Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression

Stroke

Volumn 27, Issue 8, 1996, Pages 1381-1385

  Lo, Eng H ^a,b   Hara, Hideaki ^a   Rogowska, Jadwiga ^a   Trocha, Marek ^a   Pierce, Allen R ^a   Huang, Paul L ^a   Fishman, Mark C ^a   Wolf, Gerald L ^a   Moskowitz, Michael A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

cerebral ischemia, focal; hemodynamics; mice; nitric oxide synthase; tomography

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN MAPPING; DELETION MUTANT; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029821693     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.27.8.1381     Document Type: Article

References (27)

1. Dalkara T, Moskowitz MA. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 1994;4: 49-57.
2. Dawson DA. Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcomes. Cerebrovasc Brain Metab Rev. 1994;6:299-324.
3. Faraci FM, Brian JE. Nitric oxide and the cerebral circulation. Stroke. 1994;25:692-703.
4. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. 1994;14:175-192.
5. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
6. Hara H, Huang PL, Panahian N, Fishman MC, Moskowitz MA. Reduced brain edema and infarction volume in mice lacking neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab. 1996;16:605-611.
7. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-1885.
8. Huang Z, Huang PL, Fishman MC, Moskowitz MA. Focal cerebral ischemia in mice deficient in either endothelial (eNOS) or neuronal nitric oxide (nNOS) synthase. Stroke. 1996;27:173. Abstract.
9. Yoshida T, Limmroth V, Irikura K, Moskowitz MA. The NOS inhibitor 7-nitroindazole decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J Cereb Blood Flow Metab. 1994;14:924-930.
10. Morikawa E, Moskowitz M, Huang C, Yoshida T, Irikura K, Dalkara T. L-Arginine infusion promotes nitric oxide-dependent vasodilation, increases rCBF, and reduces infarct volume in rats. Stroke. 1993; 25:429-435.
11. Morikawa E, Huang Z, Rosenblatt S, Yoshida T, Moskowitz MA. Therapeutic potential of L-arginine, a precursor of nitric oxide in focal ischemia. Br J Pharmacol. 1994;107:905-908.
12. Zhang F, White JG, Iadecola C. Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab. 1994;14:217-226.
13. Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC, Moskowitz MA. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab. In press.
14. Lo EH, Rogowska J, Bogorodzki P, Trocha M, Matsumoto K, Saffran BN, Wolf GL. Temporal correlation analysis of penumbral dynamics in focal cerebral ischemia. J Cereb Blood Flow Metab. 1995;16: 60-68.
15. Lo EH, Rogowska J, Bogorodzki P, Trocha M, Matsumoto K, Saffran BN, Wolf GL. A new method for imaging the penumbra in focal ischemia: temporal evolution and correlation with histologic out-comes. J Cereb Blood Flow Metab. 1995;15(suppl 1):s324. Abstract.
16. Lo EH, Rogowska J, Batchelder K, Wolf GL. Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging. Neurol Res. 1996;18:150-156.
17. Rogowska J, Preston K, Hunter GJ, Hamberg LM, Kwong KK, Salonen O, Wolf GL. Applications of similarity mapping in dynamic MRI. IEEE Trans Med Imaging. 1995;14:480-486.
18. Rogowska J, Lo EH, Bogorodzki P, Trocha M, Wolf GL. New temporal correlation techniques for imaging the penumbra in stroke. Pharm Res. 1995;12:s102. Abstract.
19. Zierler KL. Theoretical basis for indicator dilution methods for measuring flow and volume. Circ Res. 1962;10:393-407.
20. Axel L. Cerebral blood flow determination by rapid sequence computed tomography: a theoretical analysis. Radiology. 1980;137: 679-686.
21. Goetze AHG, Bock JC, Heyer C, Weinmann HJ, Felix R. Experimental validation of susceptibility-contrast cerebral blood flow measurement by a microsphere reference method. Proc Soc Magn Reson. 1994;1:446. Abstract.
22. Muller TB, Haraldseth O, Jones RA, Sebastiani G, Godtliebsen F, Lindboe CF, Unsgard G. Combined perfusion and diffusion-weighted MRI in a rat model of reversible middle cerebral artery occlusion. Stroke. 1995;26:451-458.
23. Weisskoff RM, Chesler D, Boxerman J, Rosen BR. Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? Magn Reson Med. 1993;29:553-559.
24. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
25. Sober BJ, Gillard JH, Barker PB, Oppenheimer SM, Bryan RN. Dynamic GdDTPA MRI in acute stroke: comparison of relative cerebral blood volume and bolus arrival times. Proc Am Soc Neuroradiol. 1995;33:22. Abstract.
26. Warach S, Wielopski P, Edelman R. Identification and characterization of the ischemic penumbra of acute human stroke using echoplanar diffusion and perfusion imaging. Soc Magn Reson Med Abstr. 1993;12:249. Abstract.
27. Heiss WD, Graf R, Weinhard K, Lottgen J, Sito R, Fujita T, Rosner G, Wagner R. Dynamic penumbra demonstrated by sequential multitracer PET after MCAO in cats. J Cereb Blood Flow Metab. 1994;14:892-902.