiwen X., Fisher I.B., Rajkumar V., Abraham D.J., et al. Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis Rheum 48 (2003) 1979-1991
    • (2003) Arthritis Rheum , vol.48 , pp. 1979-1991
    • Ong, V.H.1    Evans, L.A.2    Shiwen, X.3    Fisher, I.B.4    Rajkumar, V.5    Abraham, D.J.6
  • 207
    • 0035149215 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis
    • Distler O., Pap T., Kowal-Bielecka O., Meyringer R., Guiducci S., Landthaler M., et al. Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis. Arthritis Rheum 44 (2001) 2665-2678
    • (2001) Arthritis Rheum , vol.44 , pp. 2665-2678
    • Distler, O.1    Pap, T.2    Kowal-Bielecka, O.3    Meyringer, R.4    Guiducci, S.5    Landthaler, M.6
  • 208
    • 0034988135 scopus 로고    scopus 로고
    • Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis
    • Yamamoto T., Eckes B., Hartmann K., and Krieg T. Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis. J Dermatol Sci 26 (2001) 133-139
    • (2001) J Dermatol Sci , vol.26 , pp. 133-139
    • Yamamoto, T.1    Eckes, B.2    Hartmann, K.3    Krieg, T.4
  • 209
    • 29144443977 scopus 로고    scopus 로고
    • Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation
    • Carulli M.T., Ong V.H., Ponticos M., Shiwen X., Abraham D.J., Black C.M., et al. Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation. Arthritis Rheum 52 (2005) 3772-3782
    • (2005) Arthritis Rheum , vol.52 , pp. 3772-3782
    • Carulli, M.T.1    Ong, V.H.2    Ponticos, M.3    Shiwen, X.4    Abraham, D.J.5    Black, C.M.6
  • 210
    • 0034966873 scopus 로고    scopus 로고
    • Chemokine expression by systemic sclerosis fibroblasts: abnormal regulation of monocyte chemoattractant protein 1 expression
    • Galindo M., Santiago B., Rivero M., Rullas J., Alcami J., and Pablos J.L. Chemokine expression by systemic sclerosis fibroblasts: abnormal regulation of monocyte chemoattractant protein 1 expression. Arthritis Rheum 44 (2001) 1382-1386
    • (2001) Arthritis Rheum , vol.44 , pp. 1382-1386
    • Galindo, M.1    Santiago, B.2    Rivero, M.3    Rullas, J.4    Alcami, J.5    Pablos, J.L.6
  • 211
    • 0041333160 scopus 로고    scopus 로고
    • Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma
    • Yamamoto T., and Nishioka K. Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol 121 (2003) 510-516
    • (2003) J Invest Dermatol , vol.121 , pp. 510-516
    • Yamamoto, T.1    Nishioka, K.2
  • 212
    • 29144490583 scopus 로고    scopus 로고
    • Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
    • Yanaba K., Komura K., Kodera M., Matsushita T., Hasegawa M., Takehara K., et al. Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. Ann Rheum Dis 65 (2006) 124-126
    • (2006) Ann Rheum Dis , vol.65 , pp. 124-126
    • Yanaba, K.1    Komura, K.2    Kodera, M.3    Matsushita, T.4    Hasegawa, M.5    Takehara, K.6
  • 214
    • 0031763952 scopus 로고    scopus 로고
    • Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers
    • Denton C.P., Shi-Wen X., Sutton A., Abraham D.J., Black C.M., and Pearson J.D. Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers. Clin Exp Immunol 114 (1998) 293-300
    • (1998) Clin Exp Immunol , vol.114 , pp. 293-300
    • Denton, C.P.1    Shi-Wen, X.2    Sutton, A.3    Abraham, D.J.4    Black, C.M.5    Pearson, J.D.6
  • 215
    • 31044456861 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T-cells
    • Distler J.H., Jüngel A., Caretto D., Schulze-Horsel U., Kowal-Bielecka O., Gay R.E., et al. Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T-cells. Arthritis Rheum 54 (2006) 214-225
    • (2006) Arthritis Rheum , vol.54 , pp. 214-225
    • Distler, J.H.1    Jüngel, A.2    Caretto, D.3    Schulze-Horsel, U.4    Kowal-Bielecka, O.5    Gay, R.E.6
  • 216
    • 0037103183 scopus 로고    scopus 로고
    • Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
    • McQuibban G.A., Gong J.H., Wong J.P., Wallace J.L., Clark-Lewis I., and Overall C.M. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 100 (2002) 1160-1167
    • (2002) Blood , vol.100 , pp. 1160-1167
    • McQuibban, G.A.1    Gong, J.H.2    Wong, J.P.3    Wallace, J.L.4    Clark-Lewis, I.5    Overall, C.M.6
  • 217
    • 0034777651 scopus 로고    scopus 로고
    • High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts
    • Yamamoto T., Eckes B., and Krieg T. High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts. Eur J Immunol 31 (2001) 2936-2941
    • (2001) Eur J Immunol , vol.31 , pp. 2936-2941
    • Yamamoto, T.1    Eckes, B.2    Krieg, T.3
  • 218
    • 0035144005 scopus 로고    scopus 로고
    • Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts
    • Galindo M., Santiago B., Alcami J., Rivero M., Martín-Serrano J., and Pablos J.L. Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts. Clin Exp Immunol 123 (2001) 36-41
    • (2001) Clin Exp Immunol , vol.123 , pp. 36-41
    • Galindo, M.1    Santiago, B.2    Alcami, J.3    Rivero, M.4    Martín-Serrano, J.5    Pablos, J.L.6
  • 220
    • 0037087365 scopus 로고    scopus 로고
    • IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
    • Zhu Z., Ma B., Zheng T., Homer R.J., Lee C.G., Charo I.F., et al. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 168 (2002) 2953-2962
    • (2002) J Immunol , vol.168 , pp. 2953-2962
    • Zhu, Z.1    Ma, B.2    Zheng, T.3    Homer, R.J.4    Lee, C.G.5    Charo, I.F.6
  • 221
    • 0036240743 scopus 로고    scopus 로고
    • Genetic epidemiology: systemic sclerosis
    • Herrick A.L., and Worthington J. Genetic epidemiology: systemic sclerosis. Arthritis Res 4 (2002) 165-168
    • (2002) Arthritis Res , vol.4 , pp. 165-168
    • Herrick, A.L.1    Worthington, J.2
  • 224
    • 27744454481 scopus 로고    scopus 로고
    • High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity
    • Brix T.H., Knudsen G.P., Kristiansen M., Kyvik K.O., Ørstavik K.H., and Hegedüs L. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab 90 (2005) 5949-5953
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5949-5953
    • Brix, T.H.1    Knudsen, G.P.2    Kristiansen, M.3    Kyvik, K.O.4    Ørstavik, K.H.5    Hegedüs, L.6
  • 225
    • 33744503390 scopus 로고    scopus 로고
    • Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity
    • Ozcelik T., Uz E., Akyerli C.B., Bagislar S., Mustafa C.A., Gursoy A., et al. Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity. Eur J Hum Genet 14 (2006) 791-797
    • (2006) Eur J Hum Genet , vol.14 , pp. 791-797
    • Ozcelik, T.1    Uz, E.2    Akyerli, C.B.3    Bagislar, S.4    Mustafa, C.A.5    Gursoy, A.6
  • 227
    • 11144241470 scopus 로고    scopus 로고
    • Induction of endothelial cell damage by hCMV molecular mimicry
    • Lunardi C., Bason C., Corrocher R., and Puccetti A. Induction of endothelial cell damage by hCMV molecular mimicry. Trends Immunol 26 (2005) 19-24
    • (2005) Trends Immunol , vol.26 , pp. 19-24
    • Lunardi, C.1    Bason, C.2    Corrocher, R.3    Puccetti, A.4
  • 228
    • 0033498335 scopus 로고    scopus 로고
    • Autoimmunity and vascular involvement in systemic sclerosis (SSc)
    • Kahaleh M.B., and LeRoy E.C. Autoimmunity and vascular involvement in systemic sclerosis (SSc). Autoimmunity 31 (1999) 195-214
    • (1999) Autoimmunity , vol.31 , pp. 195-214
    • Kahaleh, M.B.1    LeRoy, E.C.2
  • 230
    • 0038799783 scopus 로고    scopus 로고
    • Scleroderma epidemiology
    • Mayes M.D. Scleroderma epidemiology. Rheum Dis Clin North Am 29 (2003) 239-254
    • (2003) Rheum Dis Clin North Am , vol.29 , pp. 239-254
    • Mayes, M.D.1
  • 231
    • 9444226445 scopus 로고    scopus 로고
    • Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype
    • Arnett F.C., Howard R.F., Tan F., Moulds J.M., Bias W.B., Durban E., et al. Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. Arthritis Rheum 39 (1996) 1362-1370
    • (1996) Arthritis Rheum , vol.39 , pp. 1362-1370
    • Arnett, F.C.1    Howard, R.F.2    Tan, F.3    Moulds, J.M.4    Bias, W.B.5    Durban, E.6
  • 236
    • 0029584869 scopus 로고
    • A study of scleroderma in South Australia: prevalence, subset characteristics and nailfold capillaroscopy
    • Chandran G., Smith M., Ahern M.J., and Roberts-Thomson P.J. A study of scleroderma in South Australia: prevalence, subset characteristics and nailfold capillaroscopy. Aust NZ J Med 25 (1995) 688-694
    • (1995) Aust NZ J Med , vol.25 , pp. 688-694
    • Chandran, G.1    Smith, M.2    Ahern, M.J.3    Roberts-Thomson, P.J.4
  • 237
    • 33745584356 scopus 로고    scopus 로고
    • Scleroderma in South Australia: further epidemiological observations supporting a stochastic explanation
    • Roberts-Thomson P.J., Walker J.G., Lu T.Y., Esterman A., Hakendorf P., Smith M.D., et al. Scleroderma in South Australia: further epidemiological observations supporting a stochastic explanation. Intern Med J 36 (2006) 489-497
    • (2006) Intern Med J , vol.36 , pp. 489-497
    • Roberts-Thomson, P.J.1    Walker, J.G.2    Lu, T.Y.3    Esterman, A.4    Hakendorf, P.5    Smith, M.D.6
  • 238
    • 0025936232 scopus 로고
    • Epidemiological study of patients with systemic sclerosis in Tokyo
    • Tamaki T., Mori S., and Takehara K. Epidemiological study of patients with systemic sclerosis in Tokyo. Arch Dermatol Res 283 (1991) 366-371
    • (1991) Arch Dermatol Res , vol.283 , pp. 366-371
    • Tamaki, T.1    Mori, S.2    Takehara, K.3
  • 239
    • 0035044928 scopus 로고    scopus 로고
    • Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants
    • Reveille J.D., Fischbach M., McNearney T., Friedman A.W., Aguilar M.B., Lisse J., et al. Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. Semin Arthritis Rheum 30 (2001) 332-346
    • (2001) Semin Arthritis Rheum , vol.30 , pp. 332-346
    • Reveille, J.D.1    Fischbach, M.2    McNearney, T.3    Friedman, A.W.4    Aguilar, M.B.5    Lisse, J.6
  • 240
    • 0035003217 scopus 로고    scopus 로고
    • European multicentre study to define disease activity criteria for systemic sclerosis. I. Clinical and epidemiological features of 290 patients from 19 centers
    • Della Rossa A., Valentini G., Bombardieri S., Bencivelli W., Silman A.J., D'Angelo S., et al. European multicentre study to define disease activity criteria for systemic sclerosis. I. Clinical and epidemiological features of 290 patients from 19 centers. Ann Rheum Dis 60 (2001) 585-591
    • (2001) Ann Rheum Dis , vol.60 , pp. 585-591
    • Della Rossa, A.1    Valentini, G.2    Bombardieri, S.3    Bencivelli, W.4    Silman, A.J.5    D'Angelo, S.6
  • 241
    • 0036124419 scopus 로고    scopus 로고
    • Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients
    • Ferri C., Valentini G., Cozzi F., Sebastiani M., Michelassi C., La Montagna G., et al. Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine 81 (2002) 139-153
    • (2002) Medicine , vol.81 , pp. 139-153
    • Ferri, C.1    Valentini, G.2    Cozzi, F.3    Sebastiani, M.4    Michelassi, C.5    La Montagna, G.6
  • 243
    • 0030866707 scopus 로고    scopus 로고
    • Predictors of survival in 171 patients with systemic sclerosis (scleroderma)
    • Nagy Z., and Czirják L. Predictors of survival in 171 patients with systemic sclerosis (scleroderma). Clin Rheumatol 16 (1997) 454-460
    • (1997) Clin Rheumatol , vol.16 , pp. 454-460
    • Nagy, Z.1    Czirják, L.2
  • 245
