Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma

Journal of Clinical Investigation

Volumn 98, Issue 3, 1996, Pages 785-792

  Sgonc, Roswitha ^a   Gruschwitz, Matthias S ^b   Dietrich, Hermann ^a   Recheis, Heldrun ^a   Gershwin, M Eric ^c   Wick, Georg ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

anti endothelial cell antibodies; apoptosis; autoimmunity; systemic sclerosis; TUNEL

Indexed keywords

CELL ANTIBODY;

ADOLESCENT; ADULT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FOWL; HUMAN; HUMAN TISSUE; INFLAMMATION; KELOID; MALE; NONHUMAN; PRIORITY JOURNAL; SCLERODERMA; SKIN BIOPSY; SKIN FIBROSIS;

EID: 0029999963     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118851     Document Type: Article

References (32)

1. Haynes, D.C., and M.E. Gershwin. 1982. The immunopathology of progressive systemic sclerosis (PSS). Semin. Arthritis Rheum. 11:331-351.
2. Krieg, T., and M. Meurer. 1988. Systemic scleroderma. Clinical and pathophysiologic aspects. J. Am. Acad. Dermatol. 18:457-481.
3. Black, C.M. 1993. The aetiopathogenesis of systemic sclerosis. J. Intern. Med. 234:3-8.
4. Fleischmajer, R. 1995. Localized and systemic scleroderma. In Connective Tissue Diseases of the Skin. C.M. Lapière and T. Krieg, editors. Marcel Dekker, Inc., New York. 295-314.
5. Russel, M.L. 1983. The tight-skin mouse: is it a model for scleroderma? J. Rheumatol. 10:679-688.
6. Jimenez, S.A., A. Millan, and R.I. Bashey. 1984. Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight-skin) mouse. Arthritis Rheum. 27:180-185.
7. Gershwin, M.E., H. Abplanalp, R.M. Castles, J. Ikeda, J. Van De Water, J. Eklund, and D. Haynes. 1981. Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J. Exp. Med. 153:1640-1659.
8. Van De Water, J., M.E. Gershwin, H. Abplanalp, G. Wick, and K. von der Mark. 1984. Serial observations and definition of mononuclear cell infiltrates in avian scleroderma, an inherited fibrotic disease of chickens. Arthritis Rheum. 27:807-815.
9. Wilson, T.J., J. Van De Water, F.C. Mohr, R.L. Boyd, A. Ansari, G. Wick, and M.E. Gershwin. 1992. Avian scleroderma: evidence for qualitative and quantitative T cell defects. J. Autoimmun. 5:261-276.
10. Van De Water, J., and M.E. Gershwin. 1986. Avian scleroderma. An inherited fibrotic disease of White Leghorn chickens resembling progressive systemic sclerosis. Am. J. Pathol. 120:478-482.
11. Van De Water, J., L. Haapanen, R. Boyd, H. Abplanalp, and M.E. Gershwin. 1989. Identification of T cells in early dermal lymphocytic infiltrates in avian scleroderma. Arthritis Rheum. 32:1031-1040.
12. Gruschwitz, M.S., Y. Shoenfeld, M. Krupp, M.E. Gershwin, E. Penner, H.-P. Brezinschek, and G. Wick. 1993. Antinuclear antibody profile in UCD line 200 chickens: a model for progressive systemic sclerosis. Int. Arch. Allergy Immunol. 100:307-313.
13. Gruschwitz, M., S. Moormann, H. Dietrich, R. Timpl, A. Colombatti, and G. Wick. 1992. Distribution of matrix proteins in the skin of UCD 200 chickens, a model for progressive systemic sclerosis. Arch. Dermatol. Res. 284:64a. (Abstr.)
14. Gruschwitz, M.S., S. Moormann, G. Krömer, R. Sgonc, H. Dietrich, G. Boeck, M.E. Gershwin, R. Boyd, and G. Wick. 1991. Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma. J. Autoimmun. 4:577-593.
15. Prescott, R.J., A.J. Freemont, C.J. Jones, J. Hoyland, and P. Fielding. 1992. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J. Pathol. 166:255-263.
16. Kahaleh, B. 1993. Immunologic aspects of scleroderma. Curr. Opin. Rheumatol. 5:760-765.
17. Blann, A.D., K. Illingworth, and M.I. Jayson. 1993. Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud's phenomenon. J Rheumatol. 20:1325-1330.
18. Abplanalp, H., M.E. Gershwin, E. Johnston, and J. Reid. 1990. Genetic control of avian scleroderma. Immunogenetics. 31:291-295.
19. Wick, G., K. Hála, H.P. Brezinschek, H. Dietrich, H. Wolf, and G. Kroemer. 1989. The obese strain (OS) of chicken: an animal model for spontaneous autoimmune thyroiditis. Adv. Immunol. 47:433-500.
20. Dietrich, H.M. 1989. Housing, breeding and selecting chickens of the obese strain (OS) with spontaneous autoimmune thyroiditis. Lab. Anim. 23: 345-352.
21. "Arbeitsgruppe Sklerodermie" der Arbeitsgemeinschaft Dermatologische Forschung (ADF). 1986. Klinik der progressiven systemischen Sklerodermie (PSS). Hautarzt. 37:320-324.
22. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. 1980. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 23:581-590.
23. Gruschwitz, M.S., O.P. Hornstein, and P. von den Driesch. 1995. Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity. Arthritis Rheum. 38: 184-189.
24. Kahaleh, M.B., G.L. Sultany, E.A. Smith, J.E. Huffstutter, C.B. Loadholt, and E.C. LeRoy. 1986. A modified scleroderma skin scoring method. Clin. Exp. Rheumatol. 4:367-369.
25. Sgonc, R., G. Boeck, H. Dietrich, J. Gruber, H. Recheis, and G. Wick. 1994. Simultaneous determination of cell surface antigens and apoptosis. Trends Genet. 10:41-42.
26. Rosenbaum, J., B.E. Pottinger, P. Woo, C.M. Black, S. Loizou, M.A. Byron, and J.D. Pearson. 1988. Measurement and characterization of circulating anti-endothelial cell IgG in connective tissue diseases. Clin. Exp. Immunol. 72:450-156.
27. Yoshio, T. 1993. Anti-endothelial cell antibodies. Rinsho. Byori. 41:851-858.
28. Carvalho, D., C.O. Savage, C.M. Black, and J.D. Pearson. 1996. IgG anti-endothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J. Clin. Invest. 97:111-119.
29. Marks, R.M., M. Czerniecki, B.S. Andrews, and R. Penny. 1988. The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody-dependent cellular cytotoxicity. Arthritis Rheum. 31:1524-1534.
30. Holt, C.M., N. Lindsey, J. Moult, R.G. Malia, M. Greaves, A. Hume, N.R. Rowell, and P. Hughes. 1989. Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis. Clin. Exp. Immunol. 78:359-365.
31. Penning, C.A., J. Cunningham, M.A. French, G. Harrison, N.R. Rowell, and P. Hughes. 1984. Antibody-dependent cellular cytotoxicity of human vascular endothelium in systemic sclerosis. Clin. Exp. Immunol 57:548-556.
32. Vismara, A., P.L. Meroni, A. Tincani, E.N. Harris, W. Barcellini, A. Brucato, M. Khamashta, G.R.V. Hughes, C. Zanussi, and G. Balestrieri. 1988. Relationship between anti-cardiolipin and anti-endothelial cell antibodies in systemic lupus erythematosus. Clin. Exp. Immunol. 74:247-253.