Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor β receptors

Arthritis and Rheumatism

Volumn 44, Issue 2, 2001, Pages 474-480

  Ihn, Hironobu ^a   Yamane, Kenichi ^a   Kubo, Masahide ^a   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; COLLAGEN SYNTHESIS; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SCLERODERMA; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0035089825     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200102)44:2<474::aid-anr67>3.0.co;2-%23     Document Type: Article

References (32)

1. Systemic sclerosis (scleroderma)
2. Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis
3. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
4. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblast
5. Increased collagen accumulation in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma)
6. Increased expression of type VI collagen genes in systemic sclerosis
7. Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-β
8. Elevated expression of type VII collagen in the skin of patients with systemic sclerosis: Regulation by transforming growth factor-beta
9. Transforming growth factor beta: Selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis
10. Myofibroblasts from scleroderma skin synthesize elevated levels of collagen tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TMP-1
11. Activation of tissue inhibitor of metalloproteinase-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts
12. Expression and function of surface antigens on scleroderma fibroblasts
13. Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: Enhancement by inflammatory cytokines
14. Selective upregulation of platelet-derived growth factor α receptors by transforming growth factor β in scleroderma fibroblasts
15. Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts; insensitivity to TGF-β stimulation
16. Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts; Insensitivity of sclerodermal and keloidal fibroblasts
17. Regulation of interleukin-4 on collagen gene expression by systemic sclerosis fibroblasts in culture
18. The transforming growth factor-β family
19. A strategy for determining the pathogenesis of systemic sclerosis: Is transforming growth factor β the answer?
20. Increased expression of TGF-βreceptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
21. Transcriptional regulation of the human α2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting elements
22. Plasma transforming growth factor-α1 in patients with hepatocellular carcinoma
23. Sp3 is a transcriptional activator of the human α2(I) collagen gene
24. Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3 binding site
25. Stimulation of collagen synthesis by anabolic steroid stanozol
26. Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal and mouse embryonic palate fusion
27. Secretion and binding of transforming growth factor β by scleroderma and normal dermal fibroblasts
28. Transcriptional activation of the α1(I) procollagen gene in systemic sclerosis dermal fibroblasts: Role of intronic sequences
29. Physiological actions and clinical applications of transforming growth factor-β(TGF-β)
30. Transforming growth factor β in tissue fibrosis
31. Transforming growth factor β1 positively regulates its own expression in normal and transformed cells
32. Anti-sclerotic effect of transforming growth factor-β antibody in a mouse model of bleomycin-induced scleroderma