    • 31044444627 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension is a major mortality factor in diffuse systemic sclerosis, independent of interstitial lung disease
    • Trad S., Amoura Z., Beigelman C., Haroche J., Costedoat N., Boutin le T.H., et al. Pulmonary arterial hypertension is a major mortality factor in diffuse systemic sclerosis, independent of interstitial lung disease. Arthritis Rheum 54 (2006) 184-191
    • (2006) Arthritis Rheum , vol.54 , pp. 184-191
    • Trad, S.1    Amoura, Z.2    Beigelman, C.3    Haroche, J.4    Costedoat, N.5    Boutin le, T.H.6
  • 246
    • 0142187600 scopus 로고    scopus 로고
    • Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach
    • Mukerjee D., St. George D., Coleiro B., Knight C., Denton C.P., Davar J., et al. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 62 (2003) 1088-1093
    • (2003) Ann Rheum Dis , vol.62 , pp. 1088-1093
    • Mukerjee, D.1    St. George, D.2    Coleiro, B.3    Knight, C.4    Denton, C.P.5    Davar, J.6
  • 247
    • 22244434954 scopus 로고    scopus 로고
    • The prevalence of undiagnosed pulmonary arterial hypertension in subjects with connective tissue disease at the secondary health care level of community-based rheumatologists (the UNCOVER study)
    • Wigley F.M., Lima J.A., Mayes M., McLain D., Chapin J.L., and Ward-Able C. The prevalence of undiagnosed pulmonary arterial hypertension in subjects with connective tissue disease at the secondary health care level of community-based rheumatologists (the UNCOVER study). Arthritis Rheum 52 (2005) 2125-2132
    • (2005) Arthritis Rheum , vol.52 , pp. 2125-2132
    • Wigley, F.M.1    Lima, J.A.2    Mayes, M.3    McLain, D.4    Chapin, J.L.5    Ward-Able, C.6
  • 248
    • 0043074631 scopus 로고    scopus 로고
    • Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population
    • Mayes M.D., Lacey Jr. J.V., Beebe-Dimmer J., Gillespie B.W., Cooper B., Laing T.J., et al. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum 48 (2003) 2246-2255
    • (2003) Arthritis Rheum , vol.48 , pp. 2246-2255
    • Mayes, M.D.1    Lacey Jr., J.V.2    Beebe-Dimmer, J.3    Gillespie, B.W.4    Cooper, B.5    Laing, T.J.6
  • 250
    • 0029910577 scopus 로고    scopus 로고
    • Survival following the onset of scleroderma: results from a retrospective inception cohort study of the UK patient population
    • Bryan C., Howard Y., Brennan P., Black C., and Silman A. Survival following the onset of scleroderma: results from a retrospective inception cohort study of the UK patient population. Br J Rheumatol 35 (1996) 1122-1126
    • (1996) Br J Rheumatol , vol.35 , pp. 1122-1126
    • Bryan, C.1    Howard, Y.2    Brennan, P.3    Black, C.4    Silman, A.5
  • 251
    • 0031771507 scopus 로고    scopus 로고
    • Mortality and causes of death in a Swedish series of systemic sclerosis patients
    • Hesselstrand R., Scheja A., and Åkesson A. Mortality and causes of death in a Swedish series of systemic sclerosis patients. Ann Rheum Dis 57 (1998) 682-686
    • (1998) Ann Rheum Dis , vol.57 , pp. 682-686
    • Hesselstrand, R.1    Scheja, A.2    Åkesson, A.3
  • 252
    • 0031855190 scopus 로고    scopus 로고
    • Mortality and causes of death of 344 Danish patients with systemic sclerosis (scleroderma)
    • Jacobsen S., Halberg P., and Ullman S. Mortality and causes of death of 344 Danish patients with systemic sclerosis (scleroderma). Br J Rheumatol 37 (1998) 750-755
    • (1998) Br J Rheumatol , vol.37 , pp. 750-755
    • Jacobsen, S.1    Halberg, P.2    Ullman, S.3
  • 253
    • 10544251839 scopus 로고    scopus 로고
    • Epidemiological analysis of prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc). Scleroderma Research Committee Japan
