The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia

Neuroscience Letters

Volumn 284, Issue 1-2, 2000, Pages 109-112

  Plaschke, Konstanze ^a   Kopitz, Jürgen ^a   Weigand, Markus A ^a   Martin, Eike ^a   Bardenheuer, Hubert J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

3 aminobenzamide; Energy state; Global ischemia; Poly(ADP ribose) polymerase; Rat brain

Indexed keywords

3 AMINOBENZAMIDE; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; COMMON CAROTID ARTERY; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; HYPOTENSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BENZAMIDES; BRAIN ISCHEMIA; CAROTID ARTERY, COMMON; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; ENERGY METABOLISM; HYPOTENSION; MALE; NEUROPROTECTIVE AGENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0034697060     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00988-5     Document Type: Article

References (24)

1. Aalto T.K., Raivio K.O. Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants and 3-aminobenzamide. Pediatr. Res. 34:1993;572-576.
2. Berger N.A. Poly(ADP-ribose) in the cellular response to DNA damage. Radiat. Res. 101:1985;4-15.
3. Bowes J., Thiemermann C. Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers. Br. J. Pharmacol. 124:1998;1254-1260.
4. Cosi C., Suzuki H., Milani D., Facci L., Vantini G., Kanai Y., Skaper S.D. Poly(ADP-ribose)polymerase: early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cells. J. Neurosci. Res. 39:1994;38-46.
5. Cuzzocrea S., Zingarelli B., O'Connor M., Salzman A.L., Caputi A.P., Szabo C. Role of peroxynitrite in the vascular failure induced by zymosan-activated plasma. Br. J. Pharmacol. 122:1997;493-503.
6. Endres M., Wang Z.Q., Namura S., Waeber C., Moskowitz M.A. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J. Cereb. Blood Flow Metab. 17:1997;1143-1151.
7. Eliasson M.J.L., Sampei K., Mandir A.S., Hurn P.D., Traystman R.J., Bao J., Pieper A., Wang Z.O., Dawson T.M., Snyder S.H., Dawson V.L. Poly(ADP-ribose)polymerase gene disruption render mice resistant to cerebral ischemia. Nat. Med. 3:1997;1089-1095.
8. Heller B., Wang Z.Q., Wagner E.F., Radons J., Burkle A., Fehsel K., Burkart V., Kolb H. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem. 270:1995;11176-11180.
9. Johnson G.S. Benzamide and its derivatives inhibit nicotinamide methylation as well as ADP-ribosylation. Biochem. Int. 2:1981;611-617.
10. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin Phenol reagent. J. Biol. Chem. 193:1951;265-275.
11. Milam K.M., Cleaver J.E. Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes. Science. 223:1984;589-591.
12. Plaschke K., Bardenheuer H.J., Weigand M.A., Martin E., Hoyer S. Increased ATP production during long-term brain ischemia in the presence of propentofylline. Eur. J. Pharmacol. 349:1998;33-40.
13. Plaschke K., Yun S.W., Martin E., Hoyer S., Bardenheuer H.J. Interrelation between cerebral energy metabolism and rat behaviour in a rat model of permanent brain vessel occlusion. Brain Res. 830:1999;320-329.
14. Prasad S.C., Soldatenkov V., Notario V., Smulson M., Dritschilo A. Detection of heterogeneity of poly (ADP-ribose) polymerase in MDA-MD-468 breast cancer cells: two-dimensional gel analysis. Electrophoresis. 20:1999;618-625.
15. Radons J., Heller B., Burkle A., Hartmann B., Rodriguez M., Kroncke K., Burkart V., Kolb H. Nitric oxide toxicity in islet cells involves poly (ADP-ribose) polymerase activation and concomitant NAD depletion. Biochem. Biophys. Res. Commun. 199:1994;1270-1277.
16. Schraufstatter I.U., Hyslop P.A., Hinshaw D.B., Spragg R.G., Sklar L.A., Cochrane C.G. Hydrogene peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose)polymerase. Proc. Natl. Acad. Sci. USA. 83:1986;4908-4912.
17. Smith M.L., Auer R.N., Siesjö B.K. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. 64:1984;319-332.
18. Szabo C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA. 93:1996;1753-1758.
19. Thiemermann C., Bowes J., Myint F., Vane J.R. Inhibition of activity of poly(ADP)ribose synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. USA. 94:1997;679-683.
20. Thies R., Autor A. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch. Biochem. Biophys. 2:1991;353-363.
21. Tokime T., Nozaki K., Sugino T., Kikuchi H., Hashimoto N., Ueda K. Enhanced poly(ADP-ribolsyl)ation after focal ischemia in rat brain. J. Cereb. Blood Flow Metab. 18:1998;991-997.
22. Wallis R.A., Panizzon K.L., Hanry D., Wasterlain C.G. Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation. NeuroReport. 5:1993;245-248.
23. Zingarelli B., Cuzzocrea S., Zsengeller Z., Salzman A.L., Szabo C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase. Cardiovasc. Res. 36:1997;205-215.
24. Zhang J., Dawson T.M., Snyder S.H. Nitric oxide activation of poly(ADP-ribose)synthetase in neurotoxicity. Science. 263:1994;687-689.