Antagonistic effects of TNF-α on TGF-β signaling through down-regulation of TGF-β receptor type II in human dermal fibroblasts

Journal of Immunology

Volumn 171, Issue 7, 2003, Pages 3855-3862

  Yamane, Kenichi ^a   Ihn, Hironobu ^a   Asano, Yoshihide ^a   Jinnin, Masatoshi ^a   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CALPASTATIN; COLLAGEN; I KAPPA B ALPHA; INHIBITOR PROTEIN; LYMPHOTOXIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SMAD3 PROTEIN; SMAD7 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; DESENSITIZATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SYSTEMIC SCLEROSIS; TISSUE REPAIR; TRANSACTIVATION;

EID: 0141955064     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3855     Document Type: Article

References (54)

1. Massagué, J. 1990. The transforming growth factor-β family. Annu. Rev. Cell Biol. 6:597.
2. Border, W. A., and N. A. Noble. 1994. Transforming growth factor β in tissue fibrosis. N. Engl. J. Med. 331:1286.
3. Miyazono, K., P. ten Dijke, and C. H. Heldin. 2000. TGF-β signaling by Smad proteins. Adv. Immunol. 75:115.
4. Attisano, L., and J. L. Wrana. 1996. Signal transduction by members of the transforming growth factor-β superfamily. Cytokine Growth Factor Rev. 7:327.
5. Wrana, J. L., L. Atissano, R. Weiser, F. Ventura, and J. Massagué. 1994. Mechanism of activation of the TGF-β receptor. Nature 370:341.
6. Heldin, C. H., K. Miyazono, and P. ten Dijke. 1997. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390:465.
7. Massagué, J. 1998. TGF-β signal transduction. Annu. Rev. Biochem. 67:753.
8. Chen, X., M. J. Rubock, and M. Whitman. 1996. A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383:691.
9. Dennler, S., S. Itoh, D. Vivien, P. ten Dijke, S. Huet, and J. M. Gauthier. 1998. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:3091.
10. Song, C. Z., T. E. Siok, and T. D. Gelehrter, 1998. Smad4/DPC4 and Smad3 mediate transforming growth factor-β (TGF-β) signaling through direct binding to a novel TGF-β-responsive element in the human plasminogen activator inhibitor-1 promoter. J. Biol. Chem. 273:29287.
11. Labbe, E., C. Silvestri, P. A. Hoodless, J. L. Wrana, and L. Attisano. 1998. Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2:109.
12. Goldring, M. B. 1999. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect. Tissue Res. 40:1.
13. Solis-Herruzo, J. A., D. A. Brenner, and M. Chojkier. 1988. Tumor necrosis factor α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J. Biol. Chem. 263:5841.
14. Kahari, V. M., Y. Q. Chen, M. M. Bashir, J. Rosenbloom, and J. Uitto. 1992. Tumor necrosis factor-α down-regulates human elastin gene expression: evidence for the role of AP-1 in the suppression of promoter activity. J. Biol. Chem. 267:26134.
15. Kahari, V. M., Y. Q. Chen, M. W. Su, F. Ramirez, and J. Uitto. 1990. Tumor necrosis factor-α and interferon-γ suppress; the activation of human type 1 collagen gene expression by transforming growth factor-β1: evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels. J. Clin. Invest. 86:1489.
16. Verrecchia, F., M. Pessah, A. Atfi, and A. Mauviel. 2000. Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation. J. Biol. Chem. 275:30226.
17. Bitzer, M., von G. Gersdorff, D. Liang, A. Dominguez-Rosales, A. A. Beg, M. Rojkind, and E. P. Böttinger. 2000. A mechanism of suppression of TGF-β/SMAD signaling by NF-κB/RelA. Genes Dev. 14:187.
18. Nagarajan, R. P., F. Chen, W. Li, E. Vig, M. A. Harrington, H. Nakshatri, and Y. Chen. 2000. Repression of transforming-growth-factor-β-mediated transcription by nuclear factor κB. Biochem. J. 348:591.
19. Zhang, Y., X. H. Feng, and R. Derynck. 1998. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394:909.
20. Ihn, H., K. Ohnishi, T. Tamaki, E. C. LeRoy, and M. Trojanowska. 1996. Transcriptional regulation of the human α2(I) collagen gene: combined action of upstream stimulatory and inhibitory cis-acting elements. J. Biol. Chem. 271:26717.
21. Ihn, H., E. C. LeRoy, and M. Trojanowska. 1997. Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site. J. Biol. Chem. 272:24666.
22. Ihn, H., K. Yamane, M. Kubo, and K. Tamaki. 2001. Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors. Arthritis Rheum. 44:474.
23. Choi, S. G., Y. Yi, Y. S. Kim, M. Kato, J. Chang, H. W. Chung, K. B. Hahm, H. K. Yang, H. H. Rhee, Y. J. Bang, and S. J. Kim. 1998. A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-β type II receptor. J. Biol. Chem. 273:110.
24. Wood, W. M., M. Y. Kao, D. F. Gordon, and E. C. Ridgway. 1989. Thyroid hormone regulates the mouse thyrotropin β-subunit gene promoter in transfected primary thyrotropes. J. Biol. Chem. 264:14840.
25. Maxwell, I. H., G. H. Harrison, W. M. Wood, and F. Maxwell. 1989. A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription. BioTechniques 7:276.
26. Kawakami, T., H. Ihn, W. Xu, E. Smith, E. C. LeRoy, and M., Trojanowska. 1998. Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype. J. Invest. Dermatol. 110:47.
27. Nakao, A., M. Afrakhte, A. Moren, T. Nakayama, J. L. Christian, R. Heuchel, S. Itoh, M. Kawabata, N.-E. Heldin, C.-H. Heldin, and P. ten Dijke. 1997. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389:631.
28. Brodin, G., A. Ahgren, P. ten Dijke, C.-H. Heldin, and R. Heuchel. 2000. Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J. Biol. Chem. 275:29023.
29. Gersdorff, G. V., K. Susztak, F. Rezvani, M. Bitzer, D. Lian, and E. P. Bottinger. 2000. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β. J. Biol. Chem. 275:11320.
30. Denissova, N. G., C. Pouponnot, J. Long, D. He, and F. Liu. 2000. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter, Proc. Natl. Acad. Sci. USA 97:6397.
31. Topper, J. N., J. Cai, Y. Qiu, K. R. Anderson, Y.-Y. Xu, J. D. Deeds, R. Feeley, C. J. Gimeno, E. A. Woolf. O. Tayber, et al. 1997. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. USA 94:9314.
32. LeRoy, E. C. 1992. Systemic sclerosis (scleroderma). In Cecil Text Book of Medicine, 19th Ed. J. B. Wyngaarden, L. H. Smith, and J. C. Bennett, eds. WB Saunders. Philadelphia, pp. 1530-1535.
33. Kulozik, M., A. Hogg, B. Lankat-Buttgereit, and T. Krieg. 1990. Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. J. Clin. Invest. 86:917.
34. Jelaska, A., M. Arakawa, G. Broketa, and J. H. Korn. 1996. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: increased proportion of high collagen-producing cells in systemic sclerosis skin fibroblasts. Arthritis Rheum. 39:1338.
35. Bou-Gharios, G., J. Osman, C. Black, and L. Olsen. 1994. Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis. Clin. Chim. Acta 231:69.
36. Kirk, T. Z., M. E. Mark, C. C. Chua, B. H. Chua, and M. D. Mayes. 1995. Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1. J. Biol. Chem. 270:3423.
37. Fine, A., M. P. Panchenko, B. D. Smith, Q. Yu, and R. H. Goldstein. 1995. Discordant regulation of transforming growth factor-β receptors by prostaglandin E2. Biochim. Biophys. Acta 1261:19.
38. Iimura, T., S. Oida, H. Ichijo, M. Goseki, Y. Maruoka, K. Takeda, and S. Sasaki. 1994. Modulation of responses to TGF-β by 1, 25 dihydroxyvitamin D3 in MG-63 osteoblastic cells: possible involvement of regulation of TGF-β type II receptor. Biochem. Biophys. Res. Commun. 204:918.
39. Brandes, M. E., L. M. Wakefield, and S. M. Wahl. 1991. Modulation of monocyte type 1 transforming growth factor-β receptors by inflammatory stimuli. J. Biol. Chem. 266:19697.
40. Bloom, B. B., D. E. Humphries, P. P. Kuang, A. Fine, and R. H. Goldstein, 1996. Structure and expression of the promoter for the R4/ALK5 human type 1 transforming growth factor-β receptor: regulation by TGF-β. Biochim. Biophys. Acta 1312:243.
41. Moreland, R. B., A. Traish, M. A. McMillin, B. Smith, I. Goldstein, and I. Saenz de Tejada. 1995. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-β1 in human corpus cavernosum smooth muscle. J. Urol. 153:826.
42. 1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J. Biol. Chem. 272:29309.
43. Wang, D., L. Sun, E. Zborowska, J. K. Willson, J. Gong, J. Verraraghavan, and M. G. Brattain. 1999. Control of type II transforming growth factor-β receptor expression by integrin ligation. J. Biol. Chem. 274:12840.
44. Ebisawa, T., M. Fukuchi, G. Murakami, T. Chiba, K. Tanaka, T. Imamura, and K. Miyazono, 2001. Smurf1 interacts with transforming growth factor-β type 1 receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276:12477.
45. Kavsak, P., R. K. Rasmussen, C. G. Causing, S. Bonni, H. Zhu, G. H. Thomsen, and J. L. Wrana. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation. Mol. Cell 6:1365.
46. Kim, S. J., Y. H. Im, S. D. Markowitz, and Y. J. Bang. 2000. Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis. Cytokine Growth Factor Rev. 11:159.
47. Kubo, M., H. Ihn, K. Yamane, and K. Tamaki. 2001. Up-regulated expression of transforming growth factor β receptors in dermal fibroblasts in skin sections from patients with localized scleroderma. Arthritis Rheum. 44:731.
48. Roulot, D., A. M. Sevcsik, T. Coste, A. D. Strosberg, and S. Marullo. 1999. Role of transforming growth factor β type II receptor in hepatic fibrosis: studies of human chronic hepatitis C and experimental fibrosis in rats. Hepatology 29:1730.
49. Li, G., R. K. Li, D. A. Mickle, R. D. Weisel, F. Merante, W. T. Ball, G. T. Christakis, R. J. Cusimano, and W. G. Williams. 1998. Elevated insulin-like growth factor-1 and transforming growth factor-β1 and their receptors in patients with idiopathic hypertrophic obstructive cardiomyopathy: a possible mechanism. Circulation 98:144.
50. Kanzaki, T., R. Shiina, Y. Saito, L. Zardi, and N. Morisaki, 1997. Transforming growth factor-β receptor and fibronectin expressions in aortic smooth muscle cells in diabetic rats. Diabetologia 40:383.
51. Needleman, B. W., J. Choi, A. Burrows-Mezu, and J. A. Fontana. 1990. Secretion and binding of transforming growth factor β by scleroderma and normal dermal fibroblasts. Arthritis Rheum. 33:650.
52. Laiho, M., M. B. Weis, and J. Massagué. 1990. Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β-resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265:18518.
53. Laiho, M., M. B. Weis, F. T. Boyd, R. A. Ignotz, and J. Massagué. 1991. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J. Biol. Chem. 266:9108.
54. Wrana, J. L., and L. Attisano. 2000. The Smad pathway. Cytokine Growth Factor Rev. 11:5.