    • Nishioka K., Katayama I., Kondo H., Shinkai H., Ueki H., Tamaki K., et al. Epidemiological analysis of prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc). Scleroderma Research Committee Japan. J Dermatol 23 (1996) 677-682
    • (1996) J Dermatol , vol.23 , pp. 677-682
    • Nishioka, K.1    Katayama, I.2    Kondo, H.3    Shinkai, H.4    Ueki, H.5    Tamaki, K.6
  • 254
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., Mimura Y., and Tamaki K. Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts. J Immunol 175 (2005) 7708-7718
    • (2005) J Immunol , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 255
    • 1642329882 scopus 로고    scopus 로고
    • Increased expression levels of integrin αvβ5 on scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., Kubo M., and Tamaki K. Increased expression levels of integrin αvβ5 on scleroderma fibroblasts. Am J Pathol 164 (2004) 1275-1292
    • (2004) Am J Pathol , vol.164 , pp. 1275-1292
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Kubo, M.4    Tamaki, K.5
  • 257
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
    • Kawakami T., Ihn H., Xu W., Smith E., LeRoy C., and Trojanowska M. Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype. J Invest Dermatol 110 (1998) 47-51
    • (1998) J Invest Dermatol , vol.110 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3    Smith, E.4    LeRoy, C.5    Trojanowska, M.6
  • 258
    • 7044263334 scopus 로고    scopus 로고
    • Recent advances in fibroblast signaling and biology in scleroderma
    • Pannu J., and Trojanowska M. Recent advances in fibroblast signaling and biology in scleroderma. Curr Opin Rheumatol 16 (2004) 739-745
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 739-745
    • Pannu, J.1    Trojanowska, M.2
  • 259
    • 0028168597 scopus 로고
    • IL-1α gene expression and protein production by fibroblasts from patients with systemic sclerosis
    • Kawaguchi Y. IL-1α gene expression and protein production by fibroblasts from patients with systemic sclerosis. Clin Exp Immunol 97 (1994) 445-450
    • (1994) Clin Exp Immunol , vol.97 , pp. 445-450
    • Kawaguchi, Y.1
  • 260
    • 0026767273 scopus 로고
    • Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma
    • Feghali C.A., Bost K.L., Boulware D.W., and Levy L.S. Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma. J Rheumatol 19 (1992) 1207-1211
    • (1992) J Rheumatol , vol.19 , pp. 1207-1211
    • Feghali, C.A.1    Bost, K.L.2    Boulware, D.W.3    Levy, L.S.4
  • 261
    • 0028812401 scopus 로고
    • Different effects of basic fibroblast growth factor and transforming growth factor-β on the two platelet-derived growth factor receptors' expression in scleroderma and healthy human dermal fibroblasts
    • Ichiki Y., Smith E., LeRoy E.C., and Trojanowska M. Different effects of basic fibroblast growth factor and transforming growth factor-β on the two platelet-derived growth factor receptors' expression in scleroderma and healthy human dermal fibroblasts. J Invest Dermatol 104 (1995) 124-127
    • (1995) J Invest Dermatol , vol.104 , pp. 124-127
    • Ichiki, Y.1    Smith, E.2    LeRoy, E.C.3    Trojanowska, M.4
  • 262
    • 0035788742 scopus 로고    scopus 로고
    • Differential regulation of transforming growth factor-β receptors type I and II by platelet-derived growth factor in human dermal fibroblasts
    • Czuwara-Ladykowska J., Gore E.A., Shegogue D.A., Smith E.A., and Trojanowska M. Differential regulation of transforming growth factor-β receptors type I and II by platelet-derived growth factor in human dermal fibroblasts. Br J Dermatol 145 (2001) 569-575
    • (2001) Br J Dermatol , vol.145 , pp. 569-575
    • Czuwara-Ladykowska, J.1    Gore, E.A.2    Shegogue, D.A.3    Smith, E.A.4    Trojanowska, M.5


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