Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway

Arthritis and Rheumatism

Volumn 44, Issue 11, 2001, Pages 2653-2664

  Sambo, Paola ^a   Baroni, Silvia Svegliati ^a   Luchetti, Michele ^a   Paroncini, Paolo ^a   Dusi, Stefano ^b   Orlandini, Guido ^c   Gabrielli, Armando ^a,d  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d Istituto di Clinica Medica Generale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SCLERODERMA; SYSTEMIC SCLEROSIS;

ACETYLCYSTEINE; ALLOPURINOL; ALPHA-TOCOPHEROL; BIPHENYL COMPOUNDS; CELL DIVISION; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GROWTH SUBSTANCES; HUMANS; HYDROGEN PEROXIDE; MICROSCOPY, CONFOCAL; NADPH OXIDASE; ONIUM COMPOUNDS; OXIDATIVE STRESS; PHENOTYPE; PHOSPHOPROTEINS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; ROTENONE; SCLERODERMA, LOCALIZED; SCLERODERMA, SYSTEMIC; SKIN; UP-REGULATION;

EID: 0035149214     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200111)44:11<2653::AID-ART445>3.0.CO;2-1     Document Type: Article

References (42)

1. Systemic sclerosis (scleroderma) and related disorders
2. Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma
3. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblast
4. Scleroderma: Increased biosynthesis of triple-helical type I and III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture
5. Increased type I collagen mRNA levels in cultured scleroderma fibroblasts
6. Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts
7. Elevated pro α2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene
8. Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts
9. C-myb proto-oncogene is expressed by quiescent scleroderma fibroblast and, unlike B-myb, does not correlate with proliferation
10. Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma
11. Increased susceptibility to oxidation of low-density lipoproteins isolated from patients with systemic sclerosis
12. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: Implication for pathogenesis
13. Monocytes of patients with systemic sclerosis (scleroderma) spontaneously release in vitro increased amounts of superoxide anion
14. Preliminary criteria for the classification of systemic sclerosis (scleroderma)
15. Desensitization of macrophage oxygen metabolism on immobilized ligands: Different effect of immunoglobulin G and complement
16. Receptor-ligand internalization
17. Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils: Its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton
18. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
19. Fluorescent calcium indicators: Subcellular behavior and use in confocal imaging
20. Genetic, biochemical and clinical features of chronic granulomatous disease
21. A radical proposal for the pathogenesis of scleroderma
22. 2 for platelet-derived growth factor signal transduction
23. Nerve growth factor-induced neuronal differentiation requires generation of Rac 1-regulated reactive oxygen species
24. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: Role in EGF receptor-mediated tyrosine phosphorylation
25. Regulation of reactive-oxygen species generation in fibroblasts by Rac1
26. Production of hydrogen peroxide by transforming growth factor-β1 and its involvement in induction of egr-1 in mouse osteoblastic cells
27. 2-generating NADPH oxidase in human lung fibroblasts by transforming growth factor β1
28. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α
29. Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes
30. Phorbol 12-myristate 13-acetate (PMA)-induced oxyradical production in rheumatoid synovial cells
31. Detection of superoxide and NADPH oxidase in porcine articular chondrocytes
32. Localization of a constitutively active, phagocytelike NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II
33. Expression of phagocyte NADPH oxidase components in human endothelial cells
34. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
35. Oxidative stress, caloric restriction, and aging
36. Genetic analysis of ageing: Role of oxidative damage and environmental stresses
37. The free radical theory of aging matures
38. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
39. Prooxidant state and tumor promotion
40. A role of oxygen radicals as second messengers
41. d-α-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties