Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

Blood

Volumn 100, Issue 4, 2002, Pages 1160-1167

  Angus McQuibban, G ^a,b   Gong, Jiang Hong ^a,b   Wong, Julie P ^a,b   Wallace, John L ^a,b   Clark Lewis, Ian ^a,b   Overall, Christopher M ^a,b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c 2199 Wesbrook Mall ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CARRAGEENAN; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; GELATINASE A; MATRILYSIN; METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENZYME ACTIVITY; IMMUNE RESPONSE; LEUKEMIA CELL LINE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; WOUND HEALING;

EID: 0037103183     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v100.4.1160.h81602001160_1160_1167     Document Type: Article

References (43)

1. Multistep navigation and the combinatorial control of leukocyte chemotaxis
2. Chemokines: A new classification system and their role in immunity
3. Early responses to infection: Chemokines as mediators of inflammation
4. Chemokines and leukocyte traffic
5. Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: Effects of posttranslation modifications on receptor usage, chemotactic and anti-HIV-1 activity
6. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity: Functional comparison of different natural isoforms
7. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
8. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
9. Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues
10. The role of CD26/DPP IV in chemokine processing
11. Rapid inactivation of stromal cell-derived factor-1 by cathpsin G associated with lymphocytes
12. Matrix metalloproteinases
13. In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse
14. Cell migration in the immune system: The evolving inter-related roles of adhesion molecules and proteinases
15. Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type I collagenase), and -3 (stromelysin)
16. The serpin alphal-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
17. Processing of tumor necrosis factor-alpha precursor by metalloproteinases
18. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1
19. The metalloproteinase matrilysin (MMP-7) proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
20. Matrilysin expression selects for cells with reduced sensitivity to apoptosis
21. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
22. Mannose binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: Potential role in MBL deficiency
23. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact
24. Tissue inhibitor of metalloproteinases-4 (TIMP-4) inhibits, but does not support, the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
25. RANTES MCP-3 antagonists bind multiple chemokine receptors
26. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
27. Extracellular matrix remodeling during morphogenesis
28. Matrix degradation in hard and soft connective tissues
29. Matrix metalloproteinases in tumor invasion and metastasis
30. Molecular determinants of substrate specificity: Matrix metalloproteinase substrate binding domains, modules and exosites
31. Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2
32. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts: Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases
33. O-glycan analysis of natural human neturophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: Implications for the domain organization of the enzyme
34. Mechanism of cell surface activation of 72-kDa type IV collagenase: Isolation of the activated form of the membrane metalloproteinase
35. Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: Identification of MCP-2(6-76) as a natural chemokine inhibitor
36. Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1,2, and 3
37. Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines
38. Differential MMP and TIMP production by human marrow and peripheral blood CD34(+) cells in response to chemokines
39. Soluble factor(s) released from neutrophils activates endothelial cell matrix metalloproteinase-2
40. Transcriptional and post-translational regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts: Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression
41. Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA
42. Chemokines: Immunology's high impact factors